Research Topics
| J N BellaSummaryCountry: USA Publications
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Publications
Genetic influences on aortic root size in American Indians: the Strong Heart Study Jonathan N Bella
Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Arterioscler Thromb Vasc Biol 22:1008-11. 2002..Echocardiographic screening of family members with aortic root dilatation may identify other individuals predisposed to aortic dissection or rupture...
Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults: the Strong Heart StudyJonathan N Bella
Weill Medical College of Cornell University, New York, NY, USA
Circulation 105:1928-33. 2002..However, the prognostic significance of low or high E/A in older adults remains to be elucidated in population-based samples...
Sex-related difference in regression of left ventricular hypertrophy with antihypertensive treatment: the LIFE studyJ N Bella
Weill Medical College of Cornell University, New York, NY, USA
J Hum Hypertens 18:411-6. 2004..Further studies are needed to identify the mechanisms and prognostic implications of this sex-related difference...
Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart StudyJonathan N Bella
Weill Medical College of Cornell University, New York, New York, USA
J Hypertens 22:281-6. 2004..We sought to determine the heritability of left ventricular dimensions and mass in adult American Indians...
Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network StudyJonathan N Bella
Weill Medical College, Cornell University, New York, NY, USA
Hypertension 49:453-60. 2007..1-q22.3 and suggestive linkage to chromosome 19p13.11-p11 and identifies several other promising genomic regions that may contain specific susceptibility loci for valve calcification...
Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) studyV Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
Circulation 103:102-7. 2001..It remains to be elucidated in a large, population-based sample whether diabetes is associated with changes in left ventricular (LV) structure and systolic function independent of obesity and systolic blood pressure (BP)...
Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension: the LIFE studyV Palmieri
Weill Medical College of Cornell University, New York, NY, USA
Am Heart J 141:784-91. 2001..The ratio of observed/predicted LV mass may allow more physiologically correct comparisons of LV geometry, systolic and diastolic functions, and hemodynamics among hypertensive patients...
Aortic root dilatation at sinuses of valsalva and aortic regurgitation in hypertensive and normotensive subjects: The Hypertension Genetic Epidemiology Network Study V Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
Hypertension 37:1229-35. 2001..Sinuses of Valsalva dilatation was associated with higher left ventricular mass and lower systolic function, which may contribute to higher cardiovascular risk in subjects with aortic root dilatation...
Left ventricular systolic dysfunction in a biracial sample of hypertensive adults: The Hypertension Genetic Epidemiology Network (HyperGEN) StudyR B Devereux
Weill Medical College of Cornell University, New York, NY, USA
Hypertension 38:417-23. 2001....
The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart StudyJ E Liu
Department of Medicine, The New York Hospital Cornell Medical Center, New York 10021, USA
J Am Coll Cardiol 37:1943-9. 2001..We sought to determine the effect of diabetes mellitus (DM) on left ventricular (LV) filling pattern in normotensive (NT) and hypertensive (HTN) individuals...
Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study)V Palmieri
Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Cardiol 88:1163-8. 2001..83), and total peripheral resistance-height(1.83) detected significant preclinical cardiovascular abnormalities with obesity...
Separate and joint effects of systemic hypertension and diabetes mellitus on left ventricular structure and function in American Indians (the Strong Heart Study)J N Bella
Department of Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York 10021, USA
Am J Cardiol 87:1260-5. 2001..001). In conclusion, DM and SH each have adverse effects on LV geometry and function, and the combination of SH and DM results in the greatest degree of LV hypertrophy, myocardial dysfunction, and arterial stiffness...
Relation of left ventricular geometry and function to systemic hemodynamics in hypertension: the LIFE Study. Losartan Intervention For Endpoint Reduction in Hypertension StudyJ N Bella
Cornell Medical Center, New York, USA
J Hypertens 19:127-34. 2001..CONCLUSION: In patients with moderate hypertension and ECG LV hypertrophy, the levels of SV and pulse pressure/ SV, are associated with, and may be stimuli to different LV geometric phenotypes...
Relationship between left ventricular diastolic relaxation and systolic function in hypertension: The Hypertension Genetic Epidemiology Network (HyperGEN) StudyJ N Bella
New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10021, USA
Hypertension 38:424-8. 2001..Whether combined diastolic and systolic dysfunction identifies hypertensive patients at especially high risk of cardiovascular events requires further study...
