Research Topics
| Aniela JakubowskiSummaryAffiliation: Biogen Idec Country: USA Publications
| Collaborators
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Detail Information
Publications
TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and diseaseLinda C Burkly
Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Cytokine 40:1-16. 2007..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer...
TWEAK induces liver progenitor cell proliferationAniela Jakubowski
Department of Exploratory Science, Biogen Idec Inc, Cambridge, Massachusetts 02142, USA
J Clin Invest 115:2330-40. 2005..We conclude that TWEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors...
Dual role for TWEAK in angiogenic regulationAniela Jakubowski
Department of Exploratory Science, Biogen Inc, 12 Cambridge Center, Cambridge, Massachusetts 02142, USA
J Cell Sci 115:267-74. 2002..Thus, our observations suggest that TWEAK may differentially regulate microvascular growth, remodeling and/or maintenance in vivo, depending upon the angiogenic context...
The cytokine TWEAK modulates renal tubulointerstitial inflammationAna Belen Sanz
Unidad de Dialisis, Fundacion Jimenez Diaz, Avda Reyes Catolicos 2, 28040 Madrid, Spain
J Am Soc Nephrol 19:695-703. 2008..Moreover, blockade of TWEAK reduces tubular chemokine expression and macrophage infiltration, suggesting that TWEAK modulates acute kidney injury by regulating the inflammatory response...
