MICHAEL PAUL BUSCH

Summary

Affiliation: Blood Systems Research Institute
Country: USA

Publications

  1. ncbi request reprint Transfusion-transmitted viral infections: building bridges to transfusion medicine to reduce risks and understand epidemiology and pathogenesis
    Michael P Busch
    Blood Systems Research Institute, University of California at San Francisco, California 94118, USA
    Transfusion 46:1624-40. 2006
  2. pmc Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Blood 119:6326-34. 2012
  3. pmc Temporal changes in HCV genotype distribution in three different high risk populations in San Francisco, California
    Paulo Telles Dias
    Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas NEPAD Universidade do Estado do Rio de Janeiro State University of Rio de Janeiro, 20940 200 Rio de Janeiro, RJ, Brasil
    BMC Infect Dis 11:208. 2011
  4. pmc Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progression
    Peter Bacchetti
    Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Infect Dis 7:145. 2007
  5. pmc West Nile virus infections projected from blood donor screening data, United States, 2003
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Emerg Infect Dis 12:395-402. 2006
  6. ncbi request reprint Evolving approaches to estimate risks of transfusion-transmitted viral infections: incidence-window period model after ten years
    M R Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Dev Biol (Basel) 127:87-112. 2007
  7. doi request reprint Virus and antibody dynamics in acute west nile virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 198:984-93. 2008
  8. doi request reprint Risk assessment and cost-effectiveness/utility analysis
    Michael Busch
    Blood Systems Research Institute, San Francisco, CA, USA
    Biologicals 37:78-87. 2009
  9. ncbi request reprint Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing
    Michael P Busch
    Blood Systems Research Institute, San Francisco, USA
    N Engl J Med 353:460-7. 2005
  10. ncbi request reprint Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:469-75. 2006

Detail Information

Publications93

  1. ncbi request reprint Transfusion-transmitted viral infections: building bridges to transfusion medicine to reduce risks and understand epidemiology and pathogenesis
    Michael P Busch
    Blood Systems Research Institute, University of California at San Francisco, California 94118, USA
    Transfusion 46:1624-40. 2006
  2. pmc Infectivity in chimpanzees (Pan troglodytes) of plasma collected before HCV RNA detectability by FDA-licensed assays: implications for transfusion safety and HCV infection outcomes
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Blood 119:6326-34. 2012
    ....
  3. pmc Temporal changes in HCV genotype distribution in three different high risk populations in San Francisco, California
    Paulo Telles Dias
    Núcleo de Estudos e Pesquisas em Atenção ao Uso de Drogas NEPAD Universidade do Estado do Rio de Janeiro State University of Rio de Janeiro, 20940 200 Rio de Janeiro, RJ, Brasil
    BMC Infect Dis 11:208. 2011
    ..In the United States (U.S.) HCV GT 1 is reported as the most common infecting GT among chronically infected patients. In Europe, however, recent studies have suggested that the epidemiology of HCV GTs is changing...
  4. pmc Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progression
    Peter Bacchetti
    Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Infect Dis 7:145. 2007
    ..We sought to examine the accuracy of such imputation and implications for modeling factors that influence progression rates...
  5. pmc West Nile virus infections projected from blood donor screening data, United States, 2003
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Emerg Infect Dis 12:395-402. 2006
    ..In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population...
  6. ncbi request reprint Evolving approaches to estimate risks of transfusion-transmitted viral infections: incidence-window period model after ten years
    M R Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Dev Biol (Basel) 127:87-112. 2007
  7. doi request reprint Virus and antibody dynamics in acute west nile virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 198:984-93. 2008
    ..The dynamics of the early stages of West Nile virus (WNV) infection can be assessed by follow-up studies of viremic blood donors...
  8. doi request reprint Risk assessment and cost-effectiveness/utility analysis
    Michael Busch
    Blood Systems Research Institute, San Francisco, CA, USA
    Biologicals 37:78-87. 2009
    ..This set of articles will introduce risk assessment and cost-effectiveness methodologies and discuss recent applications of these methods in transfusion medicine...
