Research Topics
Genomes and Genes | Jennifer S MichaelsonSummaryAffiliation: Biogen Idec Country: USA Publications
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Detail Information
Publications
Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathwayJennifer S Michaelson
Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Results Probl Cell Differ 49:145-60. 2009....
Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaRJennifer S Michaelson
Biogen Idec, Inc, Cambridge, MA 02142, USA
MAbs 1:128-41. 2009..These studies support that stability-engineering is an enabling step for producing scalable IgG-like BsAbs with properties desirable for biopharmaceutical development...
The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft modelsJennifer S Michaelson
Biogen Idec, Cambridge, MA, USA
Cancer Biol Ther 13:812-21. 2012..Taken together, the data presented herein suggest that BIIB036 warrants evaluation in the clinic...- Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort studyNoa Schwartz
Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Arthritis Res Ther 11:R143. 2009..Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently introduced. Thus, TWEAK levels may serve as an indication of LN presence and activity... - Tweak induces mammary epithelial branching morphogenesisJennifer S Michaelson
Department of Exploratory Science, Biogen Idec, 12 Cambridge Center, Bio6 320, Cambridge MA, USA
Oncogene 24:2613-24. 2005..Together, our results suggest that the Tweak/Fn14 pathway may be protumorigenic in human breast cancer... - Development of an Fn14 agonistic antibody as an anti-tumor agentJennifer S Michaelson
Molecular Discovery, Biogen Idec, 12 Cambridge Center, Cambridge, MA, USA
MAbs 3:362-75. 2011..Taken together, the anti-tumor properties of BIIB036 validate Fn14 as a promising target in oncology and demonstrate its potential therapeutic utility in multiple solid tumor indications... - TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regenerationMahasweta Girgenrath
Boston Biomedical Research Institute, Watertown, MA, USA
EMBO J 25:5826-39. 2006.... - TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and diseaseLinda C Burkly
Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Cytokine 40:1-16. 2007..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer... - Stability engineering of scFvs for the development of bispecific and multivalent antibodiesBrian R Miller
Biogen Idec, Inc, 5200 Research Place, San Diego, CA 92122, USA
Protein Eng Des Sel 23:549-57. 2010..Introduction of a stability-engineered scFv as part of an IgG-like BsAb enabled scalable production and purification of BsAb with favorable biophysical properties... - TWEAK induces liver progenitor cell proliferationAniela Jakubowski
Department of Exploratory Science, Biogen Idec Inc, Cambridge, Massachusetts 02142, USA
J Clin Invest 115:2330-40. 2005..We conclude that TWEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors... - TWEAK/Fn14 pathway: an immunological switch for shaping tissue responsesLinda C Burkly
Immunology Discovery Research, Biogen Idec, Inc, Cambridge, MA 02142, USA
Immunol Rev 244:99-114. 2011..Whereas transient TWEAK/Fn14 activation promotes productive tissue responses after injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration... - Role of TWEAK in lupus nephritis: a bench-to-bedside reviewJennifer S Michaelson
Immunology Discovery Biology, Biogen Idec, Cambridge, MA 02142, USA
J Autoimmun 39:130-42. 2012..Taken together, targeting the TWEAK/Fn14 axis represents a potential new therapeutic paradigm for achieving renal protection in LN patients... - TWEAK signals through JAK-STAT to induce tumor cell apoptosisMark S Chapman
Molecular Discovery, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States
Cytokine 61:210-7. 2013..These findings may have implications for the appropriately targeted clinical development of Fn14 agonists as anti-cancer therapy... - Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcomeNhan L Tran
Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
Cancer Res 66:9535-42. 2006..Such a feedback loop argues for aggressive targeting of the Fn14 axis as a unique and specific driver of glioma malignant behavior... - Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cellsSean Campbell
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 176:1889-98. 2006..Our results support Ab inhibition of TWEAK as a potential new approach for the treatment of chemokine-dependent inflammatory kidney diseases... - TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosusZeguo Zhao
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 179:7949-58. 2007..Thus, TWEAK blockade may be a novel therapeutic approach to reduce renal damage in SLE... - Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritisNoa Schwartz
Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Ann N Y Acad Sci 1109:265-74. 2007..Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN... - Urinary TWEAK and the activity of lupus nephritisNoa Schwartz
Division of Rheumatology, Forchheimer 701N, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Autoimmun 27:242-50. 2006..An accurate, non-invasive method to repeatedly assess kidney disease in lupus would be very helpful in managing these often challenging patients. Our study indicates that urinary TWEAK levels may be useful as a novel biomarker in LN... - Critical role for Daxx in regulating Mdm2Jun Tang
Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Nat Cell Biol 8:855-62. 2006..These findings reveal that Daxx modulates the function of Mdm2 at multiple levels and suggest that the disruption of the Mdm2-Daxx interaction may be important for p53 activation in response to DNA damage... - TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemiaXiaohui Zhang
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
J Cereb Blood Flow Metab 27:534-44. 2007..These findings show that the cytokine TWEAK plays a role in the disruption of the structure of the NVU during cerebral ischemia and that TWEAK antagonism is a potential therapeutic strategy for acute cerebral ischemia... - Elucidation of a downstream boundary of the 3' IgH regulatory regionJohn P Manis
Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School Boston, Enders Building, Room 861, 320 Longwood Avenue, Boston, MA 02115, USA
Mol Immunol 39:753-60. 2003..These findings, coupled with previous pgk-neo insertion studies, suggest that key elements of the 3' IgH RR lie within a 17kb region between HS1,2 and 2kb downstream of HS4... - Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activityJeffrey A Ecsedy
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 23:950-60. 2003..Taken together, our results indicate that HIPK1 and Daxx collaborate in regulating transcription... - Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differentlyIsabelle Nefkens
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
J Cell Sci 116:513-24. 2003..The fact that enzymatic activation of protein release or segregation after stress modifies the heat-shock response strengthens the concept of ND10 as a regulated depot of effector proteins... - RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXXJennifer S Michaelson
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cell Sci 116:345-52. 2003..Thus, depletion of DAXX by RNAi has verified the crucial role of endogenous DAXX as an anti-apoptotic regulator, and has allowed the identification of probable physiological targets of DAXX transcriptional repression...