Sha Mi

Summary

Affiliation: Biogen Idec
Country: USA

Publications

  1. ncbi request reprint LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 7:221-8. 2004
  2. ncbi request reprint LINGO-1 negatively regulates myelination by oligodendrocytes
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 8:745-51. 2005
  3. doi request reprint Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection
    Qing Ling Fu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Invest Ophthalmol Vis Sci 49:975-85. 2008
  4. ncbi request reprint Troy/Taj and its role in CNS axon regeneration
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
    Cytokine Growth Factor Rev 19:245-51. 2008
  5. pmc Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis
    G Huang
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Cell Death Dis 4:e841. 2013
  6. pmc A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death
    Y Hu
    Department of Discovery Neurobiology, BiogenIdec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Cell Death Dis 4:e579. 2013
  7. doi request reprint Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic
    Sha Mi
    Department of Discovery Neurobiology, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    CNS Drugs 27:493-503. 2013
  8. doi request reprint Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination
    Sha Mi
    Biogen Idec, Cambridge, Massachusetts, USA
    Nat Med 17:816-21. 2011
  9. doi request reprint Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
    Sha Mi
    Biogen Idec, Cambridge, MA 02142, USA
    Ann Neurol 65:304-15. 2009
  10. doi request reprint LINGO-1 and its role in CNS repair
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
    Int J Biochem Cell Biol 40:1971-8. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 7:221-8. 2004
    ..This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology...
  2. ncbi request reprint LINGO-1 negatively regulates myelination by oligodendrocytes
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 8:745-51. 2005
    ..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination...
  3. doi request reprint Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection
    Qing Ling Fu
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China
    Invest Ophthalmol Vis Sci 49:975-85. 2008
    ..The authors sought to examine whether blocking LINGO-1 function with LINGO-1 antagonists promotes retinal ganglion cell (RGC) survival after ocular hypertension and optic nerve transection...
  4. ncbi request reprint Troy/Taj and its role in CNS axon regeneration
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
    Cytokine Growth Factor Rev 19:245-51. 2008
    ..The discovery of TROY function in axon growth is an important step for understanding the complex regulation of axonal regeneration by diverse members of the TNF receptor family...
  5. pmc Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis
    G Huang
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Cell Death Dis 4:e841. 2013
    ..Blocking DR6 function represents a new approach for the treatment of neurodegenerative disorders involving motor neuron death and axon degeneration, such as ALS. ..
  6. pmc A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death
    Y Hu
    Department of Discovery Neurobiology, BiogenIdec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Cell Death Dis 4:e579. 2013
    ..Targeting the disruption of the DR6/p75(NTR) complex to prevent Aβ cytotoxicity represents a new approach for the treatment of neurodegenerative disorders such as AD...
  7. doi request reprint Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic
    Sha Mi
    Department of Discovery Neurobiology, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    CNS Drugs 27:493-503. 2013
    ..The targeted inhibition of LINGO-1 function presents a novel therapeutic approach for the treatment of CNS diseases. ..
  8. doi request reprint Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination
    Sha Mi
    Biogen Idec, Cambridge, Massachusetts, USA
    Nat Med 17:816-21. 2011
    ..These studies reveal a pivotal role for DR6 signaling in immature oligodendrocyte maturation and myelination that may provide new therapeutic avenues for the treatment of demyelination disorders such as multiple sclerosis...
  9. doi request reprint Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
    Sha Mi
    Biogen Idec, Cambridge, MA 02142, USA
    Ann Neurol 65:304-15. 2009
    ..In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo...
  10. doi request reprint LINGO-1 and its role in CNS repair
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States
    Int J Biochem Cell Biol 40:1971-8. 2008
    ..The targeted inhibition of LINGO-1 therefore presents a novel therapeutic approach for the treatment of neurological diseases...
  11. ncbi request reprint LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Med 13:1228-33. 2007
    ..Antagonism of LINGO-1 or its pathway is therefore a promising approach for the treatment of demyelinating diseases of the CNS...
  12. ncbi request reprint TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration
    Zhaohui Shao
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Neuron 45:353-9. 2005
    ..Given the limited expression of p75, the discovery of TAJ function is an important step for understanding the regulation of axonal regeneration...
  13. pmc Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury
    Benxiu Ji
    Department of Discovery Biology, Biogen Idec Inc, 14 Cambridge Center, Cambridge MA 02142, USA
    Mol Cell Neurosci 39:258-67. 2008
    ..However, OMgp(-/-) mice on a BL/6 genetic background showed neither statistically significant functional recovery nor axonal sprouting following dorsal hemisection...
