Neil Theise

Summary

Affiliation: Beth Israel Medical Center
Country: USA

Publications

  1. pmc Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
    Es Swenson
    Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    Clin Exp Gastroenterol 3:1-10. 2010
  2. ncbi request reprint Implications of 'postmodern biology' for pathology: the Cell Doctrine
    Neil D Theise
    Department of Pathology, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY 10003, USA
    Lab Invest 86:335-44. 2006
  3. ncbi request reprint Understanding cell lineages as complex adaptive systems
    Neil D Theise
    Division of Digestive Diseases, Departments of Medicine and Pathology, The Milton and Carroll Petrie Division of Beth Israel Medical Center, New York, NY 10003, USA
    Blood Cells Mol Dis 32:17-20. 2004
  4. ncbi request reprint Hepatic 'stem cell' malignancies in adults: four cases
    N D Theise
    Department of Pathology, New York University Medical Center, New York, NY, USA
    Histopathology 43:263-71. 2003
  5. ncbi request reprint Stem cell research: elephants in the room
    Neil D Theise
    Department of Pathology, Division of Digestive Diseases, Beth Israel Medical Center, New York, NY 10003, USA
    Mayo Clin Proc 78:1004-9. 2003
  6. ncbi request reprint Liver stem cells: prospects for treatment of inherited and acquired liver diseases
    Neil D Theise
    Beth Israel Medical Center, Division of Digestive Diseases, 1st Avenue at 16th Street, New York, NY 10003, USA
    Expert Opin Biol Ther 3:403-8. 2003
  7. ncbi request reprint The stem cell niche and tissue biology
    Neil D Theise
    Department of Pathology, Division of Digestive Diseases, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA
    Stem Cell Rev 2:169-70. 2006
  8. ncbi request reprint Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach
    Neil D Theise
    Department of Pathology, Beth Israel Medical Center of Albert Einstein College of Medicine, New York, NY, USA
    Mod Pathol 20:S3-14. 2007
  9. ncbi request reprint Stem cell plasticity: tools for investigation and repair
    Neil D Theise
    Liver and Stem Cell Research Laboratory, Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center, New York, New York, USA
    J Pediatr Gastroenterol Nutr 40:S48-9. 2005
  10. ncbi request reprint Perspective: stem cells react! Cell lineages as complex adaptive systems
    Neil D Theise
    Beth Israel Medical Center, New York, NY 10003, USA
    Exp Hematol 32:25-7. 2004