Usefulness of the assessment of the appropriateness of left ventricular mass to detect left ventricular systolic and diastolic abnormalities in absence of echocardiographic left ventricular hypertrophy: the LIFE studyV Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hum Hypertens 18:423-30. 2004..In conclusion, inappropriately high LV mass was associated with relevant, often preclinical, manifestations of cardiac disease in the absence of traditionally defined echocardiographic LV hypertrophy and concentric geometry...
Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: the prospective randomized enalapril study evaluatR B Devereux
Cornell Medical Center, New York, NY, 10021, USA
Circulation 104:1248-54. 2001....
Treatment of diastolic dysfunction in hypertensionP Ginelli
Department of Medicine, Bronx Lebanon Hospital Center and Albert Einstein College of Medicine, Bronx, NY, USA
Nutr Metab Cardiovasc Dis 22:613-8. 2012..This and other studies will provide further insight into the pathophysiology and management of patients with diastolic dysfunction...
Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS)Jorge R Kizer
Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Am Heart J 151:412-8. 2006..Less is known about the predictive ability of anteroposterior LA diameter, a simpler measure of LA size obtained routinely during echocardiographic evaluation...
Metabolic syndrome and left ventricular structure and functional abnormalitiesVittorio Palmieri
Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy
Am J Hypertens 19:206-7. 2006
Relation of left ventricular geometry and function to aortic root dilatation in patients with systemic hypertension and left ventricular hypertrophy (the LIFE study)Jonathan N Bella
Cornell Medical Center, New York, New York, USA
Am J Cardiol 89:337-41. 2002
Left atrial systolic force and cardiovascular outcome. The Strong Heart StudyMarcello Chinali
Department of Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 18:1570-6; discussion 1577. 2005....
Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a losartan intervention for endpoint-reduction in hypertension (LIFE) substudyMichael H Olsen
Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
Am J Hypertens 18:1430-6. 2005..We aimed to investigate whether they predicted cardiovascular (CV) events independently in patients with hypertension and electrocardiographic left ventricular (LV) hypertrophy...
Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) StudyMarcello Chinali
Department of Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 18:899-905. 2005..01). CONCLUSIONS: Enhanced LASF is associated with LV hypertrophy, normal LV chamber function, increased cardiac output, and prolonged relaxation. The LASF is a preload-dependent measure...
Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudyMichael H Olsen
Departemtn fo Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
Blood Press 14:177-83. 2005..We wanted to investigate whether treatment with losartan, an angiotensin II receptor blocker, induced regression of carotid artery hypertrophy as compared to the beta-receptor blocker, atenolol...
Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network studyFelizen S Agno
Weill Medical College of Cornell University, New York, New York, USA
J Hypertens 23:867-73. 2005..4%) and associated with a proatherogenic clinical profile and abnormal left ventricular geometry and filling, increased left atrial size and mitral annular calcification, which may contribute to the adverse prognosis associated with AVS...
Normalization for body size and population-attributable risk of left ventricular hypertrophy: the Strong Heart StudyGiovanni de Simone
Division of Cardiology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 18:191-6. 2005..The presence of LVH detected by these indices predicts increased cardiovascular (CV) events. Whether different indexations of LVH differ in their ability to predict excess risk is unknown...
Association of pulse pressure with cardiovascular outcome is independent of left ventricular hypertrophy and systolic dysfunction: the Strong Heart StudyVittorio Palmieri
Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
Am J Hypertens 19:601-7. 2006..CONCLUSIONS: Wider PP was associated with a higher hazard ratio of CV mortality independent of traditional CV risk factors, LVH and reduced EF in adults without overt coronary heart disease...
Treatment of diastolic dysfunction in hypertensive left ventricular hypertrophyJonathan N Bella
Division of Cardiology, Department of Medicine, Bronx-Lebanon Hospital Center and Albert Einstein College of Medicine, Bronx, New York 10457, USA
Am J Hypertens 19:937-8. 2006
Marked regional left ventricular heterogeneity in hypertensive left ventricular hypertrophy patients: a losartan intervention for endpoint reduction in hypertension (LIFE) cardiovascular magnetic resonance and echocardiographic substudyRobert W W Biederman
Division of Cardiology, Department of Cardiovascular MRI, Gerald McGuiness Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
Hypertension 52:279-86. 2008....
Change in pulse pressure/stroke index in response to sustained blood pressure reduction and its impact on left ventricular mass and geometry changes: the life studyVittorio Palmieri
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
Am J Hypertens 21:701-7. 2008..In cross-sectional data in hypertensive subjects, brachial pulse pressure (PP)/Doppler stroke index (SVi), (PP/SVi) correlates weakly but significantly with left ventricular (LV) mass and relative wall thickness (RWT)...
