Affiliation: Biogen Idec
- TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and diseaseLinda C Burkly
Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
Cytokine 40:1-16. 2007..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer...
- TWEAK induces liver progenitor cell proliferationAniela Jakubowski
Department of Exploratory Science, Biogen Idec Inc, Cambridge, Massachusetts 02142, USA
J Clin Invest 115:2330-40. 2005..We conclude that TWEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors...
- Dual role for TWEAK in angiogenic regulationAniela Jakubowski
Department of Exploratory Science, Biogen Inc, 12 Cambridge Center, Cambridge, Massachusetts 02142, USA
J Cell Sci 115:267-74. 2002..Thus, our observations suggest that TWEAK may differentially regulate microvascular growth, remodeling and/or maintenance in vivo, depending upon the angiogenic context...
- The cytokine TWEAK modulates renal tubulointerstitial inflammationAna Belen Sanz
Unidad de Dialisis, Fundacion Jimenez Diaz, Avda Reyes Catolicos 2, 28040 Madrid, Spain
J Am Soc Nephrol 19:695-703. 2008..Moreover, blockade of TWEAK reduces tubular chemokine expression and macrophage infiltration, suggesting that TWEAK modulates acute kidney injury by regulating the inflammatory response...