  9. ncbi request reprint Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing
    Michael P Busch
    Blood Systems Research Institute, San Francisco, USA
    N Engl J Med 353:460-7. 2005
    ..We report the yield and characteristics of positive donations and the incremental yield and safety of nucleic acid amplification tests of individual donations...
  10. ncbi request reprint Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:469-75. 2006
    ..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia...
  11. ncbi request reprint Relative sensitivities of licensed nucleic acid amplification tests for detection of viremia in early human immunodeficiency virus and hepatitis C virus infection
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 45:1853-63. 2005
    ..We compared these assays with respect to detection of RNA in early HIV and HCV infection...
  12. ncbi request reprint Blood transfusion is associated with donor leukocyte microchimerism in trauma patients
    Garth H Utter
    Department of Surgery, University of California, Davis, Medical Center, Blood Centers of the Pacific, San Francisco, California 95817, USA
    J Trauma 57:702-7; discussion 707-8. 2004
    ..We have found, however, that microchimerism may be more common in trauma patients...
  13. ncbi request reprint Should HBV DNA NAT replace HBsAg and/or anti-HBc screening of blood donors?
    Michael P Busch
    Blood Systems Research Institute, University of California, 270 Masonic Avenue, San Francisco, CA 94904, USA
    Transfus Clin Biol 11:26-32. 2004
    ..Finally it will address the cost effectiveness of incorporation of HBV DNA detection into HBV screening and NAT testing algorithms...
  14. ncbi request reprint Current and emerging infectious risks of blood transfusions
    Michael P Busch
    Blood Centers of the Pacific, and University of California, San Francisco, 270 Masonic Ave, San Francisco, CA 94118, USA
    JAMA 289:959-62. 2003
  15. pmc Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates
    Kimberly Page-Shafer
    University of California, San Francisco, California, USA
    J Clin Microbiol 46:499-506. 2008
    ..4; 95% CI, 28.0 to 39.9). This study demonstrates the value of applying a cross-sectional screening strategy to detect acute HCV infections and to estimate HCV incidence...
  16. ncbi request reprint A new strategy for estimating risks of transfusion-transmitted viral infections based on rates of detection of recently infected donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 45:254-64. 2005
    ....
  17. pmc Hepatitis C virus prevalence and clearance among US blood donors, 2006-2007: associations with birth cohort, multiple pregnancies, and body mass index
    Edward L Murphy
    University of California, San Francisco, CA, USA
    J Infect Dis 202:576-84. 2010
    ..During the period 1992-1993, the prevalence of hepatitis C virus (HCV) antibodies (anti-HCV) among US blood donors was 0.36%, but contemporary data on the prevalence of antibody to HCV and the prevalence of HCV RNA are lacking...
  18. pmc Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection
    Philip J Norris
    Blood Systems Research Institute, San Francisco, California 94118, USA
    AIDS Res Hum Retroviruses 22:757-62. 2006
    ..Cytokine alterations occurred within 7 days of detectable HIV-1 viremia, emphasizing the need to study the earliest events of infection...
  19. ncbi request reprint Integration of nucleic acid amplification test results into hepatitis C virus supplemental serologic testing algorithms: implications for donor counseling and revision of existing algorithms
    Steven H Kleinman
    Blood Systems Research Institute, San Francisco, California, USA
    Transfusion 46:695-702. 2006
    ..The FDA has approved variance requests to use a new algorithm that eliminates the need to perform RIBA when HCV NAT results are reactive. Data are provided in support of this new algorithm...
  20. ncbi request reprint Surveillance of the genetic variation in incident HIV, HCV, and HBV infections in blood and plasma donors: implications for blood safety, diagnostics, treatment, and molecular epidemiology
    Eric Delwart
    Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA
    J Med Virol 78:S30-5. 2006
    ..A systematic program is proposed for the genetic characterization of viral genomes in donors with incident HIV, HCV, or HBV infections...
