S Bantia

Summary

Affiliation: BioCryst Pharmaceuticals
Country: USA

Publications

  1. doi Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, Birmingham, AL 35244, USA
    Antiviral Res 88:276-80. 2010
  2. pmc Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140
    S Bantia
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Antimicrob Agents Chemother 42:801-7. 1998
  3. doi A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice
    Shanta Bantia
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 90:17-21. 2011
  4. doi Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies
    Shanta Bantia
    BioCryst Pharmaceuticals, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 10:784-90. 2010
  5. ncbi Anti-influenza virus activity of peramivir in mice with single intramuscular injection
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 69:39-45. 2006
  6. ncbi Purine nucleoside phosphorylase inhibitors in T-cell malignancies
    Shanta Bantia
    BioCryst Pharmaceuticals Inc, Birmingham, AL 35244, USA
    Curr Opin Drug Discov Devel 7:243-7. 2004
  7. doi Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 91:288-91. 2011
  8. ncbi Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 3:879-87. 2003
  9. ncbi Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent
    S Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 1:1199-210. 2001
  10. ncbi Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777
    Shanta Banti
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, Birmingham, AL 35244, USA
    Int Immunopharmacol 2:913-23. 2002

Collaborators

Detail Information

Publications23

  1. doi Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, Birmingham, AL 35244, USA
    Antiviral Res 88:276-80. 2010
    ..05 vs. vehicle and individual agent). The three-dimensional analysis of the weight loss for the majority of the drug combinations of peramivir and rimantadine tested demonstrated synergistic antiviral effects...
  2. pmc Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140
    S Bantia
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Antimicrob Agents Chemother 42:801-7. 1998
    ..However, drug-induced changes in the HA can result in a virus that is less dependent on NA activity for growth in cells and, hence, resistant to NA inhibitors...
  3. doi A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice
    Shanta Bantia
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 90:17-21. 2011
    ..These data demonstrate efficacy of parenterally administered peramivir against the recently isolated pandemic influenza virus in murine infection models...
  4. doi Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies
    Shanta Bantia
    BioCryst Pharmaceuticals, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 10:784-90. 2010
    ..These data support the evaluation of BCX-4208 in the treatment of T-cell and B-cell mediated diseases. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout...
  5. ncbi Anti-influenza virus activity of peramivir in mice with single intramuscular injection
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 69:39-45. 2006
    ..A single intramuscular injection of peramivir may successfully treat influenza infections and provide an alternate option to oseltamivir during an influenza outbreak...
  6. ncbi Purine nucleoside phosphorylase inhibitors in T-cell malignancies
    Shanta Bantia
    BioCryst Pharmaceuticals Inc, Birmingham, AL 35244, USA
    Curr Opin Drug Discov Devel 7:243-7. 2004
    ..Clinical trials with BCX-1777 have demonstrated that inhibition of PNP leads to T-cell-selective suppression, confirming PNP to be a promising target for the treatment of T-cell-mediated diseases...
  7. doi Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Antiviral Res 91:288-91. 2011
    ....
  8. ncbi Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777
    Shanta Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 3:879-87. 2003
    ..High kinase and low nucleotidase levels make CEM-SS cells more sensitive to inhibition by BCX-1777 and dGuo than human lymphocytes. Currently, BCX-1777 is in phase I/II clinical trial for the treatment of T cell malignancies...
  9. ncbi Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent
    S Bantia
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Suite B, Birmingham, AL 35244, USA
    Int Immunopharmacol 1:1199-210. 2001
    ..Furthermore, these dGuo levels are also required for in vitro T-cell inhibition by BCX-1777. Thus, BCX-1777 represents a novel class of selective immunosuppressive agents that could have therapeutic utility in various T-cell disorders...
  10. ncbi Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777
    Shanta Banti
    Department of Biological Sciences, BioCryst Pharmaceuticals, Inc, Birmingham, AL 35244, USA
    Int Immunopharmacol 2:913-23. 2002
