RICHARD HERBERT ASTER

Summary

Affiliation: Blood Research Institute
Country: USA

Publications

  1. pmc Hypersensitivity reaction and acute immune-mediated thrombocytopenia from oxaliplatin: two case reports and a review of the literature
    Marnelli A Bautista
    Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    J Hematol Oncol 3:12. 2010
  2. ncbi request reprint Heparin-independent activation of platelets by HIT antibodies: a clue to the etiology of delayed thrombocytopenia/thrombosis in patients given heparin?
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53201, USA
    J Thromb Haemost 3:2166-7. 2005
  3. ncbi request reprint Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:678-9. 2006
  4. pmc Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:911-8. 2009
  5. ncbi request reprint Heparin-induced immune thrombocytopenia - a clinical or laboratory diagnosis?
    R H Aster
    Medical College of Wisconsin and Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:757-8. 2006
  6. ncbi request reprint Drug-induced immune thrombocytopenia
    Richard H Aster
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 357:580-7. 2007
  7. pmc Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain
    Cunji Gao
    Blood Research Institute, Blood Center of Wisconsin, 638 N 18th Street, Milwaukee, WI 53201, USA
    J Clin Invest 119:504-11. 2009
  8. ncbi request reprint Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, 53201 2178, USA
    Am J Hematol 81:193-8. 2006
  9. pmc Patients with quinine-induced immune thrombocytopenia have both "drug-dependent" and "drug-specific" antibodies
    Daniel W Bougie
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, USA
    Blood 108:922-7. 2006
  10. pmc Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA
    Julie A Peterson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    Blood 111:1234-9. 2008

Research Grants

  1. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2010
  2. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
  3. RESEARCH TRAINING IN TRANSFUSION SCIENCE
    RICHARD ASTER; Fiscal Year: 2006
  4. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2007
  5. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 1980

