S Amar

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings
    Monika Madan
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3204. 2008
  2. pmc Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection
    Guilhem Richard
    Department of Bioinformatics, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e70320. 2013
  3. pmc Bioinformatics analysis of macrophages exposed to Porphyromonas gingivalis: implications in acute vs. chronic infections
    Wen Han Yu
    Bioinformatics Graduate Program, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15613. 2010
  4. pmc Novel regulation of CCL2 gene expression by murine LITAF and STAT6B
    Xiaoren Tang
    Center for Anti Inflammatory Therapeutics, School of Dental Medicine, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25083. 2011
  5. pmc Controlling the outcome of the Toll-like receptor signaling pathways
    Guilhem Richard
    Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31341. 2012
  6. pmc LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages
    Kristen N Bushell
    Boston University School of Medicine Department of Pharmacology and Experimental Therapeutics, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25849. 2011
  7. ncbi request reprint Periodontal innate immune mechanisms relevant to obesity
    S Amar
    Center for Anti Inflammatory Therapeutics, Boston University, School of Dental Medicine, Boston, MA 02118, USA
    Mol Oral Microbiol 28:331-41. 2013
  8. ncbi request reprint The impact of periodontal infection on systemic diseases
    Salomon Amar
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, U S A
    Med Sci Monit 9:RA291-9. 2003
  9. pmc Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge
    Salomon Amar
    Department of Periodontology and Oral Biology, School of Dental Medicine, School of Medicine, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:20466-71. 2007
  10. ncbi request reprint Moesin: a potential LPS receptor on human monocytes
    S Amar
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Endotoxin Res 7:281-6. 2001

Research Grants

  1. INFLAMMATORY PROCESS PERIODONTAL WOUND HEALING
    Salomon Amar; Fiscal Year: 1999
  2. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2007
  3. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2007
  4. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2007
  5. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2009
  6. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2009
  7. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2009
  8. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2010
  9. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2009
  10. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2010

Collaborators

Detail Information

Publications58

  1. pmc Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings
    Monika Madan
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3204. 2008
    ..Toll-like receptors are principal sensors of the innate immune system. Here we report an assessment of the role of the TLR2 pathway in atherosclerosis associated with a high-fat diet and/or bacteria in ApoE(+/-) mice...
  2. pmc Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection
    Guilhem Richard
    Department of Bioinformatics, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e70320. 2013
    ..gingivalis exposure. These data indicate that thrombospondin 1 and arginase 1 are important bacterial response genes, whose regulation is altered in macrophages from obese mice...
  3. pmc Bioinformatics analysis of macrophages exposed to Porphyromonas gingivalis: implications in acute vs. chronic infections
    Wen Han Yu
    Bioinformatics Graduate Program, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15613. 2010
    ..Microarray data from treated macrophages or control cells were analyzed to define molecular signatures. Changes in genes identified in relevant pathways were validated by RT-PCR...
  4. pmc Novel regulation of CCL2 gene expression by murine LITAF and STAT6B
    Xiaoren Tang
    Center for Anti Inflammatory Therapeutics, School of Dental Medicine, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25083. 2011
    ..Mice knockdown for mSTAT6B by 6BsiRNA1 tail vein injection resulted in a decrease in serum TNF-α and CCL2 production. mLITAF/mSTAT6B complex is proposed to play a role in LPS-induced CCL2 expression and possibly other cytokines...
  5. pmc Controlling the outcome of the Toll-like receptor signaling pathways
    Guilhem Richard
    Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31341. 2012
    ..We mapped the species of the TLR network to genes in human and mouse, and determined more than 10,000 Essential Gene Sets (EGS). Each EGS provides genes whose deletion suppresses the network's outputs...
  6. pmc LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages
    Kristen N Bushell
    Boston University School of Medicine Department of Pharmacology and Experimental Therapeutics, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25849. 2011
    ....