  21. ncbi request reprint Community blood supply model: development of a new model to assess the safety, sufficiency, and cost of the blood supply
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, USA
    Med Decis Making 25:571-82. 2005
    ..However, as a result of increasingly stringent screening measures, one of the greatest threats may be an insufficient supply. The balance between safety and adequacy of the blood supply has not received enough attention...
  22. ncbi request reprint Intermittent low-level viremia in very early primary HIV-1 infection
    Eberhard W Fiebig
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 39:133-7. 2005
    ..It is not known if blood is infectious during this period; however, given the low viral concentrations and transient nature of the observed viremic "blips," the risk of infectivity can be assumed to be small...
  23. ncbi request reprint The cost-effectiveness of screening the U.S. blood supply for West Nile virus
    Brian Custer
    Blood Systems Research Institute, University of California, San Francisco, CA 94118 4417, USA
    Ann Intern Med 143:486-92. 2005
    ..The spread of West Nile virus across North America and evidence of transmission by transfusion prompted the U.S. Food and Drug Administration to encourage the development of methods to screen the blood supply...
  24. pmc Long-term in vitro reactivity for human leukocyte antigen antibodies and comparison of detection using serum versus plasma
    Philip J Norris
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:243-51. 2009
    ..Serum is the manufacturer's recommended sample, but plasma may be easier to obtain for studies of HLA antibody prevalence and TRALI case investigations...
  25. ncbi request reprint Safety and donor acceptance of an abbreviated donor history questionnaire
    Hany T Kamel
    Blood Systems, Inc, Scottsdale, Arizona 85257, USA
    Transfusion 46:1745-53. 2006
    ..Surveys have shown donor dissatisfaction with the duration of the donation process and repetitive questioning. An abbreviated donor history questionnaire (AQ) may improve satisfaction, but must be safe...
  26. pmc Effects of blood sample age at time of separation on measured cytokine concentrations in human plasma
    Rachael P Jackman
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, CA 94118, USA
    Clin Vaccine Immunol 18:318-26. 2011
    ..When this is not possible, care should be taken to account for differences due to sample age...
  27. doi request reprint Cost-effectiveness of screening the US blood supply for Trypanosoma cruzi
    Maria Agapova
    Blood Systems Research Institute, San Francisco, California 94117, USA
    Transfusion 50:2220-32. 2010
    ..Component-specific strategies are based on screening platelet-containing donations...
  28. pmc A case-control study of factors associated with resolution of hepatitis C viremia in former blood donors (CME)
    Leslie H Tobler
    Blood Systems Research Institute, San Francisco, California, USA
    Transfusion 50:1513-23. 2010
    ..We report a case-control study of factors associated with HCV resolution...
  29. pmc Identification of specificities of antibodies against human leukocyte antigens in blood donors
    Robert O Endres
    Blood Systems Research Institute, San Francisco, California 85282, USA
    Transfusion 50:1749-60. 2010
    ..Blood centers are implementing TRALI risk reduction strategies based on screening apheresis donors for antibodies to human leukocyte antigens (HLA)...
  30. pmc Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection
    Kimberly Page
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 50 Beale St, Ste 1200, San Francisco, CA 94105, USA
    J Infect Dis 200:1216-26. 2009
    ..Hepatitis C virus (HCV) infection, clearance, and reinfection are best studied in injection drug users (IDUs), who have the highest incidence of HCV and are likely to represent most infections...
  31. doi request reprint Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screening
    Brian Custer
    Blood Systems Research Institute, University of California, San Francisco, USA
    Transfusion 49:278-88. 2009
    ..Little data are available on subsequent manifestations of WNV-specific disease outcomes in viremic donors...
  32. doi request reprint Interferon and interferon-induced chemokine expression is associated with control of acute viremia in West Nile virus-infected blood donors
    Leslie H Tobler
    University of California, San Francisco, CA 94118, USA
    J Infect Dis 198:979-83. 2008
    ..These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication...
  33. ncbi request reprint The consequences of temporary deferral on future whole blood donation
    Brian Custer
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    Transfusion 47:1514-23. 2007
    ..The consequences of temporary deferral are not well understood. This study sought to investigate blood donor return after deferral expiration...
