T T Rohn

Summary

Affiliation: Boise State University
Country: USA

Publications

  1. pmc Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease
    Troy T Rohn
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Int J Mol Sci 14:14908-22. 2013
  2. pmc The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease
    Troy T Rohn
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Oxid Med Cell Longev 2013:860959. 2013
  3. pmc Caspase-cleaved glial fibrillary acidic protein within cerebellar white matter of the Alzheimer's disease brain
    Troy T Rohn
    Department of Biology, Boise State University Boise, ID 83725, USA
    Int J Clin Exp Pathol 6:41-8. 2013
  4. doi request reprint Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain
    Troy T Rohn
    Boise State University, Department of Biology, Science Nursing Building, Room 228, Boise, ID 83725, USA
    Brain Res 1475:106-15. 2012
  5. ncbi request reprint Targeting alpha-synuclein for the treatment of Parkinson's disease
    Troy T Rohn
    Department of Biology, Boise State University, Boise, Idaho 83725, USA
    CNS Neurol Disord Drug Targets 11:174-9. 2012
  6. pmc Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease
    Troy T Rohn
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Brain Res 1228:189-98. 2008
  7. ncbi request reprint Caspase activation in Alzheimer's disease: early to rise and late to bed
    Troy T Rohn
    Department of Biology, Science Nursing Building, Room 228, Boise State University, Boise, Idaho, 83725, USA
    Rev Neurosci 19:383-93. 2008
  8. pmc Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: a potential role for caspases
    Troy T Rohn
    Department of Biology, Science Nursing Building, Room 228, Boise State University, Boise, Idaho 83725, USA
    Histol Histopathol 24:1081-6. 2009
  9. doi request reprint The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities
    Troy T Rohn
    Department of Biology, Boise State University, Science Nursing Building, Room 228, Boise, Idaho 83725, USA
    Apoptosis 15:1403-9. 2010
  10. pmc Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
    Troy T Rohn
    Department of Biological Sciences, Science Nursing Building, Room 228, Boise State University, Boise, ID 83725, USA
    Neurobiol Dis 43:68-78. 2011

