Michael W Mosesson

Summary

Affiliation: Blood Research Institute
Country: USA

Publications

  1. ncbi Evidence that catalytically-inactivated thrombin forms non-covalently linked dimers that bridge between fibrin/fibrinogen fibers and enhance fibrin polymerization
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 110:93-100. 2004
  2. ncbi The ultrastructure of fibrinogen-420 and the fibrin-420 clot
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:209-14. 2004
  3. ncbi John Ferry and the mechanical properties of cross-linked fibrin
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:215-8. 2004
  4. ncbi Fibrinogen gamma chain functions
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, Wisconsin 53201 2178, USA
    J Thromb Haemost 1:231-8. 2003
  5. ncbi John Douglass Ferry (1912-2002)--a memorial tribute
    Michael W Mosesson
    The Blood Center of Southeastern Wisconsin, The Blood Research Institute, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:91-3. 2004
  6. ncbi Antithrombin I. Inhibition of thrombin generation in plasma by fibrin formation
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Thromb Haemost 89:9-12. 2003
  7. ncbi The structure and biological features of fibrinogen and fibrin
    M W Mosesson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, Wisconsin 53201, USA
    Ann N Y Acad Sci 936:11-30. 2001
  8. ncbi Fibrinogen and fibrin structure and functions
    M W Mosesson
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 3:1894-904. 2005
  9. ncbi Fibrinogen assembly and crosslinking on a fibrin fragment E template
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, Milwaukee 53201 2178, USA
    Thromb Haemost 87:651-8. 2002
  10. pmc Studies on the basis for the properties of fibrin produced from fibrinogen-containing gamma' chains
    Kevin R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, Schroeder Health Complex, 426, PO Box 1881, Milwaukee, WI 53233 1881, USA
    Blood 106:2730-6. 2005