  34. ncbi request reprint Evaluation of a new enzyme-linked immunosorbent assay for detection of Chagas antibody in US blood donors
    Leslie H Tobler
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 47:90-6. 2007
    ..An anonymized preclinical study of a prototype T. cruzi lysate-based enzyme-linked immunosorbent assay (ELISA) developed by Ortho-Clinical Diagnostics was conducted...
  35. ncbi request reprint Transfusion-associated microchimerism: a new complication of blood transfusions in severely injured patients
    William Reed
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Semin Hematol 44:24-31. 2007
    ....
  36. ncbi request reprint Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:1870-8. 2006
    ..To address this, a panel of 12 MC assays based on insertion-deletion (InDel) polymorphisms had been optimized...
  37. ncbi request reprint High-level long-term white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury
    Tzong Hae Lee
    Blood Systems Research Institute, Department of Pathology, University of California, Davis, California 94118, USA
    Transfusion 45:1280-90. 2005
    ..Twenty-seven patients transfused with LR and non-LR blood products were studied after severe traumatic injury. A secondary aim was to explore donor-recipient mixed lymphocyte reactivity in vitro...
  38. ncbi request reprint Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection
    Eberhard W Fiebig
    Department of Laboratory Medicine, University of California, San Francisco, CA, USA
    AIDS 17:1871-9. 2003
    ..The characterization of primary HIV infection by the analysis of serial plasma samples from newly infected persons using multiple standard viral assays...
  39. ncbi request reprint Quantifying losses to the donated blood supply due to donor deferral and miscollection
    Brian Custer
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, Washington, USA
    Transfusion 44:1417-26. 2004
    ..Donors are deferred for multiple reasons. Losses related to disease marker rates are well established. Donor and donation losses for other reasons, however, have not been extensively quantified...
  40. ncbi request reprint Triggers for switching from minipool testing by nucleic acid technology to individual-donation nucleic acid testing for West Nile virus: analysis of 2003 data to inform 2004 decision making
    Brian Custer
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 44:1547-54. 2004
    ..Strategies were investigated for the application of limited ID-NAT capacity in 2004...
  41. ncbi request reprint Clinical significance of nondiscriminated reactive results with the Chiron Procleix HIV-1 and HCV assay
    Joan D McAuley
    Blood Systems Laboratory and Arizona State University, Tempe, 85282, USA
    Transfusion 44:91-6. 2004
    ..This study was designed to determine the clinical significance of NDR results...
  42. ncbi request reprint Hepatitis B and C viral load changes following initiation of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection
    David M Asmuth
    Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA
    Antiviral Res 63:123-31. 2004
    ....
  43. ncbi request reprint HIV RNA testing in the context of nonoccupational postexposure prophylaxis
    Michelle E Roland
    Positive Health Program at San Francisco General Hospital, Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Infect Dis 190:598-604. 2004
    ..The specificity and positive predictive value of human immunodeficiency virus (HIV) RNA assays have not been evaluated in the setting of postexposure prophylaxis (PEP)...
  44. ncbi request reprint Hepatitis C virus seroconversion among young injection drug users: relationships and risks
    Judith A Hahn
    Department of Epidemiology, University of California, San Francisco, 94110, USA
    J Infect Dis 186:1558-64. 2002
    ..Interventions to reduce HCV transmission must recognize the importance of relationships on injecting risk...
  45. pmc Tregs control the development of symptomatic West Nile virus infection in humans and mice
    Marion C Lanteri
    Blood Systems Research Institute, San Francisco, California 94118, USA
    J Clin Invest 119:3266-77. 2009
    ..Together, these results suggest that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans...
  46. ncbi request reprint Performance of a transcription-mediated-amplification HIV-1 RNA assay in pooled specimens
    Nicola M Zetola
    Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, United States
    J Clin Virol 40:68-70. 2007
    ..Very limited data exist on the comparative performance of nucleic acid amplification tests (NATs) for the screening of pooled specimens for acute human immunodeficiency virus (HIV) infection...
