Justin T McCue

Summary

Affiliation: Biogen Idec
Country: USA

Publications

  1. doi request reprint Modeling of protein monomer/aggregate purification and separation using hydrophobic interaction chromatography
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    Bioprocess Biosyst Eng 31:261-75. 2008
  2. ncbi request reprint Use of an alternative scale-down approach to predict and extend hydroxyapatite column lifetimes
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, MA 02142, USA
    J Chromatogr A 1165:78-85. 2007
  3. doi request reprint Use and application of hydrophobic interaction chromatography for protein purification
    Justin T McCue
    Biogen Idec Corporation, 14 Cambridge Center, Cambridge, MA, USA Electronic address
    Methods Enzymol 541:51-65. 2014
  4. doi request reprint Application of a novel affinity adsorbent for the capture and purification of recombinant factor VIII compounds
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:7824-30. 2009
  5. doi request reprint Modeling the effects of column packing quality and residence time changes on protein monomer/aggregate separation
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:4895-901. 2009
  6. doi request reprint Effect of phenyl sepharose ligand density on protein monomer/aggregate purification and separation using hydrophobic interaction chromatography
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:902-9. 2009
  7. ncbi request reprint Application of a two-dimensional model for predicting the pressure-flow and compression properties during column packing scale-up
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1145:89-101. 2007
  8. doi request reprint Theory and use of hydrophobic interaction chromatography in protein purification applications
    Justin T McCue
    Biogen Idec Corporation, Cambridge, Massachusetts, USA
    Methods Enzymol 463:405-14. 2009
  9. doi request reprint Enveloped virus inactivation using neutral arginine solutions and applications in therapeutic protein purification processes
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, MA, 02142
    Biotechnol Prog 30:108-12. 2014
  10. ncbi request reprint Evaluation of protein-A chromatography media
    Justin T McCue
    Millipore Corporation, Biopharmaceutical Division, 32 Wiggins Avenue, L2B, Bedford, MA 01730, USA
    J Chromatogr A 989:139-53. 2003

Detail Information

Publications10

  1. doi request reprint Modeling of protein monomer/aggregate purification and separation using hydrophobic interaction chromatography
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    Bioprocess Biosyst Eng 31:261-75. 2008
    ..The model successfully predicted the separation performance of the adsorbent with the examined feed...
  2. ncbi request reprint Use of an alternative scale-down approach to predict and extend hydroxyapatite column lifetimes
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, MA 02142, USA
    J Chromatogr A 1165:78-85. 2007
    ..The alternative scale-down model, together with relatively rapid mobile phase screening studies, provides a practical approach for predicting and optimizing the useful lifetime of CHT columns for large scale applications...
  3. doi request reprint Use and application of hydrophobic interaction chromatography for protein purification
    Justin T McCue
    Biogen Idec Corporation, 14 Cambridge Center, Cambridge, MA, USA Electronic address
    Methods Enzymol 541:51-65. 2014
    ..The section will give step by step instructions on how to use HIC in the laboratory to purify proteins. General guidelines and relevant background information is also provided. ..
  4. doi request reprint Application of a novel affinity adsorbent for the capture and purification of recombinant factor VIII compounds
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:7824-30. 2009
    ..Following laboratory-scale process development, the VIIISelect adsorbent was scaled up and used in the large scale manufacturing of a FVIII compound...
  5. doi request reprint Modeling the effects of column packing quality and residence time changes on protein monomer/aggregate separation
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:4895-901. 2009
    ....
  6. doi request reprint Effect of phenyl sepharose ligand density on protein monomer/aggregate purification and separation using hydrophobic interaction chromatography
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1216:902-9. 2009
    ..In addition, the underlying mechanism responsible for the adsorbent lot variability, which was based upon differences in protein adsorption characteristics, was also investigated using both experimental and modeling approaches...
  7. ncbi request reprint Application of a two-dimensional model for predicting the pressure-flow and compression properties during column packing scale-up
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Chromatogr A 1145:89-101. 2007
    ..Use of the described theoretical model potentially improves the accuracy of the column scale-up process, allowing the use of limited laboratory scale data to predict column performance in large scale applications...
  8. doi request reprint Theory and use of hydrophobic interaction chromatography in protein purification applications
    Justin T McCue
    Biogen Idec Corporation, Cambridge, Massachusetts, USA
    Methods Enzymol 463:405-14. 2009
    ..The basic procedures for using HIC adsorbents are described next, in order to provide the reader with useful starting points to apply HIC in protein purification applications...
  9. doi request reprint Enveloped virus inactivation using neutral arginine solutions and applications in therapeutic protein purification processes
    Justin T McCue
    Biogen Idec Corporation, Bioprocess Development, 14 Cambridge Center, MA, 02142
    Biotechnol Prog 30:108-12. 2014
    ....
  10. ncbi request reprint Evaluation of protein-A chromatography media
    Justin T McCue
    Millipore Corporation, Biopharmaceutical Division, 32 Wiggins Avenue, L2B, Bedford, MA 01730, USA
    J Chromatogr A 989:139-53. 2003
    ..A larger dynamic capacity was also found for the smaller pore size media. The permeability of large scale packed beds was also reported and used in conjunction with the dynamic capacity to calculate the process production rate...