Xiaodong Zhou

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
  2. ncbi M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis
    Xingwu Zhong
    Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, 510060, China
    Arch Immunol Ther Exp (Warsz) 55:173-7. 2007
  3. ncbi Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
    X Zhou
    Division of Rheumatology and Clinical Immunogenetics and Division of Medical Genetics, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 167:7126-33. 2001
  4. ncbi Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype"
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center, Houston 77030, USA
    J Immunol 175:4555-60. 2005
  5. ncbi cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Med Sci Monit 10:BR191-7. 2004
  6. ncbi SPARC, an upstream regulator of connective tissue growth factor in response to transforming growth factor beta stimulation
    X D Zhou
    University of Texas Houston Health Science Center, TX 77030, USA
    Arthritis Rheum 54:3885-9. 2006
  7. ncbi Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston Medical School, 6431 Fannin, MSB 5 270, Houston, TX 77030, USA
    Arthritis Rheum 46:2990-9. 2002
  8. ncbi Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
    Xiaodong Zhou
    Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Res Ther 13:R128. 2011
  9. ncbi Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Rheum 52:257-61. 2005
  10. ncbi Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma
    Xiaodong Zhou
    University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 54:2626-31. 2006

Research Grants

  1. Regulation of SPARC in Scleroderma Fibroblasts
    Xiaodong Zhou; Fiscal Year: 2007

Detail Information

Publications29

  1. ncbi Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
    ..The purpose of this study was to examine whether inhibition of SPARC can regulate collagen expression in vitro and in vivo, and subsequently attenuate fibrotic stimulation by bleomycin in mouse skin and lungs...
  2. ncbi M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis
    Xingwu Zhong
    Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, 510060, China
    Arch Immunol Ther Exp (Warsz) 55:173-7. 2007
    ..The objective was to study the pathogenesis of contact lens-associated giant papillary conjunctivitis (CL-GPC)...
  3. ncbi Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
    X Zhou
    Division of Rheumatology and Clinical Immunogenetics and Division of Medical Genetics, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 167:7126-33. 2001
    ..Therefore, SSc-associated autoantigen genes are selectively overexpressed in SSc dermal fibroblasts, a major tissue involved in disease pathogenesis...
  4. ncbi Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype"
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Health Science Center, Houston 77030, USA
    J Immunol 175:4555-60. 2005
    ....
  5. ncbi cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Med Sci Monit 10:BR191-7. 2004
    ..This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis...
  6. ncbi SPARC, an upstream regulator of connective tissue growth factor in response to transforming growth factor beta stimulation
    X D Zhou
    University of Texas Houston Health Science Center, TX 77030, USA
    Arthritis Rheum 54:3885-9. 2006
    ....
  7. ncbi Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, University of Texas Houston Medical School, 6431 Fannin, MSB 5 270, Houston, TX 77030, USA
    Arthritis Rheum 46:2990-9. 2002
    ..SPARC (secreted protein, acidic and rich in cysteine) regulates the deposition or assembly of ECM components. The aim of this study was to investigate the role of SPARC in SSc susceptibility by functional and genetic association studies...
  8. ncbi Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts
    Xiaodong Zhou
    Division of Rheumatology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Arthritis Res Ther 13:R128. 2011
    ..The aims of this study were to examine the catalytic function and sumoylation of topo I in the nuclei of SSc fibroblasts, a major cell type involved in the fibrotic process...
  9. ncbi Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas Houston Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Arthritis Rheum 52:257-61. 2005
    ..The purpose of this study was to examine whether specific inhibition of SPARC can influence the expression of type I collagen and ameliorate the profibrotic activity of TGFbeta1 on normal human fibroblasts...
  10. ncbi Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma
    Xiaodong Zhou
    University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Arthritis Rheum 54:2626-31. 2006
    ..The purpose of this study was to examine whether inhibition of SPARC with small interfering RNA (siRNA) can be used to ameliorate the overproduction of major extracellular matrix components in SSc fibroblasts...
  11. ncbi Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice
    J C Wang
    MOE Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Int J Immunopathol Pharmacol 24:595-601. 2011
    ..Therefore, our results indicated that both SPARC and CTGF appeared to be involved in the same biological pathway, and they have the potential to serve as a therapeutic target for fibrotic diseases such as SSc...
  12. ncbi HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans
    Xiaodong Zhou
    University of Texas Health Science Center at Houston, Houston, TX, USA
    Arthritis Rheum 60:3807-14. 2009
    ..To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study...
  13. ncbi Differential dynamic properties of scleroderma fibroblasts in response to perturbation of environmental stimuli
    Momiao Xiong
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston UTHSC H, Houston, Texas, USA
    PLoS ONE 3:e1693. 2008
    ..Our findings may open a new avenue in exploring the functions of cells and mechanism operative in disease development...