  47. pmc Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    Hiroyu Hatano
    San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 83:329-35. 2009
    ..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
  48. ncbi request reprint Use of the sensitive/less-sensitive (detuned) EIA strategy for targeting genetic analysis of HIV-1 to recently infected blood donors
    Daisy M Machado
    Blood Centers of the Pacific, San Francisco, California 94118, USA
    AIDS 16:113-9. 2002
    ....
  49. ncbi request reprint Phylogenetic analysis of WNV in North American blood donors during the 2003-2004 epidemic seasons
    Belinda L Herring
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 363:220-8. 2007
    ..Amino acid mutations associated with newly expanding genetic variants reflect either selectively neutral mutational drift and/or mutations providing replicative advantages over the previously dominant forms of WNV...
  50. ncbi request reprint Persistence of primary drug resistance among recently HIV-1 infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141 9100, USA
    AIDS 18:1683-9. 2004
    ..We sought to determine if primary drug resistance would be lost at a rapid rate, and viral pol replication capacity would increase, in the absence of treatment...
  51. pmc The TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients
    Ryan M Gill
    Department of Laboratory Medicine, University of California, San Francisco, USA
    Blood 111:3880-3. 2008
    ..Hence predisposing genetic factors may explain, in part, why only a subset of trauma patients develops transfusion-associated microchimerism...
  52. ncbi request reprint Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection
    C Bradley Hare
    Positive Health Program, University of California, San Francisco, San Francisco, CA, USA
    Clin Infect Dis 42:700-8. 2006
    ....
  53. ncbi request reprint Impact of HCV 3.0 EIA relative to HCV 2.0 EIA on blood-donor screening
    Leslie H Tobler
    Blood Centers of the Pacific, Irwin Center, San Francisco, California 94118, USA
    Transfusion 43:1452-9. 2003
    ..0 EIA; the second study evaluated the differential performance of HCV 3.0 EIA in plasma donors acutely infected with HCV, identified during routine Abbott HCV 2.0 EIA and HCV NAT (using Roche Ampliscreen plate assay) donor screening...
  54. ncbi request reprint Two percent of HIV-positive U.S. blood donors are infected with non-subtype B strains
    Eric L Delwart
    Blood Systems Research Institute, San Francisco 94118, California, USA
    AIDS Res Hum Retroviruses 19:1065-70. 2003
    ..The frequency of genetically confirmed non-subtype-B HIV infection in a geographically dispersed group of infected U.S. blood donors in 1977-2000 was therefore 2.0% (6/312)...
  55. ncbi request reprint Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    J Infect Dis 190:251-6. 2004
    ....
  56. ncbi request reprint Absence of activation of CMV by blood transfusion to HIV-infected, CMV-seropositive patients
    W Lawrence Drew
    University of California, San Francisco, Mount Zion Medical Center, California 94115, USA
    Transfusion 43:1351-7. 2003
    ....
  57. doi request reprint Comprehensive analysis of west nile virus-specific T cell responses in humans
    Marion C Lanteri
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Infect Dis 197:1296-306. 2008
    ..However, little is known about the immunogenic regions of the virus or the phenotype of responding T cells in human infection...
  58. ncbi request reprint Development of a new less-sensitive enzyme immunoassay for detection of early HIV-1 infection
    Bhupat D Rawal
    Blood Centers of the Pacific, San Francisco, California 94118, USA
    J Acquir Immune Defic Syndr 33:349-55. 2003
    ..These results support the potential use of the Vironostika-LS EIA for detection of recent HIV-1 infections for incidence projections and for other epidemiologic, clinical, and molecular surveillance applications...
  59. ncbi request reprint Emerging infections in transfusion medicine
    Eberhard W Fiebig
    Department of Laboratory Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Clin Lab Med 24:797-823, viii. 2004
    ....
  60. ncbi request reprint Time trends in primary HIV-1 drug resistance among recently infected persons
    Robert M Grant
    Gladstone Institute of Virology and Immunology, PO Box 914100, San Francisco, CA 94141, USA
    JAMA 288:181-8. 2002
    ..Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy...
