Research Topics
| Kimberly A BazarSummaryCountry: USA Publications
| Collaborators
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Detail Information
Publications
Temporal variation of autonomic balance and diseases during circadian, seasonal, reproductive, and lifespan cyclesA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:155-62. 2004..Termination of organisms during senescence, achieved by emergence of autonomic imbalance and other systemic dysfunctions, is explored from a Darwinian perspective...- Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disordersKimberly A Bazar
San Mateo Medical Center, Department of Dermatology, 987 Addison Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 66:263-9. 2006.... - "Starve a fever and feed a cold": feeding and anorexia may be adaptive behavioral modulators of autonomic and T helper balanceKimberly A Bazar
Department of Dermatology, San Mateo Medical Center, 222 West, 39th Avenue, San Mateo, CA 94403, USA
Med Hypotheses 64:1080-4. 2005..Modulating feeding, hydration, and sleep may prove beneficial in treating other conditions associated with abnormal autonomic and Th balance... - An "eye" in the gut: the appendix as a sentinel sensory organ of the immune intelligence networkKimberly A Bazar
Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
Med Hypotheses 63:752-8. 2004..Appendicitis may represent a momentary maladaptation in the evolutionary transition of sensory leadership from the gut to the eye. Relationships between immune dysfunctions and cognition are explored... - Debunking a myth: neurohormonal and vagal modulation of sleep centers, not redistribution of blood flow, may account for postprandial somnolenceKimberly A Bazar
Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
Med Hypotheses 63:778-82. 2004..Emerging evidence suggest that these pathways are also modulators of neural sleep centers. Potential adaptive explanations of postprandial somnolence are explored from a Darwinian perspective... - The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotineAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:1073-9. 2005..Other conditions associated with tobacco exposure may also operate through similar autonomic and immune dysfunctions. Therapeutic implications are discussed... - The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeuticsAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:173-8. 2005..Generalizing from these observations, we anticipate benefits of therapeutic and lifestyle approaches that expand, rather than reduce, the dynamic range of many biologic experiences... - Integrating the theories of Darwin and Bernoulli: maladaptive baroreceptor network dysfunction may explain the pathogenesis of aortic aneurysmsBuford R Conley
Palo Alto Institute, Palo Alto, CA, USA
Med Hypotheses 65:266-72. 2005..Lessons learned from bifurcation sensors and their potential maladaptations may generalize to other types of branching systems including botany, civil engineering, and Pitot tube aeronautics... - Clinical benefits of hydration and volume expansion in a wide range of illnesses may be attributable to reduction of sympatho-vagal ratioA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:646-50. 2005..The empiric benefits of hydration and volume expansion portend novel methods to treat a wide range of clinical conditions through pharmacologic or electrical modulation of cardiovascular or gastrointestinal baroreceptors... - Modulation of host immunity by HIV may be partly achieved through usurping host autonomic functionsA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:362-6. 2004..Autonomic remodeling by HIV may exemplify this phenomenon. Our hypothesis has implications for treatment of HIV and its associated syndromes... - Menstrual variation of autonomic balance may be a factor in exacerbations of certain diseases during the menstrual cyclePatrick Y Lee
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:163-7. 2004..Our hypothesis portends new therapeutic paradigms based on cyclical modulation of autonomic balance to address catamenial variations of medical conditions... - The incorporation of iodine in thyroid hormone may stem from its role as a prehistoric signal of ecologic opportunity: an evolutionary perspective and implications for modern diseasesAnthony J Yun
Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 65:804-10. 2005..Iodine acquired through sodium iodide supplementation may independently contribute to some biologic dysfunctions currently attributed to sodium... - Hypertrophic osteoarthropathy may be a marker of underlying sympathetic biasKimberly A Bazar
San Mateo Medical Center, San Mateo, CA, USA
Med Hypotheses 63:357-61. 2004..The exact pathway linking adrenergic excess to HOA remains to be clarified, but a plausible scenario based on current molecular evidence is offered... - Can chronic use of anti-inflammatory agents paradoxically promote chronic inflammation through compensatory host response?John D Doux
