STEVEN F contact ZIEGLER

Summary

Affiliation: Benaroya Research Institute
Country: USA

Publications

  1. pmc Sensing the outside world: TSLP regulates barrier immunity
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 11:289-93. 2010
  2. pmc Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
    Jane Yoo
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA
    J Exp Med 202:541-9. 2005
  3. pmc Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells
    Michael M Miazgowicz
    Immunology Program, Benaroya Research Institute, Seattle, WA Department of Immunology, University of Washington School of Medicine, Seattle, WA
    J Inflamm Res 6:53-61. 2013
  4. pmc Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma
    H Han
    Immunology Program, Benaroya Research Institute, Seattle, Washington, USA
    Mucosal Immunol 5:342-51. 2012
  5. ncbi request reprint The biology of thymic stromal lymphopoietin (TSLP)
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA, USA
    Adv Pharmacol 66:129-55. 2013
  6. pmc Thymic stromal lymphopoietin and allergic disease
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Allergy Clin Immunol 130:845-52. 2012
  7. pmc The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond
    Florence Roan
    Immunology Program, Benaroya Research Institute, Seattle, WA, USA
    J Leukoc Biol 91:877-86. 2012
  8. pmc Fusion of green fluorescent protein to the C-terminus of granulysin alters its intracellular localization in comparison to the native molecule
    Dennis A Hanson
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195, USA
    J Negat Results Biomed 3:2. 2004
  9. pmc The role of thymic stromal lymphopoietin (TSLP) in allergic disorders
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, United States
    Curr Opin Immunol 22:795-9. 2010
  10. doi request reprint Regulatory T cells and inflammation: better late than never
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Immunity 29:5-7. 2008

Research Grants

  1. FoxP3 control of peripheral regulatory T cell generation
    Steven Ziegler; Fiscal Year: 2007
  2. TSLP and the Pathophysiology of Asthma
    Steven Ziegler; Fiscal Year: 2007
  3. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2010
  4. Regulation of TSLP-Mediated Skin Inflammation
    STEVEN F contact ZIEGLER; Fiscal Year: 2010
  5. TSLP and Contact Hypersensitivity
    Steven F Ziegler; Fiscal Year: 2010
  6. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 1999
  7. TSLP and Contact Hypersensitivity
    Steven Ziegler; Fiscal Year: 2009
  8. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2009
  9. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2007
  10. TSLP receptor in the regulation of cell development
    Steven F Ziegler; Fiscal Year: 2010