Collaborators

Detail Information

Publications35

  1. pmc Hypersensitivity reaction and acute immune-mediated thrombocytopenia from oxaliplatin: two case reports and a review of the literature
    Marnelli A Bautista
    Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    J Hematol Oncol 3:12. 2010
    ..The incidence of hypersensitivity reaction in patients receiving oxaliplatin is approximately 15%, with severe reaction (grade 3 and 4) occurring in 2% of patients...
  2. ncbi request reprint Heparin-independent activation of platelets by HIT antibodies: a clue to the etiology of delayed thrombocytopenia/thrombosis in patients given heparin?
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53201, USA
    J Thromb Haemost 3:2166-7. 2005
  3. ncbi request reprint Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:678-9. 2006
  4. pmc Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
    R H Aster
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 7:911-8. 2009
    ..Further studies to address these issues and characterize more completely the range of drugs and drug metabolites that can cause DITP are needed...
  5. ncbi request reprint Heparin-induced immune thrombocytopenia - a clinical or laboratory diagnosis?
    R H Aster
    Medical College of Wisconsin and Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 4:757-8. 2006
  6. ncbi request reprint Drug-induced immune thrombocytopenia
    Richard H Aster
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 357:580-7. 2007
  7. pmc Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain
    Cunji Gao
    Blood Research Institute, Blood Center of Wisconsin, 638 N 18th Street, Milwaukee, WI 53201, USA
    J Clin Invest 119:504-11. 2009
    ....
  8. ncbi request reprint Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, 53201 2178, USA
    Am J Hematol 81:193-8. 2006
    ....
  9. pmc Patients with quinine-induced immune thrombocytopenia have both "drug-dependent" and "drug-specific" antibodies
    Daniel W Bougie
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, USA
    Blood 108:922-7. 2006
    ..In addition to having implications for pathogenesis, drug-specific antibodies may provide a surrogate measure of drug sensitivity in patients with drug-induced immune cytopenia...
  10. pmc Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA
    Julie A Peterson
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    Blood 111:1234-9. 2008
    ..The observations are consistent with a recently proposed model in which drug reacts noncovalently with both target protein and antibody to promote binding of an otherwise nonreactive immunoglobulin...
  11. pmc Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI 53201 2178, USA
    Transfusion 48:358-64. 2008
    ..The implications of this trait for transfusion medicine are undefined...
  12. pmc Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    Blood 113:1105-11. 2009
    ..1 in the course of the immune response. These monoclonal reagents are the first of their kind and should facilitate studies to define the molecular basis for drug-dependent antibody binding and platelet destruction in DITP...
  13. pmc The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 and appears to be encoded by an R>Q154 amino acid substitution
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Blood 115:2073-6. 2010
    ....
  14. ncbi request reprint A site involving the "hybrid" and PSI homology domains of GPIIIa (beta 3-integrin subunit) is a common target for antibodies associated with quinine-induced immune thrombocytopenia
    Julie A Peterson
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Department of Cellular Biology, Medical College of Wisconsin, Milwaukee 53201 2178, USA
    Blood 101:937-42. 2003
    ..The findings suggest this region of GPIIIa may be a favored target for quinine-dependent antibodies and may provide a basis for further studies to elucidate the molecular basis of glycoprotein-drug-antibody interaction...
  15. pmc Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia
    Daniel W Bougie
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Blood 116:3033-8. 2010
    ....
  16. ncbi request reprint Thrombocytopenia after second exposure to abciximab is caused by antibodies that recognize abciximab-coated platelets
    Brian R Curtis
    Platelet Neutrophil Immunology Laboratory, The Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Blood 99:2054-9. 2002
    ..It may be possible to identify patients at risk for developing thrombocytopenia if given abciximab by screening for antibodies that recognize 7E3-coated platelets...
  17. ncbi request reprint Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa
    Daniel W Bougie
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Blood 100:2071-6. 2002
    ..These antibodies may be human analogs of mouse monoclonal antibodies that recognize ligand-induced binding sites (LIBS) induced in the GPIIb/IIIa heterodimer when it reacts with a ligand-mimetic drug...
  18. ncbi request reprint Thrombocytopenia resulting from sensitivity to GPIIb-IIIa inhibitors
    Richard H Aster
    Medical College of Wisconsin, Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
    Semin Thromb Hemost 30:569-77. 2004
    ..Additional studies are needed to more fully define the characteristics of these antibodies and to identify risk factors that predispose patients to this complication...
  19. ncbi request reprint Drug-induced immune cytopenias
    Richard H Aster
    Medical College of Wisconsin, Milwaukee, WI 53201 2178, USA
    Toxicology 209:149-53. 2005
    ..We will review here current understanding of the immune mechanisms by which drugs promote immune-mediated platelet destruction resulting in thrombocytopenia...
  20. ncbi request reprint Acute thrombocytopenia in patients treated with the oral glycoprotein IIb/IIIa inhibitors xemilofiban and orbofiban: evidence for an immune etiology
    Jacqueline A Brassard
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    Thromb Haemost 88:892-7. 2002
