Ronenn Roubenoff

Summary

Affiliation: Biogen Idec
Country: USA

Publications

  1. ncbi request reprint Physical activity, inflammation, and muscle loss
    Ronenn Roubenoff
    School of Medicine, Tufts University, Boston, Massachusetts, USA
    Nutr Rev 65:S208-12. 2007
  2. doi request reprint Molecular basis of inflammation: relationships between catabolic cytokines, hormones, energy balance, and muscle
    Ronenn Roubenoff
    Immunology R and D, Biogen Idec, Cambridge, Massachusetts 02142, USA
    JPEN J Parenter Enteral Nutr 32:630-2. 2008
  3. pmc Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century
    Ronenn Roubenoff
    Immunology R and D, Biogen Idec, Inc, Cambridge, MA 02142, USA
    Arthritis Res Ther 11:108. 2009
  4. ncbi request reprint Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
    Ronenn Roubenoff
    United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Am J Med 115:429-35. 2003
  5. ncbi request reprint Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress
    Jennifer M Sacheck
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Physiol Endocrinol Metab 291:E340-9. 2006
  6. pmc Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit
    Naomi Brooks
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Appl Physiol 105:241-8. 2008
  7. ncbi request reprint Anthropometric assessment of 10-y changes in body composition in the elderly
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 80:475-82. 2004
  8. pmc Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    Lydia Sakakeeny
    Vitamin Metabolism Laboratory, Tufts University, Boston, MA, USA
    J Nutr 142:1280-5. 2012
  9. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
  10. pmc Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Box 406, Tufts University School of Medicine, Boston, MA 02111, USA
    Arthritis Rheum 61:1545-53. 2009