Collaborators

Detail Information

Publications47

  1. pmc Sensing the outside world: TSLP regulates barrier immunity
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 11:289-93. 2010
    ....
  2. pmc Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
    Jane Yoo
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA
    J Exp Med 202:541-9. 2005
    ..These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease...
  3. pmc Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells
    Michael M Miazgowicz
    Immunology Program, Benaroya Research Institute, Seattle, WA Department of Immunology, University of Washington School of Medicine, Seattle, WA
    J Inflamm Res 6:53-61. 2013
    ..Taken together, the data suggest that induction of TSLPR and a direct response to TSLP by epithelial cells may play a novel role in the development of allergic inflammation...
  4. pmc Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma
    H Han
    Immunology Program, Benaroya Research Institute, Seattle, Washington, USA
    Mucosal Immunol 5:342-51. 2012
    ..This study, which provides a clean mouse model to study human atopic march, indicates that skin-derived TSLP may represent an important factor that triggers progression from AD to asthma...
  5. ncbi request reprint The biology of thymic stromal lymphopoietin (TSLP)
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA, USA
    Adv Pharmacol 66:129-55. 2013
    ..Importantly, these insights into TSLP's multifaceted roles could potentially allow for novel therapeutic manipulations of these disorders...
  6. pmc Thymic stromal lymphopoietin and allergic disease
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Allergy Clin Immunol 130:845-52. 2012
    ..Importantly, these insights into TSLP's multifaceted role could potentially allow for novel therapeutic manipulations of these disorders...
  7. pmc The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond
    Florence Roan
    Immunology Program, Benaroya Research Institute, Seattle, WA, USA
    J Leukoc Biol 91:877-86. 2012
    ..Importantly, these insights into the multifaceted roles of TSLP could potentially allow for novel, therapeutic manipulations of these disorders...
  8. pmc Fusion of green fluorescent protein to the C-terminus of granulysin alters its intracellular localization in comparison to the native molecule
    Dennis A Hanson
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195, USA
    J Negat Results Biomed 3:2. 2004
    ..This example is offered as a cautionary account for other researchers who contemplate using this technology...
  9. pmc The role of thymic stromal lymphopoietin (TSLP) in allergic disorders
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, United States
    Curr Opin Immunol 22:795-9. 2010
    ..This review will discuss this work and place TSLP in the inflammatory cascade that leads to allergic disease...
  10. doi request reprint Regulatory T cells and inflammation: better late than never
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Immunity 29:5-7. 2008
    ..2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation...
  11. pmc FOXP3 and the regulation of Treg/Th17 differentiation
    Steven F Ziegler
    Immunology, Benaroya Research Institute, Seattle, WA 98101, USA
    Microbes Infect 11:594-8. 2009
    ..Therefore, it is the balance between FOXP3 and RORgammat function that determines CD4 T cell fate and the type of immune response that will be generated...
  12. ncbi request reprint Influence of FOXP3 on CD4(+)CD25(+) regulatory T cells
    Steven F Ziegler
    Benaroya Research Institute, Immunology Program, Seattle, WA 98101, USA
    Expert Rev Clin Immunol 2:639-47. 2006
    ..A finding that has implications on both how autoimmunity is regulated in vivo as well an impact on the development of therapeutic interventions for the treatment of autoimmunity...
  13. ncbi request reprint FOXP3: not just for regulatory T cells anymore
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101 USA
    Eur J Immunol 37:21-3. 2007
    ..This finding suggests a new role for FOXP3 in human CD4+ T cells: down-modulating responses to TCR-mediated stimulation...
  14. pmc Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses
    Ryan P Larson
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 184:2974-84. 2010
    ....
  15. ncbi request reprint Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
    Baohua Zhou
    Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
    Nat Immunol 6:1047-53. 2005
    ..These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation...
  16. ncbi request reprint Thymic stromal lymphopoietin in normal and pathogenic T cell development and function
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
    Nat Immunol 7:709-14. 2006
    ....
  17. ncbi request reprint Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4+ T cell effector function
    Deborah J Kasprowicz
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Immunol 171:1216-23. 2003
    ..Overall, these findings show that overexpression of scurfin reduces T cell responses in vivo such that CD4(+) T cells cannot provide help to B cells during a T cell-dependent Ab response...
  18. pmc Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor
    Hai Chon Lee
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 181:5189-93. 2008
    ..Taken as a whole, these data demonstrate that inhibition of IL-1beta-dependent genes by active retinoid X receptors involves antagonism of NF-kappaB signaling...
  19. pmc Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis
    Masayuki Iyoda
    Department of Pathology, University of Washington, 1959 NE Pacific Avenue, Box 357470, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:68-77. 2009
    ..These data suggest that treatment with imatinib may be a novel therapeutic approach for cryoglobulinemia and MPGN in humans...
  20. ncbi request reprint Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death
    Deborah J Kasprowicz
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Eur J Immunol 35:3424-32. 2005
    ..Concomitant with differentiation is a loss of FoxP3 mRNA and protein. These data demonstrate that FoxP3 levels regulate T cell function, and that FoxP3 itself is dynamically regulated during effector T cell differentiation...
  21. ncbi request reprint FOXP3 acts as a rheostat of the immune response
    Hans D Ochs
    University of Washington and Children s Hospital Regional Medical Center, Seattle, WA, USA
    Immunol Rev 203:156-64. 2005
    ....
  22. pmc Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice
    Johnna D Wesley
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 185:4760-8. 2010
    ..These results help define the events leading to diabetes in DORmO mice and provide new insights into the cellular interactions required for disease development in an Ag-specific model of T1D...
  23. pmc Regulating the immune system: the induction of regulatory T cells in the periphery
    Jane H Buckner
