Philip Norris

Summary

Affiliation: Blood Systems Research Institute
Country: USA

Publications

  1. pmc Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells
    Philip J Norris
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 78:8844-51. 2004
  2. pmc Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells
    Philip J Norris
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    Virulence 1:19-28. 2010
  3. pmc Long-term in vitro reactivity for human leukocyte antigen antibodies and comparison of detection using serum versus plasma
    Philip J Norris
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:243-51. 2009
  4. pmc Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
    Philip J Norris
    Blood Systems Research Institute, Department of Laboratory Medicine, University of California, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Mol Immunol 43:1349-57. 2006
  5. pmc Loss of T cell responses following long-term cryopreservation
    Rachel E Owen
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    J Immunol Methods 326:93-115. 2007
  6. doi request reprint Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donors
    Leslie H Tobler
    University of California, San Francisco, CA 94118, USA
    J Infect Dis 198:979-83. 2008
  7. doi request reprint Virus and antibody dynamics in acute west nile virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 198:984-93. 2008
  8. pmc Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma
    Rachael P Jackman
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    Clin Vaccine Immunol 18:318-26. 2011
  9. pmc Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment
    Rachael P Jackman
    Department of Laboratory Medicine and Medicine, Blood Systems Research Institute, University of California, San Francisco, California, USA
    Transfusion 49:2686-99. 2009
  10. pmc Identification of specificities of antibodies against human leukocyte antigens in blood donors
    Robert O Endres
    Blood Systems Research Institute, San Francisco, California 85282, USA
    Transfusion 50:1749-60. 2010