Prognostic implications of relations of left ventricular systolic dysfunction with body composition and myocardial energy expenditure: the Strong Heart StudyVittorio Palmieri
Weill Medical College of Cornell University, New York, New York 10021, USA
J Am Soc Echocardiogr 21:66-71. 2008....
Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 25:1079-85. 2007....
Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the Hypertension Genetic Epidemiology Network studyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY, USA
Am Heart J 145:1071-7. 2003..However, the relations of valvular regurgitation to body composition and myocardial bioenergetic expenditure have not been previously investigated in a population-based sample...
Is echocardiography essential in the management of newly diagnosed hypertension?Jonathan N Bella
Division of Cardiology, Department of Medicine, Bronx Lebanon Hospital Center Albert Einstein College of Medicine, Bronx, New York 10457, USA
Am J Hypertens 19:1156-7. 2006
Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: the LIFE studyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 24:2079-84. 2006....
Gender differences in left ventricular systolic function in American Indians (from the Strong Heart Study)Jonathan N Bella
Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA
Am J Cardiol 98:834-7. 2006..Gender-specific partition values for measures of LV systolic function may be necessary to detect abnormal contractility in clinical and epidemiologic studies...
Aortic valve sclerosis relates to cardiovascular events in patients with hypertension (a LIFE substudy)Michael H Olsen
Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK 2600 Glostrup, Denmark
Am J Cardiol 95:132-6. 2005..AV sclerosis was associated with several CV risk factors and predicted CV events independently of prevalent CV disease and traditional CV risk factors, including LV mass and ejection fraction...
Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy)Michael H Olsen
Glostrup University Hospital, Glostrup, Denmark
Am J Cardiol 94:1076-80. 2004....
Relation of impaired left ventricular filling to systolic midwall mechanics in hypertensive patients with normal left ventricular systolic chamber function: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) studyKristian Wachtell
Department of Medicine, Copenhagen County University Hospital, Glostrup, Denmark
Am Heart J 148:538-44. 2004..LV systolic midwall shortening (MWS) may be impaired in hypertensive patients with normal LV ejection fraction. However, it is unclear whether impaired LV filling is related to depressed systolic midwall mechanics...
Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes: the strong heart studyVittorio Palmieri
Weill Medical College of Cornell University, New York, New York 10021, USA
Diabetes Care 26:2764-9. 2003..In the presence of microangiopathy, we found that the atherothrombotic risk profile associated with LVH was independent of BMI and possibly reflected the association of LVH with a higher degree of endothelial dysfunction...
Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN StudyGiovanni de Simone
Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 21:1747-52. 2003....
Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes: the Strong Heart StudyJennifer E Liu
Division of Cardiology, Box 222, New York Presbyterian Hospital Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
J Am Coll Cardiol 41:2022-8. 2003..We sought to compare systolic and diastolic function in American Indians with diabetes mellitus (DM) based on albuminuria status...
Gender difference in diastolic function in hypertension (the HyperGEN study)Jonathan N Bella
Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
Am J Cardiol 89:1052-6. 2002..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
Pulse pressure/stroke index and left ventricular geometry and function: the LIFE StudyVittorio Palmieri
Weill Medical College of Cornell University, New York, NY 10021, USA
J Hypertens 21:781-7. 2003..To evaluate the relationship between arterial stiffness estimated by the pulse pressure/stroke index ratio (PP/SVi) and prognostically relevant abnormalities of left ventricular geometry and function...
Change of left ventricular geometric pattern after 1 year of antihypertensive treatment: the Losartan Intervention For Endpoint reduction in hypertension (LIFE) studyKristian Wachtell
Department of Medicine, Copenhagen County University Hospital, Glostrup, Denmark
Am Heart J 144:1057-64. 2002..Patients with hypertension have different types of left ventricular (LV) geometry, but the impact of blood pressure (BP) reduction on LV geometry change during antihypertensive treatment remains unclear...
Left ventricular hypertrophy is associated with reduced vasodilatory capacity in the brachial artery in patients with longstanding hypertension. A LIFE substudyMichael Hecht Olsen
Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
Blood Press 11:285-92. 2002..Whether similar relations exist in patients with longstanding hypertension and target organ damage remain to be elucidated...
Progressive hypertrophy regression with sustained pressure reduction in hypertension: the Losartan Intervention For Endpoint Reduction studyRichard B Devereux
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Hypertens 20:1445-50. 2002..To examine the time course of left ventricular (LV) geometric response to blood pressure (BP) control during 2 years of systematic antihypertensive treatment...
