Gang Yao

Summary

Affiliation: Biogen Idec
Country: USA

Publications

  1. ncbi request reprint Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists
    Gang Yao
    Departments of Medicinal Chemistry and Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 15:511-5. 2005
  2. ncbi request reprint Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists
    Hairuo Peng
    Department of Medicinal Chemistry, Biogen Idec Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    J Med Chem 47:6218-29. 2004
  3. ncbi request reprint Synthetic studies toward bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus
    Gang Yao
    Department of Chemistry, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA
    Org Lett 4:485-8. 2002
  4. ncbi request reprint Identification of core functional region of murine IL-4 using peptide phage display and molecular modeling
    Gang Yao
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Int Immunol 18:19-29. 2006

Detail Information

Publications4

  1. ncbi request reprint Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists
    Gang Yao
    Departments of Medicinal Chemistry and Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 15:511-5. 2005
    ..Compound 12, in particular, was found to be orally active at 3mg/kg in both a mouse catalepsy model and a 6-hydroxydopamine-lesioned rat model...
  2. ncbi request reprint Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists
    Hairuo Peng
    Department of Medicinal Chemistry, Biogen Idec Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    J Med Chem 47:6218-29. 2004
    ..Among a number of compounds tested, compounds 21a and 21c exhibited significantly improved metabolic stability. Compounds 21a, 21c, and 18a showed good oral efficacy in rodent catalepsy models of Parkinson's disease...
  3. ncbi request reprint Synthetic studies toward bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus
    Gang Yao
    Department of Chemistry, Metcalf Center for Science and Engineering, 590 Commonwealth Avenue, Boston University, Boston, Massachusetts 02215, USA
    Org Lett 4:485-8. 2002
    ..By comparing spectral data of the synthesized compounds and the natural material, we tentatively assign the absolute stereochemistry for the natural product as 3S,6R,8S,10R...
  4. ncbi request reprint Identification of core functional region of murine IL-4 using peptide phage display and molecular modeling
    Gang Yao
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Int Immunol 18:19-29. 2006
    ..In addition, the results demonstrate that 11B.11 binds to a core functional region of murine IL-4, which prevents this cytokine from interacting with its cognate receptor...