Collaborators

Detail Information

Publications54

  1. pmc Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
    Es Swenson
    Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    Clin Exp Gastroenterol 3:1-10. 2010
    ..For all of these stem cell therapy applications for IBD, only cases and small series have been reported. Larger clinical trials are planned or ongoing...
  2. ncbi request reprint Implications of 'postmodern biology' for pathology: the Cell Doctrine
    Neil D Theise
    Department of Pathology, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY 10003, USA
    Lab Invest 86:335-44. 2006
    ..In this paper, these themes will be considered and some implications for the investigative pathologist will be explored...
  3. ncbi request reprint Understanding cell lineages as complex adaptive systems
    Neil D Theise
    Division of Digestive Diseases, Departments of Medicine and Pathology, The Milton and Carroll Petrie Division of Beth Israel Medical Center, New York, NY 10003, USA
    Blood Cells Mol Dis 32:17-20. 2004
    ....
  4. ncbi request reprint Hepatic 'stem cell' malignancies in adults: four cases
    N D Theise
    Department of Pathology, New York University Medical Center, New York, NY, USA
    Histopathology 43:263-71. 2003
    ..We report four cases of small tumours identified in livers with features of chronic hepatitis which may suggest a role for malignant transformation of hepatic stem cells in hepatic malignancies...
  5. ncbi request reprint Stem cell research: elephants in the room
    Neil D Theise
    Department of Pathology, Division of Digestive Diseases, Beth Israel Medical Center, New York, NY 10003, USA
    Mayo Clin Proc 78:1004-9. 2003
    ..Perhaps open, careful, and unbiased discussions of these elephants will help the cleanup work be less odious and completed sooner, rather than later...
  6. ncbi request reprint Liver stem cells: prospects for treatment of inherited and acquired liver diseases
    Neil D Theise
    Beth Israel Medical Center, Division of Digestive Diseases, 1st Avenue at 16th Street, New York, NY 10003, USA
    Expert Opin Biol Ther 3:403-8. 2003
    ....
  7. ncbi request reprint The stem cell niche and tissue biology
    Neil D Theise
    Department of Pathology, Division of Digestive Diseases, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA
    Stem Cell Rev 2:169-70. 2006
  8. ncbi request reprint Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach
    Neil D Theise
    Department of Pathology, Beth Israel Medical Center of Albert Einstein College of Medicine, New York, NY, USA
    Mod Pathol 20:S3-14. 2007
    ..Sample approaches to composing useful diagnostic reports are also presented...
  9. ncbi request reprint Stem cell plasticity: tools for investigation and repair
    Neil D Theise
    Liver and Stem Cell Research Laboratory, Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center, New York, New York, USA
    J Pediatr Gastroenterol Nutr 40:S48-9. 2005
  10. ncbi request reprint Perspective: stem cells react! Cell lineages as complex adaptive systems
    Neil D Theise
    Beth Israel Medical Center, New York, NY 10003, USA
    Exp Hematol 32:25-7. 2004
    ....
  11. ncbi request reprint Gastrointestinal stem cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity
    Neil D Theise
    Division of Digestive Diseases, 16th St at 1st Ave, New York, NY 10003
    Am J Physiol Gastrointest Liver Physiol 290:G189-93. 2006
    ....
  12. ncbi request reprint On experimental design and discourse in plasticity research
    Neil D Theise
    Department of Pathology and Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, New York, NY 10003, USA
    Stem Cell Rev 1:9-13. 2005
    ..In different models of injury there are likely to be significant differences in promoting cell localization, proliferation, and predominance of "plasticity pathway," if any are involved, in determining outcome...
  13. doi request reprint Beyond cell doctrine: complexity theory informs alternate models of the body for cross-cultural dialogue
    Neil D Theise
    Department of Pathology, Beth Israel Medical Center of Albert Einstein College of Medicine New York, New York, USA
    Ann N Y Acad Sci 1172:263-9. 2009
    ..Additionally, the seemingly metaphorical concepts from Tibetan medicine of the coarse, energy, and subtle bodies may represent precise, though somewhat poetically expressed representations of the body at different levels of scale...
  14. ncbi request reprint Cell doctrine in a complex and uncertain world: time for reappraisal?
    Neil D Theise
    Department of Pathology, Division of Digestive Diseases, Beth Israel Medical Center Albert Einstein College of Medicine, New York, New York 10003, USA
    Cloning Stem Cells 7:209-13. 2005
  15. doi request reprint Liver biopsies in chronic viral hepatitis: beyond grading and staging
    Rachel Hudacko
    Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA
    Arch Pathol Lab Med 135:1320-8. 2011
    ....
  16. ncbi request reprint Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    Tania A Roskams
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Hepatology 39:1739-45. 2004
    ....
  17. ncbi request reprint The tissue biology of ductular reactions in human chronic liver disease
    Neil D Theise
    Gastroenterology 133:350-2. 2007
  18. ncbi request reprint Stem-cell therapy for diabetes mellitus
    Mehboob A Hussain
    Liver and Stem Cell Research Laboratory, Division of Digestive Diseases, Department of Internal Medicine, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA
    Lancet 364:203-5. 2004
    ..Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (found in the postnatal organism) have been used to generate surrogate beta cells or otherwise restore beta-cell functioning...
  19. ncbi request reprint Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury
    Alexander V Kofman
    Department of Medicine, Division of Digestive Diseases, Liver and Stem Cell Research Laboratory, Beth Israel Medical Center, New York, NY 10003, USA
    Hepatology 41:1252-61. 2005