Assessment of left ventricular mass and geometry by cardiac single photon emission computed tomographyYudthsak Damrongpipatkij
Division of Cardiology, Department of Medicine, Bronx Lebanon Hospital Center, NY 10457, USA
Med Sci Monit 9:MT107-11. 2003..8+/-0.1) for relative wall thickness. CONCLUSIONS: Assessment of left ventricular mass and geometry using cardiac SPECT is feasible and may provide prognostic information beyond measurement of perfusion and function...
Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)Marcello Chinali
Department of Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Cardiol 93:40-4. 2004..Therefore, abnormal LV geometry and function are related to the MS. Increased BP is the component of the MS most strongly associated with cardiac markers of preclinical disease, even in the absence of traditionally defined hypertension...
Change in diastolic left ventricular filling after one year of antihypertensive treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) StudyKristian Wachtell
Copenhagen County University Hospital, Glostrup, Denmark
Circulation 105:1071-6. 2002..It is well established that hypertensive patients with left ventricular (LV) hypertrophy have impaired diastolic filling. However, the impact of antihypertensive treatment and LV mass reduction on LV diastolic filling remains unclear...
Association of inappropriate left ventricular mass with systolic and diastolic dysfunction: the HyperGEN studyGiovanni de Simone
Weill Medical College of Cornell University, New York, New York, USA
Am J Hypertens 17:828-33. 2004..No information is available on whether inappropriate LVM is associated with alterations of LV diastolic properties in unselected population-based studies...
Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN studyGiovanni de Simone
Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
J Hypertens 20:323-31. 2002..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network studyJorge R Kizer
Division of Cardiology, Weill Medical College of Cornell University, New York, USA
Hypertension 43:1182-8. 2004..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
Genomics of aortic valve diseaseJonathan N Bella
J Am Coll Cardiol 52:498; 498-9. 2008
Do electrocardiographic changes with adenosine myocardial perfusion imaging predict ischaemia in patients with left ventricular hypertrophy?Aseem Vashist
Department of Medicine, Bronx Lebanon Hospital Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10457, USA
Nucl Med Commun 25:553-6. 2004..However, the significance of these changes during adenosine MPI in patients with left ventricular hypertrophy (LVH) on baseline electrocardiogram is less well understood...
A longitudinal study of risk factors for incident albuminuria in diabetic American Indians: the Strong Heart StudyJiaqiong Xu
Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Am J Kidney Dis 51:415-24. 2008..There have been no studies that use longitudinal data with more than 2 measurements and methods of longitudinal data analysis to identify risk factors for incident albuminuria over time more effectively...
Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN StudyGiovanni de Simone
Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA
Am J Clin Nutr 81:757-61. 2005..We have shown that increased cardiac output is related to both fat-free mass and fat mass in obesity...
Echocardiographic wall motion abnormalities in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE StudyVittorio Palmieri
Cornell Medical Center, New York, New York, USA
Hypertension 41:75-82. 2003..No significant differences were found between patients with global or segmental wall motion abnormalities...
Efficacy and time-efficiency of a "sonographer-driven" contrast echocardiography protocol in a high-volume echocardiography laboratoryRamon Castello
Division of Cardiology, Department of Medicine, University Hospitals of Cleveland Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Am Heart J 145:535-41. 2003..Contrast echocardiography (CE) has not gained widespread use despite numerous studies demonstrating its efficacy in the assessment of left ventricular (LV) function...
Indexation of left ventricular mass to identify blood pressure-related left ventricular hypertrophyJonathan N Bella
Am J Hypertens 18:1263-5. 2005
Urine albumin/creatinine ratio and echocardiographic left ventricular structure and function in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention for Endpoint ReductionKristian Wachtell
Laboratory of Cardiology, Department of Medicine, Copenhagen County University Hospital, Glostrup, Denmark
Am Heart J 143:319-26. 2002..However, the relationship between these markers of cardiovascular damage has not been evaluated in a large hypertensive population...
BDNF-mediated enhancement of inflammation and injury in the aging heartDongqing Cai
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Physiol Genomics 24:191-7. 2006....
Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN studyVittorio Palmieri
Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Med 112:710-5. 2002..9 to 15). CONCLUSION: In a population-based sample, use of fenfluramine or dexfenfluramine, alone or in combination with phentermine, was associated with aortic regurgitation independent of aortic dilatation or fibrocalcification...
