Kelly J Gauger

Summary

Affiliation: Baystate Medical Center
Country: USA

Publications

  1. pmc Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    Cancer Cell Int 9:11. 2009
  2. pmc SFRP1 reduction results in an increased sensitivity to TGF-β signaling
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Cancer 11:59. 2011
  3. pmc The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, 3601 Main St, Springfield, MA 01199, USA
    Mol Cancer 13:117. 2014
  4. doi request reprint Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014
  5. pmc Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, United States of America Biology Department, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 8:e78320. 2013
  6. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012

Detail Information

Publications6

  1. pmc Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    Cancer Cell Int 9:11. 2009
    ..CONCLUSION: Our study suggests that loss of SFRP1 allows non-malignant cells to acquire characteristics associated with breast cancer cells...
  2. pmc SFRP1 reduction results in an increased sensitivity to TGF-β signaling
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Cancer 11:59. 2011
    ..Considering that ZEB2 has been shown to interact with mediators of TGF-β signaling, we sought to determine whether TGF-β signaling is altered in TERT-siSFRP1 cells...
  3. pmc The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, 3601 Main St, Springfield, MA 01199, USA
    Mol Cancer 13:117. 2014
    ..The work described here was initiated to investigate whether obesity exacerbates the aforementioned pathways, as they each play a key roles in the development of breast cancer...
  4. doi request reprint Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014
    ..The role SFRP1 plays in p53 target gene expression was also noted, which suggests that this pathway may be worth exploiting for novel therapies. ..
  5. pmc Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, United States of America Biology Department, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 8:e78320. 2013
    ..Our findings demonstrate that the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity. ..
  6. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012
    ....