    ..The close fidelity of mechanism and histology of acetaminophen injury between mouse and human livers makes it a useful model for investigating liver regeneration and the participation of stem/progenitor cells in that process...
  20. ncbi request reprint Post-natal stem cells as participants in complex systems and the emergence of tissue integrity and function
    Mehboob A Hussain
    Section of Endocrinology, Department of Medicine, Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue M267, Chicago, IL 60637, USA
    Pediatr Diabetes 5:75-8. 2004
    ..We would like to make this contribution a means of adding a somewhat different perspective to this collection of essays. This conceptual piece is merely intended to be an invitation to further thoughts and discussions...
  21. ncbi request reprint Liver stem cells: the fall and rise of tissue biology
    Neil D Theise
    Hepatology 38:804-6. 2003
  22. ncbi request reprint Sonographic detection of hepatocellular carcinoma and dysplastic nodules in cirrhosis: correlation of pretransplantation sonography and liver explant pathology in 200 patients
    Genevieve L Bennett
    Department of Abdominal Radiology, New York University Medical Center, 560 First Avenue, New York, NY 10016, USA
    AJR Am J Roentgenol 179:75-80. 2002
    ....
  23. ncbi request reprint Immunohistochemical evidence for hepatic progenitor cells in liver diseases
    Jianyou Tan
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Liver 22:365-73. 2002
    ..We investigated bile ductular reactions in liver diseases, paying particular attention to the presence of cells with intermediate (hepatocytic/biliary) features (oval-like cells)...
  24. ncbi request reprint Bone marrow to liver: the blood of Prometheus
    Neil D Theise
    Department of Pathology, New York University School of Medicine, Room 461, 560 First Avenue, New York, NY 10016, USA
    Semin Cell Dev Biol 13:411-7. 2002
    ..Moreover, the physiological importance and therapeutic utility of this phenomenon remains controversial...
  25. pmc The hepatic stem cell niche: identification by label-retaining cell assay
    Reiichiro Kuwahara
    Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center Albert Einstein College of Medicine, New York, NY 10003, USA
    Hepatology 47:1994-2002. 2008
    ....
  26. ncbi request reprint Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow
    Neil D Theise
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Exp Hematol 30:1333-8. 2002
    ..To better understand the process by which pneumocytes can be derived from bone marrow cells, we investigated the in vivo kinetics of such engraftment following lethal irradiation...
  27. ncbi request reprint Hepatic precancerous lesions and small hepatocellular carcinoma
    Prodromos Hytiroglou
    Department of Pathology, Aristotle University Medical School, 54006 Thessaloniki, Greece
    Gastroenterol Clin North Am 36:867-87, vii. 2007
    ..High-grade dysplastic nodules and small HCCs should be treated by local ablation, surgical resection, or liver transplantation...
  28. ncbi request reprint Comment on "Little evidence for developmental plasticity of adult hematopoietic stem cells"
    Neil D Theise
    Science 299:1317; author reply 1317. 2003
  29. ncbi request reprint Cell plasticity: flexible arrangement
    Neil D Theise
    Division of Digestive Diseases, Beth Israel Medical Center, New York 10003, USA
    Nature 425:21. 2003
  30. ncbi request reprint Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells
    Olga Falkowski
    Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA
    J Hepatol 39:357-64. 2003
    ..We investigate derivation of intraseptal hepatocytes (ISHs) from DRs and from the biliary tree in cirrhosis...
  31. ncbi request reprint Fibrin ring granuloma in chronic hepatitis C: virus-related vasculitis and/or immune complex disease?
    Emily Glazer
    Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center, New York, New York 10003, USA
    Semin Liver Dis 27:227-30. 2007
    ....
  32. ncbi request reprint Telomerase activation in human hepatocarcinogenesis
    Prodromos Hytiroglou
    Am J Gastroenterol 101:839-41. 2006
    ..Most importantly, tackling the mechanisms of telomerase activation may provide new means of therapy for HCC and other cancers...
  33. ncbi request reprint Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry
    Christopher R Cogle
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida, ARB R4 216B, Gainesville, FL 32610 0277, USA
    Stem Cells 25:1881-7. 2007
    ..Disclosure of Potential Conflicts of Interest is found at the end of this article...
  34. ncbi request reprint Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules
    Young Nyun Park
    Department of Pathology and Institute of Gastroenterology, Center for Chronic Metabolic Disease, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Cancer 109:915-23. 2007
    ..The authors hypothesized that ductular reaction (DR) takes place around noninvasive hepatocellular nodules but not within the stroma contiguous to invasive HCC...
  35. ncbi request reprint Necrotizing granulomatous hepatitis as an unusual manifestation of Lyme disease
    Antonela C Zanchi
    Division of Digestive Diseases, Department of Pathology, Beth Israel Medical Center, New York, New York 10013, USA
    Dig Dis Sci 52:2629-32. 2007
  36. ncbi request reprint Efficient generation of human hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep
    Jason Chamberlain
    Department of Animal Biotechnology, University of Nevada at Reno, Reno, NV 89557 0104, USA
    Hepatology 46:1935-45. 2007
    ..Furthermore, hepatocytes were generated from MSCs without the need to first migrate/lodge to the bone marrow and give rise to hematopoietic cells...
  37. pmc Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration
    E Scott Swenson
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    Liver Int 28:308-18. 2008
    ..Stem cell factor (SCF) and stromal-derived factor-1 (SDF-1) regulate the regenerative response to liver injury, possibly through activation of liver progenitor 'oval' cells and recruitment of circulating, marrow-derived progenitors...