Collaborators

Detail Information

Publications29

  1. pmc Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells
    Philip J Norris
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    J Virol 78:8844-51. 2004
    ..While the antiviral effector activity of CD8(+) T cells has been well documented, these results strongly suggest that HIV-1-specific CD4(+) T cells are capable of directly contributing to antiviral immunity...
  2. pmc Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells
    Philip J Norris
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    Virulence 1:19-28. 2010
    ....
  3. pmc Long-term in vitro reactivity for human leukocyte antigen antibodies and comparison of detection using serum versus plasma
    Philip J Norris
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:243-51. 2009
    ..Serum is the manufacturer's recommended sample, but plasma may be easier to obtain for studies of HLA antibody prevalence and TRALI case investigations...
  4. pmc Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
    Philip J Norris
    Blood Systems Research Institute, Department of Laboratory Medicine, University of California, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Mol Immunol 43:1349-57. 2006
    ....
  5. pmc Loss of T cell responses following long-term cryopreservation
    Rachel E Owen
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    J Immunol Methods 326:93-115. 2007
    ..Long-term cryopreservation, however, may lead to the loss of CD4(+) T cell responses and mild skewing of T cell phenotypic marker expression...
  6. doi request reprint Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donors
    Leslie H Tobler
    University of California, San Francisco, CA 94118, USA
    J Infect Dis 198:979-83. 2008
    ..These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication...
  7. doi request reprint Virus and antibody dynamics in acute west nile virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 198:984-93. 2008
    ..The dynamics of the early stages of West Nile virus (WNV) infection can be assessed by follow-up studies of viremic blood donors...
  8. pmc Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma
    Rachael P Jackman
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    Clin Vaccine Immunol 18:318-26. 2011
    ..When this is not possible, care should be taken to account for differences due to sample age...
  9. pmc Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment
    Rachael P Jackman
    Department of Laboratory Medicine and Medicine, Blood Systems Research Institute, University of California, San Francisco, California, USA
    Transfusion 49:2686-99. 2009
    ..In addition to pathogens, WBCs treated with this system are affected and fail to stimulate proliferation of allogeneic peripheral blood mononuclear cells (PBMNCs) in vitro...
  10. pmc Identification of specificities of antibodies against human leukocyte antigens in blood donors
    Robert O Endres
    Blood Systems Research Institute, San Francisco, California 85282, USA
    Transfusion 50:1749-60. 2010
    ..Blood centers are implementing TRALI risk reduction strategies based on screening apheresis donors for antibodies to human leukocyte antigens (HLA)...
  11. ncbi request reprint Transfusion-associated microchimerism: a new complication of blood transfusions in severely injured patients
    William Reed
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Semin Hematol 44:24-31. 2007
    ....
  12. pmc Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California 94110, USA
    AIDS 22:990-2. 2008
    ..These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells...
  13. pmc Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    Hiroyu Hatano
    San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 83:329-35. 2009
    ..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
  14. pmc Tregs control the development of symptomatic West Nile virus infection in humans and mice
    Marion C Lanteri
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Clin Invest 119:3266-77. 2009
    ..Together, these results suggest that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans...
  15. doi request reprint Comprehensive analysis of west nile virus-specific T cell responses in humans
    Marion C Lanteri
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 197:1296-306. 2008
    ..However, little is known about the immunogenic regions of the virus or the phenotype of responding T cells in human infection...
  16. pmc Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection
    Philip J Norris
    Blood Systems Research Institute, San Francisco, California 94118, USA
    AIDS Res Hum Retroviruses 22:757-62. 2006
    ..Cytokine alterations occurred within 7 days of detectable HIV-1 viremia, emphasizing the need to study the earliest events of infection...
  17. pmc CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
    Sandra Lopez-Verges
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Blood 116:3865-74. 2010
    ....
  18. pmc A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, and HIV AIDS Division, San Francisco General Hospital, San Francisco, CA 94110, USA
    Eur J Immunol 40:134-41. 2010
    ..We propose that this novel CD4+ T-cell population counterbalances the suppressive activity of suppressor Treg in peripheral blood and serves as a calibrator of immunoregulation...
  19. pmc The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells
    Jacqueline P Law
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Cytometry A 75:1040-50. 2009
    ..The experiments presented here will aid in optimization of flow cytometry staining panels to quantify T(reg) frequencies in humans...
  20. pmc Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    Daniel E Kaufmann
    Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
    J Virol 78:4463-77. 2004
    ..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines...
  21. pmc Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells
    Philip J Norris
    Partners AIDS Research Center and Infectious Disease Unit, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    AIDS Res Hum Retroviruses 20:315-25. 2004
    ..Abrogated recognition of variant CD4(+) T cell epitopes presents a potential obstacle to vaccine development...
  22. ncbi request reprint Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II
    Devi SenGupta
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 173:1987-93. 2004
    ....
  23. pmc A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition
    Zarixia Zavala-Ruiz
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:13279-84. 2004
    ..These results demonstrate a previously unrecognized mode of MHC-peptide-T cell receptor interaction...
  24. ncbi request reprint The antigenic determinants on HIV p24 for CD4+ T cell inhibiting antibodies as determined by limited proteolysis, chemical modification, and mass spectrometry
    Jason G Williams
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Am Soc Mass Spectrom 17:1560-9. 2006
    ..These results suggest that, possibly due to epitope competition, antibodies produced during HIV infection can negatively affect CD4+ T cell-mediated immunity against the virus...
  25. ncbi request reprint Nanoparticle-Based biobarcode amplification assay (BCA) for sensitive and early detection of human immunodeficiency type 1 capsid (p24) antigen
    Shixing Tang
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:231-7. 2007
    ....
  26. ncbi request reprint Influenza viremia and the potential for blood-borne transmission
    Anna M Likos
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Transfusion 47:1080-8. 2007
  27. ncbi request reprint CD4(+) T helper cells and the role they play in viral control
    Philip J Norris
    Massachusetts General Hospital and Partners AIDS Research Center, Massachusetts General Hospital, 55 Fruit Street, GRJ 504, Boston, MA 02114, USA
    J Mol Med (Berl) 80:397-405. 2002
    ..We then focus on the role T helper cells play in viral control in murine and nonhuman primate models, and finally review what is known of CD4(+) T helper cell function in HIV-1 infection...
  28. ncbi request reprint The effects of early antiretroviral therapy and its discontinuation on the HIV-specific antibody response
    M Scott Killian
    Department of Medicine, University of California San Francisco, 94143, USA
    AIDS Res Hum Retroviruses 22:640-7. 2006
    ..These results demonstrate that early ART prevents the typical evolution of the HIV-1-specific antibody response and can alter the expected kinetics of this response in subjects discontinuing therapy...
  29. ncbi request reprint Labeling antigen-specific CD4(+) T cells with class II MHC oligomers
    Thomas O Cameron
    Department of Chemistry, MIT, 77 Massachusetts Avenue, Cambridge 02139, USA
    J Immunol Methods 268:51-69. 2002
    ....

Research Grants3

  1. CHARACTERIZATION OF HIV-1-SPECIFIC T HELPER CELL CLONES
    Philip Norris; Fiscal Year: 2003
    ..The knowledge to be gained regarding the generation and function of CD4+ T lymphocytes may further the understanding of HIV immunopathogenesis and shed insight into potential vaccine development and immunotherapeutic approaches. ..
  2. Properties of stored RBCs: minimization of immune and vascular reactivity
    Philip J Norris; Fiscal Year: 2010
    ..This proposal tests whether or not storage of red blood cells causes changes in these cells that might be harmful to transfusion recipients and explores ways of preventing any harmful effects of red blood cell storage. ..