Paul L Bollyky

Summary

Affiliation: Benaroya Research Institute
Country: USA

Publications

  1. ncbi CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity
    Paul L Bollyky
    Diabetes Research Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Immunol Cell Biol 82:307-14. 2004
  2. ncbi Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 179:744-7. 2007
  3. pmc The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation
    Paul L Bollyky
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Curr Diab Rep 12:471-80. 2012
  4. pmc Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse
    Paul L Bollyky
    Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Cell Mol Immunol 7:211-20. 2010
  5. pmc The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury
    Paul L Bollyky
    Benaroya Research Institute, Seattle, Washington, United States of America
    PLoS ONE 4:e5063. 2009
  6. pmc Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Leukoc Biol 86:567-72. 2009
  7. pmc CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 183:2232-41. 2009
  8. pmc ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors
    Paul L Bollyky
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 108:7938-43. 2011
  9. pmc Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration
    Stephen P Evanko
    Benaroya Research Institute, Seattle, WA 98101, United States
    Matrix Biol 31:90-100. 2012
  10. pmc Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
    S Alice Long
    Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    Diabetes 59:407-15. 2010

Collaborators

Detail Information

Publications14

  1. ncbi CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity
    Paul L Bollyky
    Diabetes Research Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Immunol Cell Biol 82:307-14. 2004
    ..Important functional subsets of CD1d-restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed...
  2. ncbi Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 179:744-7. 2007
    ....
  3. pmc The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation
    Paul L Bollyky
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Curr Diab Rep 12:471-80. 2012
    ....
  4. pmc Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse
    Paul L Bollyky
    Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, USA
    Cell Mol Immunol 7:211-20. 2010
    ..These data point to a pivotal role for HA in DC-T cell interactions at the IS...
  5. pmc The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury
    Paul L Bollyky
    Benaroya Research Institute, Seattle, Washington, United States of America
    PLoS ONE 4:e5063. 2009
    ..These data suggest that Myd88 signaling and certain TLR ligands mediate a homeostatic effect on beta-cells primarily in the setting of injury...
  6. pmc Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Leukoc Biol 86:567-72. 2009
    ....
  7. pmc CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
    Paul L Bollyky
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 183:2232-41. 2009
    ..We propose that intact but not fragmented extracellular is capable of cross-linking CD44 and thereby maintains immunologic tolerance in uninjured or healing tissue...
  8. pmc ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors
    Paul L Bollyky
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 108:7938-43. 2011
    ..These results reveal important roles for the matrix microenvironment in immune regulation and suggest unique strategies for immunomodulation...
  9. pmc Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration
    Stephen P Evanko
    Benaroya Research Institute, Seattle, WA 98101, United States
    Matrix Biol 31:90-100. 2012
    ..Together, these data suggest that hyaluronan and versican play a role in T-cell trafficking and function in inflamed tissues...
  10. pmc Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
    S Alice Long
    Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    Diabetes 59:407-15. 2010
    ..Here, we address whether altered IL-2 responsiveness impacts persistence of FOXP3 expression in Tregs of type 1 diabetic subjects...
  11. pmc Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells
    S Alice Long
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Immunol 187:3511-20. 2011
    ..These adaptive Tregs could function to reduce ongoing inflammatory responses and promote low-dose tolerance in humans, especially when Ag exposure and tolerance is transient...
  12. pmc Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses
    Xinhui Ge
    Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    PLoS ONE 5:e11355. 2010
    ....
  13. doi Reversal of diabetes in mice with a bioengineered islet implant incorporating a type I collagen hydrogel and sustained release of vascular endothelial growth factor
    Robert B Vernon
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Cell Transplant 21:2099-110. 2012
    ..In future studies, the BIs described here will serve as platforms to evaluate the capability of immunomodulatory compounds, delivered locally within the BI, to prevent or reverse diabetes in the setting of autoimmune (type 1) diabetes...
  14. pmc Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus
    Xinhui Ge
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Virol 84:3312-9. 2010
    ..These findings suggest that without protective antibody responses, individuals vaccinated against seasonal influenza A may still benefit from preexisting cross-reactive memory CD4 T cells reducing their susceptibility to S-OIV infection...