Kelly J Gauger

Summary

Affiliation: Baystate Medical Center
Country: USA

Publications

  1. pmc Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    Cancer Cell Int 9:11. 2009
  2. pmc SFRP1 reduction results in an increased sensitivity to TGF-β signaling
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Cancer 11:59. 2011
  3. pmc The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, 3601 Main St, Springfield, MA 01199, USA
    Mol Cancer 13:117. 2014
  4. pmc Mice deficient in sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, United States of America Biology Department, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 8:e78320. 2013
  5. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012
  6. doi request reprint Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014

Detail Information

Publications6

  1. pmc Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    Cancer Cell Int 9:11. 2009
    ..CONCLUSION: Our study suggests that loss of SFRP1 allows non-malignant cells to acquire characteristics associated with breast cancer cells...
  2. pmc SFRP1 reduction results in an increased sensitivity to TGF-β signaling
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Cancer 11:59. 2011
    ..Considering that ZEB2 has been shown to interact with mediators of TGF-β signaling, we sought to determine whether TGF-β signaling is altered in TERT-siSFRP1 cells...
  3. pmc The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, 3601 Main St, Springfield, MA 01199, USA
    Mol Cancer 13:117. 2014
    ..The work described here was initiated to investigate whether obesity exacerbates the aforementioned pathways, as they each play a key roles in the development of breast cancer...
  4. pmc Mice deficient in sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, United States of America Biology Department, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 8:e78320. 2013
    ..Our findings demonstrate that the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity. ..
  5. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012
    ....
  6. doi request reprint Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014
    ..The role SFRP1 plays in p53 target gene expression was also noted, which suggests that this pathway may be worth exploiting for novel therapies. ..