Collaborators

Detail Information

Publications38

  1. ncbi Evidence that catalytically-inactivated thrombin forms non-covalently linked dimers that bridge between fibrin/fibrinogen fibers and enhance fibrin polymerization
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 110:93-100. 2004
    ....
  2. ncbi The ultrastructure of fibrinogen-420 and the fibrin-420 clot
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:209-14. 2004
    ..However, their location on the fiber surface would facilitate cellular interactions through the integrin receptor binding site...
  3. ncbi John Ferry and the mechanical properties of cross-linked fibrin
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:215-8. 2004
    ..This article describes the role John Ferry played in relating the location of cross-linked gamma-chains in fibrin fibrils to the mechanical properties of fibrin clot...
  4. ncbi Fibrinogen gamma chain functions
    M W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, Wisconsin 53201 2178, USA
    J Thromb Haemost 1:231-8. 2003
    ....
  5. ncbi John Douglass Ferry (1912-2002)--a memorial tribute
    Michael W Mosesson
    The Blood Center of Southeastern Wisconsin, The Blood Research Institute, Milwaukee, WI 53201 2178, USA
    Biophys Chem 112:91-3. 2004
  6. ncbi Antithrombin I. Inhibition of thrombin generation in plasma by fibrin formation
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Thromb Haemost 89:9-12. 2003
    ..e., via gamma' chains) plays a dominant role in this process. AT-1 should be considered when assessing the pathogenesis of thromboembolic disease...
  7. ncbi The structure and biological features of fibrinogen and fibrin
    M W Mosesson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, Wisconsin 53201, USA
    Ann N Y Acad Sci 936:11-30. 2001
    ....
  8. ncbi Fibrinogen and fibrin structure and functions
    M W Mosesson
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 3:1894-904. 2005
    ..vii) Leukocyte binding to fibrin(ogen) via integrin alpha(M)beta2 (Mac-1), which is a high affinity receptor on stimulated monocytes and neutrophils...
  9. ncbi Fibrinogen assembly and crosslinking on a fibrin fragment E template
    Michael W Mosesson
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, Milwaukee 53201 2178, USA
    Thromb Haemost 87:651-8. 2002
    ....
  10. pmc Studies on the basis for the properties of fibrin produced from fibrinogen-containing gamma' chains
    Kevin R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, Schroeder Health Complex, 426, PO Box 1881, Milwaukee, WI 53233 1881, USA
    Blood 106:2730-6. 2005
    ..Fourth, fibrinolysis of fibrin 2 was delayed compared with fibrin 1. Altogether, differences between the structure and function of fibrins 1 and 2 are attributable to the effects of thrombin binding to gamma' chains...
  11. ncbi Disintegration and reorganization of fibrin networks during tissue-type plasminogen activator-induced clot lysis
    D A Meh
    The Blood Research Institute of the Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Blood Coagul Fibrinolysis 12:627-37. 2001
    ..These results provide new perspectives on the major structural events that occur in the fibrin clot matrix during fibrinolysis...
  12. ncbi Cause-effect relation between hyperfibrinogenemia and vascular disease
    Bryce Kerlin
    Blood Research Institute, Blood Center of SE Wisconsin, Milwaukee 53226, USA
    Blood 103:1728-34. 2004
    ....
  13. pmc Caveolin-1-dependent apoptosis induced by fibrin degradation products
    Yi He Guo
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226 3548, USA
    Blood 113:4431-9. 2009
    ....
  14. ncbi Update on antithrombin I (fibrin)
    Michael W Mosesson
    The Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Thromb Haemost 98:105-8. 2007
    ..g. fibrinogen Naples 1), or a reduced plasma gamma' chain content (reduced antithrombin I activity), predispose to intravascular thrombosis...
  15. ncbi The amino acid sequence in fibrin responsible for high affinity thrombin binding
    D A Meh
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee 53201 2178, USA
    Thromb Haemost 85:470-4. 2001
    ..The reverse gamma' peptide or the forward sequence with repositioned Tyr residues did not compete well for thrombin binding, indicating that the positions of charged residues are important for thrombin binding affinity...
  16. ncbi Position of gamma-chain carboxy-terminal regions in fibrinogen/fibrin cross-linking mixtures
    K R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, P O Box 1881, Milwaukee, Wisconsin 53233 1881, USA
    Biochemistry 39:14171-5. 2000
    ..These findings provide no evidence that longitudinal (DD-long) gamma chain positioning occurs in cross-linked fibrin and indicate instead that most, if not all, gamma-chain positioning in an assembled fibrin polymer is transverse...
  17. ncbi Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis
    Ann K Rosenthal
    Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, USA
    Thromb Haemost 91:558-68. 2004
    ..Such increases in potential transglutaminase activity may facilitate pathological matrix calcification in degenerative arthritis...
  18. doi Evidence that alpha2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    J Thromb Haemost 6:1565-70. 2008
    ..We propose that alpha2AP becomes ligated to fibrinogen while in the circulation through the action of FXIII, and that its immediate presence in plasma fibrinogen contributes to regulation of in vivo fibrinolysis...
  19. doi Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma' chain sequence
    M W Mosesson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:102-10. 2009
    ..This feature prompted us to produce a 'gain-of-function' transgenic mouse in which the wild-type (WT) C-terminal mu-gamma' chain fibrinogen sequence had been replaced with the C-terminal thrombin-binding human gamma' sequence...
