Affiliation: Boston University
- Adiponectin in cardiovascular inflammation and obesityTamar R Aprahamian
Renal Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Int J Inflam 2011:376909. 2011..This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies...
- The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosusChristophe Richez
Service de Rhumatologie, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France
PLoS ONE 8:e61042. 2013..This data suggests that the effects of MMF on the immune system may not only be beneficial for lupus, but also for inflammation driving lupus-associated atherosclerosis...
- Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesityTamar R Aprahamian
Department of Medicine Renal Section, Boston University School of Medicine, 650 Albany Street, X536, Boston, MA 02118, USA Electronic address
Metabolism 62:1730-8. 2013..Here, I focused on the fat-derived cytokine adiponectin as a model system to understand the mechanism underlying adipose tissue vascularity, perfusion, inflammation, and systemic metabolic function...
- Ageing is associated with diminished apoptotic cell clearance in vivoT Aprahamian
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
Clin Exp Immunol 152:448-55. 2008..These data show that the ageing process is accompanied by a diminished ability to clear apoptotic debris. This accumulation of apoptotic debris could contribute to immune system dysfunction that occurs in aged organisms...
- Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient miceR Summer
The Pulmonary Center, R 304, Boston Univ School of Medicine, 80 E Concord St, Boston, MA 02118, USA
Am J Physiol Lung Cell Mol Physiol 294:L1035-42. 2008..Together, our findings show that adiponectin leads to macrophage suppression in the lung and suggest that adiponectin-deficient states may contribute to the pathogenesis of inflammatory lung conditions such as emphysema...