Stanford University, 470 University Ave, Palo Alto, CA 94301, USA
Med Hypotheses 65:389-91. 2005..Inflammation is a promoter of adrenergia and thrombosis, and the constellation of these effects may predispose to excess risk of acute cardiovascular events... - Autonomic dysfunction may be an under-recognized cause of female fertility disordersA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:172-7. 2004..Our hypothesis portends new potential methods to treat fertility disorders by modulating autonomic balance... - Immunomodulatory function of seminal catecholamines may be an adaptation for reproductionKimberly A Bazar
San Mateo Medical Center, San Mateo, CA, USA
Med Hypotheses 63:168-71. 2004.... - Acute coronary syndromes and heart failure may reflect maladaptations of trauma physiology that was shaped during pre-modern evolutionPatrick Y Lee
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:861-7. 2004.... - Autonomic dysregulation as a basis of cardiovascular, endocrine, and inflammatory disturbances associated with obstructive sleep apnea and other conditions of chronic hypoxia, hypercapnia, and acidosisA Joon Yun
Stanford University, 300 Pasteur Drive, Palo Alto, CA 94310, USA
Med Hypotheses 62:852-6. 2004..Our proposal may extend to any chronic respiratory or metabolic conditions that manifest hypoxia, hypercapnia, and acidosis and elicit a maladaptive autonomic and inflammatory response... - Adventitial dysfunction: an evolutionary model for understanding atherosclerosisAnthony J Yun
Department of Radiology, Stanford University, Palo Alto, CA 94301, USA
Med Hypotheses 65:962-5. 2005..We envision novel mechanical and biopharmaceutical solutions that target the adventitia to prevent or treat atherosclerosis including novel drug delivery strategies, exo-stents that wrap vessels, and neuromodulation of vessels... - A new wrinkle: skin manifestations of aging may relate to autonomic dysfunctionKimberly A Bazar
Stanford University, Palo Alto, CA 94301, USA
Med Hypotheses 67:1274-6. 2006..For all of these dermatologic conditions, local and systemic administration of drugs and medical devices that pharmacologically or electrically modulate autonomic nervous system activity may yield benefits as well... - Pineal attrition, loss of cognitive plasticity, and onset of puberty during the teen years: is it a modern maladaptation exposed by evolutionary displacement?A Joon Yun
Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:939-50. 2004..Pineal involution may represent a potential target for therapeutic extension or restoration of plasticity after puberty. Extending plasticity may have far-reaching consequences for human evolution... - Tumors may modulate host immunity partly through hypoxia-induced sympathetic biasA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:352-6. 2004..Validation of our hypothesis may shed more light on the biology of cancer and reveal novel diagnostic and therapeutic strategies... - Modulation of autonomic balance by tumors and virusesA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 63:344-51. 2004..A more general for understanding spatial distribution of diseases based on gradients of autonomic balance in the body are explored. Darwinian perspectives are discussed... - Conditions of aging as manifestations of sympathetic bias unmasked by loss of parasympathetic functionPatrick Y Lee
Department of Medicine, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:868-70. 2004..Maintenance and restoration of parasympathetic function may enable upstream control over the deleterious aspects of inherent end-organ adrenergic bias... - Can thromboembolism be the result, rather than the inciting cause, of acute vascular events such as stroke, pulmonary embolism, mesenteric ischemia, and venous thrombosis?: a maladaptation of the prehistoric trauma responseAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:706-16. 2005..Unexplained hypercoagulability of cancer may also operate through tumor-induced adrenergia and inflammation... - Many diseases may reflect dysfunctions of autonomic balance attributable to evolutionary displacementA Joon Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 62:847-51. 2004..We postulate that many diseases are manifestations of this general phenomenon. Implications for existing and future therapeutic strategies are discussed... - Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effectAnthony J Yun
Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
Med Hypotheses 64:1050-9. 2005..Perhaps alternating agonists and antagonist may exercise the entire dynamic range of pathways and improve health... - A new mechanism for diverticular diseases: aging-related vagal withdrawalAnthony J Yun
Stanford University, USA
Med Hypotheses 64:252-5. 2005..Novel approaches to preventing and treating diverticular diseases by promoting vagal activity are proposed including the electrical or pharmacologic modulation of the autonomic system...