Xinhua Lin

Summary

Affiliation: BioSurface Engineering Technologies
Country: USA

Publications

  1. doi request reprint B2A as a positive BMP receptor modulator
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, Rockville, MD 20850, USA
    Growth Factors 30:149-57. 2012
  2. pmc B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    J Orthop Res 30:1221-8. 2012
  3. ncbi request reprint Augmentation of osseous phenotypes in vivo with a synthetic peptide
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    J Orthop Res 25:531-9. 2007
  4. ncbi request reprint Enhancement of cell attachment and tissue integration by a IKVAV containing multi-domain peptide
    X Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, MD 20850, USA
    Biochim Biophys Acta 1760:1403-10. 2006
  5. ncbi request reprint Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo
    X Lin
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Int J Mol Med 17:833-9. 2006
  6. ncbi request reprint Alleviation of experimental ulcerative colitis with the synthetic peptide, F2A4-K-NS (Fibratide)
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    Dig Dis Sci 52:2054-62. 2007
  7. ncbi request reprint A synthetic, bioactive PDGF mimetic with binding to both alpha-PDGF and beta-PDGF receptors
    Xinhua Lin
    BioSurface Engineering Technologies Inc, 9430 Key West Avenue, Rockville, MD 20850, USA
    Growth Factors 25:87-93. 2007
  8. ncbi request reprint Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic
    Xinhua Lin
    Medical Department, Brookhaven National Laboratory, USA
    J Orthop Res 24:2051-8. 2006
  9. ncbi request reprint Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro
    Xinhua Lin
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Bone Miner Res 20:693-703. 2005
  10. doi request reprint Biocompatibility and inflammation profile of B2A-coated granules used in arthrodesis
    Paul O Zamora
    BioSurface Engineering Technologies, Inc, Rockville, MD 20850, USA
    Int J Toxicol 32:154-61. 2013

