T S Zheng

Summary

Affiliation: Biogen Inc
Country: USA

Publications

  1. ncbi request reprint Caspase knockouts: matters of life and death
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell Death Differ 6:1043-53. 1999
  2. ncbi request reprint Divinations and surprises: genetic analysis of caspase function in mice
    T S Zheng
    Biogen, Inc, Department of Inflammation, Immunology and Cell Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Exp Cell Res 256:67-73. 2000
  3. ncbi request reprint Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Med 6:1241-7. 2000
  4. ncbi request reprint Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    K Kuida
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 384:368-72. 1996
  5. ncbi request reprint Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    D D Yang
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 389:865-70. 1997
  6. pmc Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:13618-23. 1998
  7. ncbi request reprint Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways
    A U Zaidi
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 21:169-75. 2001
  8. ncbi request reprint DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3
    C D'Sa-Eipper
    Department of Pathology, Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 128:137-46. 2001
  9. pmc Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
    K A Roth
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:466-71. 2000
  10. ncbi request reprint Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary
    T Matikainen
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Endocrinology 142:2468-80. 2001

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Caspase knockouts: matters of life and death
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell Death Differ 6:1043-53. 1999
    ..We will also provide our prediction on the direction of future studies in this ever-growing field of caspases...
  2. ncbi request reprint Divinations and surprises: genetic analysis of caspase function in mice
    T S Zheng
    Biogen, Inc, Department of Inflammation, Immunology and Cell Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Exp Cell Res 256:67-73. 2000
    ....
  3. ncbi request reprint Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Med 6:1241-7. 2000
    ..Our findings provide direct experimental evidence for compensatory pathways of caspase activation. This issue should therefore be considered in developing caspase inhibitors for therapeutic applications...
  4. ncbi request reprint Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    K Kuida
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 384:368-72. 1996
    ..Thus CPP32 is shown to play a critical role during morphogenetic cell death in the mammalian brain...
  5. ncbi request reprint Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    D D Yang
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 389:865-70. 1997
    ..These data indicate that the observed neuroprotection is due to the extinction of a Jnk3-mediated signalling pathway, which is an important component in the pathogenesis of glutamate neurotoxicity...
  6. pmc Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
    T S Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 95:13618-23. 1998
    ..The altered cleavage of these key substrates is likely responsible for the aberrant apoptosis observed in both hepatocytes and thymocytes deficient in caspase-3...
  7. ncbi request reprint Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways
    A U Zaidi
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 21:169-75. 2001
    ..In total, these results indicate a transition from Caspase-9- to Bax- and Bcl-X(L)-mediated neuronal apoptosis...
  8. ncbi request reprint DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3
    C D'Sa-Eipper
    Department of Pathology, Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 128:137-46. 2001
    ....
  9. pmc Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death
    K A Roth
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:466-71. 2000
    ....
  10. ncbi request reprint Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary
    T Matikainen
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    Endocrinology 142:2468-80. 2001
    ..We conclude that caspase-3 is functionally required for granulosa cell apoptosis during follicular atresia, but that the enzyme is dispensable for germ cell apoptosis in the female...
  11. ncbi request reprint Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis
    J P Medema
    Tumorimmunology Program, German Cancer Research Center, Heidelberg
    Eur J Immunol 27:3492-8. 1997
    ..We therefore conclude that FLICE not only plays a central role in CD95(APO-1/Fas)-induced apoptosis but can also be directly activated during perforin/GrB-induced apoptosis...