  61. pmc Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors
    Anne M Guiltinan
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Am J Epidemiol 167:743-50. 2008
    ..High rates of mortality from drug/alcohol and trauma/suicide causes are likely due to lifestyle factors and may be at least partially preventable...
  62. ncbi request reprint Estimating blood donor loss due to the variant CJD travel deferral
    Edward L Murphy
    University of California and Blood Centers of the Pacific, San Francisco, California, USA
    Transfusion 44:645-50. 2004
    ..The FDA recommended new travel deferrals in May 2002 to prevent the potential transmission of variant CJD (vCJD). The predicted impact of such deferrals on the blood supply was controversial...
  63. ncbi request reprint Clinical investigation of posttransfusion Kidd blood group typing using a rapid normalized quantitative polymerase chain reaction
    Lani Montalvo
    Blood Systems Research Institute, Blood Centers of the Pacific, San Francisco, California 94118, USA
    Transfusion 44:694-702. 2004
    ..We applied this method in a clinical investigation of 54 multiple-transfusion patients...
  64. ncbi request reprint Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Clin Virol 31:275-82. 2004
    ..Human T-lymphotropic virus type II (HTLV-II) is associated with HAM/TSP and, in HIV coinfected patients only, rare cases of cutaneous T cell lymphoma. Proviral load may be important in the pathogenesis of HTLV-associated disease...
  65. ncbi request reprint Use of laboratory tests and clinical symptoms for identification of primary HIV infection
    Frederick M Hecht
    Positive Health Program HIV Section at San Francisco General Hospital, tUniversity of California at San Francisco, 94110, USA
    AIDS 16:1119-29. 2002
    ..To determine the sensitivity and specificity of symptoms, three HIV-1 RNA assays, a p24 antigen EIA and a third-generation enzyme immunoassay (EIA) antibody test for diagnosis of primary HIV infection (PHI)...
  66. doi request reprint Experience of German Red Cross blood donor services with nucleic acid testing: results of screening more than 30 million blood donations for human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus
    Michael K Hourfar
    Institute of Transfusion and Immunohematology, German Red Cross Baden Württemberg Hessen, Johann Wolfgang Goethe University, Frankfurt, Germany
    Transfusion 48:1558-66. 2008
    ..In 1997, nucleic acid amplification technique (NAT)-testing was introduced at the German Red Cross (GRC) blood donor services to reduce this diagnostic window period (WP)...
  67. doi request reprint Dengue viremia in blood donors from Honduras, Brazil, and Australia
    Jeffrey M Linnen
    Gen Probe, Inc, San Diego, California, USA
    Transfusion 48:1355-62. 2008
    ..Documented transfusion transmission of West Nile virus raised concern regarding transfusion-transmitted DENV...
  68. ncbi request reprint International application of the incidence rate/window period model
    Simone A Glynn
    Transfusion 42:966-72. 2002
  69. pmc Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV
    Eishiro Mizukoshi
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    J Infect Dis 198:203-12. 2008
    ..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)...
  70. ncbi request reprint Impact of changes in viral marker screening assays
    Usha K Sharma
    Westat, Rockville, Maryland, USA
    Transfusion 43:202-14. 2003
    ..Monitoring the performance of routinely used infectious disease serologic tests is necessary to evaluate their effectiveness in identifying true-positive units and erroneously disqualifying safe blood donors...
  71. ncbi request reprint Frequency and duration of plasma CMV viremia in seroconverting blood donors and recipients
    W Lawrence Drew
    UCSF Mount Zion Medical Center, University of California and the Blood Centers of the Pacific, USA
    Transfusion 43:309-13. 2003
    ..To explain this residual risk, evidence of cell-free viremia was sought in seroconverting and seroprevalent blood donors and seroconverting transfusion recipients by means of a plasma-based assay for CMV DNA...
