Linda C Burkly

Summary

Affiliation: Biogen Idec
Country: USA

Publications

  1. ncbi Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice
    Li Chun Wang
    Department of Exploratory Science, Biogen Inc, Cambridge, Massachusetts 02142, USA
    Gastroenterology 122:469-82. 2002
  2. pmc TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration
    Mahasweta Girgenrath
    Boston Biomedical Research Institute, Watertown, MA, USA
    EMBO J 25:5826-39. 2006
  3. ncbi The 14th International TNF Conference, Québec City, Canada - Des Progrės Récents aux Défis Futurs (Recent Advances toward Future Challenges)
    Linda Burkly
    Department of Immunology, Biogen Idec, Cambridge, MA, USA Electronic address
    Cytokine Growth Factor Rev 25:77-81. 2014
  4. doi The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases
    Taeko Dohi
    Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    J Leukoc Biol 92:265-79. 2012
  5. pmc Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
    Noa Schwartz
    Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arthritis Res Ther 11:R143. 2009
  6. doi TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses
    Linda C Burkly
    Immunology Discovery Research, Biogen Idec, Inc, Cambridge, MA 02142, USA
    Immunol Rev 244:99-114. 2011
  7. ncbi TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease
    Linda C Burkly
    Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Cytokine 40:1-16. 2007
  8. pmc TWEAK induces liver progenitor cell proliferation
    Aniela Jakubowski
    Department of Exploratory Science, Biogen Idec Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 115:2330-40. 2005
  9. ncbi Tweak induces mammary epithelial branching morphogenesis
    Jennifer S Michaelson
    Department of Exploratory Science, Biogen Idec, 12 Cambridge Center, Bio6 320, Cambridge MA, USA
    Oncogene 24:2613-24. 2005
  10. doi No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies
    Timothy S Zheng
    R and D Immunology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Leukoc Biol 84:338-47. 2008

