S L Kalled

Summary

Affiliation: Biogen Inc
Country: USA

Publications

  1. ncbi request reprint Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis
    S L Kalled
    Department of Inflammation, Biogen Inc, Cambridge, Massachusetts 02142, USA
    Lupus 10:9-22. 2001
  2. ncbi request reprint Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatment
    S L Kalled
    Department of Immunology and Inflammation, Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 167:1740-7. 2001
  3. ncbi request reprint B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation
    Svetlana Shulga-Morskaya
    Biogen Idec, Cambridge, MA 02142, USA
    J Immunol 173:2331-41. 2004
  4. ncbi request reprint BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders
    Susan L Kalled
    Department of Immunology and Inflammation, Biogen, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Expert Opin Ther Targets 7:115-23. 2003
  5. ncbi request reprint BAFF: a novel therapeutic target for autoimmunity
    Susan L Kalled
    Biogen Inc, Cambridge, MA 02142, USA
    Curr Opin Investig Drugs 3:1005-10. 2002
  6. pmc BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
    J S Thompson
    Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    J Exp Med 192:129-35. 2000
  7. ncbi request reprint BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus
    William Stohl
    Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:2080-91. 2005
  8. ncbi request reprint Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling
    Ingrid Mecklenbrauker
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    Nature 431:456-61. 2004
  9. ncbi request reprint The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge
    Janine L Ferrant
    Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA, USA
    Int Immunol 16:1583-94. 2004
  10. ncbi request reprint The biochemistry and biology of BAFF, APRIL and their receptors
    Susan L Kalled
    Biogen Idec, Inc, Cambridge, MA 02142, USA
    Curr Dir Autoimmun 8:206-42. 2005