  7. ncbi request reprint Periodontal innate immune mechanisms relevant to obesity
    S Amar
    Center for Anti Inflammatory Therapeutics, Boston University, School of Dental Medicine, Boston, MA 02118, USA
    Mol Oral Microbiol 28:331-41. 2013
    ..This review focuses on exploring the immunological consequences of obesity that exacerbate effects of infection by pathogens, with focus on infection by the periodontal bacterium Porphyromonas gingivalis as a running example...
  8. ncbi request reprint The impact of periodontal infection on systemic diseases
    Salomon Amar
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, U S A
    Med Sci Monit 9:RA291-9. 2003
    ..These findings place oral health in the perspective of systemic health, and they suggest that the dental and medical professions should develop even closer ties in the future...
  9. pmc Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge
    Salomon Amar
    Department of Periodontology and Oral Biology, School of Dental Medicine, School of Medicine, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:20466-71. 2007
    ..gingivalis infection and suggest that this immune dysregulation participates in the increased alveolar bone loss after bacterial infection observed in mice with DIO...
  10. ncbi request reprint Moesin: a potential LPS receptor on human monocytes
    S Amar
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Endotoxin Res 7:281-6. 2001
    ..The data suggest that Moesin functions as an independent LPS receptor on human monocytes...
  11. ncbi request reprint Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications
    Salomon Amar
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 182:1584-92. 2009
    ..The present data offer new insights into the pathophysiological pathways involved in atherosclerosis and pave the way for new pharmacological interventions aimed at reducing atherosclerosis...
  12. pmc p53 is an important regulator of CCL2 gene expression
    X Tang
    Center for Anti Inflammatory Therapeutics, Boston University, 650 Albany Street, X 343, Boston, MA 02118, USA
    Curr Mol Med 12:929-43. 2012
    ....
  13. ncbi request reprint Inhibition of SFRP1 reduces severity of periodontitis
    C H Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Dent Res 86:873-7. 2007
    ..The results of our studies suggest that SFRP1 may be involved in the development of periodontitis, since inhibiting SFRP1 resulted in reduced periodontal breakdown...
  14. ncbi request reprint Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis
    A J Delima
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, MA, USA
    J Clin Periodontol 28:233-40. 2001
    ....
  15. ncbi request reprint Doxycycline affects diet- and bacteria-associated atherosclerosis in an ApoE heterozygote murine model: cytokine profiling implications
    Monika Madan
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Atherosclerosis 190:62-72. 2007
    ..We hypothesized that Doxycycline would be beneficial in diet- and/or Pg-induced atherosclerosis given its role in various cell functions and matrix remodeling...
  16. ncbi request reprint p53 peptide prevents LITAF-induced TNF-alpha-mediated mouse lung lesions and endotoxic shock
    X Tang
    Center for Anti Inflammatory Therapeutics, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    Curr Mol Med 11:439-52. 2011
    ..Our findings highlight the regulation of LITAF/TNF-α by p53 and its short peptide 162-motif. These in vitro and in vivo observations serve to pave the way for pharmacotherapeutic approaches in the treatment of inflammatory diseases...
  17. ncbi request reprint Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 179:7777-90. 2007
    ..gingivalis LPS uniquely induces ISRE-containing genes, which requires IFNalphabetaR signaling involving IRF7, KLF4, and pY701 STAT1...
  18. ncbi request reprint Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications
    Hunghui Chi
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Circulation 110:1678-85. 2004
    ..Studies presented here tested the hypothesis that IL-1 receptor (IL-1R1) signaling plays a crucial role in bacteria- and/or high-fat diet (HFD)-enhanced atherogenesis...
  19. pmc Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 106:10740-5. 2009
    ..These findings unveil a link between obesity and innate immunity...
  20. ncbi request reprint IGF-1 signaling enhances cell survival in periodontal ligament fibroblasts vs. gingival fibroblasts
    X Han
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 700 Albany Street, W 201E, Boston, MA, 02118, USA
    J Dent Res 82:454-9. 2003
    ..Analysis of the present data suggests an enhanced cell survival in PDLF compared with GF by the up-regulation of IGF-1 signaling pathway...
