F Mackay

Summary

Affiliation: Biogen Inc
Country: USA

Publications

  1. pmc Induction of germinal centers by MMTV encoded superantigen on B cells
    W J Simmons
    Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine, NY 10016, USA
    Dev Immunol 8:201-11. 2001
  2. ncbi Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, MA 02142, USA
    Gastroenterology 115:1464-75. 1998
  3. pmc Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, Massachusetts 02142, USA
    J Exp Med 190:1697-710. 1999
  4. pmc Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines
    J L Browning
    Department of Immunology and Inflammation, Biogen, Cambridge, Massachusetts 02142, USA
    J Exp Med 183:867-78. 1996
  5. pmc BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
    J S Thompson
    Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    J Exp Med 192:129-35. 2000
  6. ncbi Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, MA 02142, USA
    Eur J Immunol 27:2033-42. 1997
  7. ncbi Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
    P D Rennert
    Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    Immunity 9:71-9. 1998
  8. ncbi Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types
    F Mackay
    Department of Cell Biology, Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 271:24934-8. 1996
  9. ncbi Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes
    F Mackay
    Department of Immunology, Biogen, Cambridge, MA 02142, USA
    J Immunol 159:3299-310. 1997
  10. pmc Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
    P Schneider
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
    J Exp Med 194:1691-7. 2001

Collaborators

Detail Information

Publications13

  1. pmc Induction of germinal centers by MMTV encoded superantigen on B cells
    W J Simmons
    Department of Pathology and Comprehensive Kaplan Cancer Center, New York University School of Medicine, NY 10016, USA
    Dev Immunol 8:201-11. 2001
    ..Anti-TNFalpha had no effect. These results suggest that endogenous vSAg mediated GC formation is independent of antigen trapping by FDCs...
  2. ncbi Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, MA 02142, USA
    Gastroenterology 115:1464-75. 1998
    ....
  3. pmc Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, Massachusetts 02142, USA
    J Exp Med 190:1697-710. 1999
    ..This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity...
  4. pmc Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines
    J L Browning
    Department of Immunology and Inflammation, Biogen, Cambridge, Massachusetts 02142, USA
    J Exp Med 183:867-78. 1996
    ..The delineation of a biological signaling event mediated by the LT-beta-R opens a window for further studies on its immunological role, and furthermore, activation of the LT-beta-R may have an application in tumor therapy...
  5. pmc BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
    J S Thompson
    Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    J Exp Med 192:129-35. 2000
    ..Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population...
  6. ncbi Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice
    F Mackay
    Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, MA 02142, USA
    Eur J Immunol 27:2033-42. 1997
    ..Therefore relative to TNF, the LT system has the dominant influence on splenic organization and anti-SRBC Ig formation in the adult mouse...
  7. ncbi Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
    P D Rennert
    Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    Immunity 9:71-9. 1998
    ..Therefore, LTbeta-R signaling during gestation is not sufficient to establish normal cellular microarchitecture. We conclude that LT and TNF play critical roles in the genesis and cellular organization of lymph nodes...
  8. ncbi Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types
    F Mackay
    Department of Cell Biology, Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 271:24934-8. 1996
    ..Thus, like several other members of the TNF receptor family, the LTbeta-R can activate NFkappaB following receptor ligation in some but not all LTbeta-R-positive cells...
  9. ncbi Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes
    F Mackay
    Department of Immunology, Biogen, Cambridge, MA 02142, USA
    J Immunol 159:3299-310. 1997
    ..Combined, these observations suggest that secreted mLT alpha may not play a role in the mouse via interactions with TNF-R55, and the ramifications of this hypothesis are discussed...
  10. pmc Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen
    P Schneider
    Institute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, Epalinges, Switzerland
    J Exp Med 194:1691-7. 2001
    ..This demonstrates a crucial role for BAFF in B cell maturation and strongly suggests that it signals via a BCMA-independent pathway and in an APRIL-dispensable way...
  11. ncbi Targeted inactivation of Gh/tissue transglutaminase II
    N Nanda
    Molecular Cardiology and Enzyme Research Units, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    J Biol Chem 276:20673-8. 2001
    ..These results indicate that G(h) may be importantly involved in stabilizing apoptotic cells before clearance, and in responses such as wound healing that require fibroblast adhesion mediated by extracellular matrix cross-linking...
  12. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function...
  13. ncbi Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation
    F Mackay
    Central Nervous System Department, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Immunol 153:5274-84. 1994
    ..act. than human TNF-alpha (recognizing only mouse TNF-R55) in wild-type fibroblasts, whereas both mouse and human TNF-alpha had similar cytotoxic activities in WEHI 164 cells...