F R Taylor

Summary

Affiliation: Biogen Inc
Country: USA

Publications

  1. ncbi request reprint Biochemical analysis of retroviral structural proteins to identify and quantify retrovirus expressed by an NS0 murine myeloma cell line
    F R Taylor
    Biogen Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Biotechnol 84:33-43. 2001
  2. ncbi request reprint Enhanced potency of human Sonic hedgehog by hydrophobic modification
    F R Taylor
    Biogen, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Biochemistry 40:4359-71. 2001
  3. ncbi request reprint Identification of a palmitic acid-modified form of human Sonic hedgehog
    R B Pepinsky
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 273:14037-45. 1998
  4. ncbi request reprint Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
    K P Williams
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Cell Sci 112:4405-14. 1999
  5. ncbi request reprint Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody
    M Karpusas
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    Structure 9:321-9. 2001
  6. ncbi request reprint Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
    L C Wang
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Invest Dermatol 114:901-8. 2000
  7. ncbi request reprint The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    R Pola
    Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nat Med 7:706-11. 2001

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Biochemical analysis of retroviral structural proteins to identify and quantify retrovirus expressed by an NS0 murine myeloma cell line
    F R Taylor
    Biogen Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Biotechnol 84:33-43. 2001
    ..The Western blot method has higher throughput and less variability than transmission electron microscopy methods and has potential for monitoring viral titer and clearance during development of manufacturing processes...
  2. ncbi request reprint Enhanced potency of human Sonic hedgehog by hydrophobic modification
    F R Taylor
    Biogen, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Biochemistry 40:4359-71. 2001
    ..Activation of Desert Hh through modification of its N-terminus was also observed, suggesting that this is a common feature of Hh proteins...
  3. ncbi request reprint Identification of a palmitic acid-modified form of human Sonic hedgehog
    R B Pepinsky
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 273:14037-45. 1998
    ..The observation that an extracellular protein such as Shh is palmitoylated is highly unusual and further adds to the complex nature of this protein...
  4. ncbi request reprint Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
    K P Williams
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Cell Sci 112:4405-14. 1999
    ..The ability to dissect patched-1 binding from signaling events in C3H10T1/2 cells suggests the presence of unidentified factors that contribute to hedgehog responses...
  5. ncbi request reprint Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody
    M Karpusas
    Biogen, Inc, Cambridge, Massachusetts 02142, USA
    Structure 9:321-9. 2001
    ..It results in various B cell responses, including immunoglobulin isotype switching and B cell differentiation and proliferation. These responses can be inhibited by the monoclonal antibody 5c8, which binds with high affinity to CD40L...
  6. ncbi request reprint Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
    L C Wang
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Invest Dermatol 114:901-8. 2000
    ..Our system of generating an inducible and reversible hairless phenotype by anti-hedgehog monoclonal antibody treatment will be valuable for studying the regulation and mechanism of hair regeneration...
  7. ncbi request reprint The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    R Pola
    Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nat Med 7:706-11. 2001
    ..These findings reveal a novel role for Shh as an indirect angiogenic factor regulating expression of multiple angiogenic cytokines and indicate that Shh might have potential therapeutic use for ischemic disorders...