Research Topics
Genomes and Genes
| Peter J NewmanSummaryAffiliation: Blood Research Institute Country: USA Publications
| Collaborators
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Detail Information
Publications
PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosisCunji Gao
Laboratories of PECAM 1 Research and Cell Biology, Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
Blood 102:169-79. 2003....- Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biologyPeter J Newman
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, Wis 53201, USA
Arterioscler Thromb Vasc Biol 23:953-64. 2003.... 
Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cellT Zhao
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53201, USA
J Cell Biol 152:65-73. 2001....- Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domainCunji Gao
Blood Research Institute, Blood Center of Wisconsin, 638 N 18th Street, Milwaukee, WI 53201, USA
J Clin Invest 119:504-11. 2009.... - The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapyCarmen Bergom
Blood Research Institute, Blood Center of Wisconsin, and Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53201, USA
Cancer Biol Ther 5:1699-707. 2006..In addition, reducing PECAM-1 levels in the tumor endothelium may aid in low-dose, anti-angiogenic therapy... - Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human plateletsBrian Boylan
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, USA
Blood 112:2780-6. 2008.... - Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 bindingMatthias Maas
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
Am J Physiol Heart Circ Physiol 285:H2336-44. 2003..These findings support a role for PECAM-1 as a sensor of oxidative stress, perhaps most importantly during the process of inflammation... - Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopeniaDaniel W Bougie
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
Blood 116:3033-8. 2010.... - PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte traffickingJamie R Privratsky
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, United States
Life Sci 90:177-84. 2012..The purpose of the present investigation was to test the hypothesis that PECAM-1 influences circulating cytokine levels by regulating the trafficking of activated, cytokine-producing leukocytes to sites of inflammation... - PECAM-1: conflicts of interest in inflammationJamie R Privratsky
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
Life Sci 87:69-82. 2010..A better understanding of how inflammatory responses are regulated should enable the development of new therapeutics that can be used in the treatment of acute and chronic inflammatory disorders... - Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylationCathy Paddock
Blood Research Institute, BloodCenter of Wisconsin and Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Blood 117:6012-23. 2011..On the basis of these findings, we propose a novel model for regulation of inhibitory signaling by ITIM-containing receptors that relies on reversible plasma membrane interactions and sequential ITIM phosphorylation... - Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signalingCunji Gao
Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, USA
Blood 117:4946-52. 2011.... - Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient miceReema Goel
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
Arterioscler Thromb Vasc Biol 28:1996-2002. 2008..PECAM-1 also inhibits inflammatory responses, on which basis it is predicted to be atheroprotective... - Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout miceYanping Liu
Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Am J Physiol Regul Integr Comp Physiol 290:R57-65. 2006..In the absence of this adhesion and signaling molecule, ONOO- production is increased concomitant with a reduction in both the EDHF and INDO-sensitive components of FMD... - Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine plateletsVipul B Rathore
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
Biochem J 403:275-81. 2007..These observations support the notion that Hic-5 and paxillin function as negative feedback regulators of SFKs in aggregated platelets and that, when both are present, paxillin is preferentially used... - The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitisReema Goel
Blood Research Institute, BloodCenter of Wisconsin, P O Box 2178, Milwaukee, WI 53201, USA
Am J Physiol Gastrointest Liver Physiol 293:G1205-14. 2007..Future examination of recently identified PECAM-1 allelic isoforms in humans as potential risk factors for developing NASH may be warranted... - An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signalingCarmen Bergom
Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Road, Milwaukee, WI 53201, USA
J Cell Sci 121:1235-42. 2008..These studies suggest a novel role for the PECAM-1 C-terminus in cytoprotective signaling and highlight a need for further characterization of expression of PECAM-1 isoforms in normal and malignant tissues... - Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agentsBrian Boylan
Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, 53201, USA
Blood 108:908-14. 2006.... 
Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopeniaTamam Bakchoul
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, 53201, USA
Transfusion 49:265-70. 2009....- Endothelial cell PECAM-1 confers protection against endotoxic shockMatthias Maas
Blood Research Institute, Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
Am J Physiol Heart Circ Physiol 288:H159-64. 2005..The diverse functional roles played by PECAM-1 in thrombosis, inflammation, apoptosis, and the immune response may make this molecule an attractive target for the development of novel therapeutics to manage and treat endotoxic shock... - PECAM-1 negatively regulates GPIb/V/IX signaling in murine plateletsVipul Rathore
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
Blood 102:3658-64. 2003.... - Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregationZhangyin Ming
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
Blood 117:3903-6. 2011..These results support a model in which PECAM-1/SHP-2 complexes, formed in a Lyn-dependent manner, suppress GPVI signaling... - Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survivalCarmen Bergom
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Milwaukee, WI, USA
Leuk Lymphoma 46:1409-21. 2005.... - Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrityJamie R Privratsky
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201, USA
J Cell Sci 124:1477-85. 2011..Taken together, these studies suggest that PECAM-1-PECAM-1 homophilic interactions are more important than its signaling function for maintaining the integrity of endothelial cell junctions... - Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier functionChristopher J Kuckleburg
Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd, Milwaukee, WI 53051
Arterioscler Thromb Vasc Biol 33:275-84. 2013..We examined whether neutrophils might secrete factors that promote vascular integrity during the latter stages of neutrophil transmigration, in particular, the role of neutrophil serine proteinase 3 (PR3)... - Phospholipase Cgamma2 contributes to stable thrombus formation on VWFVipul Rathore
Blood Research Institute The Blood Center of Southeastern Wisconsin, P O Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
FEBS Lett 573:26-30. 2004..While absence of PLCgamma2 had only a minimal effect on platelet adhesion to immobilized VWF, its absence impaired spreading and profoundly affected thrombus growth and stability on VWF... - Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surfaceBrian Boylan
Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, 638 N 18th St, Milwaukee, WI 53201, USA
Blood 104:1350-5. 2004.... - The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa BJamie R Privratsky
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
J Immunol 184:3157-63. 2010..Taken together, these studies strongly suggest that the anti-inflammatory actions of PECAM-1 in endothelial cells are not likely to involve its regulation of NF-kappaB... - A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopeniaJulie A Peterson
Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Department of Cellular Biology, Medical College of Wisconsin, Milwaukee 53201 2178, USA
Blood 101:937-42. 2003..The findings suggest this region of GPIIIa may be a favored target for quinine-dependent antibodies and may provide a basis for further studies to elucidate the molecular basis of glycoprotein-drug-antibody interaction... - Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexesQi hong Sun
Blood Research Institute, Blood Center of Southeastern Wisconsin, 8727 Watertown Plank Road, PO Box 2178, Milwaukee, WI 53233, USA
Blood 100:2094-101. 2002..Additionally, these studies may provide a molecular explanation for the previously reported ability of mild reducing agents to activate the GPIIb-IIIa complex and promote platelet aggregation... - Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivoHuiying Zhi
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
Blood 121:1858-67. 2013.... - Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophilsChristopher J Kuckleburg
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201, USA
J Immunol 188:2419-26. 2012..These data demonstrate that PR3 contributes in the selective recruitment of the NB1-positive neutrophil population... - Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 bindingDebra K Newman
Blood Research Institute, The Blood Center of Southeastern Wisconsin, 53226, Milwaukee, WI, USA
Biochem Biophys Res Commun 296:1171-9. 2002..These data suggest that ITIM tyrosine nitration may represent a mechanism for modulating phosphotyrosine-dependent signal transduction pathways... - GPIbα regulates platelet size by controlling the subcellular localization of filaminTaisuke Kanaji
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53266 3548, USA
Blood 119:2906-13. 2012..Taken together, these data demonstrate that coordinated expression of GPIbα and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets... - The alleles of PECAM-1Melanie S Novinska
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
Gene 376:95-101. 2006..Identification of these PECAM-1 allelic isoforms should facilitate future detailed examination of PECAM-1-related disease associations, and may help resolve previously disparate results... - Tests of the extension and deadbolt models of integrin activationJieqing Zhu
The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:11914-20. 2007..The data demonstrate that integrin extension is required for ligand binding during integrin inside-out signaling and that the deadbolt does not regulate integrin activation... - The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)Ulrich J H Sachs
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Langhansstrasse 7, Giessen D 35392, Germany
J Biol Chem 282:23603-12. 2007..Our findings provide direct evidence that neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1. This interaction may constitute a new pathway that participates in neutrophil transmigration... - Platelet PECAM-1 inhibits thrombus formation in vivoShahrokh Falati
Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Blood 107:535-41. 2006..In PECAM-1-deficient mice the time to 75% vessel occlusion was significantly shorter than in control mice. These data provide evidence for the involvement of platelet PECAM-1 in the negative regulation of thrombus formation... - Integrins: dynamic scaffolds for adhesion and signaling in plateletsSanford J Shattil
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
Blood 104:1606-15. 2004.... - Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotectionCaroline T Sardjono
Kronheimer Building, Burnet Institute incorporating the Austin Research Institute, Studley Road, Heidelberg, Victoria, 3084 Australia
Thromb Haemost 96:756-66. 2006..These results show that cysteine 595 is required for constitutive association of PECAM-1 with membrane microdomains and PECAM-1-mediated cytoprotection, where it may act as a crucial regulator of signaling and apoptosis events... - Mapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformationW Beau Mitchell
Department of Pediatrics, Mount Sinai School of Medicine, and New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
Blood 109:3725-32. 2007..Our data suggest a working model in which pro-alphaIIb adopts a bent conformation soon after synthesis, and then beta3 assumes its bent conformation by virtue of its interaction with the bent pro-alphaIIb...