Collaborators

Detail Information

Publications33

  1. ncbi Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice
    Li Chun Wang
    Department of Exploratory Science, Biogen Inc, Cambridge, Massachusetts 02142, USA
    Gastroenterology 122:469-82. 2002
    ..The hedgehog (hh) signaling pathway has been shown to play crucial roles in the development of embryonic gut. However, its role in intestinal development and function beyond the embryonic stage is still undefined...
  2. pmc TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration
    Mahasweta Girgenrath
    Boston Biomedical Research Institute, Watertown, MA, USA
    EMBO J 25:5826-39. 2006
    ....
  3. ncbi The 14th International TNF Conference, Québec City, Canada - Des Progrės Récents aux Défis Futurs (Recent Advances toward Future Challenges)
    Linda Burkly
    Department of Immunology, Biogen Idec, Cambridge, MA, USA Electronic address
    Cytokine Growth Factor Rev 25:77-81. 2014
    ..We await with anticipation the next (15th) International TNF Conference to be held May 20-23rd, 2015 in Ghent, Belgium. Until then, À Bientôt!. ..
  4. doi The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases
    Taeko Dohi
    Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    J Leukoc Biol 92:265-79. 2012
    ....
  5. pmc Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
    Noa Schwartz
    Division of Rheumatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arthritis Res Ther 11:R143. 2009
    ..Evidence for the importance of TWEAK in the pathogenesis of lupus nephritis (LN) has been recently introduced. Thus, TWEAK levels may serve as an indication of LN presence and activity...
  6. doi TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses
    Linda C Burkly
    Immunology Discovery Research, Biogen Idec, Inc, Cambridge, MA 02142, USA
    Immunol Rev 244:99-114. 2011
    ..Whereas transient TWEAK/Fn14 activation promotes productive tissue responses after injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration...
  7. ncbi TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease
    Linda C Burkly
    Department of Immunobiology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Cytokine 40:1-16. 2007
    ..In addition to a perspective of the biology, we discuss potential therapeutic strategies targeting this pathway for the treatment of tissue injury, chronic inflammatory diseases and cancer...
  8. pmc TWEAK induces liver progenitor cell proliferation
    Aniela Jakubowski
    Department of Exploratory Science, Biogen Idec Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 115:2330-40. 2005
    ..We conclude that TWEAK has a selective mitogenic effect for liver oval cells that distinguishes it from other previously described growth factors...
  9. ncbi Tweak induces mammary epithelial branching morphogenesis
    Jennifer S Michaelson
    Department of Exploratory Science, Biogen Idec, 12 Cambridge Center, Bio6 320, Cambridge MA, USA
    Oncogene 24:2613-24. 2005
    ..Together, our results suggest that the Tweak/Fn14 pathway may be protumorigenic in human breast cancer...
  10. doi No end in site: TWEAK/Fn14 activation and autoimmunity associated- end-organ pathologies
    Timothy S Zheng
    R and D Immunology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Leukoc Biol 84:338-47. 2008
    ..The highly specific and localized nature of its pathogenic contribution, therefore, makes the TWEAK/Fn14 pathway a unique and promising therapeutic target...
  11. pmc TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice
    Fei Wu
    Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e72132. 2013
    ..Here we test whether the TNF family member TWEAK (TNF-like weak inducer of apoptosis) promotes β-cell neogenesis from proliferating pancreatic ductal epithelium in adult mice...
  12. ncbi TWEAK is a novel arthritogenic mediator
    Stuart J Perper
    Exploratory Sciences, Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Immunol 177:2610-20. 2006
    ....
  13. pmc TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
    Bhanu P Pappu
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 205:1049-62. 2008
    ..These observations thus establish an important role of the TL1A-DR3 pathway in promoting Th17 cell function and Th17-mediated autoimmune disease...
  14. pmc Development of an Fn14 agonistic antibody as an anti-tumor agent
    Jennifer S Michaelson
    Molecular Discovery, Biogen Idec, 12 Cambridge Center, Cambridge, MA, USA
    MAbs 3:362-75. 2011
    ..Taken together, the anti-tumor properties of BIIB036 validate Fn14 as a promising target in oncology and demonstrate its potential therapeutic utility in multiple solid tumor indications...
  15. doi Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway
    Jennifer S Michaelson
    Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Results Probl Cell Differ 49:145-60. 2009
    ....
  16. pmc Role of TWEAK in lupus nephritis: a bench-to-bedside review
    Jennifer S Michaelson
    Immunology Discovery Biology, Biogen Idec, Cambridge, MA 02142, USA
    J Autoimmun 39:130-42. 2012
    ..Taken together, targeting the TWEAK/Fn14 axis represents a potential new therapeutic paradigm for achieving renal protection in LN patients...
  17. pmc PGC1α plays a critical role in TWEAK-induced cardiac dysfunction
    Jianru Shi
    Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e54054. 2013
    ..The molecular mechanisms underlying TWEAK-induced cardiac pathology, however, remain unknown...
  18. ncbi Anti-alpha4 integrin monoclonal antibody inhibits multiple myeloma growth in a murine model
    Dian L Olson
    Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cancer Ther 4:91-9. 2005
    ..The ability of the (VLA-4) mAb to affect multiple variables in this model, even as monotherapy, suggests this pathway plays a central role in disease progression...
  19. ncbi Dual role for TWEAK in angiogenic regulation
    Aniela Jakubowski
    Department of Exploratory Science, Biogen Inc, 12 Cambridge Center, Cambridge, Massachusetts 02142, USA
    J Cell Sci 115:267-74. 2002
    ..Thus, our observations suggest that TWEAK may differentially regulate microvascular growth, remodeling and/or maintenance in vivo, depending upon the angiogenic context...
  20. ncbi Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Pascal Schneider
    Department of Exploratory Sciences, Biogen, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 278:5444-54. 2003
    ....
  21. ncbi The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge
    Janine L Ferrant
    Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA, USA
    Int Immunol 16:1583-94. 2004
    ..Thus, the mechanisms required for efficacy of anti-CD154 mAbs depend on the nature of the immune challenge...
  22. ncbi Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates
    He Xu
    The NIDDK Navy Transplantation and Autoimmunity Branch, Bethesda, Maryland 20892, USA
    Transplantation 74:940-3. 2002
    ..Hu5C8 effectively reverses acute but not chronic allograft rejection and appears to have no synergistic effect with conventional rescue agents...
  23. ncbi Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation
    Sean P Montgomery
    The Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Transplantation 74:1365-9. 2002
    ....
  24. doi TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model
    Heather A Iocca
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599 7295, United States
    J Neuroimmunol 194:97-106. 2008
    ..Thus, this study identifies a primary role of TWEAK in promoting neuroinflammation and exacerbating demyelination during cuprizone-induced damage...
  25. ncbi FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies
    Lex Nagelkerken
    Division of Immunological and Infectious Diseases, The Netherlands Organization for Applied Scientific Research TNO, Prevention and Health, Leiden, The Netherlands
    J Immunol 173:993-9. 2004
    ..It is concluded that FcR interactions do not play a major role in the protective effect of anti-CD154 mAb in the context of EAE, though they may contribute to the full abrogation of peripheral peptide-specific lymphocyte responses...
  26. ncbi Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells
    Sean Campbell
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 176:1889-98. 2006
    ..Our results support Ab inhibition of TWEAK as a potential new approach for the treatment of chemokine-dependent inflammatory kidney diseases...
  27. ncbi Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome
    Nhan L Tran
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Cancer Res 66:9535-42. 2006
    ..Such a feedback loop argues for aggressive targeting of the Fn14 axis as a unique and specific driver of glioma malignant behavior...
  28. ncbi Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation
    He Xu
    Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Transplant 3:1350-4. 2003
    ..Although daclizumab and hu5c8 are additively effective in MLR, they do not appear to be synergistic in vivo in rhesus monkeys...
  29. ncbi Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells
    C A Hamill
    Department of Neurology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neurosci Res 85:3535-44. 2007
    ..These studies indicate that TWEAK/Fn14 receptor activation exerts different effects on neural progenitor cells and their progeny depending on the developmental stage of the cells...
  30. ncbi TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus
    Zeguo Zhao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 179:7949-58. 2007
    ..Thus, TWEAK blockade may be a novel therapeutic approach to reduce renal damage in SLE...
  31. ncbi Urinary TWEAK and the activity of lupus nephritis
    Noa Schwartz
    Division of Rheumatology, Forchheimer 701N, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Autoimmun 27:242-50. 2006
    ..An accurate, non-invasive method to repeatedly assess kidney disease in lupus would be very helpful in managing these often challenging patients. Our study indicates that urinary TWEAK levels may be useful as a novel biomarker in LN...
  32. ncbi Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection
    Yuzhu Tang
    Department of Internal Medicine, Washington University School of Medicine, St Louis Veterans Affairs Medical Center, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1280-8. 2006
    ..These data indicate that Hh signaling plays a role in adult gut epithelial homeostasis by regulating epithelial cell migration from crypt to villus tip and by enhancing apoptosis...
  33. ncbi Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain
    Kimberly K Buhman
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Nutr 134:2979-84. 2004
    ..These findings point to a potential role for Hh signaling pathways in diet-induced abnormalities of lipid metabolism...