  72. ncbi request reprint Dynamics of viremia in early hepatitis C virus infection
    Simone A Glynn
    Westat, Rockville, Maryland, USA
    Transfusion 45:994-1002. 2005
    ....
  73. ncbi request reprint Risk factors for incident HIV infection among anonymous HIV testing site clients in Santos, Brazil: 1996-1999
    Katia Alves
    Blood Centers of the Pacific, San Francisco, California, U S A
    J Acquir Immune Defic Syndr 32:551-9. 2003
    ..To determine temporal trends in HIV infection and risk factors among persons seeking anonymous HIV testing in Santos, Brazil...
  74. ncbi request reprint Effect of a national disaster on blood supply and safety: the September 11 experience
    Simone A Glynn
    Westat, Rockville, Md 20850 2062, USA
    JAMA 289:2246-53. 2003
    ..An understanding of characteristics of blood donors donating in times of crisis may help predict blood supply safety and donor return patterns...
  75. ncbi request reprint Frequency of HBV DNA detection in US blood donors testing positive for the presence of anti-HBc: implications for transfusion transmission and donor screening
    Steven H Kleinman
    Westat, Rockville, Maryland, USA
    Transfusion 43:696-704. 2003
    ..An estimate of the rate of HBV DNA-positive, anti-HBc-positive units is important for evaluating the need for anti-HBc donor screening, especially in the context of HBV NAT...
  76. ncbi request reprint Leukoreduction of blood transfusions does not diminish transfusion-associated microchimerism in trauma patients
    Garth H Utter
    Department of Surgery, Harborview Medical Center University of Washington, Seattle, Washington, USA
    Transfusion 46:1863-9. 2006
    ..The aim was to determine whether leukoreduction of blood transfusions, advocated to reduce the immunomodulatory effect of transfusion, decreases the likelihood of developing TA-MC...
  77. ncbi request reprint Microchimerism in transfused trauma patients is associated with diminished donor-specific lymphocyte response
    Garth H Utter
    Department of Surgery, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Trauma 58:925-31; discussion 931-2. 2005
    ..We sought to determine whether changes in general or antigen-specific lymphocyte activation may be associated with the subsequent development of microchimerism...
  78. ncbi request reprint The impact of male-to-male sexual experience on risk profiles of blood donors
    Ana M Sanchez
    Westat, Rockville, Maryland 20850, USA
    Transfusion 45:404-13. 2005
    ..Excluding only men who engaged in male-to-male sex within either the prior 12 months or 5 years has been proposed. Little is known about infectious disease risks of MSM who donate blood...
  79. pmc Development and persistence of West Nile virus-specific immunoglobulin M (IgM), IgA, and IgG in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    J Clin Microbiol 43:4316-20. 2005
    ..Thus, unlike some other flavivirus infections, WNV infection is not characterized by a relatively rapid disappearance of virus-specific IgA...
  80. pmc Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    Clin Diagn Lab Immunol 12:1123-6. 2005
    ..Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection...
  81. ncbi request reprint Prevalence, incidence, and residual risk of human immunodeficiency virus among community and replacement first-time blood donors in São Paulo, Brazil
    Claudia C Barreto
    Fundação Pró Sangue Hemocentro de São Paulo Pro Blood Foundation Blood Center of Sao Paolo FPS HSP, Brazil
    Transfusion 45:1709-14. 2005
    ..HIV residual risk from FT-donor transfusions, and projected yield of p24 antigen and nucleic acid test (NAT) screening were estimated...
  82. ncbi request reprint Prevalence of HIV-1 in blood donations following implementation of a structured blood safety policy in South Africa
    Anthon du P Heyns
    South African National Blood Service, Weltevreden Park, South Africa
    JAMA 295:519-26. 2006
    ..The prevalence of HIV-1 in blood donations increased to 0.26% (1:385) in 1998, indicating that a significant number of window-period infective units were entering the blood supply (risk 3.4/100,000)...
