Deborah J Anderson

Summary

Affiliation: Boston University School of Medicine
Country: USA

Publications

  1. doi request reprint A quantitative glycogen assay to verify use of self-administered vaginal swabs
    Deborah J Anderson
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston 02118, MA
    Sex Transm Dis 39:949-53. 2012
  2. pmc HIV infection and immune defense of the penis
    Deborah Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    Am J Reprod Immunol 65:220-9. 2011
  3. doi request reprint Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluid
    Deborah J Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany St, Suite 516, Boston, MA 02118, USA
    Am J Reprod Immunol 61:121-9. 2009
  4. pmc Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually active HIV-infected men who have sex with men
    Joseph A Politch
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    AIDS 26:1535-43. 2012
  5. ncbi request reprint Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men
    Joseph A Politch
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Reprod 22:2928-35. 2007
  6. pmc Depletion of CD4+ T cells in semen during HIV infection and their restoration following antiretroviral therapy
    Joseph A Politch
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 50:283-9. 2009
  7. pmc Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
    Guntram Bezold
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 87:1087-97. 2007
  8. ncbi request reprint Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    Jeffrey Pudney
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:1253-63. 2005
  9. ncbi request reprint Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cycles
    Antonio R Gargiulo
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 82:1226-34. 2004
  10. pmc Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia
    Caitlin D Blaskewicz
    Department of Molecular Medicine, Obstetrics and Gynecology, and Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biol Reprod 85:97-104. 2011

Research Grants

Collaborators

Detail Information

Publications22

  1. doi request reprint A quantitative glycogen assay to verify use of self-administered vaginal swabs
    Deborah J Anderson
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston 02118, MA
    Sex Transm Dis 39:949-53. 2012
    ..The goal of this study was to determine whether a quantitative glycogen assay can be used to assess whether a swab has been exposed to the vagina to assure study compliance...
  2. pmc HIV infection and immune defense of the penis
    Deborah Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Boston, MA 02118, USA
    Am J Reprod Immunol 65:220-9. 2011
    ..The penile urethral mucosa contains accumulations of IgA(+) plasma cells and T lymphocytes and may provide a responsive target for future mucosal vaccines to prevent HIV sexual transmission...
  3. doi request reprint Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluid
    Deborah J Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany St, Suite 516, Boston, MA 02118, USA
    Am J Reprod Immunol 61:121-9. 2009
    ..The purpose of this study was to determine whether use of a diaphragm with microbicide or placebo gel causes cervicovaginal inflammation or perturbations in cervicovaginal immune defense...
  4. pmc Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually active HIV-infected men who have sex with men
    Joseph A Politch
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    AIDS 26:1535-43. 2012
    ..In this study, we determined the prevalence of seminal HIV shedding in HIV-infected MSM on stable HAART, and its relationship with a number of clinical, behavioral and biological variables...
  5. ncbi request reprint Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men
    Joseph A Politch
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Reprod 22:2928-35. 2007
    ..The purpose of this study was to establish normal reference values for several immunologic factors in semen to provide a foundation for understanding their physiologic significance in health and disease...
  6. pmc Depletion of CD4+ T cells in semen during HIV infection and their restoration following antiretroviral therapy
    Joseph A Politch
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 50:283-9. 2009
    ....
  7. pmc Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia
    Guntram Bezold
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 87:1087-97. 2007
    ....
  8. ncbi request reprint Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone
    Jeffrey Pudney
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:1253-63. 2005
    ....
  9. ncbi request reprint Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cycles
    Antonio R Gargiulo
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 82:1226-34. 2004
    ..To determine whether cytokines implicated in uterine receptivity are detectable in cervicovaginal secretions and/or serum of fertile women, and whether their concentrations undergo hormonal regulation during the menstrual cycle...
  10. pmc Structure and function of intercellular junctions in human cervical and vaginal mucosal epithelia
    Caitlin D Blaskewicz
    Department of Molecular Medicine, Obstetrics and Gynecology, and Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biol Reprod 85:97-104. 2011
    ....
  11. ncbi request reprint Separation of human immunodeficiency virus type 1 from motile sperm by the double tube gradient method versus other methods
    Joseph A Politch
    Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Fertil Steril 81:440-7. 2004
    ....
  12. pmc Expression of toll-like receptors in genital tract tissues from normal and HIV-infected men
    Jeffrey Pudney
    Department of Obstetrics Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Reprod Immunol 65:28-43. 2011
    ..This study was carried out to characterize TLR expression in the human male genital tract, an initial infection site for several sexually transmitted pathogens...
  13. pmc The structure of the human vaginal stratum corneum and its role in immune defense
    Deborah J Anderson
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, USA Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Reprod Immunol 71:618-23. 2014
    ..A better understanding of the molecular and physicochemical properties of the vaginal SC could promote the design of more effective topical drugs and microbicides. ..
  14. ncbi request reprint Cell-associated genital tract virus and vertical transmission of human immunodeficiency virus type 1 in antiretroviral-experienced women
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 187:375-84. 2003
    ..28; 95% CI, 1.09-4.78; P=.03). The cell-associated genital tract compartment is important in the pathophysiology and prevention of vertical HIV-1 transmission...
  15. ncbi request reprint Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss
    Zhigang C Wang
    Fearing Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Reprod 21:818-22. 2006
    ....
  16. ncbi request reprint Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells
    Kerstin Kleine-Lowinski
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Cancer 107:407-15. 2003
    ..These observations are consistent with a model in which MCP-1 expression by infected keratinocytes, which would stimulate an immune attack on HPV-transformed cells, is suppressed for invasive cervical cancer to appear...
  17. ncbi request reprint Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    Raina N Fichorova
    Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:2424-32. 2002
    ..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling...
  18. ncbi request reprint T-lymphocyte profile and total and virus-specific immunoglobulin concentrations in the cervix of HIV-1-infected women
    Alison J Quayle
    Department of Immunology, Microbiology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Acquir Immune Defic Syndr 44:292-8. 2007
    ..The mucosal lymphocyte population is the largest in the body, and the gastrointestinal compartment has been well characterized in HIV infection. Much less is known about the effects of HIV on the genital tract...
  19. ncbi request reprint Implications of blood contamination for assessment of local cellular immunity in the endocervix
    Alison J Quayle
    Department of Immunology, Microbiology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    AIDS Res Hum Retroviruses 20:543-6. 2004
    ....
  20. pmc Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
    ....
  21. ncbi request reprint Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products
    Seyoum Ayehunie
    MatTek Corporation, 200 Homer Avenue, Ashland, MA 01760, USA
    Toxicol In Vitro 20:689-98. 2006
    ..In conclusion, the VEC tissue model is a highly reproducible, non-animal means to assess the irritation of contraceptives, microbicides, and vaginal-care products...

Research Grants15

  1. Seminal HIV-1 Shedding and Drug Resistance in HIV-1/HSV-2 Coinfected Men on HAART
    Deborah Anderson; Fiscal Year: 2007
    ..abstract_text> ..
  2. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah Anderson; Fiscal Year: 2007
    ....
  3. An In Vitro Model of Cell-Associated HIV-1 Transmission
    Deborah Anderson; Fiscal Year: 2006
    ....
  4. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 2003
    ....
  5. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 2003
    ....
  6. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 2002
    ....
  7. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 2000
    ....
  8. HIV 1 IMMUNITY IN THE HUMAN MALE UROGENITAL TRACT
    Deborah Anderson; Fiscal Year: 1999
    ....