  21. ncbi request reprint Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model
    Li Li
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Mass 02118, USA
    Circulation 105:861-7. 2002
    ....
  22. pmc Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University Medical Center, 700 Albany Street, W 201E, Boston, MA 02118, USA
    Infect Immun 73:935-43. 2005
    ..These results indicate that host immune cells sense live P. gingivalis and its components differently, which translates into the expression of different inflammatory cytokine profiles...
  23. pmc A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment
    F Myokai
    Boston University, Department of Periodontology and Oral Biology, School of Dental Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 96:4518-23. 1999
    ..3. Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression...
  24. ncbi request reprint Identification of genes differentially expressed in cultured human osteoblasts versus human fibroblasts by DNA microarray analysis
    X Han
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, G05, Boston, MA 02118, USA
    Connect Tissue Res 43:63-75. 2002
    ..The present findings suggest that HO and HF differ not only phenotypically but in the expression level of tissue specific genes to assure the turnover and homeostasis of their respective tissues...
  25. pmc Identification and characterization of kava-derived compounds mediating TNF-alpha suppression
    Michael P Pollastri
    Department of Chemistry, Boston University, Boston, MA 02215, USA
    Chem Biol Drug Des 74:121-8. 2009
    ....
  26. pmc Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting
    Qingde Zhou
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University Medical Center, 700 Albany Street W 201E, Boston, MA 02118, USA
    Infect Immun 74:1204-14. 2006
    ..gingivalis, LPS, and FimA. These differential changes are interpreted as preferential signal pathway activation in host immune/inflammatory responses to P. gingivalis infection...
  27. ncbi request reprint Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists
    Andrew J Delima
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Massachusetts 02118, USA
    J Infect Dis 186:511-6. 2002
    ..The results indicate that inhibition of IL-1 alone significantly reduces inflammation, connective tissue attachment loss, and bone resorption that are induced by periodontal pathogens...
  28. ncbi request reprint Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis
    Dana T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Endotoxin Res 11:13-8. 2005
    ..These results indicate that FimA is a potent inducer of inflammatory cytokine expression but, in the context of P. gingivalis infection, it is not a principal stimulator of the innate host response...
  29. pmc Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model
    Monika Madan
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, 700 Albany Street, W201E, Boston, MA 02118, USA
    Atherosclerosis 197:504-14. 2008
    ....
  30. pmc LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways
    Xiaoren Tang
    Department of Periodontology, Boston University Medical Center, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 103:13777-82. 2006
    ..We conclude that LITAF is an important mediator of the LPS-induced inflammatory response that can be distinguished from NF-kappaB pathway and that p38alpha is the specific kinase involved in the pathway linking LPS/MyD88/LITAF to TNF...
  31. ncbi request reprint Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis
    X Han
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 East Newton Street, G05, Boston, MA 02118, USA
    J Dent Res 81:399-405. 2002
    ..We concluded that PDLF and GF appear to display different gene expression patterns that may reflect intrinsic functional differences of the two cell populations and may well coordinate with their tissue-specific activities...
  32. pmc Moesin functions as a lipopolysaccharide receptor on human monocytes
    Z N Tohme
    Goldman School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    Infect Immun 67:3215-20. 1999
    ..Antimoesin blocked only LPS-mediated events. The data suggest that moesin functions as an independent LPS receptor on human monocytes. The role of moesin in transduction of CD14-mediated signals is discussed...
  33. ncbi request reprint IL-1 plays a critical role in oral, but not dermal, wound healing
    D T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Immunol 167:5316-20. 2001
    ..In a less challenging environment, the production of new connective tissue and its coverage by migrating epithelium are minimally affected by the absence of IL-1 activity...
  34. pmc LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth
    J Zhou
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Oncogene 30:1892-900. 2011
    ..Therefore, our studies for the first time establish the regulatory axis of AMPK-LITAF-TNFSF15 and also suggest that LITAF may function as a tumor suppressor...