    ..These results suggest that BCX-1777 may be useful for the treatment of disease characterized by activated T-cell responses...
  11. pmc Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
    S Bantia
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Antimicrob Agents Chemother 45:1162-7. 2001
    ..No drug-related toxicity was observed in mice receiving 100 mg/kg/day of RWJ-270201 for 5 days. These efficacy and safety profiles justify further consideration of RWJ-270201 for the treatment and prevention of human influenza...
  12. ncbi Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity
    P Chand
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, Alabama 35244, USA
    J Med Chem 44:4379-92. 2001
    ..Further manipulation was required to prepare deoxy derivative 50. Because the activities of the two compounds are comparable and 54 [RWJ-270201 (BCX-1812)] is the easier to synthesize, it was selected for further clinical evaluation...
  13. ncbi Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa
    Raman Krishnan
    BioCryst Pharmaceuticals, 2190 Parkway Lake Drive, Birmingham, AL 35216, USA
    Acta Crystallogr D Biol Crystallogr 63:689-97. 2007
    ....
  14. ncbi The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor
    C Shane Arnold
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Thromb Res 117:343-9. 2006
    ..Therefore, BCX-3607 might block the TF/FVIIa-mediated coagulation and inflammation associated with pathological conditions...
  15. ncbi Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo
    Pooran Chand
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Bioorg Med Chem 13:4071-7. 2005
    ..On comparison with oseltamivir carboxylate and zanamivir, these four cyclopentane derivatives have shown equal or better efficacies. The synthesis of two new compounds, BCX-1898 and BCX-1923, is also described...
  16. ncbi Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase
    Pooran Chand
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Bioorg Med Chem 13:2665-78. 2005
    ..The fourth substituent seems to disturb the binding of the other three substituents, so the activity is reduced as compared to tri-substituted benzene and pyridine derivatives...
  17. ncbi Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives
    Pooran Chand
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    J Med Chem 47:1919-29. 2004
    ..1 (mg/kg)/day...
  18. doi Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores
    Pravin L Kotian
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Bioorg Med Chem 17:3934-58. 2009
    ..Compounds with these two substituents are the most potent compounds in this series with good selectivity over related serine proteases. These compounds will be further explored for structure-activity relationship...
  19. ncbi Discovery of highly potent small molecule kallikrein inhibitors
    J Zhang
    Biology Department, BioCryst Pharmaceuticals, Inc 2190 Parkway Lake Drive, Birmingham, Alabama 35244, USA
    Med Chem 2:545-53. 2006
    ..The information presented in the current study provides an initial approach to develop more selective and therapeutically useful small molecule inhibitors...
  20. ncbi Synthesis of a potent transition-state inhibitor of 5'-deoxy-5'-methylthioadenosine phosphorylase
    Vivekanand P Kamath
    BioCryst Pharmaceuticals Inc, 2190 Parkway Lake Drive, Birmingham, Alabama 35244
    J Med Chem 47:1322-4. 2004
    ..Presented herein is the synthesis of 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylsulfanylmethylpyrrolidin-3,4-diol (1), a potent inhibitor of MTAP...
  21. ncbi An efficient synthesis of acyclic N7- and N9-adenine nucleosides via alkylation with secondary carbon electrophiles to introduce versatile functional groups at the C-1 position of acyclic moiety
    Pravin L Kotian
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Nucleosides Nucleotides Nucleic Acids 25:121-40. 2006
    ..The functional groups, ester and allyl, were converted to the desired hydroxymethyl and hydroxyethyl groups, and subsequently to phosphonomethyl derivatives and corresponding pyrophosphorylphosphonates...
  22. ncbi Synthesis of 9-[1-(substituted)-2-(phosphonomethoxy)ethyl]adenine derivatives as possible antiviral agents
    Minwan Wu
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Nucleosides Nucleotides Nucleic Acids 24:1569-85. 2005
    ..Other substituents, such as ethyl and ea-hydroxyethyl were also prepared. The resulting phosphonomethoxy derivatives were converted to prodrugs...
  23. ncbi Synthesis of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents
    Yahya El-Kattan
    BioCryst Pharmaceuticals, Inc, 2190 Parkway Lake Drive, Birmingham, AL 35244, USA
    Nucleosides Nucleotides Nucleic Acids 24:1597-611. 2005
    ..The syntheses of the corresponding prodrugs of these compounds are also reported. These compounds showed poor activity against HCV in replicon assay...