  83. ncbi request reprint Trends in antiretroviral drug resistance and clade distributions among HIV-1--infected blood donors in Sao Paulo, Brazil
    Claudia C Barreto
    Fundação Pró Sangue Hemocentro de São Paulo, Av Dr Enéas de Carvalho Aguilar, 15505403 000 Saõ Paulo, Brazil
    J Acquir Immune Defic Syndr 41:338-41. 2006
    ..We analyzed rates of drug resistance mutations in antiretroviral-naive São Paulo blood donors with recently acquired or established HIV-1 infections and characterized clade diversity in this population...
  84. ncbi request reprint Lack of correlation between HBsAg and HBV DNA levels in blood donors who test positive for HBsAg and anti-HBc: implications for future HBV screening policy
    Mary C Kuhns
    Abbott Laboratories, Abbott Park, Illinois, USA
    Transfusion 44:1332-9. 2004
    ..Studies showing a significant correlation between hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) deoxyribonucleic acid (DNA) levels have focused on the HBV seroconversion window period...
  85. ncbi request reprint Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing
    Susan L Stramer
    American Red Cross, Gaithersburg, MD, USA
    N Engl J Med 351:760-8. 2004
    ....
  86. ncbi request reprint Lessons and opportunities from epidemiologic and molecular investigations of infected blood donors
    Michael P Busch
    Transfusion 46:1663-6. 2006
  87. ncbi request reprint Strategies for testing blood donors for West Nile virus
    Susan L Stramer
    Transfusion 46:2036-7. 2006
  88. ncbi request reprint Donation archives and prospective donor-recipient repositories: indispensable tools for monitoring blood safety
    Jean Pierre Allain
    Transfusion 47:1110-4. 2007
  89. pmc Persistence of West Nile virus-specific antibodies in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, California, USA
    Clin Vaccine Immunol 14:1228-30. 2007
    ..At 1-year of follow-up, 17% of the donors (n = 23) were positive for WNV IgM, 57% were positive for WNV IgA, and 100% were positive for WNV IgG...
  90. ncbi request reprint Behavioral and infectious disease risks in young blood donors: implications for recruitment
    Mark A Damesyn
    Westat, Rockville, Maryland 20850 2062, USA
    Transfusion 43:1596-603. 2003
    ..Recruitment of young donors is critical to expand the donor base and sustain the blood supply. Nevertheless, there is concern that younger blood donors may have a higher risk profile than their older counterparts...
  91. ncbi request reprint Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donations
    Richard J Benjamin
    Biomedical Services, Medical Office, American Red Cross, Washington, DC 20006, USA
    Transfusion 48:295-303. 2008
    ....
  92. ncbi request reprint HCV viral load in anti-HCV-reactive donors and infectivity for their recipients
    Eva A Operskalski
    Transfusion Viruses Program, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9560, USA
    Transfusion 43:1433-41. 2003
    ..This is important for considerations about assay sensitivity, use of minipool versus single-donation testing, and continued use of serologic testing...
  93. ncbi request reprint Yield of hepatitis C virus nucleic acid testing among antibody-reactive or confirmed-positive samples
    Michael Schmidt
    Transfusion 45:1040-2. 2005

Research Grants15

  1. Mechanisms and clinical effects of microchimerism in transfused trauma patients
    Michael Busch; Fiscal Year: 2009
    ..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
  2. Natural History and Pathogenesis of WNV in Viremic Dono*
    Michael Busch; Fiscal Year: 2007
    ..abstract_text> ..
  3. Mechanisms and clinical effects of microchimerism in transfused trauma patients
    Michael Busch; Fiscal Year: 2007
    ..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
  4. Natural history of acute and chronic HCV in blood donors
    Michael Busch; Fiscal Year: 2007
    ..These investigations will yield important insights into HCV pathogenesis and clarify the natural history of disease for the large number of HCV infected persons identified through donor screening. ..
  5. Natural History and Pathogenesis of WNV in Viremic Dono*
    Michael Busch; Fiscal Year: 2006
    ..abstract_text> ..
  6. Mechanisms and clinical effects of microchimerism in transfused trauma patients
    MICHAEL PAUL BUSCH; Fiscal Year: 2010
    ..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..