Detail Information

Publications62

  1. ncbi request reprint Physical activity, inflammation, and muscle loss
    Ronenn Roubenoff
    School of Medicine, Tufts University, Boston, Massachusetts, USA
    Nutr Rev 65:S208-12. 2007
    ..Without a doubt, exercise is an intervention that reliably counteracts the loss of muscle mass, strength, and power common in our increasingly aged, and pervasively sedentary, population...
  2. doi request reprint Molecular basis of inflammation: relationships between catabolic cytokines, hormones, energy balance, and muscle
    Ronenn Roubenoff
    Immunology R and D, Biogen Idec, Cambridge, Massachusetts 02142, USA
    JPEN J Parenter Enteral Nutr 32:630-2. 2008
    ..Improved understanding of the interplay of the immune system and metabolism can lead to new treatments for both cachexia and obesity...
  3. pmc Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century
    Ronenn Roubenoff
    Immunology R and D, Biogen Idec, Inc, Cambridge, MA 02142, USA
    Arthritis Res Ther 11:108. 2009
    ....
  4. ncbi request reprint Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
    Ronenn Roubenoff
    United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Am J Med 115:429-35. 2003
    ..We hypothesized that these factors are independently linked to mortality in community-dwelling older persons...
  5. ncbi request reprint Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress
    Jennifer M Sacheck
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Physiol Endocrinol Metab 291:E340-9. 2006
    ....
  6. pmc Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit
    Naomi Brooks
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Appl Physiol 105:241-8. 2008
    ..These data support the efficacy of combined AA and RT as a countermeasure against muscle wasting due to low gravity...
  7. ncbi request reprint Anthropometric assessment of 10-y changes in body composition in the elderly
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 80:475-82. 2004
    ..An increased central distribution of fat with advancing age is associated with chronic metabolic and cardiovascular abnormalities. Little is known about the magnitude or pattern of fat distribution and its association with healthy aging...
  8. pmc Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    Lydia Sakakeeny
    Vitamin Metabolism Laboratory, Tufts University, Boston, MA, USA
    J Nutr 142:1280-5. 2012
    ..We discuss 2 possible roles for PLP in the inflammatory process, including tryptophan metabolism and serine hydroxymethyltransferase activity...
  9. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  10. pmc Tai Chi is effective in treating knee osteoarthritis: a randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Box 406, Tufts University School of Medicine, Boston, MA 02111, USA
    Arthritis Rheum 61:1545-53. 2009
    ..To evaluate the effectiveness of Tai Chi in the treatment of knee osteoarthritis (OA) symptoms...
  11. ncbi request reprint Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise
    Koichiro Hamada
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    FASEB J 19:264-6. 2005
    ..057) but not in old men. Our results suggest that aging impairs the adaptive response of human skeletal muscle to eccentric exercise by differential modulation of a discrete set of inflammatory and anti-inflammatory cytokine genes...
  12. ncbi request reprint Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis
    Joseph Walsmith
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Rheumatol 31:23-9. 2004
    ..To examine the relationship between inflammatory cytokine production and body cell mass (BCM) in women with stable, medically well-controlled rheumatoid arthritis (RA)...
  13. pmc Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 141:1146-53. 2011
    ..04-0.96). No significant associations were observed among intakes of EPA, DHA, EPA+DHA, or fish. These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men...
  14. pmc Plasma phosphatidylcholine concentrations of polyunsaturated fatty acids are differentially associated with hip bone mineral density and hip fracture in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Bone Miner Res 27:1222-30. 2012
    ..00). Opposing effects of PC DHA on FN-BMD loss observed in women and men need further clarification. Bone loss associated with PC LA may be confounded by BMI. High PC AA concentrations may be associated with reduced hip fracture risk...
  15. pmc Muscle fiber size and function in elderly humans: a longitudinal study
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Appl Physiol 105:637-42. 2008
    ..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity...
  16. ncbi request reprint Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion
    Laura C Rall
    Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arthritis Rheum 46:2574-7. 2002
    ..quot;..
  17. pmc Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes
    Naomi Brooks
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Med Sci 4:19-27. 2007
    ..However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes...
  18. ncbi request reprint Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study
    Hélène Payette
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, Massachusetts, USA
    J Am Geriatr Soc 51:1237-43. 2003
    ..To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders...
  19. ncbi request reprint Low physical activity reduces total energy expenditure in women with rheumatoid arthritis: implications for dietary intake recommendations
    Ronenn Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:774-9. 2002
    ..It is not known which effect predominates in regulating total energy expenditure (TEE), and thus whether the dietary energy requirements of subjects with RA are higher or lower than those of healthy subjects...
  20. ncbi request reprint Eating behavior and weight change in healthy postmenopausal women: results of a 4-year longitudinal study
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Gerontol A Biol Sci Med Sci 61:608-15. 2006
    ..However, the association of eating behavior with unexplained weight change in old age is relatively unexplored...
  21. ncbi request reprint Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:143-8. 2004
    ..Although a vitamin E-vitamin K interaction was proposed to underlie this effect, it has not been systematically investigated in adults with normal baseline coagulation status...