  35. pmc Periodontal disease and systemic conditions: a bidirectional relationship
    Jemin Kim
    Boston University Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston, MA, USA
    Odontology 94:10-21. 2006
    ....
  36. pmc Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis
    Cataldo W Leone
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, 700 Albany Street, W 201, Boston, MA 02118, USA
    Infect Immun 74:2286-92. 2006
    ..gingivalis increases the inflammatory and destructive responses which occur in part through up-regulating the innate immune response and enhancing osteoclastogenesis and fibroblast apoptosis...
  37. ncbi request reprint p53 short peptide (p53pep164) regulates lipopolysaccharide-induced tumor necrosis factor-alpha factor/cytokine expression
    Xiaoren Tang
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University Medical Center, 700 Albany Street, Boston, MA 02118, USA
    Cancer Res 67:1308-16. 2007
    ..The present finding proposes a novel link between p53 and the inflammatory processes and highlights potential interventional approaches to control p53-associated inflammatory processes...
  38. pmc Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo
    Li Li
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Massachusetts 02118, USA
    Infect Immun 70:3915-22. 2002
    ..IL-11 and PGs mediate LPS-induced bone resorption by enhancing osteoclastogenesis independently of the IL-1 or TNF signaling...
  39. pmc Role of secreted frizzled-related protein 1 (SFRP1) in wound healing
    C H Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Dent Res 85:374-8. 2006
    ..Analysis of the present data suggests that SFRP1 may be partly responsible for the poorer healing performance of the palatal wounds compared with dermal wounds. Blocking SFRP1 results in improvement of palatal healing outcomes...
  40. ncbi request reprint Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model
    Chung Hsing Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Periodontol 78:1120-8. 2007
    ..The aims of this study were to assess periodontal inflammatory lesions after P. gingivalis-induced periodontitis and use this model to compare three approaches for assessing alveolar bone loss...
  41. pmc A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock
    Xiaoren Tang
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA
    J Innate Immun 2:43-55. 2010
    ..All together, these results reveal a previously unrecognized role for the PTP4A3 pathway in response to LPS...
  42. pmc Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice
    Sreedevi Srinivasan
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Clin Vaccine Immunol 17:699-704. 2010
    ..Therapeutic intervention aimed at reducing LITAF via kinase modulators may prove useful in preventing LPS-induced mortality...
  43. pmc Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components
    Julian A Saba
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Proteome Res 6:2211-21. 2007
    ..These differential changes by the bacteria and its components are interpreted as preferential signal pathway activation in host immune/inflammatory responses to P.g. infection...
  44. ncbi request reprint A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC
    Arthur Stucchi
    Department of Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Inflamm Bowel Dis 12:581-7. 2006
    ....
  45. ncbi request reprint Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression
    Anne Laure Bolcato-Bellemin
    Center for the Advanced Biomedical Research, Boston University, Massachusetts 02118, USA
    J Endotoxin Res 10:15-23. 2004
    ..Taken together, these results highlight the important role of LITAF in the regulation of TNF-alpha gene expression and suggest a potential role of LITAF in mouse organogenesis...
  46. doi request reprint An application of monotone functions decomposition to the reconstruction of gene regulatory networks
    H Chang
    Dept of Mechanical Engineering, Boston University, Boston, MA 02215, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:2430-3. 2011
    ..Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy...
  47. ncbi request reprint Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue
    Huafei Lu
    Boston University School of Dental Medicine, W 202D, 700 Albany Street, Boston, Massachusetts 02118, USA
    Endocrinology 145:4934-9. 2004
    ..Given that infection, bacteremia, and endotoxemia are relatively frequent events in humans, these results identify a putative mechanism for increased cardiovascular heart disease in diabetes...
  48. pmc Identification and functional characterization of a novel binding site on TNF-alpha promoter
    Xiaoren Tang
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 100:4096-101. 2003
    ....
  49. pmc Role for moesin in lipopolysaccharide-stimulated signal transduction
    Iveta Iontcheva
    Department of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 72:2312-20. 2004
    ..These data suggest an important role for moesin in lipopolysaccharide-induced TNF-alpha production, highlighting its importance in lipopolysaccharide-mediated signal transduction...