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Long-term anti-CD154 dosing in nephritic mice is required to maintain survival and inhibit mediators of renal fibrosis
    S L Kalled
    Department of Inflammation, Biogen Inc, Cambridge, Massachusetts 02142, USA
    Lupus 10:9-22. 2001
    ..Potential reasons for differential therapeutic efficacy in moderately vs severely nephritic mice are discussed...
  2. ncbi request reprint Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatment
    S L Kalled
    Department of Immunology and Inflammation, Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 167:1740-7. 2001
    ..We suggest that these mechanisms comprise an autostimulatory loop, maintaining the cascade of autoimmunity by DC presentation of self-Ags derived from apoptotic cells and CD154-mediated costimulation...
  3. ncbi request reprint B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation
    Svetlana Shulga-Morskaya
    Biogen Idec, Cambridge, MA 02142, USA
    J Immunol 173:2331-41. 2004
    ..These studies clearly demonstrate that BAFF regulates Ab responses in vivo through receptors in addition to BAFF-R...
  4. ncbi request reprint BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders
    Susan L Kalled
    Department of Immunology and Inflammation, Biogen, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Expert Opin Ther Targets 7:115-23. 2003
    ..Several potential therapeutic inhibitors targeting BAFF are under investigation, including an anti-BAFF antibody and receptor-Fc fusion proteins...
  5. ncbi request reprint BAFF: a novel therapeutic target for autoimmunity
    Susan L Kalled
    Biogen Inc, Cambridge, MA 02142, USA
    Curr Opin Investig Drugs 3:1005-10. 2002
    ..Recent discovery of the BAFF-mediated B-cell survival pathway provides a unique opportunity for developing focused intervention for autoreactive B-cell function...
  6. pmc BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population
    J S Thompson
    Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    J Exp Med 192:129-35. 2000
    ..Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population...
  7. ncbi request reprint BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus
    William Stohl
    Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:2080-91. 2005
    ..To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus-associated end-organ disease in hosts with an underlying autoimmune diathesis...
  8. ncbi request reprint Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling
    Ingrid Mecklenbrauker
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    Nature 431:456-61. 2004
    ..Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival...
  9. ncbi request reprint The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge
    Janine L Ferrant
    Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA, USA
    Int Immunol 16:1583-94. 2004
    ..Thus, the mechanisms required for efficacy of anti-CD154 mAbs depend on the nature of the immune challenge...
  10. ncbi request reprint The biochemistry and biology of BAFF, APRIL and their receptors
    Susan L Kalled
    Biogen Idec, Inc, Cambridge, MA 02142, USA
    Curr Dir Autoimmun 8:206-42. 2005
    ..Herein we will discuss the discovery, structure, cognate receptors and functions of these two proteins...
  11. ncbi request reprint Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines
    Junko Ohata
    Division of Hematology Oncology, University of California, San Diego, La Jolla 92093, USA
    J Immunol 174:864-70. 2005
    ..The induced expression of BAFF on FLS by proinflammatory cytokines may enhance the capacity of such cells to protect B cells from apoptosis in inflammatory microenvironments in vivo...
  12. pmc BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    Markus Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Exp Med 201:195-200. 2005
    ..This paper identifies astrocytes as a nonimmune source of BAFF. CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma...
  13. ncbi request reprint The role of BAFF in immune function and implications for autoimmunity
    Susan L Kalled
    Biogen Idec, Inc, Cambridge, MA 02142, USA
    Immunol Rev 204:43-54. 2005
    ..The role of BAFF in B-cell biology, T-cell biology, and autoimmunity is discussed, as well as current efforts to develop BAFF inhibitors for clinical testing in autoimmune disorders...
  14. ncbi request reprint Treatment of autoimmune hyperthyroidism in a murine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathology
    Jacqueline A Gilbert
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, Bessemer Road, London SE5 9PJ, United Kingdom
    Endocrinology 147:4561-8. 2006
    ....
  15. pmc Identification of proteoglycans as the APRIL-specific binding partners
    Karine Ingold
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    J Exp Med 201:1375-83. 2005
    ....
  16. ncbi request reprint Innate immunity and human B cell clonal expansion: effects on the recirculating B2 subpopulation
    Patricia K A Mongini
    Department of Rheumatology, Hospital for Joint Diseases, New York University Medical Center, NY 10003, USA
    J Immunol 175:6143-54. 2005
    ..When rare autoantigen-presenting B cells undergo such expansions, both B cell and T cell autoimmunity may be promoted...
  17. ncbi request reprint B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    Lai Guan Ng
    Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Immunol 173:807-17. 2004
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells...
  18. ncbi request reprint Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    Robin Lesley
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 USA
    Immunity 20:441-53. 2004
    ..These findings indicate that under conditions where BAFF levels are elevated, autoantigen-engaged cells will be rescued from rapid competitive elimination, predisposing to the development of autoimmune disease...
  19. pmc Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    Joanna Groom
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, NSW, Australia
    J Clin Invest 109:59-68. 2002
    ..We conclude that altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis...
  20. ncbi request reprint Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes
    Michael Karpusas
    Biogen, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Mol Biol 315:1145-54. 2002
    ..Analysis of the putative receptor binding sites of BAFF and APRIL suggests that differences in the D-E loop structure and electrostatic surface potentials may be important for determining binding specificities for BCMA, TACI and BAFF-R...
  21. ncbi request reprint Suppression of murine cardiac allograft arteriopathy by long-term blockade of CD40-CD154 interactions
    Catherine Y Wang
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Circulation 105:1609-14. 2002
    ..The interaction between CD40 on antigen-presenting cells and CD40L on T cells is critical in allograft rejection. CD154 blockade suppresses allograft rejection, but the role of this pathway in allograft vasculopathy remains obscure...
  22. ncbi request reprint TNF ligands and receptors in autoimmunity: an update
    Fabienne Mackay
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Curr Opin Immunol 14:783-90. 2002
    ..These new findings revealed exciting innovative strategies for the treatment of autoimmune diseases...
  23. ncbi request reprint Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF
    Marc Pelletier
    Department of Protein Engineering, Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:33127-33. 2003
    ..Indeed, we show BAFF-R-Fc is 10-fold more efficacious than BCMA-Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo...
  24. ncbi request reprint Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function
    Kalpit A Vora
    Department of Immunology and Inflammation, Biogen, Inc, Cambridge, MA 02142, USA
    J Immunol 171:547-51. 2003
    ..This is the first evidence that BAFF is required for maintenance, but not initiation, of the GC reaction, and it further hints that somatic hypermutation within the GC and selection of Ag-specific high-affinity Ab could be uncoupled...
  25. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  26. pmc Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells
    Leonid Gorelik
    Biogen Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 198:937-45. 2003
    ..Interestingly, immunization of both types of chimeras stimulated high levels of antigen-specific antibody secretion, indicating that either stromal cell- or hematopoietic cell-derived BAFF is sufficient for B cell antibody responses...
  27. pmc Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice
    Ziaur S M Rahman
    Department of Microbiology and Immunology, and the Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19017 5541, USA
    J Exp Med 198:1157-69. 2003
    ..These data demonstrate a multifaceted role for the BAFF pathway in regulating GC progression...
  28. ncbi request reprint Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function
    Leonid Gorelik
    Department of Immunology and Inflammation, Biogen Idec Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 172:762-6. 2004
    ..These data broaden our understanding of BAFF function and correct the view that BAFF-null mice lack mature B cells...
  29. ncbi request reprint Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production
    Susan L Kalled
    Biogen Idec, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Semin Immunol 18:290-6. 2006
    ..These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. More importantly, a role for BAFF in B cell biology has been validated in vivo in humans...
  30. ncbi request reprint BAFF is elevated in serum of patients with Wegener's granulomatosis
    Markus Krumbholz
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Autoimmun 25:298-302. 2005
    ..We propose that BAFF might be a pathogenic factor in WG and that targeting BAFF may represent a new therapeutic strategy in a subset of chronically relapsing WG patients with elevated BAFF levels...
  31. ncbi request reprint A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses
    Nicholas D Huntington
    Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Bundoora, Victoria 3086, Australia
    Int Immunol 18:1473-85. 2006
    ..Our findings demonstrate that hBCMA-Fc acts on both effector arms of the immune response in EAE, a characteristic that may be of significant therapeutic value in the treatment of MS...