Magdalena Chrzanowska-Wodnicka

Summary

Affiliation: Blood Research Institute
Country: USA

Publications

  1. doi request reprint Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction
    Magdalena Chrzanowska-Wodnicka
    Blood Center of Wisconsin, Blood Research Institute, PO Box 2178, Milwaukee 53201, USA
    Exp Cell Res 319:2350-9. 2013
  2. pmc Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 111:2647-56. 2008
  3. doi request reprint Regulation of angiogenesis by a small GTPase Rap1
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Vascul Pharmacol 53:1-10. 2010
  4. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
  5. ncbi request reprint Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity
    Haiyan Chu
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 181:3373-83. 2008
  6. pmc Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃
    Sribalaji Lakshmikanthan
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 118:2015-26. 2011
  7. pmc A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 111:4627-36. 2008
  8. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005

Collaborators

Detail Information

Publications8

  1. doi request reprint Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction
    Magdalena Chrzanowska-Wodnicka
    Blood Center of Wisconsin, Blood Research Institute, PO Box 2178, Milwaukee 53201, USA
    Exp Cell Res 319:2350-9. 2013
    ..Lastly, we provide a brief summary of studies in cardiac and smooth muscle cells, where the Epac-Rap1 signaling axis is emerging as an important regulator of contractility...
  2. pmc Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 111:2647-56. 2008
    ..These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells...
  3. doi request reprint Regulation of angiogenesis by a small GTPase Rap1
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Vascul Pharmacol 53:1-10. 2010
    ....
  4. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
    ..These results reveal a previously unrecognized role for Rap1b in NK cell signaling and effector functions...
  5. ncbi request reprint Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity
    Haiyan Chu
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 181:3373-83. 2008
    ..However, absence of Rap1b did not affect splenic B cell proliferation, BCR-mediated activation of Erk1/2, p38 MAPKs, and AKT. Thus, Rap1b is crucial for early B cell development, MZ B cell homeostasis and T-dependent humoral immunity...
  6. pmc Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃
    Sribalaji Lakshmikanthan
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 118:2015-26. 2011
    ..We conclude that Rap1b promotes VEGF-mediated angiogenesis by promoting VEGFR2 activation in ECs via integrin α(v)β(3). These results provide a novel insight into the role of Rap1 in VEGF signaling in ECs...
  7. pmc A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 111:4627-36. 2008
    ..Thus, we have discovered a critical and distinct role of Rap1b in mature B-cell trafficking and development of MZ B cells...
  8. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...