Collaborators

Detail Information

Publications24

  1. pmc Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease
    Troy T Rohn
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Int J Mol Sci 14:14908-22. 2013
    ..In this context, a discussion of whether targeting apoE4 therapeutically is a rationale approach to treating this disease will be assessed. ..
  2. pmc The triggering receptor expressed on myeloid cells 2: "TREM-ming" the inflammatory component associated with Alzheimer's disease
    Troy T Rohn
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Oxid Med Cell Longev 2013:860959. 2013
    ..In this context, an overview of the pathways linking beta-amyloid, neurofibrillary tangles (NFTs), oxidative stress, and inflammation will be discussed...
  3. pmc Caspase-cleaved glial fibrillary acidic protein within cerebellar white matter of the Alzheimer's disease brain
    Troy T Rohn
    Department of Biology, Boise State University Boise, ID 83725, USA
    Int J Clin Exp Pathol 6:41-8. 2013
    ..It is suggested that the observed pathological changes found in the white matter of the cerebellum may contribute to the declined motor performance in AD...
  4. doi request reprint Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain
    Troy T Rohn
    Boise State University, Department of Biology, Science Nursing Building, Room 228, Boise, ID 83725, USA
    Brain Res 1475:106-15. 2012
    ..Taken together, these results suggest a novel cleavage event of apoE4, generating an amino-terminal fragment that localizes within NFTs of the AD brain...
  5. ncbi request reprint Targeting alpha-synuclein for the treatment of Parkinson's disease
    Troy T Rohn
    Department of Biology, Boise State University, Boise, Idaho 83725, USA
    CNS Neurol Disord Drug Targets 11:174-9. 2012
    ....
  6. pmc Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease
    Troy T Rohn
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Brain Res 1228:189-98. 2008
    ..These results suggest that caspase-cleaved TDP-43 is a major pathological finding in AD and may contribute to the neurodegeneration associated with this disease...
  7. ncbi request reprint Caspase activation in Alzheimer's disease: early to rise and late to bed
    Troy T Rohn
    Department of Biology, Science Nursing Building, Room 228, Boise State University, Boise, Idaho, 83725, USA
    Rev Neurosci 19:383-93. 2008
    ..e. cell death), but also a proximal event that promotes the pathology underlying this disease. Therefore, therapeutics aimed at preventing the activation and execution of apoptosis may provide an effective means of treating AD...
  8. pmc Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: a potential role for caspases
    Troy T Rohn
    Department of Biology, Science Nursing Building, Room 228, Boise State University, Boise, Idaho 83725, USA
    Histol Histopathol 24:1081-6. 2009
    ..In this review a summary of the major findings regarding the proteolytic modification of TDP-43 will be discussed as well as potential toxic-gain mechanisms these fragments may cause including cytoskeletal disruptions...
  9. doi request reprint The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities
    Troy T Rohn
    Department of Biology, Boise State University, Science Nursing Building, Room 228, Boise, Idaho 83725, USA
    Apoptosis 15:1403-9. 2010
    ..In addition, a discussion of the therapeutic value and dangers of targeting caspase inhibition in the treatment of AD using caspase inhibitors such as Q-VD-OPh will be evaluated...
  10. pmc Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
    Troy T Rohn
    Department of Biological Sciences, Science Nursing Building, Room 228, Boise State University, Boise, ID 83725, USA
    Neurobiol Dis 43:68-78. 2011
    ..Collectively, these data support a depletion of Beclin-1 in AD following caspase-cleavage. This article is part of a Special Issue entitled "Autophagy and protein degradation in neurological diseases."..
  11. pmc Immunolocalization of influenza A virus and markers of inflammation in the human Parkinson's disease brain
    Troy T Rohn
    Department of Biology, Boise State University, Boise, Idaho, United States of America
    PLoS ONE 6:e20495. 2011
    ..The presence of influenza A virus together with macrophages and T-lymphocytes may contribute to the neuroinflammation associated with this disease...
  12. doi request reprint Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2
    Troy T Rohn
    Department of Biology, Boise State University, Boise, Idaho 83725, USA
    J Neurosci 28:3051-9. 2008
    ..These findings suggest that the activation of apoptotic pathways may be an early event in AD and contributes to the pathological processes that promote the disease mechanisms underlying AD...
  13. ncbi request reprint Caspase activation independent of cell death is required for proper cell dispersal and correct morphology in PC12 cells
    Troy T Rohn
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Exp Cell Res 295:215-25. 2004
    ....
  14. ncbi request reprint Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    Troy T Rohn
    Department of Biology, Boise State University, Idaho 83725, USA
    Neurobiol Dis 11:341-54. 2002
    ..Taken together, these results demonstrate the activation of caspases and cleavage of tau in the AD brain, events which may precede and lead to the formation of NFTs...
  15. ncbi request reprint Activation of caspase-8 in the Alzheimer's disease brain
    T T Rohn
    Department of Biology, Boise State University, Boise, Idaho 83725, USA
    Neurobiol Dis 8:1006-16. 2001
    ..These results suggest a role for caspase-8 and the receptor-mediated apoptotic pathway as a mechanism leading to the activation of caspase-3 within neurons of the AD brain...
  16. ncbi request reprint Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology
    Jodie Newman
    Department of Biology, Boise State University, Boise, Idaho, USA
    Acta Neuropathol 110:135-44. 2005
    ....
  17. pmc Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain
    Peter E Mouser
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Am J Pathol 168:936-46. 2006
    ..These data suggest that the activation of caspases and cleavage of cellular proteins such as GFAP may contribute to astrocyte injury and damage in the AD brain...
  18. ncbi request reprint Suppression of MeCP2beta expression inhibits neurite extension in PC12 cells
    Sorcha M Cusack
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Exp Cell Res 299:442-53. 2004
    ..In addition, unique functions may exist for the two isoforms of MeCP2. Our results indicate that the inhibition of neurite elaboration caused by a reduction in MeCP2 may be reversible...
  19. ncbi request reprint 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis
    T T Rohn
    Department of Biology, Boise State University, ID 83725, USA
    Neuroreport 12:839-43. 2001
    ....
  20. pmc Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation
    Brian M Dufty
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Am J Pathol 170:1725-38. 2007
    ..These findings suggest that calpain I may participate in the disease-linked aggregation of alpha-Syn in various alpha-synucleinopathies...
  21. pmc Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
    Robert A Rissman
    Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
    J Clin Invest 114:121-30. 2004
    ..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...
  22. ncbi request reprint Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California at Irvine, Irvine, CA 92697 4540, USA
    Neurosci Lett 330:99-103. 2002
    ..Abeta within or around neurons in addition to contributing to NFT formation may also trigger apoptotic pathways. Caspase activation may lead to the cleavage of critical cellular proteins and neuronal cell death associated with DS...
  23. ncbi request reprint Neutrophil priming in host defense: role of oxidants as priming agents
    Steve D Swain
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    Antioxid Redox Signal 4:69-83. 2002
    ..In this review, we describe key features of the priming response in host defense and disease pathogenesis and focus on the unique role of reactive oxygen species as priming agents...
  24. ncbi request reprint Caspase-3 activation in astrocytes following postnatal excitotoxic damage correlates with cytoskeletal remodeling but not with cell death or proliferation
    Laia Acarin
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine and Institute of Neurosciences, Autonomous University of Barcelona, Spain
    Glia 55:954-65. 2007
    ....