  20. ncbi Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains
    K R Siebenlist
    Department of Basic Health Sciences, School of Dentistry, Marquette University, Milwaukee, Wisconsin 53233, USA
    Biochemistry 35:10448-53. 1996
    ....
  21. ncbi Protransglutaminase (factor XIII) mediated crosslinking of fibrinogen and fibrin
    K R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, Milwaukee, WI, USA
    Thromb Haemost 86:1221-8. 2001
    ..Since fibrin is a considerably better substrate for fXIII than is fibrinogen, the rate at which crosslinking takes place in a fibrinogen-containing plasma environment is much lower than it would be if fibrin were present...
  22. ncbi Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities
    D A Meh
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53201-2178, USA
    Thromb Res 103:63-73. 2001
    ..Thus, reduced high-affinity thrombin binding to homozygotic Naples I fibrin may be related to the absence of low-affinity binding sites...
  23. pmc The location of the carboxy-terminal region of gamma chains in fibrinogen and fibrin D domains
    M W Mosesson
    Sinai Samaritan Medical Center, Milwaukee Clinical Campus, University of Wisconsin Medical School, Milwaukee, WI 53233, USA
    Proc Natl Acad Sci U S A 95:10511-6. 1998
    ....
  24. ncbi Characterization of a mouse model for thrombomodulin deficiency
    H Weiler
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA
    Arterioscler Thromb Vasc Biol 21:1531-7. 2001
    ..The phenotypic penetrance of the TM(Pro) mutation is determined by as-yet-uncharacterized genetic modifiers of thrombosis other than TM...
  25. ncbi Cross-linked gamma-chains in fibrin fibrils bridge 'transversely' between strands: yes
    M W Mosesson
    The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA
    J Thromb Haemost 2:388-93. 2004
  26. ncbi Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome
    M W Mosesson
    The Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:62-9. 2007
    ..Together, the gamma'(423P) and gamma'(427L) chains comprise the total plasma fibrinogen gamma' chain content...
  27. ncbi Coexisting dysfibrinogenemia (gammaR275C) and factor V Leiden deficiency associated with thromboembolic disease (fibrinogen Cedar Rapids)
    K R Siebenlist
    Department of Biomedical Sciences, College of Health Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Blood Coagul Fibrinolysis 11:293-304. 2000
    ..Most subjects with gammaR275 mutations do not experience clinical thrombotic disorders, suggesting that the combination of a factor V Leiden defect and a gammaR275C dysfibrinogenemia predisposes to thromboembolic disease...
  28. ncbi Fibrinogen Columbus: a novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia
    Ryan L Davis
    Haematologica 92:1151-2. 2007
    ..2-5 Here we report the identification of a novel point mutation gammaG200V (fibrinogen Columbus) causing hypofibrinogenemia and co-segregating with three genetic thrombophilia risk factors...
  29. ncbi The effect of a thrombin exosite 2-binding DNA aptamer (HD-22) on non-catalytic thrombin-enhanced fibrin polymerization
    Michael W Mosesson
    Thromb Haemost 97:327-8. 2007
  30. ncbi Crystal structure of thrombin in complex with fibrinogen gamma' peptide
    Agustin O Pineda
    Biophys Chem 125:556-9. 2007
    ..These findings are consistent with functional data and broaden our understanding of how thrombin interacts with fibrinogen at the molecular level...
  31. pmc Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly
    Igor Pechik
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    Biochemistry 45:3588-97. 2006
    ..These findings provide a coherent rationale for the preferential removal of fpA from fibrinogen at the first stage of fibrin assembly and the accelerated cleavage of fpB from protofibrils and/or fibrils at the second stage...
  32. ncbi Theme issue: fibrinogen and fibrin--structure, function, interactions and clinical applications
    Carl Erik Dempfle
    Thromb Haemost 89:599-600. 2003
  33. pmc Crystal structure of the complex between thrombin and the central "E" region of fibrin
    Igor Pechik
    Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Proc Natl Acad Sci U S A 101:2718-23. 2004
    ..Thus, despite the highly charged nature of the interacting surfaces, hydrophobic contacts make a substantial contribution to the interaction...
  34. ncbi John D. Ferry's patents
    John L Schrag
    Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI 53706, USA
    Biophys Chem 112:95-101. 2004
  35. ncbi Dysfibrinogenemia (fibrinogen Wilmington) due to a novel Aalpha chain truncation causing decreased plasma expression and impaired fibrin polymerisation
    Stephen O Brennan
    Canterbury Health Laboratories, Christchurch Hospital, Cnr Hagley Ave and Tuam St, Christchurch, New Zealand
    Thromb Haemost 96:88-9. 2006
  36. ncbi Hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bbeta58 (3404del A) associated with thrombotic stroke in infancy
    Stephen O Brennan
    Molecular Pathology Laboratory, Canterbury Health Laboratories, P O Box 151, Christchurch, New Zealand
    Thromb Haemost 95:738-9. 2006
  37. ncbi Fibrinogen Saint-Germain II: hypofibrinogenemia due to heterozygous gamma N345S mutation
    Emmanuelle de Raucourt
    Laboratoire d Hematologie, CHI Poissy St Germain en Laye, St Germain en Laye, France
    Thromb Haemost 94:965-8. 2005
    ..The hypofibrinogenemia may be contributory to the thrombophilic manifestations...
  38. ncbi Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a gamma320Asp deletion at the Ca2+ binding site
    Stephen O Brennan
    Molecular Pathology Laboratory, Christchurch School of Medicine, Christchurch, New Zealand
    Thromb Haemost 98:467-9. 2007