  50. pmc LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines
    Xiaoren Tang
    Department of Periodontology and Oral Biology, Center for Advanced Biomedical Research, Boston University School of Dental Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:5132-7. 2005
    ..Overall, these findings describe roles for LITAF, STAT6(B), and the LITAF-STAT6(B) complex in the regulation of inflammatory cytokines in response to LPS stimulation in mammalian cells...
  51. ncbi request reprint A role for advanced glycation end products in diminished bone healing in type 1 diabetes
    Ronaldo B Santana
    Goldman School of Dental Medicine, Division of Oral Biology, Boston University, 100 East Newton Street, Boston, MA 02118, USA
    Diabetes 52:1502-10. 2003
    ..05). Evidence for the expression of RAGE was obtained in mouse and rat osteoblastic cultures. These results support the contribution of AGEs to diminished bone healing in type 1 diabetes, possibly mediated by RAGE...
  52. pmc Metabolic network model of a human oral pathogen
    Varun Mazumdar
    Boston University, Bioinformatics Program, Boston, MA 02215, USA
    J Bacteriol 191:74-90. 2009
    ..The current model, which is amenable to further experimental testing and refinements, could prove useful in evaluating the oral microbiome dynamics and in the development of novel biomedical applications...
  53. ncbi request reprint Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing
    Xuemei Zhang
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Immunol 173:3514-23. 2004
    ..Short-term blockade of IL-1 and TNF may facilitate periodontal wound healing, whereas prolonged blockade may have adverse effects...
  54. pmc Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
    Andrew A Wilson
    Pulmonary Center and Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Invest 120:379-89. 2010
    ..Our results challenge the dogma that AMs are short lived and suggest that these differentiated cells may be a possible target cell population for in vivo gene therapy applications, including the sustained correction of hAAT deficiency...
  55. ncbi request reprint Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter
    Nobuyuki Shiomi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, Okayama, Japan
    FEMS Immunol Med Microbiol 47:360-8. 2006
    ..These results suggest that the consensus sequence for HNF-3alpha, or a nuclear binding protein to the CTCCC motif, may play an important role in regulating LPS-dependent LITAF transcription...
  56. ncbi request reprint Role of interleukin-1 in bacterial atherogenesis
    Mike Hoge
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Drugs Today (Barc) 42:683-8. 2006
    ..IL-1 holds potential as a target for future antiatherosclerotic therapies, although given its ubiquity in the body, this would not come without unwanted side effects, such as immunosuppression...
  57. ncbi request reprint Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
    Salomon Amar
    Department of Periodontology, Boston University School of Dental Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 23:1245-9. 2003
    ..Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown...
  58. ncbi request reprint Localized ridge augmentation with allogenic block grafts prior to implant placement: case reports and histologic evaluations
    Paul S Petrungaro
    Institute for Advanced Dental Education Inc, Lake Elmo, Minnesota, Lake Elmo, Minnesota, USA
    Implant Dent 14:139-48. 2005
    ..The analysis is supported by re-entry procedures and histologic evaluations to substantiate predictability...

Research Grants32

  1. INFLAMMATORY PROCESS PERIODONTAL WOUND HEALING
    Salomon Amar; Fiscal Year: 1999
    ..Aim-2 will focus on gaining insight into the molecular mechanisms which underlie changes in granulation tissue and matrix formation when IL-1 and TNF soluble blockers are injected in periodontal wounds. ..
  2. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2007
    ..The long-term goal of this application is to develop therapeutic strategies aimed at controlling the deleterious effects of the inflammatory response in atherosclerosis. ..
  3. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2007
    ..Our goal is to develop pharmacological approaches Aimed at modulating inflammation and angiogenesis. ..
  4. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2007
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
  5. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2009
    ..Our goal is to develop pharmacological approaches aimed at modulating inflammation and angiogenesis. ..