    ..Measurement of drug-dependent antibodies may be helpful in determining the basis for acute thrombocytopenia in fiban-treated patients and possibly for identification of patients at risk to develop thrombocytopenia...
  21. ncbi request reprint Immune thrombocytopenia caused by glycoprotein IIb/IIIa inhibitors
    Richard H Aster
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, PO Box 2178, Milwaukee, WI 53201 2178, USA
    Chest 127:53S-59S. 2005
    ..In this review, we will consider the clinical aspects of thrombocytopenia resulting from sensitivity to GPIIb/IIIa inhibitors and will review evidence that the platelet destruction is antibody-mediated...
  22. ncbi request reprint Vancomycin-induced immune thrombocytopenia
    Annette Von Drygalski
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 356:904-10. 2007
    ..We conducted a study to determine whether thrombocytopenia is caused by vancomycin-dependent antibodies in patients being treated with vancomycin...
  23. ncbi request reprint Neonatal neutropenia and bacterial sepsis associated with placental transfer of maternal neutrophil-specific autoantibodies
    Anne Davoren
    Blood Center of Southeastern Wisconsin, Inc, Milwaukee, Wisconsin, USA
    Transfusion 44:1041-6. 2004
    ..The firstborn developed Citrobacter meningitis and was permanently disabled. The second was success-fully managed with pre- and postnatal injections of recombinant human granulocyte colony-stimulating factor (rHuG-CSF)...
  24. ncbi request reprint Neonatal alloimmune neutropenia attributed to maternal immunoglobulin G antibodies against the neutrophil alloantigen HNA-1c (SH): a report of five cases
    Brian R Curtis
    Platelet and Neutrophil Immunology Laboratory, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53233, USA
    Transfusion 45:1308-13. 2005
    ..In this report, we describe five cases of NAN, in which only anti-HNA-1c was detected in maternal serum...
  25. ncbi request reprint Fetal and neonatal alloimmune thrombocytopenia in pregnancies involving in vitro fertilization: a report of four cases
    Brian R Curtis
    The Blood Center of Southeastern Wisconsin, Milwaukee, Wis, USA
    Am J Obstet Gynecol 192:543-7. 2005
    ..We report four cases of neonatal alloimmune thrombocytopenia (NATP) in pregnancies achieved with in vitro fertilization...
  26. ncbi request reprint Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25- (nonregulatory) T cells
    Chao Yan Liu
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 174:2680-6. 2005
    ....
  27. ncbi request reprint Human platelet antigen-specific alloantibodies implicated in 1162 cases of neonatal alloimmune thrombocytopenia
    Anne Davoren
    Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Transfusion 44:1220-5. 2004
    ..As a national reference center for NATP investigations, our experience with this entity over a 12-year period was reviewed...
  28. ncbi request reprint Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension
    Shereif H Rezkalla
    Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA
    Catheter Cardiovasc Interv 58:76-9. 2003
    ..Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode...
  29. pmc Maternal alloimmunization against the rare platelet-specific antigen HPA-9b (Max a) is an important cause of neonatal alloimmune thrombocytopenia
    Julie A Peterson
    The Blood Research Institute, The BloodCenter of Wisconsin, 8727 Watertown Plank Road, Wauwatosa, WI 53226, USA
    Transfusion 45:1487-95. 2005
    ..This study investigated whether this can be explained in part by maternal immunization against the "rare" alloantigen HPA-9b (Max(a)), implicated previously only in a single NATP case...
  30. ncbi request reprint Quinine/quinidine-induced thrombocytopenia: a great imitator
    Josina C Reddy
    Genetech Inc, South San Francisco, CA 94080 4990, USA
    Arch Intern Med 164:218-20. 2004
  31. ncbi request reprint Heparin-induced thrombocytopenia associated with fondaparinux
    Theodore E Warkentin
    N Engl J Med 356:2653-5; discussion 2653-5. 2007
  32. ncbi request reprint Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Thromb Thrombolysis 22:95-102. 2006
    ..To assess etiology and impact of thrombocytopenia in a large oral glycoprotein (GP) IIb/IIIa inhibitor trial...
  33. ncbi request reprint Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen
    Daniel W Bougie
    Blood 109:3608-9. 2007
  34. ncbi request reprint Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature
    Brian R Curtis
    Platelet and Neutrophil Immunology Lab, Blood Center of Southeastern Wisconsin, Milwaukee 53233, USA
    Transfusion 42:1173-9. 2002
    ..A subset of these individuals is at risk for immunization against CD36, but the magnitude of this problem and its significance in transfusion medicine have not yet been clarified...
  35. ncbi request reprint Expression of ABH antigens on platelets
    Brian R Curtis
    Blood 107:842; author reply 842-3. 2006

Research Grants27

  1. HEMORRHAGIC DISEASES
    RICHARD HERBERT ASTER; Fiscal Year: 2010
    ..The proposed studies will lead to a better understanding of causation and to improved diagnosis and treatment. ..
  2. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2002
    ..Pathogenesis of other immune-mediated platelet disorders. Patients with other immune-mediated platelet disorders relevant to the objectives of this grant will be studied as they are encountered. ..
  3. RESEARCH TRAINING IN TRANSFUSION SCIENCE
    RICHARD ASTER; Fiscal Year: 2006
    ....
  4. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 2007
    ..Pathogenesis of other immune-mediated platelet disorders. Patients with other immune-mediated platelet disorders relevant to the objectives of this grant will be studies as time and resources permit. ..
  5. HEMORRHAGIC DISEASES
    RICHARD ASTER; Fiscal Year: 1980
    ..4. Short-term platelet preservation. Changes in membrane constituents of human platelets during short-term storage will be further characterized with special emphasis on major glycoproteins. ..