Kimberly A Bazar

Summary

Country: USA

Publications

  1. ncbi request reprint Temporal variation of autonomic balance and diseases during circadian, seasonal, reproductive, and lifespan cycles
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:155-62. 2004
  2. ncbi request reprint Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders
    Kimberly A Bazar
    San Mateo Medical Center, Department of Dermatology, 987 Addison Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 66:263-9. 2006
  3. ncbi request reprint "Starve a fever and feed a cold": feeding and anorexia may be adaptive behavioral modulators of autonomic and T helper balance
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West, 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 64:1080-4. 2005
  4. ncbi request reprint An "eye" in the gut: the appendix as a sentinel sensory organ of the immune intelligence network
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 63:752-8. 2004
  5. ncbi request reprint Debunking a myth: neurohormonal and vagal modulation of sleep centers, not redistribution of blood flow, may account for postprandial somnolence
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 63:778-82. 2004
  6. ncbi request reprint The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotine
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:1073-9. 2005
  7. ncbi request reprint The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 65:173-8. 2005
  8. ncbi request reprint Integrating the theories of Darwin and Bernoulli: maladaptive baroreceptor network dysfunction may explain the pathogenesis of aortic aneurysms
    Buford R Conley
    Palo Alto Institute, Palo Alto, CA, USA
    Med Hypotheses 65:266-72. 2005
  9. ncbi request reprint Clinical benefits of hydration and volume expansion in a wide range of illnesses may be attributable to reduction of sympatho-vagal ratio
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:646-50. 2005
  10. ncbi request reprint Modulation of host immunity by HIV may be partly achieved through usurping host autonomic functions
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:362-6. 2004