  14. ncbi Classification analysis of the transcriptosome of nonlesional cultured dermal fibroblasts from systemic sclerosis patients with early disease
    Filemon K Tan
    Department of Internal Medicine, University of Texas at Houston Medical School, 77030, USA
    Arthritis Rheum 52:865-76. 2005
    ....
  15. ncbi Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors
    Terry A McNearney
    Division of Rheumatology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 1165, USA
    Arthritis Rheum 57:318-26. 2007
    ..To determine the relative contributions of genetic, clinical, serologic, sociodemographic, and behavioral/psychological variables to early pulmonary involvement in the Genetics versus Environment in Scleroderma Outcome Study cohort...
  16. ncbi Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis
    Roozbeh Sharif
    Division of Rheumatology and Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Rheumatol 38:1622-30. 2011
    ..We examined the immunogenetic, clinical, and survival correlates of AFA in a large group of AA patients with SSc...
  17. ncbi Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
    John D Reveille
    University of Texas Health Science Center at Houston, USA
    Nat Genet 42:123-7. 2010
    ..3 x 10(-12)). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility...
  18. ncbi A systems biology approach to genetic studies of complex diseases
    Momiao Xiong
    Human Genetics Center, University of Texas School of Public Health, Houston, 77030, USA
    FEBS Lett 579:5325-32. 2005
    ..To prove the concept in principle, the proposed approach is applied to genetic studies of the autoimmune disease scleroderma or systemic sclerosis...
  19. ncbi Hemophagocytic lymphohistiocytosis associated with influenza A (H1N1) infection in a patient with chronic lymphocytic leukemia: an autopsy case report and review of the literature
    Syeling Lai
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA Department of Pathology, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA Electronic address
    Ann Diagn Pathol 16:477-84. 2012
    ..We review the recently published autopsy findings in fatal influenza A (H1N1) infection and the association with resultant secondary hemophagocytic lymphohistiocytosis...
  20. ncbi Genetic signatures of pre-expansion bottleneck in the Choctaw population of Oklahoma
    Ning Wang
    Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Phys Anthropol 124:373-9. 2004
    ..Taken together, these observations are consistent with a signature of the recent population size expansion of the Choctaws, preceded by bottleneck event(s)...
  21. ncbi Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalence
    Xiaodong Zhou
    University of Texas-Houston Medical School
    Arthritis Rheum 48:2585-92. 2003
    ....
  22. ncbi Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles
    Xiaodong Zhou
    University of Texas Medical School at Houston, USA
    Arthritis Rheum 52:3305-14. 2005
    ..Thus, a stronger genetic predisposition to SSc (than can be detected clinically) is apparent at the molecular level in skin fibroblasts...
  23. ncbi Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    Eng-Juh Yeoh
    Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 1:133-43. 2002
    ..Thus, the single platform of expression profiling should enhance the accurate risk stratification of pediatric ALL patients...
  24. ncbi Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
    Mary E Ross
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 102:2951-9. 2003
    ....
  25. ncbi [Nested case-control study on riboflavin levels in blood and urine and the risk of lung cancer]
    Xiaodong Zhou
    Dept. of Nutrition and Food Hygiene, Huaxi School of Public Health, Sichuan University, Chengdu 610041, China
    Wei Sheng Yan Jiu 32:597-8, 601. 2003
    ..05) after adjusting the confusing factors. No association of riboflavin indexes in blood and urine with the lung cancer risk among YTC miners were observed in the present study...
  26. ncbi Analysis of apoptosis and cell proliferation after high intensity-focused ultrasound ablation combined with microbubbles in rabbit livers
    Wen Luo
    Department of Ultrasound in Xijing Hospital, Fourth Military Medical University, 17th Changle Xilu, Xi an, China
    Eur J Gastroenterol Hepatol 19:962-8. 2007
    ..To analyze apoptosis and expression of proliferating cell nuclear antigen (PCNA) sequentially in the rabbit liver tissue after high-intensity focused ultrasound (HIFU) ablation combined with microbubbles...
  27. ncbi Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  28. ncbi Gene expression profiling of pediatric acute myelogenous leukemia
    Mary E Ross
    Department of Hematology-Oncology, Hartwell Center for Bioinformatics and Biotechnology, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 104:3679-87. 2004
    ..Surprisingly, AMLs containing partial tandem duplications of MLL failed to cluster with MLL chimeric fusion gene cases, suggesting a significant difference in their underlying mechanism of transformation...
  29. ncbi Early diastolic peak velocity of left ventricular wall segment lying in isovolumic relaxation period as determined by tissue Doppler imaging
    Haibin Zhang
    Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, PR China
    Int J Cardiovasc Imaging 24:389-97. 2008
    ..However, we find some segments of which early diastolic peak velocities appear in the isovolumic relaxation period (PVIVR segments). The present study aimed to investigate the characteristics of PVIVR segments...

Research Grants1

  1. Regulation of SPARC in Scleroderma Fibroblasts
    Xiaodong Zhou; Fiscal Year: 2007
    ..In addition, we will investigate whether exogenous SPARC can restore or increase fibrogenic effects of TGF-beta on cultured fibroblasts with or without suppression of the SPARC gene using recombinent SPARC protein. ..