Research Topics
| S L KalledSummaryAffiliation: Biogen Inc Country: USA Publications
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Publications
Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosisS L Kalled
Department of Inflammation, Biogen Inc, Cambridge, Massachusetts 02142, USA
Lupus 10:9-22. 2001..Potential reasons for differential therapeutic efficacy in moderately vs severely nephritic mice are discussed...- Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatmentS L Kalled
Department of Immunology and Inflammation, Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA
J Immunol 167:1740-7. 2001..We suggest that these mechanisms comprise an autostimulatory loop, maintaining the cascade of autoimmunity by DC presentation of self-Ags derived from apoptotic cells and CD154-mediated costimulation... - B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formationSvetlana Shulga-Morskaya
Biogen Idec, Cambridge, MA 02142, USA
J Immunol 173:2331-41. 2004..These studies clearly demonstrate that BAFF regulates Ab responses in vivo through receptors in addition to BAFF-R... - BAFF: B cell survival factor and emerging therapeutic target for autoimmune disordersSusan L Kalled
Department of Immunology and Inflammation, Biogen, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
Expert Opin Ther Targets 7:115-23. 2003..Several potential therapeutic inhibitors targeting BAFF are under investigation, including an anti-BAFF antibody and receptor-Fc fusion proteins... - BAFF: a novel therapeutic target for autoimmunitySusan L Kalled
Biogen Inc, Cambridge, MA 02142, USA
Curr Opin Investig Drugs 3:1005-10. 2002..Recent discovery of the BAFF-mediated B-cell survival pathway provides a unique opportunity for developing focused intervention for autoreactive B-cell function... 
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell populationJ S Thompson
Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
J Exp Med 192:129-35. 2000..Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population...- BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosusWilliam Stohl
Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
Arthritis Rheum 52:2080-91. 2005..To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis... - Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signallingIngrid Mecklenbrauker
Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
Nature 431:456-61. 2004..Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival... - The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challengeJanine L Ferrant
Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA, USA
Int Immunol 16:1583-94. 2004..Thus, the mechanisms required for efficacy of anti-CD154 mAbs depend on the nature of the immune challenge... - The biochemistry and biology of BAFF, APRIL and their receptorsSusan L Kalled
Biogen Idec, Inc, Cambridge, MA 02142, USA
Curr Dir Autoimmun 8:206-42. 2005..Herein we will discuss the discovery, structure, cognate receptors and functions of these two proteins... - Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokinesJunko Ohata
Division of Hematology Oncology, University of California, San Diego, La Jolla 92093, USA
J Immunol 174:864-70. 2005..The induced expression of BAFF on FLS by proinflammatory cytokines may enhance the capacity of such cells to protect B cells from apoptosis in inflammatory microenvironments in vivo... - BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphomaMarkus Krumbholz
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, D-82152 Martinsried, Germany
J Exp Med 201:195-200. 2005..This paper identifies astrocytes as a nonimmune source of BAFF. CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma... - The role of BAFF in immune function and implications for autoimmunitySusan L Kalled
Biogen Idec, Inc, Cambridge, MA 02142, USA
Immunol Rev 204:43-54. 2005..The role of BAFF in B-cell biology, T-cell biology, and autoimmunity is discussed, as well as current efforts to develop BAFF inhibitors for clinical testing in autoimmune disorders... - Treatment of autoimmune hyperthyroidism in a murine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathologyJacqueline A Gilbert
Division of Gene and Cell-Based Therapy, King's College London School of Medicine, Bessemer Road, London SE5 9PJ, United Kingdom
Endocrinology 147:4561-8. 2006.... - Identification of proteoglycans as the APRIL-specific binding partnersKarine Ingold
Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
J Exp Med 201:1375-83. 2005.... - Innate immunity and human B cell clonal expansion: effects on the recirculating B2 subpopulationPatricia K A Mongini
Department of Rheumatology, Hospital for Joint Diseases, New York University Medical Center, NY 10003, USA
J Immunol 175:6143-54. 2005..When rare autoantigen-presenting B cells undergo such expansions, both B cell and T cell autoimmunity may be promoted... - B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cellsLai Guan Ng
Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
J Immunol 173:807-17. 2004..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells... - Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFFRobin Lesley
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 USA
Immunity 20:441-53. 2004..These findings indicate that under conditions where BAFF levels are elevated, autoantigen-engaged cells will be rescued from rapid competitive elimination, predisposing to the development of autoimmune disease... - Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeJoanna Groom
The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
J Clin Invest 109:59-68. 2002..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis... - Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytesMichael Karpusas
Biogen, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
J Mol Biol 315:1145-54. 2002..Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D-E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA, TACI and BAFF-R... - Suppression of murine cardiac allograft arteriopathy by long-term blockade of CD40-CD154 interactionsCatherine Y Wang
Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Circulation 105:1609-14. 2002..05). CONCLUSIONS: These data show that perioperative CD154 blockade mitigates acute rejection but long-term CD154 blockade may result in decreased allograft endothelial activation and is required to suppress allograft arteriopathy... - TNF ligands and receptors in autoimmunity: an updateFabienne Mackay
Department of Arthritis and Inflammation, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Curr Opin Immunol 14:783-90. 2002..These new findings revealed exciting innovative strategies for the treatment of autoimmune diseases... - Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFFMarc Pelletier
Department of Protein Engineering, Biogen Inc, Cambridge, Massachusetts 02142, USA
J Biol Chem 278:33127-33. 2003..Indeed, we show BAFF-R-Fc is 10-fold more efficacious than BCMA-Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo... - Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and functionKalpit A Vora
Department of Immunology and Inflammation, Biogen, Inc, Cambridge, MA 02142, USA
J Immunol 171:547-51. 2003..This is the first evidence that BAFF is required for maintenance, but not initiation, of the GC reaction, and it further hints that somatic hypermutation within the GC and selection of Ag-specific high-affinity Ab could be uncoupled... - BAFF selectively enhances the survival of plasmablasts generated from human memory B cellsDanielle T Avery
Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
J Clin Invest 112:286-97. 2003..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases... - Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cellsLeonid Gorelik
Biogen Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
J Exp Med 198:937-45. 2003..Interestingly, immunization of both types of chimeras stimulated high levels of antigen-specific antibody secretion, indicating that either stromal cell- or hematopoietic cell-derived BAFF is sufficient for B cell antibody responses... - Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient miceZiaur S M Rahman
Department of Microbiology and Immunology, and the Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19017 5541, USA
J Exp Med 198:1157-69. 2003..These data demonstrate a multifaceted role for the BAFF pathway in regulating GC progression... - Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival functionLeonid Gorelik
Department of Immunology and Inflammation, Biogen Idec Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
J Immunol 172:762-6. 2004..These data broaden our understanding of BAFF function and correct the view that BAFF-null mice lack mature B cells... - Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody productionSusan L Kalled
Biogen Idec, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
Semin Immunol 18:290-6. 2006..These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. More importantly, a role for BAFF in B cell biology has been validated in vivo in humans... - BAFF is elevated in serum of patients with Wegener's granulomatosisMarkus Krumbholz
Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
J Autoimmun 25:298-302. 2005..We propose that BAFF might be a pathogenic factor in WG and that targeting BAFF may represent a new therapeutic strategy in a subset of chronically relapsing WG patients with elevated BAFF levels... - A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responsesNicholas D Huntington
Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Bundoora, Victoria 3086, Australia
Int Immunol 18:1473-85. 2006..Our findings demonstrate that hBCMA-Fc acts on both effector arms of the immune response in EAE, a characteristic that may be of significant therapeutic value in the treatment of MS...