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Temporal variation of autonomic balance and diseases during circadian, seasonal, reproductive, and lifespan cycles
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:155-62. 2004
    ..Termination of organisms during senescence, achieved by emergence of autonomic imbalance and other systemic dysfunctions, is explored from a Darwinian perspective...
  2. ncbi request reprint Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders
    Kimberly A Bazar
    San Mateo Medical Center, Department of Dermatology, 987 Addison Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 66:263-9. 2006
    ....
  3. ncbi request reprint "Starve a fever and feed a cold": feeding and anorexia may be adaptive behavioral modulators of autonomic and T helper balance
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West, 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 64:1080-4. 2005
    ..Modulating feeding, hydration, and sleep may prove beneficial in treating other conditions associated with abnormal autonomic and Th balance...
  4. ncbi request reprint An "eye" in the gut: the appendix as a sentinel sensory organ of the immune intelligence network
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 63:752-8. 2004
    ..Appendicitis may represent a momentary maladaptation in the evolutionary transition of sensory leadership from the gut to the eye. Relationships between immune dysfunctions and cognition are explored...
  5. ncbi request reprint Debunking a myth: neurohormonal and vagal modulation of sleep centers, not redistribution of blood flow, may account for postprandial somnolence
    Kimberly A Bazar
    Department of Dermatology, San Mateo Medical Center, 222 West 39th Avenue, San Mateo, CA 94403, USA
    Med Hypotheses 63:778-82. 2004
    ..Emerging evidence suggest that these pathways are also modulators of neural sleep centers. Potential adaptive explanations of postprandial somnolence are explored from a Darwinian perspective...
  6. ncbi request reprint The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotine
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:1073-9. 2005
    ..Other conditions associated with tobacco exposure may also operate through similar autonomic and immune dysfunctions. Therapeutic implications are discussed...
  7. ncbi request reprint The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 65:173-8. 2005
    ..Generalizing from these observations, we anticipate benefits of therapeutic and lifestyle approaches that expand, rather than reduce, the dynamic range of many biologic experiences...
  8. ncbi request reprint Integrating the theories of Darwin and Bernoulli: maladaptive baroreceptor network dysfunction may explain the pathogenesis of aortic aneurysms
    Buford R Conley
    Palo Alto Institute, Palo Alto, CA, USA
    Med Hypotheses 65:266-72. 2005
    ..Lessons learned from bifurcation sensors and their potential maladaptations may generalize to other types of branching systems including botany, civil engineering, and Pitot tube aeronautics...
  9. ncbi request reprint Clinical benefits of hydration and volume expansion in a wide range of illnesses may be attributable to reduction of sympatho-vagal ratio
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:646-50. 2005
    ..The empiric benefits of hydration and volume expansion portend novel methods to treat a wide range of clinical conditions through pharmacologic or electrical modulation of cardiovascular or gastrointestinal baroreceptors...
  10. ncbi request reprint Modulation of host immunity by HIV may be partly achieved through usurping host autonomic functions
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:362-6. 2004
    ..Autonomic remodeling by HIV may exemplify this phenomenon. Our hypothesis has implications for treatment of HIV and its associated syndromes...
  11. ncbi request reprint Menstrual variation of autonomic balance may be a factor in exacerbations of certain diseases during the menstrual cycle
    Patrick Y Lee
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:163-7. 2004
    ..Our hypothesis portends new therapeutic paradigms based on cyclical modulation of autonomic balance to address catamenial variations of medical conditions...
  12. ncbi request reprint The incorporation of iodine in thyroid hormone may stem from its role as a prehistoric signal of ecologic opportunity: an evolutionary perspective and implications for modern diseases
    Anthony J Yun
    Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 65:804-10. 2005
    ..Iodine acquired through sodium iodide supplementation may independently contribute to some biologic dysfunctions currently attributed to sodium...
  13. ncbi request reprint Hypertrophic osteoarthropathy may be a marker of underlying sympathetic bias
    Kimberly A Bazar
    San Mateo Medical Center, San Mateo, CA, USA
    Med Hypotheses 63:357-61. 2004
    ..The exact pathway linking adrenergic excess to HOA remains to be clarified, but a plausible scenario based on current molecular evidence is offered...
  14. ncbi request reprint Can chronic use of anti-inflammatory agents paradoxically promote chronic inflammation through compensatory host response?
    John D Doux
    Stanford University, 470 University Ave, Palo Alto, CA 94301, USA
    Med Hypotheses 65:389-91. 2005
    ..Inflammation is a promoter of adrenergia and thrombosis, and the constellation of these effects may predispose to excess risk of acute cardiovascular events...
  15. ncbi request reprint Autonomic dysfunction may be an under-recognized cause of female fertility disorders
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:172-7. 2004
    ..Our hypothesis portends new potential methods to treat fertility disorders by modulating autonomic balance...
  16. ncbi request reprint Immunomodulatory function of seminal catecholamines may be an adaptation for reproduction
    Kimberly A Bazar
    San Mateo Medical Center, San Mateo, CA, USA
    Med Hypotheses 63:168-71. 2004
    ....
  17. ncbi request reprint Acute coronary syndromes and heart failure may reflect maladaptations of trauma physiology that was shaped during pre-modern evolution
    Patrick Y Lee
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 62:861-7. 2004
    ....
  18. ncbi request reprint Autonomic dysregulation as a basis of cardiovascular, endocrine, and inflammatory disturbances associated with obstructive sleep apnea and other conditions of chronic hypoxia, hypercapnia, and acidosis
    A Joon Yun
    Stanford University, 300 Pasteur Drive, Palo Alto, CA 94310, USA
    Med Hypotheses 62:852-6. 2004
    ..Our proposal may extend to any chronic respiratory or metabolic conditions that manifest hypoxia, hypercapnia, and acidosis and elicit a maladaptive autonomic and inflammatory response...
  19. ncbi request reprint Adventitial dysfunction: an evolutionary model for understanding atherosclerosis
    Anthony J Yun
    Department of Radiology, Stanford University, Palo Alto, CA 94301, USA
    Med Hypotheses 65:962-5. 2005
    ..We envision novel mechanical and biopharmaceutical solutions that target the adventitia to prevent or treat atherosclerosis including novel drug delivery strategies, exo-stents that wrap vessels, and neuromodulation of vessels...
  20. ncbi request reprint A new wrinkle: skin manifestations of aging may relate to autonomic dysfunction
    Kimberly A Bazar
    Stanford University, Palo Alto, CA 94301, USA
    Med Hypotheses 67:1274-6. 2006
    ..For all of these dermatologic conditions, local and systemic administration of drugs and medical devices that pharmacologically or electrically modulate autonomic nervous system activity may yield benefits as well...
  21. ncbi request reprint Pineal attrition, loss of cognitive plasticity, and onset of puberty during the teen years: is it a modern maladaptation exposed by evolutionary displacement?
    A Joon Yun
    Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:939-50. 2004
    ..Pineal involution may represent a potential target for therapeutic extension or restoration of plasticity after puberty. Extending plasticity may have far-reaching consequences for human evolution...
  22. ncbi request reprint Tumors may modulate host immunity partly through hypoxia-induced sympathetic bias
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:352-6. 2004
    ..Validation of our hypothesis may shed more light on the biology of cancer and reveal novel diagnostic and therapeutic strategies...
  23. ncbi request reprint Modulation of autonomic balance by tumors and viruses
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 63:344-51. 2004
    ..A more general for understanding spatial distribution of diseases based on gradients of autonomic balance in the body are explored. Darwinian perspectives are discussed...
  24. ncbi request reprint Conditions of aging as manifestations of sympathetic bias unmasked by loss of parasympathetic function
    Patrick Y Lee
    Department of Medicine, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 62:868-70. 2004
    ..Maintenance and restoration of parasympathetic function may enable upstream control over the deleterious aspects of inherent end-organ adrenergic bias...
  25. ncbi request reprint Can thromboembolism be the result, rather than the inciting cause, of acute vascular events such as stroke, pulmonary embolism, mesenteric ischemia, and venous thrombosis?: a maladaptation of the prehistoric trauma response
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:706-16. 2005
    ..Unexplained hypercoagulability of cancer may also operate through tumor-induced adrenergia and inflammation...
  26. ncbi request reprint Many diseases may reflect dysfunctions of autonomic balance attributable to evolutionary displacement
    A Joon Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 62:847-51. 2004
    ..We postulate that many diseases are manifestations of this general phenomenon. Implications for existing and future therapeutic strategies are discussed...
  27. ncbi request reprint Paradoxical strategy for treating chronic diseases where the therapeutic effect is derived from compensatory response rather than drug effect
    Anthony J Yun
    Department of Radiology, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA
    Med Hypotheses 64:1050-9. 2005
    ..Perhaps alternating agonists and antagonist may exercise the entire dynamic range of pathways and improve health...
  28. ncbi request reprint A new mechanism for diverticular diseases: aging-related vagal withdrawal
    Anthony J Yun
    Stanford University, USA
    Med Hypotheses 64:252-5. 2005
    ..Novel approaches to preventing and treating diverticular diseases by promoting vagal activity are proposed including the electrical or pharmacologic modulation of the autonomic system...