    Diabetes Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    Arthritis Res Ther 6:215-22. 2004
    ....
  24. pmc Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    Mindi R Walker
    Diabetes Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, Washington 98101, USA
    J Clin Invest 112:1437-43. 2003
    ..These data also raise the possibility that a failure to generate peripheral TR cells properly may contribute to autoimmune disease and suggest a possible therapeutic role for FoxP3 in the treatment of such diseases...
  25. ncbi request reprint Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction
    Deborah E Isaksen
    Virginia Mason Research Center, Seattle, WA 98101, USA
    J Immunol 168:3288-94. 2002
    ..Our data demonstrate that TSLP-mediated Stat5 activation is insufficient for cell proliferation and identifies residues within the TSLP receptor complex required to mediate these downstream events...
  26. ncbi request reprint Insights into transcriptional regulation by FOXP3
    Bryan D Carson
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Front Biosci 11:1607-19. 2006
    ..Second, we review recent data concerning the molecular mechanism of FoxP3 function and its role in human disease. Finally, we consider what is known about FoxP3 target genes and their effect on T cell physiology...
  27. ncbi request reprint FOXP3 modifies the phenotypic and functional properties of regulatory T cells
    Daniel J Campbell
    Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Nat Rev Immunol 7:305-10. 2007
    ....
  28. ncbi request reprint IL-2Rbeta links IL-2R signaling with Foxp3 expression
    David M Soper
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Eur J Immunol 37:1817-26. 2007
    ..Expression of a Foxp3 transgene restored Treg and protected against the onset of autoimmunity. Thus, a signal mediated by IL-2Rbeta is essential for the development and homeostasis of Foxp3(+) Treg in vivo...
  29. ncbi request reprint FOXP3: of mice and men
    Steven F Ziegler
    Immunology Program, Benaroya Research Institute and Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98101, USA
    Annu Rev Immunol 24:209-26. 2006
    ..This review focuses on Foxp3 expression and function and highlights differences between humans and mice regarding Foxp3 regulation...
  30. ncbi request reprint Impaired T cell receptor signaling in Foxp3+ CD4 T cells
    Bryan D Carson
    Immunology Program, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Ann N Y Acad Sci 1103:167-78. 2007
    ....
  31. ncbi request reprint Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
    Jared E Lopes
    Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA
    J Immunol 177:3133-42. 2006
    ..Furthermore, we demonstrate that IPEX mutations in these domains correlate with deficiencies in FOXP3 repressor function, corroborating their in vivo relevance...
  32. pmc Functional avidity directs T-cell fate in autoreactive CD4+ T cells
    Roberto Mallone
    Benaroya Research Institute at Virginia Mason, 1201 Ninth Ave, Seattle, WA 98101, USA
    Blood 106:2798-805. 2005
    ..Regulation via down-modulation of antigen-presenting cell function, a form of cell-to-cell licensing for suppression, also offers possibilities for the application of peptide-MHC therapeutics...
  33. pmc TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses
    Mark B Headley
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 182:1641-7. 2009
    ..This study provides new insight into the unique features of the asthma pathology contributed by the innate and adaptive immune responses in response to TSLP stimulation...
  34. ncbi request reprint Functional analysis of FOXP3
    Jane H Buckner
    Translational Research, Benaroya Research Institute, Seattle, WA 98101, USA
    Ann N Y Acad Sci 1143:151-69. 2008
    ..This review will focus on the role of FOXP3 in regulating CD4 T cell function in both humans and mice, with an emphasis on recent work in human systems...
  35. ncbi request reprint Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response
    Heidi K Jessup
    Inflammation Research, Amgen, Seattle, WA 98119, USA
    J Immunol 181:4311-9. 2008
    ..TSLP-induced responses were significantly, but not completely reduced in IL-4- and IL-13-deficient mice. These results shed light on the pathways and cell types involved in TSLP-induced inflammation...
  36. pmc Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses
    Baohua Zhou
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 181:6557-62. 2008
    ....
  37. pmc Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB
    Hai Chon Lee
    Immunology Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 104:914-9. 2007
    ..Taken together, these results demonstrate that the inflammatory mediators IL-1beta and TNF-alpha regulate human TSLP gene expression in an NFkappaB-dependent manner...
  38. ncbi request reprint Foxp3 is required throughout the life of a regulatory T cell
    Jared E Lopes
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Sci STKE 2007:pe36. 2007
    ..Cells retaining aspects of Treg differentiation persist in the absence of Foxp3, which is suggestive of a Foxp3-independent aspect of Treg biology...
  39. ncbi request reprint Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3
    Jianguang Du
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 180:4785-92. 2008
    ..These data expand the possible targets of FOXP3-mediated repression and demonstrate functional differences between FOXP3 isoforms...
  40. pmc The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    J Clin Invest 115:3276-84. 2005
    ....
  41. pmc CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    Audrey L Kinter
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:331-43. 2004
    ..These in vitro data suggest that CD25(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease...
  42. ncbi request reprint Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 173:2227-30. 2004
    ..In summary, our data suggest E2 promotes tolerance by expanding the regulatory T cell compartment...
  43. ncbi request reprint FOXP3 controls regulatory T cell function through cooperation with NFAT
    Yongqing Wu
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 126:375-87. 2006
    ..Thus by switching transcriptional partners, NFAT converts the acute T cell activation program into the suppressor program of Tregs...
  44. pmc Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Clin Invest 116:1713-22. 2006
    ....
  45. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  46. ncbi request reprint Decreased FOXP3 levels in multiple sclerosis patients
    Jianya Huan
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 81:45-52. 2005
    ..Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen...
  47. ncbi request reprint TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    Yong Jun Liu
    Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 25:193-219. 2007
    ..We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses...