  22. ncbi request reprint Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease
    Carmen Castaneda
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Kidney Dis 43:607-16. 2004
    ..Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease...
  23. ncbi request reprint Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Med 114:283-7. 2003
    ..We examined whether these abnormalities are associated with clinical and biochemical indicators of disease status...
  24. ncbi request reprint Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis
    Senada Arabelovic
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Am Coll Nutr 26:453-5. 2007
    ..However, an increase in dietary folate intake could theoretically reduce the effectiveness of the anti-folate medication, methotrexate (MTX) in treating rheumatoid arthritis (RA) and other inflammatory diseases...
  25. ncbi request reprint The effects of multidimensional home-based exercise on functional performance in elderly people
    Miriam E Nelson
    John Hancock Center for Physical Activity and Nutrition, Friedman School of Nutrition Science and Policy, Tufts University, Medford, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 59:154-60. 2004
    ..This study tested the hypothesis that a home-based exercise program would improve functional performance in elderly people...
  26. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  27. ncbi request reprint Catabolism of aging: is it an inflammatory process?
    Ronenn Roubenoff
    Department of Molecular Medicine, Millennium Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    Curr Opin Clin Nutr Metab Care 6:295-9. 2003
    ..This review focuses on recent developments in the field, especially regarding the role of catabolic stimuli in causing sarcopenia...
  28. ncbi request reprint Cytokine responses differ by compartment and wasting status in patients with HIV infection and healthy controls
    Leslie W Abad
    Department of Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Cytokine 18:286-93. 2002
    ....
  29. doi request reprint Convergent Random Forest predictor: methodology for predicting drug response from genome-scale data applied to anti-TNF response
    Jadwiga R Bienkowska
    Biogen IDEC 14 Cambridge Ctr, Cambridge, MA 02142, USA
    Genomics 94:423-32. 2009
    ..For both methods performance estimates using cross-validation is similar to performance on independent samples. The method has been implemented in R and is available from the authors upon request: Jadwiga.Bienkowska@biogenidec.com...
  30. ncbi request reprint Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate
    Alex Parker
    Millennium Pharmaceuticals Inc, Cambridge, Massachusetts, USA
    J Rheumatol 34:1817-22. 2007
    ..We analyzed association of gene expression with disease activity, rheumatoid factor (RF), age, sex, disease duration, treatment modality, and clinical response...
  31. pmc Tai Chi for treating knee osteoarthritis: designing a long-term follow up randomized controlled trial
    Chenchen Wang
    Division of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    BMC Musculoskelet Disord 9:108. 2008
    ..The study will be completed by July 2009...
  32. ncbi request reprint Longitudinal changes in body composition in older men and women: role of body weight change and physical activity
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:473-81. 2002
    ..Estimates of body-composition change in older adults are mostly derived from cross-sectional data...
  33. pmc Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 302:2565-72. 2009
    ..The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes beta-amyloid clearance, and improves memory function in animal models of aging and Alzheimer disease (AD)...
  34. ncbi request reprint Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
    Ronenn Roubenoff
    Department of Community Health, Jean Mayer US Department of Agriculture Human Nutrition Research Center, Tufts University, Boston, Massachusetts 02111, USA
    Am J Physiol Endocrinol Metab 283:E138-45. 2002
    ..Even though weight loss was rare in this cohort of patients treated with highly active antiretroviral therapy, loss of LBM was common and was driven by catabolic cytokines and not by inadequate dietary intake or hypogonadism...
  35. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    ..Replications of these results in independent and larger data sets clearly are required. We provide a reference list of candidate SNPs (P < 0.01) that can be investigated in future pharmacogenomic studies...
  36. doi request reprint Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor
    Derrick J Todd
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Rheum 63:894-903. 2011
    ..The purpose of this study was to assess whether these factors confound multiplex-based immunoassays, which are used with increasing frequency to measure cytokine and chemokine analytes in patients with rheumatoid arthritis (RA)...
  37. ncbi request reprint Strength training in older women: early and late changes in whole muscle and single cells
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Muscle Nerve 28:601-8. 2003
    ..Later, cellular adaptations in specific force track closely whole muscle changes...
  38. ncbi request reprint Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men
    Jennifer M Sacheck
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:1575-88. 2003
    ....
  39. pmc Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study
    Emily K Farina
    Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA
    Am J Clin Nutr 93:1142-51. 2011
    ..Polyunsaturated fatty acids and fish may influence bone health...
  40. doi request reprint Recent advances in the biology and therapy of muscle wasting
    David Glass
    Muscle Disease Group Musculoskeletal Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA
    Ann N Y Acad Sci 1211:25-36. 2010
    ..However, there is growing excitement among researchers in this field that developments may yield new treatments for muscle wasting in the future...
  41. pmc Relation of serum leptin with cardiac mass and left atrial dimension in individuals >70 years of age
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 104:602-5. 2009
    ....
  42. ncbi request reprint Metabolic aging and predicted longevity: results of a cross-sectional study in post-menopausal women