  38. ncbi request reprint Donor-derived type II pneumocytes are rare in the lungs of allogeneic hematopoietic cell transplant recipients
    Dani S Zander
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, 6431 Fannin Street, Room 2 286, Houston, TX 77030, USA
    Ann Clin Lab Sci 36:47-52. 2006
    ..Conversely, proliferation by local stem cell populations appears to be more important for recovery from alveolar injury...
  39. pmc Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    Exp Hematol 34:230-41. 2006
    ..Previous studies have demonstrated the production of various types of lung cells from marrow cells under diverse experimental conditions. Our aim was to identify some of the variables that influence conversion in the lung...
  40. ncbi request reprint Destruction of canals of Hering in primary biliary cirrhosis
    Romil Saxena
    Lillian and Henry M Stratton Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Hum Pathol 33:983-8. 2002
    ..This destruction appears to be an early event, because CoH numbers are lowest around stage 0 portal tracts, which still contain normal bile ducts...
  41. ncbi request reprint Liver regeneration investigated in a non-human primate model (Macaca mulatta)
    Paul J Gaglio
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    J Hepatol 37:625-32. 2002
    ..An adequate model to study liver regeneration in humans is presently unavailable. We explored the feasibility of studying liver regeneration in a genetically similar species to man, the non-human primate Rhesus macaque...
  42. ncbi request reprint Transplantation for hepatocellular carcinoma and cirrhosis: sensitivity of magnetic resonance imaging
    Glenn A Krinsky
    Department of Radiology, New York University Medical Center, New York, NY 10016, USA
    Liver Transpl 8:1156-64. 2002
    ..8-cm high-grade lesion, for a sensitivity of 7%. In conclusion, MRI is sensitive for the detection of HCC measuring at least 2 cm in diameter but is insensitive for the diagnosis of small HCC (<2 cm) and carcinomatosis...
  43. ncbi request reprint New principles of cell plasticity
    Neil D Theise
    Department of Pathology, New York University School of Medicine, Room 461, 560 First Avenue, New York, NY 10003, USA
    C R Biol 325:1039-43. 2002
    ..However, in light of both the recent discoveries and older clinical or experimental findings, we have suggested principles comprising a new paradigm of cell plasticity, summarized here...
  44. ncbi request reprint Stellate-cell lipidosis in liver biopsy specimens. Recognition and significance
    Pascale Hummel Levine
    Dept of Pathology, NYU Medical Center, TH 461, 560, First Ave, New York, NY 10016 6497, USA
    Am J Clin Pathol 119:254-8. 2003
    ..In 6 patients, no cause of stellate-cell lipidosis was discerned. Stellate-cell lipidosis should be reported to alert clinicians to a potentially preventable form of liver injury...
  45. pmc In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    Andreea Ianus
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 111:843-50. 2003
    ..The results generated with the CRE-LoxP system also suggest that in vivo cell fusion is an unlikely explanation for the "transdifferentiation" of bone marrow-derived cells into differentiated cell phenotypes...
  46. ncbi request reprint Blood to liver and back again: seeds of understanding
    Neil D Theise
    Haematologica 88:361-2. 2003
  47. ncbi request reprint The canals of hering might represent a target of methotrexate hepatic toxicity
    Prodromos Hytiroglou
    Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece
    Am J Clin Pathol 121:324-9. 2004
    ..8 vs 5.2 +/- 1.7; P < .025). In specimens with moderate or severe fibrosis, fibrous septa sometimes extended along the coH. These findings suggest that scarring of the coH might be a consequence of the toxic effects of methotrexate...
  48. ncbi request reprint Paradigms of adult stem cell therapy for type 1 diabetes in mice
    Alexander V Kofman
    Liver and Stem Cell Research Laboratory, Beth Israel Medical Center, New York, and Albert Einstein Medical College, Bronx, NY, USA
    Eur J Endocrinol 150:415-9. 2004
  49. ncbi request reprint Restoring balance to liver stem cell research
    Neil D Theise
    J Hepatol 41:673-6. 2004
  50. ncbi request reprint Low-grade siderotic dysplastic nodules: determination of premalignant lesions on the basis of vasculature phenotype
    Glenn A Krinsky
    Department of Radiology, New York University Medical Center, NY 10016, USA
    Acad Radiol 9:336-41. 2002
    ..The authors performed this study to determine whether, on the basis of the vascular profile, low-grade siderotic dysplastic nodules are premalignant lesions...
  51. ncbi request reprint Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs
    Dani S Zander
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Transplantation 80:206-12. 2005
    ....
  52. ncbi request reprint Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion
    Oscar Quintana-Bustamante
    Hematopoietic Gene Therapy Division, CIEMAT M, Botín Foundation, Madrid, Spain
    Hepatology 43:108-16. 2006
    ..These findings open the possibility of using hematopoietic growth factors to treat nonhematopoietic degenerative diseases...
  53. pmc Bone marrow-derived cells contribute to epithelial engraftment during wound healing
    Xenia Borue
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Am J Pathol 165:1767-72. 2004
    ....
  54. ncbi request reprint Dysplastic nodules and hepatocarcinogenesis
    Neil D Theise
    Department of Pathology, New York University Medical Center, Room 461, 560 First Avenue, New York, NY 10016, USA
    Clin Liver Dis 6:497-512. 2002
    ....

Research Grants5

  1. Hepatic engraftment of marrow cells
    Neil Theise; Fiscal Year: 2001
    ....
  2. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2002
    ....
  3. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2003
    ....
  4. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2002
    ....
  5. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2004
    ....