CARMELA ABRAHAM

Summary

Affiliation: Boston University
Country: USA

Publications

  1. pmc Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
    Rina Yamin
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, K620, MA 02118, USA
    Mol Neurodegener 4:33. 2009
  2. pmc Small-molecule Klotho enhancers as novel treatment of neurodegeneration
    Carmela R Abraham
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Future Med Chem 4:1671-9. 2012
  3. pmc Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
    Celina V Zerbinatti
    Department of Pharmacology, Boston University School of Medicine, Boston, MA, 02118, USA
    Mol Neurodegener 3:5. 2008
  4. ncbi request reprint Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo
    C R Abraham
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, K6, Boston, MA 02118, USA
    Ann N Y Acad Sci 920:245-8. 2000
  5. ncbi request reprint Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide
    Rina Yamin
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 100:458-67. 2007
  6. doi request reprint Cell-type dependent modulation of Notch signaling by the amyloid precursor protein
    Sun Young Oh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA
    J Neurochem 113:262-74. 2010
  7. ncbi request reprint Amyloid precursor protein interacts with notch receptors
    Sun Young Oh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci Res 82:32-42. 2005
  8. ncbi request reprint Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey
    James A Duce
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Glia 56:106-17. 2008
  9. ncbi request reprint Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation
    Ci Di Chen
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 97:30-43. 2006
  10. pmc Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
    Ci Di Chen
    Departments of Biochemistry, Pharmacology, and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:19796-801. 2007

Research Grants

  1. AMYLOIDOGENESIS ROLE OF REACTIVE ASTROCYTES
    CARMELA ABRAHAM; Fiscal Year: 2001

Collaborators

  • Ann C McKee
  • Rina Yamin
  • B Wolozin
  • Rachael Lee Neve
  • Ci Di Chen
  • Sun Young Oh
  • Jason D Hinman
  • James A Duce
  • William Hollander
  • Celina V Zerbinatti
  • Sonia Podvin
  • Douglas L Rosene
  • Sokreine Suon
  • William J Ray
  • Joanna M Cordy
  • Maria Guillily
  • David Kipling
  • Guy R Seabrook
  • Earl Gillespie
  • Susan E Leeman
  • Catherine E Costello
  • Aviva Ellenstein
  • Eric A Berg
  • Robert A Siman

Detail Information

Publications12

  1. pmc Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
    Rina Yamin
    Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, K620, MA 02118, USA
    Mol Neurodegener 4:33. 2009
    ..abstract:..
  2. pmc Small-molecule Klotho enhancers as novel treatment of neurodegeneration
    Carmela R Abraham
    Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA
    Future Med Chem 4:1671-9. 2012
    ..If such a connection is found, compounds that upregulate Klotho expression could become of therapeutic interest for the treatment of multiple sclerosis, and perhaps even Alzheimer's disease...
  3. pmc Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
    Celina V Zerbinatti
    Department of Pharmacology, Boston University School of Medicine, Boston, MA, 02118, USA
    Mol Neurodegener 3:5. 2008
    ....
  4. ncbi request reprint Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo
    C R Abraham
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, K6, Boston, MA 02118, USA
    Ann N Y Acad Sci 920:245-8. 2000
    ..2000). Successful completion of this study could lead to the design of reagents that would reduce the amyloid load in AD patients...
  5. ncbi request reprint Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide
    Rina Yamin
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 100:458-67. 2007
    ..In addition, we cloned APH from human brain and from neuroblastoma cells. Most importantly, our results indicate that APH expression in AD brain is lower than in age-matched controls...
  6. doi request reprint Cell-type dependent modulation of Notch signaling by the amyloid precursor protein
    Sun Young Oh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA
    J Neurochem 113:262-74. 2010
    ..Our results provide evidence of potentially important communications between the amyloid precursor protein and Notch...
  7. ncbi request reprint Amyloid precursor protein interacts with notch receptors
    Sun Young Oh
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurosci Res 82:32-42. 2005
    ..Intracellularly, however, although some APP and Notch molecules colocalize, others reside in distinct locations. The discovery of proteins that interact with APP may aid in the identification of new functions for APP...
  8. ncbi request reprint Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey
    James A Duce
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Glia 56:106-17. 2008
    ..In conclusion, the overall changes described in this study could provide an explanation for aging changes in white matter that might be initiated or enhanced by an altered expression of life span associated genes such as Klotho...
  9. ncbi request reprint Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation
    Ci Di Chen
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 97:30-43. 2006
    ..The results were confirmed and quantified by flow cytometry. The BiFC method of specifically visualizing APP/Notch interactions can be applied to study APP and Notch signaling during development, aging and neurodegeneration...
  10. pmc Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
    Ci Di Chen
    Departments of Biochemistry, Pharmacology, and Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:19796-801. 2007
    ..Insulin enhances KL shedding without increasing ADAM10 and ADAM17 mRNA and protein levels, suggesting that it acts by stimulating their proteolytic activities...
  11. ncbi request reprint Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey
    Jason D Hinman
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Neurochem 89:430-41. 2004
    ..These data solidify the role of calpain-1 in myelin protein metabolism and further implicate activated microglia in the pathology of the aging brain...
  12. ncbi request reprint Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts
    Jason D Hinman
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Glia 56:118-33. 2008
    ..In sum, we suspect these phenomena result in age-related dysfunction of CNP in the lipid raft, which may lead to myelin and axonal pathology...

Research Grants3

  1. AMYLOIDOGENESIS ROLE OF REACTIVE ASTROCYTES
    CARMELA ABRAHAM; Fiscal Year: 2001
    ..MALDI and ESI mass spectrometry are being utilized to characterize the Ig light chain material excreted in patient urine, in order to assist in definition of the biochemical consequences of the disease and treatment. ..