    Nicholas P Hays
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Aging Clin Exp Res 14:465-73. 2002
    ..The objective of this study was to examine the association of age-related physiological and metabolic variables with predicted longevity in postmenopausal women...
  43. ncbi request reprint Sarcopenia: effects on body composition and function
    Ronenn Roubenoff
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 58:1012-7. 2003
    ..In this review, I discuss the potential mechanisms of sarcopenia and some ideas about prevention and treatment...
  44. ncbi request reprint Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis
    Hua Liao
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Arthritis Rheum 50:3792-803. 2004
    ..To identify a panel of candidate protein biomarkers of rheumatoid arthritis (RA) that can predict which patients will develop erosive, disabling disease...
  45. ncbi request reprint Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin B-6 indices in patients with rheumatoid arthritis and marginal vitamin B-6 status
    En Pei I Chiang
    Vitamin Metabolism and Aging Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 133:1056-9. 2003
    ..420, P = 0.015 and r = 0.333, P = 0.05, respectively). We suggest that in patients with RA, plasma PLP levels are a better diagnostic indicator of functional vitamin B-6 status than erythrocyte PLP levels...
  46. ncbi request reprint A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes
    Carmen Castaneda
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 25:2335-41. 2002
    ..To determine the efficacy of high-intensity progressive resistance training (PRT) on glycemic control in older adults with type 2 diabetes...
  47. pmc Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis
    Heming Xing
    Gene Network Sciences, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001105. 2011
    ....
  48. ncbi request reprint Exercise, sarcopenia, cognition, and mood
    Ronenn Roubenoff
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 6:151-9; discussion 160-2. 2002
  49. ncbi request reprint Exercise and inflammatory disease
    Ronenn Roubenoff
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Arthritis Rheum 49:263-6. 2003
  50. ncbi request reprint The healthcare costs of sarcopenia in the United States
    Ian Janssen
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:80-5. 2004
    ..To estimate the healthcare costs of sarcopenia in the United States and to examine the effect that a reduced sarcopenia prevalence would have on healthcare expenditures...
  51. pmc Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men
    Joel O Olubodun
    Department of Pharmacology and Experimental Therapeutics and the Jean Mayer USDA Human Nutrition Research Center on Ageing, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Br J Clin Pharmacol 56:297-304. 2003
    ..The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers...
  52. ncbi request reprint Cachexia in rheumatoid arthritis
    Joseph Walsmith
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cardiol 85:89-99. 2002
    ..In this review, we outline the current definition of rheumatoid cachexia, and discuss the etiology, pathogenesis, and treatment of rheumatoid cachexia...
  53. ncbi request reprint Reduction of abdominal obesity in lipodystrophy associated with human immunodeficiency virus infection by means of diet and exercise: case report and proof of principle
    Ronenn Roubenoff
    Department of Community Health, Tufts University School of Medicine, and Jean Mayer US Department of Agriculture Human Nutrition Research Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 34:390-3. 2002
    ..An exercise program combined with a moderate-fat, low-glycemic-index, high-fiber diet can reverse several aspects of lipodystrophy, and, until specific treatment is available, should be considered for treatment of lipodystrophy...
  54. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  55. ncbi request reprint Sarcopenic obesity: the confluence of two epidemics
    Ronenn Roubenoff
    Molecular Medicine, Millennium Pharmaceuticals Cambridge, MA 02139, USA
    Obes Res 12:887-8. 2004
  56. pmc Inflammation causes tissue-specific depletion of vitamin B6
    En Pei Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Arthritis Res Ther 7:R1254-62. 2005
    ..The low plasma pyridoxal 5'-phosphate levels seen in inflammation are unlikely to be due to insufficient intake or excessive vitamin B6 excretion. Possible causes of decreased levels of vitamin B6 are discussed...
  57. ncbi request reprint Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...
  58. ncbi request reprint Exercise training alters skeletal muscle mitochondrial morphometry in heart failure patients
    Cheryl Santoro
    University of Connecticut, School of Allied Health, Storrs, CT, USA
    J Cardiovasc Risk 9:377-81. 2002
    ..Previous research has demonstrated that exercise intolerance in heart failure patients is associated with significant alterations in skeletal muscle ultrastructure and oxidative metabolism that may be more consequential than cardiac output...
  59. pmc Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis
    En Pei I Chiang
    Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, Republic of China
    Arthritis Res Ther 7:R1404-11. 2005
    ..Data from the present study suggest that patients with rheumatoid arthritis may have higher requirements for vitamin B6 than those in a normal healthy population...
  60. ncbi request reprint Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women
    Ian Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Epidemiol 159:413-21. 2004
    ....
  61. ncbi request reprint Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial
    E Todd Schroeder
    Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
    Clin Trials 4:560-71. 2007
    ..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging...
  62. ncbi request reprint The role of cytokines in regulating protein metabolism and muscle function
    Elena Zoico
    Cattedra di Geriatria, Universita di Verona, Italy
    Nutr Rev 60:39-51. 2002
    ..Even though several gaps remain in our understanding, these observations may be useful in the development of strategies to control protein metabolism and muscle function in different clinical conditions...