John M Ravits

Summary

Affiliation: Benaroya Research Institute
Country: USA

Publications

  1. pmc Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology
    Stuart J Rabin
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Hum Mol Genet 19:313-28. 2010
  2. ncbi Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem
    John Ravits
    Neurogenomics Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Neurology 68:1576-82. 2007
  3. pmc Current and future directions in genomics of amyotrophic lateral sclerosis
    John Ravits
    Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA
    Phys Med Rehabil Clin N Am 19:461-77, viii. 2008
  4. ncbi Amyotrophic lateral sclerosis microgenomics
    John Ravits
    Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Phys Med Rehabil Clin N Am 16:909-24, viii. 2005
  5. pmc ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration
    John M Ravits
    Section of Neurology, Virginia Mason Medical Center, Seattle, WA, USA
    Neurology 73:805-11. 2009
  6. ncbi Focality of upper and lower motor neuron degeneration at the clinical onset of ALS
    John Ravits
    Neurogenomics Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Neurology 68:1571-5. 2007
  7. doi No evidence of HIV pol gene in spinal cord tissues in sporadic ALS by real-time RT-PCR
    Young Joo Kim
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Amyotroph Lateral Scler 11:91-6. 2010
  8. doi TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread
    Aaron Bodansky
    Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Amyotroph Lateral Scler 11:321-7. 2010
  9. ncbi Sporadic amyotrophic lateral sclerosis: a hypothesis of persistent (non-lytic) enteroviral infection
    John Ravits
    Neurology Section, Virginia Mason Medical Center, Neurogenomics Laboratory, Benaroya Research Institute, Seattle, WA 98111, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:77-87. 2005
  10. ncbi Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 61:427-34. 2007

Research Grants

  1. Microgenomic Studies of ALS
    John Ravits; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. pmc Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology
    Stuart J Rabin
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Hum Mol Genet 19:313-28. 2010
    ..Data deposition: GeneChip raw data (CEL-files) have been deposited for public access in the Gene Expression Omnibus (GEO), www.ncbi.nlm.nih.gov/geo, accession number GSE18920...
  2. ncbi Implications of ALS focality: rostral-caudal distribution of lower motor neuron loss postmortem
    John Ravits
    Neurogenomics Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Neurology 68:1576-82. 2007
    ..Because motor manifestations of ALS begin focally and progress contiguously, the anatomic distribution of underlying lower motor neuron and upper motor neuron degeneration should correlate to onset...
  3. pmc Current and future directions in genomics of amyotrophic lateral sclerosis
    John Ravits
    Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA
    Phys Med Rehabil Clin N Am 19:461-77, viii. 2008
    ..The hope is that they will lead to deeper understanding of molecular aspects of the disease and to rational therapeutic targets...
  4. ncbi Amyotrophic lateral sclerosis microgenomics
    John Ravits
    Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Phys Med Rehabil Clin N Am 16:909-24, viii. 2005
  5. pmc ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration
    John M Ravits
    Section of Neurology, Virginia Mason Medical Center, Seattle, WA, USA
    Neurology 73:805-11. 2009
    ..This also suggests opportunities for translational research to seek pathobiology directly in the less affected regions of the nervous system...
  6. ncbi Focality of upper and lower motor neuron degeneration at the clinical onset of ALS
    John Ravits
    Neurogenomics Laboratory, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Neurology 68:1571-5. 2007
    ....
  7. doi No evidence of HIV pol gene in spinal cord tissues in sporadic ALS by real-time RT-PCR
    Young Joo Kim
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Amyotroph Lateral Scler 11:91-6. 2010
    ..In conclusion, we could not find direct evidence of retroviral/HIV activity in SALS CNS to support a relationship. However, our method could miss novel retroviruses with non-homology in the pol gene...
  8. doi TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread
    Aaron Bodansky
    Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Amyotroph Lateral Scler 11:321-7. 2010
    ..Thus, TDP-43 immunoreactive cytoplasmic aggregates have a low overall average frequency that does not correlate with either disease course or clinical spread and is the prime ubiquitinated protein...
  9. ncbi Sporadic amyotrophic lateral sclerosis: a hypothesis of persistent (non-lytic) enteroviral infection
    John Ravits
    Neurology Section, Virginia Mason Medical Center, Neurogenomics Laboratory, Benaroya Research Institute, Seattle, WA 98111, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:77-87. 2005
    ....
  10. ncbi Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 61:427-34. 2007
    ..We recently identified TDP-43 as the major pathological protein in sporadic ALS. In this study, we investigated TDP-43 in a larger series of ALS cases (n = 111), including familial cases with and without SOD1 mutations...
  11. ncbi An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology
    Shangxi Xiao
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 3H2
    J Neurosci 28:1833-40. 2008
    ..These findings are the first to establish that peripherin splicing abnormalities occur in ALS, generating aggregation-prone splice isoforms...
  12. ncbi Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
    Paul H Gordon
    Department of Neurology, Columbia University, New York, NY, USA
    Lancet Neurol 6:1045-53. 2007
    ..Several trials are planned or are in progress to assess whether minocycline slows human neurodegeneration. We aimed to test the efficacy of minocycline as a treatment for amyotrophic lateral sclerosis (ALS)...
  13. ncbi Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes
    Peter M Andersen
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital East and Harvard Medical School, Charlestown, MA, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:62-73. 2003
    ..We searched for novel SOD1 mutations and for clinical characteristics of patients with these mutations...

Research Grants1

  1. Microgenomic Studies of ALS
    John Ravits; Fiscal Year: 2007
    ....