  14. ncbi request reprint LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
    Benxiu Ji
    Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell Neurosci 33:311-20. 2006
    ..These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury...
  15. doi request reprint Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration
    R Blake Pepinsky
    Department of Drug and Molecular Discovery, Biogen Idec, Inc, Cambridge, MA 02142, USA
    J Pharmacol Exp Ther 339:519-29. 2011
    ..These studies demonstrate that exposure levels achieved by passive diffusion of the Li81 monoclonal antibody into the CNS are sufficient and lead to robust remyelination...
  16. doi request reprint Oligodendrocyte differentiation and myelination defects in OMgp null mice
    Xinhua Lee
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell Neurosci 46:752-61. 2011
    ..The dramatic effects of the OMgp KO in oligodendrocyte maturation in vivo and in vitro reveal a new and important function for OMgp in regulating CNS myelination...
  17. ncbi request reprint NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination
    Xinhua Lee
    Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:220-5. 2007
    ..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...
  18. doi request reprint Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination
    R Blake Pepinsky
    Department of Drug, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States
    Bioconjug Chem 22:200-10. 2011
    ..These studies extend our understanding of the biological activity of the Li33 mAb and validate the use of an anti-LINGO-1 PEG-Fab' for treatment of CNS diseases caused by demyelination...
  19. pmc Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
    R Blake Pepinsky
    Department of Drug Discovery, Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
    Protein Sci 19:954-66. 2010
    ..Through these efforts we were able to improve the solubility of the Li33 Mab from 0.3 mg/mL to >50 mg/mL and reduce aggregation to an acceptable level. These strategies can be readily applied to other proteins with solubility issues...
  20. doi request reprint Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
    Yinghui Hu
    Biogen Idec Inc, Neuro Discovery Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States
    Mol Cell Neurosci 48:72-81. 2011
    ..These studies suggest that while FTY720 may be effective at modulating the immunological attack in MS, it may benefit from an add-on therapy to enhance the myelin repair required for long-term functional restoration in MS...
  21. doi request reprint Characterization of trisulfide modification in antibodies
    Sheng Gu
    Biogen Idec, Cambridge, MA 02142, USA
    Anal Biochem 400:89-98. 2010
    ..The peptide mapping methods developed for characterization and quantification of trisulfides should be applicable to any antibody and can be easily adapted for other types of proteins...
  22. ncbi request reprint Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor
    Dingyi Wen
    BiogenIdec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Biochemistry 44:16491-501. 2005
    ..A structural model of the LRRCT with extended residues 311-344 from the CT stalk region is proposed, and its function in coreceptor binding is discussed...
  23. ncbi request reprint LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts
    Xinhua Lee
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, United States Electronic address
    Mol Cell Neurosci 60:36-42. 2014
    ..The study demonstrates a novel regulatory mechanism of ErbB2 function whereby LINGO-1 suppresses oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts. ..
  24. ncbi request reprint Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy
    R Blake Pepinsky
    Departments of Drug and Molecular Discovery, Biogen Idec, Inc, Cambridge, Massachusetts
    J Pharmacol Exp Ther 350:110-23. 2014
    ..These studies provide new insights into the structure and biology of LINGO-1 and how Li81 monoclonal antibody can block its function. ..
  25. pmc Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
    Haruhisa Inoue
    Neuroregeneration Laboratories, Udall Parkinson s Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 104:14430-5. 2007
    ....
  26. ncbi request reprint Glial membranes at the node of Ranvier prevent neurite outgrowth
    Jeffrey K Huang
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Science 310:1813-7. 2005
    ..In OMgp-null mice, CNS nodes were abnormally wide and collateral sprouting was observed. Nodal ensheathment in the CNS may stabilize the node and prevent axonal sprouting...
  27. doi request reprint Inactivation of glycogen synthase kinase-3beta and up-regulation of LINGO-1 are involved in LINGO-1 antagonist regulated survival of cerebellar granular neurons
    Xiang Hui Zhao
    Institute of Neurosciences, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, P R China
    Cell Mol Neurobiol 28:727-35. 2008
    ..Taken together, these results suggest a new mechanism of LINGO-1 antagonist regulated neuronal survival involving protein synthesis of LINGO-1 and inactivation of GSK-3 pathway...
  28. ncbi request reprint [Extract process of cyclic adenosinemonophosphate (cAMP) in Ziziphus jujuba]
    Ming Li
    Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China
    Zhong Yao Cai 30:1143-5. 2007
    ..To study the extract process of Cyclic adenosinemonophosphate (cAMP) in Ziziphus jujuba...
  29. ncbi request reprint Dissecting demyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Neurosci 10:1351-4. 2007
    ..Defining the rate-limiting steps and most vulnerable aspects at each stage of myelin repair will provide logical targets for therapeutic intervention in demyelinating diseases such as multiple sclerosis...