  6. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2009
    ..New knowledge gained from the proposed studies will likely have profound implications for the design of new therapies and modalities aimed at reducing clinical sequelae associated with obesity. ..
  7. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2009
    ..The results of the proposed experiments will define the role of immune sensing in infection-associated atherogenesis and pave the way for pharmacological interventions aimed reducing or preventing atherogenesis. ..
  8. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2010
    ..Our goal is to develop pharmacological approaches aimed at modulating inflammation and angiogenesis. ..
  9. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2009
    ..New knowledge gained from the proposed studies will likely have profound implications for the design of new therapies and modalities aimed at reducing clinical sequelae associated with obesity. ..
  10. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2010
    ..New knowledge gained from the proposed studies will likely have profound implications for the design of new therapies and modalities aimed at reducing clinical sequelae associated with obesity. ..
  11. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2010
    ..The results of the proposed experiments will define the role of immune sensing in infection-associated atherogenesis and pave the way for pharmacological interventions aimed reducing or preventing atherogenesis. ..
  12. Genomics Periodontal Host-Parasite Interactions
    Salomon Amar; Fiscal Year: 2007
    ..Since the differential host innate response identified in our preliminary data may in fact represent different stages of the periodontal infection, the results are expected to have important therapeutic implications. ..
  13. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2006
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
  14. INFLAMMATORY PROCESS PERIODONTAL WOUND HEALING
    Salomon Amar; Fiscal Year: 2000
    ..Aim-2 will focus on gaining insight into the molecular mechanisms which underlie changes in granulation tissue and matrix formation when IL-1 and TNF soluble blockers are injected in periodontal wounds. ..
  15. INFLAMMATORY PROCESS PERIODONTAL WOUND HEALING
    Salomon Amar; Fiscal Year: 2001
    ..Aim-2 will focus on gaining insight into the molecular mechanisms which underlie changes in granulation tissue and matrix formation when IL-1 and TNF soluble blockers are injected in periodontal wounds. ..
  16. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2002
    ..abstract_text> ..
  17. INFLAMMATORY PROCESS PERIODONTAL WOUND HEALING
    Salomon Amar; Fiscal Year: 2002
    ..Aim-2 will focus on gaining insight into the molecular mechanisms which underlie changes in granulation tissue and matrix formation when IL-1 and TNF soluble blockers are injected in periodontal wounds. ..
  18. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2003
    ..abstract_text> ..
  19. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2004
    ..abstract_text> ..
  20. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2004
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
  21. Genomics Periodontal Host-Parasite Interactions
    Salomon Amar; Fiscal Year: 2004
    ..Since the differential host innate response identified in our preliminary data may in fact represent different stages of the periodontal infection, the results are expected to have important therapeutic implications. ..
  22. Role of LITAF in Inflammatory Processes
    Salomon Amar; Fiscal Year: 2005
    ..abstract_text> ..
  23. Genomics Periodontal Host-Parasite Interactions
    Salomon Amar; Fiscal Year: 2005
    ..Since the differential host innate response identified in our preliminary data may in fact represent different stages of the periodontal infection, the results are expected to have important therapeutic implications. ..
  24. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2005
    ..The long-term goal of this application is to develop therapeutic strategies aimed at controlling the deleterious effects of the inflammatory response in atherosclerosis. ..
  25. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2005
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..
  26. Genomics Periodontal Host-Parasite Interactions
    Salomon Amar; Fiscal Year: 2006
    ..Since the differential host innate response identified in our preliminary data may in fact represent different stages of the periodontal infection, the results are expected to have important therapeutic implications. ..
  27. Inflammation and Infection in Atherosclerosis
    Salomon Amar; Fiscal Year: 2006
    ..The long-term goal of this application is to develop therapeutic strategies aimed at controlling the deleterious effects of the inflammatory response in atherosclerosis. ..
  28. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2010
    ..The proposed studies will provide new insights into how periodontal disease contributes to cardiovascular disease risk in human subjects and may lead to new approaches to therapy. ..