Magdalena Chrzanowska-Wodnicka

Summary

Affiliation: Blood Research Institute
Country: USA

Publications

  1. pmc Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction
    Magdalena Chrzanowska-Wodnicka
    Blood Center of Wisconsin, Blood Research Institute, PO Box 2178, Milwaukee 53201, USA
    Exp Cell Res 319:2350-9. 2013
  2. pmc Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 111:2647-56. 2008
  3. doi request reprint Regulation of angiogenesis by a small GTPase Rap1
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Vascul Pharmacol 53:1-10. 2010
  4. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
  5. ncbi request reprint Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity
    Haiyan Chu
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 181:3373-83. 2008
  6. pmc Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃
    Sribalaji Lakshmikanthan
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 118:2015-26. 2011
  7. pmc A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 111:4627-36. 2008
  8. pmc Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure
    Sribalaji Lakshmikanthan
    From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee S L, M C W Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville B J Z, K M, M V A, A V S and Department of Pharmacology and Toxicology Z D G, J A A, Cardiovascular Center Z D G, X Z, J E M, D X Z, J A A, Department of Medicine X Z, J E M, D X Z, Department of Physiology H L, D L M, and Division of Biostatistics A S, Medical College of Wisconsin, Milwaukee
    Arterioscler Thromb Vasc Biol 34:1486-94. 2014
  9. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005

Collaborators

  • GILBERT WHITE
  • Subramaniam Malarkannan
  • David X Zhang
  • Ramani Ramchandran
  • Renren Wen
  • Sribalaji Lakshmikanthan
  • Aradhana Awasthi
  • Haiyan Chu
  • Yuhong Chen
  • David L Mattson
  • Avril V Somlyo
  • Hayley Lund
  • Aniko Szabo
  • Zhi Dong Ge
  • Xiaodong Zheng
  • Jason E Maas
  • John A Auchampach
  • Bartosz J Zieba
  • Mykhaylo V Artamonov
  • Ko Momotani
  • Changzoon Chun
  • Magdalena Sobczak
  • Jillian Dargatz
  • Angela Henschel
  • Lawrence A Quilliam
  • Rajasekaran Kamalakannan
  • Asanga Samarakoon
  • Demin Wang
  • Andrew Podd
  • Mei Yu

Detail Information

Publications10

  1. pmc Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction
    Magdalena Chrzanowska-Wodnicka
    Blood Center of Wisconsin, Blood Research Institute, PO Box 2178, Milwaukee 53201, USA
    Exp Cell Res 319:2350-9. 2013
    ..Lastly, we provide a brief summary of studies in cardiac and smooth muscle cells, where the Epac-Rap1 signaling axis is emerging as an important regulator of contractility...
  2. pmc Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 111:2647-56. 2008
    ..These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells...
  3. doi request reprint Regulation of angiogenesis by a small GTPase Rap1
    Magdalena Chrzanowska-Wodnicka
    Blood Research Institute, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Vascul Pharmacol 53:1-10. 2010
    ....
  4. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
    ..These results reveal a previously unrecognized role for Rap1b in NK cell signaling and effector functions...
  5. ncbi request reprint Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity
    Haiyan Chu
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 181:3373-83. 2008
    ..However, absence of Rap1b did not affect splenic B cell proliferation, BCR-mediated activation of Erk1/2, p38 MAPKs, and AKT. Thus, Rap1b is crucial for early B cell development, MZ B cell homeostasis and T-dependent humoral immunity...
  6. pmc Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃
    Sribalaji Lakshmikanthan
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA
    Blood 118:2015-26. 2011
    ..We conclude that Rap1b promotes VEGF-mediated angiogenesis by promoting VEGFR2 activation in ECs via integrin α(v)β(3). These results provide a novel insight into the role of Rap1 in VEGF signaling in ECs...
  7. pmc A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development
    Yuhong Chen
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 111:4627-36. 2008
    ..Thus, we have discovered a critical and distinct role of Rap1b in mature B-cell trafficking and development of MZ B cells...
  8. pmc Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure
    Sribalaji Lakshmikanthan
    From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee S L, M C W Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville B J Z, K M, M V A, A V S and Department of Pharmacology and Toxicology Z D G, J A A, Cardiovascular Center Z D G, X Z, J E M, D X Z, J A A, Department of Medicine X Z, J E M, D X Z, Department of Physiology H L, D L M, and Division of Biostatistics A S, Medical College of Wisconsin, Milwaukee
    Arterioscler Thromb Vasc Biol 34:1486-94. 2014
    ..We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of blood pressure...
  9. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...