Research Grants36

  1. FoxP3 control of peripheral regulatory T cell generation
    Steven Ziegler; Fiscal Year: 2007
    ..In this way FoxP3 expression can be manipulated under conditions designed to assess TR cell function. The experiments will also begin to test the feasibility of manipulating FoxP3 expression as a means of treating autoimmune disease. ..
  2. TSLP and the Pathophysiology of Asthma
    Steven Ziegler; Fiscal Year: 2007
    ..The data generated by these experiments will allow for a determination of the role of TSLP in airway inflammation, and will provide the model systems to test the therapeutic efficacy of TSLP interdiction. ..
  3. TSLP and the Pathophysiology of Asthma
    Steven F Ziegler; Fiscal Year: 2010
    ..The data generated by these experiments will allow for a determination of the role of TSLP in airway inflammation, and will provide the model systems to test the therapeutic efficacy of TSLP interdiction. ..
  4. Regulation of TSLP-Mediated Skin Inflammation
    STEVEN F contact ZIEGLER; Fiscal Year: 2010
    ..This in turn will help guide efforts to develop new interventions for these and other skin inflammatory diseases that directly or indirectly target TSLP. ..
  5. TSLP and Contact Hypersensitivity
    Steven F Ziegler; Fiscal Year: 2010
    ....
  6. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 1999
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..
  7. TSLP and Contact Hypersensitivity
    Steven Ziegler; Fiscal Year: 2009
    ....
  8. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2009
    ..abstract_text> ..
  9. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2007
    ..abstract_text> ..
  10. TSLP receptor in the regulation of cell development
    Steven F Ziegler; Fiscal Year: 2010
    ..abstract_text> ..
  11. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2005
    ..abstract_text> ..
  12. The Role of FoxP3 in Regulatory T Cell Function
    Steven Ziegler; Fiscal Year: 2005
    ..The experiments will also begin to test the feasibility of manipulating FoxP3 expression as a means of treating autoimmune disease. ..
  13. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2002
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  14. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 2000
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..
  15. TSLP receptor in the regulation of cell development
    Steven Ziegler; Fiscal Year: 2006
    ..abstract_text> ..
  16. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2003
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  17. Extopic FoxP3 Expression and Diabetogenic T Cells
    Steven Ziegler; Fiscal Year: 2005
    ..These experiments will provide valuable information on the efficacy of FoxP3 as a tool for therapeutic intervention in autoimmune diabetes. ..
  18. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 2001
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..
  19. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 2003
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..
  20. Regulation of TSLP-Mediated Skin Inflammation
    Steven Ziegler; Fiscal Year: 2009
    ..This in turn will help guide efforts to develop new interventions for these and other skin inflammatory diseases that directly or indirectly target TSLP. ..
  21. TSLP and the Pathophysiology of Asthma
    Steven Ziegler; Fiscal Year: 2006
    ..The data generated by these experiments will allow for a determination of the role of TSLP in airway inflammation, and will provide the model systems to test the therapeutic efficacy of TSLP interdiction. ..
  22. IPEX and Scurfin/FoxP3: Dysregulation of T cells
    Steven Ziegler; Fiscal Year: 2004
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  23. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2004
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  24. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2005
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  25. TSLP and the Pathophysiology of Asthma
    Steven Ziegler; Fiscal Year: 2009
    ..The data generated by these experiments will allow for a determination of the role of TSLP in airway inflammation, and will provide the model systems to test the therapeutic efficacy of TSLP interdiction. ..
  26. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2006
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  27. IL2 RECEPTOR SIGNALING IN T LYMPHOCYTES
    Steven Ziegler; Fiscal Year: 2003
    ..These studies should establish connections between IL-2 signaling and the control of cell cycle and will further understanding of the molecular regulation of T cell expansion during normal and pathological processes. ..
  28. FACS VANTAGE/SE
    Steven Ziegler; Fiscal Year: 2001
    ..Finally, there is a need for an instrument capable of doing DNA content and Ca2+- flux analyses. The instrument requested will provide for the current, as well as future, needs of the user group...
  29. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 2002
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..