Collaborators

Detail Information

Publications22

  1. doi request reprint B2A as a positive BMP receptor modulator
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, Rockville, MD 20850, USA
    Growth Factors 30:149-57. 2012
    ....
  2. pmc B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    J Orthop Res 30:1221-8. 2012
    ..These findings suggest that B2A induces stem cells chondrogenic differentiation in vitro and enhances cartilage repair in vivo. The results suggest that B2A might be useful to promote cartilage repair...
  3. ncbi request reprint Augmentation of osseous phenotypes in vivo with a synthetic peptide
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    J Orthop Res 25:531-9. 2007
    ..The results are consistent with the hypothesis that B2A2-K-NS augments osseous phenotypes in an osteoinductive environment, and suggests that B2A2-K-NS may have clinical utility...
  4. ncbi request reprint Enhancement of cell attachment and tissue integration by a IKVAV containing multi-domain peptide
    X Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, MD 20850, USA
    Biochim Biophys Acta 1760:1403-10. 2006
    ..The implant sites exhibited little inflammation or other untoward effects. The results indicated that the LA2 peptide improved cell adhesion and tissue integration and might be useful in a number of tissue engineering applications...
  5. ncbi request reprint Synthetic peptide F2A4-K-NS mimics fibroblast growth factor-2 in vitro and is angiogenic in vivo
    X Lin
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Int J Mol Med 17:833-9. 2006
    ..A synthetic mimetic of FGF-2, such as F2A4-K-NS, could be a useful tool in studying mechanisms of cell activation and potentially in various therapeutic applications...
  6. ncbi request reprint Alleviation of experimental ulcerative colitis with the synthetic peptide, F2A4-K-NS (Fibratide)
    Xinhua Lin
    BioSurface Engineering Technologies, Inc, 9430 Key West Avenue, Suite 220, Rockville, Maryland 20850, USA
    Dig Dis Sci 52:2054-62. 2007
    ..Collectively, the results indicate that Fibratide reduced the severity of experimental ulcerative colitis and may be potentially useful in the treatment of IBD...
  7. ncbi request reprint A synthetic, bioactive PDGF mimetic with binding to both alpha-PDGF and beta-PDGF receptors
    Xinhua Lin
    BioSurface Engineering Technologies Inc, 9430 Key West Avenue, Rockville, MD 20850, USA
    Growth Factors 25:87-93. 2007
    ..In these cell-based assays, PAB2-1c was effective at 1 microg/ml or lesser. The results support the hypothesis that PBA2-1c is a mimetic of PDGF, although it has a more promiscuous receptor interaction...
  8. ncbi request reprint Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic
    Xinhua Lin
    Medical Department, Brookhaven National Laboratory, USA
    J Orthop Res 24:2051-8. 2006
    ..In these studies, 100 ng of peptide per 0.2 mL of injectable DBM gel generated the most optimal results. The synthetic peptide F2A4-K-NS augmented DBM-induced ectopic mineralization in athymic animals...
  9. ncbi request reprint Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro
    Xinhua Lin
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Bone Miner Res 20:693-703. 2005
    ..B2A2's design permits its delivery as a local surface coating as well as a soluble co-factor, thus broadening potential bioengineering applications...
  10. doi request reprint Biocompatibility and inflammation profile of B2A-coated granules used in arthrodesis
    Paul O Zamora
    BioSurface Engineering Technologies, Inc, Rockville, MD 20850, USA
    Int J Toxicol 32:154-61. 2013
    ..Thus, traditional biocompatibility and specially designed inflammation models indicate a high degree of biocompatibility and a low possibility of toxicity, inflammation, or edema following the implant of B2A-coated granules...
  11. doi request reprint Nonclinical assessment of tumor growth enhancement potential by B2A-coated ceramic granules used in arthodesis
    Paul O Zamora
    BioSurface Engineering Technologies, Inc, Rockville, MD 20850, USA
    Int J Toxicol 32:146-53. 2013
    ..Thus, traditional genotoxicity, as well as specially designed tumor growth enhancement studies, indicates that the possibility of tumor enhancement appears unlikely...
  12. ncbi request reprint Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  13. ncbi request reprint Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation
    Xiaoming Li
    Division of Human Genetics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Biol Chem 277:27256-64. 2002
    ..These observations suggest that human MTO1 is a structural and functional homolog of yeast MTO1. Thus, it may play an important role in the pathogenesis of deafness-associated A1555G mutation in 12 S rRNA gene or mutations in tRNA genes...
  14. ncbi request reprint pygopus Encodes a nuclear protein essential for wingless/Wnt signaling
    Tatyana Y Belenkaya
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Development 129:4089-101. 2002
    ..Together, these findings demonstrate that Pygo is an essential component in the Wg/Wnt signal transduction pathway and is likely to act as a transcription co-activator required for the nuclear function of Arm/beta-catenin...
  15. ncbi request reprint Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation
    Chun Han
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 131:1563-75. 2004
    ..Our results also suggest that HSPGs have two distinct roles in Wg morphogen distribution and signalling...
  16. ncbi request reprint The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network
    Tatyana Y Belenkaya
    Division of Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 14:120-31. 2008
    ..Our findings link Wls and retromer functions in the same conserved Wnt secretion pathway. We propose that retromer influences Wnt secretion by recycling Wntless from endosomes to the trans-Golgi network (TGN)...
  17. pmc Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 312:203-16. 2007
    ..This mechanism is distinct from HSPG functions in morphogen distribution, and is likely a general paradigm for HSPG functions in FGF signaling in Drosophila...
  18. ncbi request reprint Functions of heparan sulfate proteoglycans in cell signaling during development
    Xinhua Lin
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 131:6009-21. 2004
    ..This review highlights recent findings regarding the functions of HSPGs in these signaling pathways during development...
  19. ncbi request reprint pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
    Ni Song
    Divisions of Pediatric Ophthalmology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1873-85. 2007
    ..Finally, we provide multiple lines of evidence that although Pygo2 can function in the Wnt pathway, its activity in lens development is Wnt pathway-independent...
  20. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  21. ncbi request reprint Shifted from Wnt to Hedgehog signaling pathways
    Chun Han
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Mol Cell 17:321-2. 2005
    ..2005; Gorfinkiel et al. 2005) have shown that Shifted, a Drosophila ortholog of Wnt Inhibitory Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism...
  22. ncbi request reprint Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...