Hui Zheng

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Neurodegener 9:28. 2014
  2. pmc Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
    David J Shim
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:42. 2011
  3. pmc Biology and pathophysiology of the amyloid precursor protein
    Hui Zheng
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:27. 2011
  4. pmc Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:30598-605. 2010
  5. pmc Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 5:. 2010
  6. pmc Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:2437-45. 2012
  7. pmc Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:17362-7. 2010
  8. pmc Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function
    Erica Peethumnongsin
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:13409-18. 2010
  9. pmc Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity
    Li Yang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:15660-8. 2009
  10. pmc Regulation of neuronal APL-1 expression by cholesterol starvation
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e32038. 2012

Research Grants

Collaborators

  • Hongmei Li
  • Li Yang
  • Robia G Pautler
  • Adam Antebi
  • Nicholas J Justice
  • Thomas C Sudhof
  • Zhou Songyang
  • Pritam Das
  • Todd E Golde
  • John R Cirrito
  • Joanna L Jankowsky
  • Rong Wang
  • Xiaoli Chen
  • Scott T Eblen
  • Jason B Fleming
  • Akihiko Takashima
  • Qinxi Guo
  • Zilai Wang
  • Mary Wiese
  • Baiping Wang
  • Pei Wang
  • David J Shim
  • Erica Peethumnongsin
  • Verena Kallhoff-Munoz
  • Xuefeng Xia
  • Heather A Born
  • Yuying Liu
  • Jeffrey L Noebels
  • Claudia S Robertson
  • Hong Lian
  • Samson S K Gaddam
  • Paul J Chiao
  • Bailu Peng
  • Lingyun Hu
  • Karen Dell Brown Smith
  • Verena Kallhoff
  • Yu Deng
  • Yuxiang Sun
  • Yibing Qyang
  • Jong W Yoo
  • Ricky R Savjani
  • YURI A DABAGHIAN
  • Dorothy R Schuler
  • Kelly T Dineley
  • Ji Yoen Kim
  • Lashardai Conaway
  • Scott A Weed
  • Jennifer Rutherford Bethard
  • Ji Yeun Hur
  • Amber Thompson Bradley
  • Yueming Li
  • Adnan M Al-Ayoubi
  • Allysa L Cole
  • JENNIFER RODRIGUEZ-RIVERA
  • Brittany R Bitner
  • Paul A Overbeek
  • J Graham Reed
  • Wilbur Harrison
  • Wei Jin
  • Jianhua Ling
  • David Shim
  • Huamin Wang
  • Zhe Chang
  • Shao Cong Sun
  • Andrew Joon Lee
  • Richard Zhang
  • Ya an Kang
  • Nadia Aithmitti
  • Ling Wu
  • Leonid Tarassishin
  • Yue Ming Li
  • Yan Dao Gong
  • Guang Yang
  • Kuo Fen Lee
  • Nan Ming Zhao
  • Paul Chang
  • Bertha Dominguez
  • Wen Biao Gan
  • Tahire Zaidi
  • Dennis R Mosier
  • Roy G Smith
  • Stuart M Chambers
  • Margaret A Goodell
  • Xiaoyan Sun
  • Myrna E Trumbauer
  • Duy Bui
  • Wan Kyng Shum
  • Salvador Soriano
  • J David Sweatt
  • Haruyasu Yamaguchi

Detail Information

Publications30

  1. pmc Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Neurodegener 9:28. 2014
    ....
  2. pmc Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
    David J Shim
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:42. 2011
    ..abstract:..
  3. pmc Biology and pathophysiology of the amyloid precursor protein
    Hui Zheng
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:27. 2011
    ..This review provides an overview and update on our current understanding of the pathobiology of APP...
  4. pmc Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:30598-605. 2010
    ..Our results establish an essential function of the conserved APP intracellular domain in developmental regulation, and this activity can be genetically uncoupled from APP processing and Aβ pathogenesis...
  5. pmc Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 5:. 2010
    ..The organism Caenorhabditis elegans is an attractive model as the amyloid precursor-like protein (APL-1) is the single ortholog of APP, and loss of apl-1 leads to a severe molting defect and early larval lethality...
  6. pmc Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:2437-45. 2012
    ..Our results clarify several key questions with regard to the fundamental properties of APP and offer critical cellular insights into the pathophysiology of APP...
  7. pmc Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:17362-7. 2010
    ..This unexpected APP-mediated signaling pathway may play an important role in maintaining TTR and Klotho levels and their respective functions in Aβ sequestration and aging...
  8. pmc Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function
    Erica Peethumnongsin
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:13409-18. 2010
    ..Our results strongly support a convergent role for PS and tau in axonal transport and neuronal survival and function and implicate their misregulation as a contributor to AD pathogenesis...
  9. pmc Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity
    Li Yang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:15660-8. 2009
    ..2. These results provide a direct link between APP and calcium signaling and might help explain how altered APP regulation leads to changes in synaptic function that occur with AD...
  10. pmc Regulation of neuronal APL-1 expression by cholesterol starvation
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e32038. 2012
    ....
  11. pmc IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
    Hong Lian
    Huffington Center on Aging Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 7:47. 2012
    ..Mice deficient in IκBα display deregulated and sustained NFκB activation and early postnatal lethality, highlighting a critical role of IκBα in NFκB regulation...
  12. pmc APP physiological and pathophysiological functions: insights from animal models
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 22:78-89. 2012
    ..This article will review the current physiological and pathophysiological animal models of APP...
  13. ncbi request reprint Role of APP and Aβ in synaptic physiology
    Zilai Wang
    Huffington Center on Aging, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Alzheimer Res 9:217-26. 2012
    ..Here, we review the roles that APP and Aβ play at the synapses, with particular focus on recent findings for the importance of APP in synaptogenesis and synaptic function...
  14. ncbi request reprint Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2
    Pei Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:1219-25. 2005
    ..Our results identify APP/APLP2 as key regulators of structure and function of developing neuromuscular synapses...
  15. pmc Modeling Alzheimer's Disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e80706. 2013
    ..Although mutations in the tau encoding gene MAPT leads to a subtype of frontotemporal dementia and these mutations have been used to model AD tauopathy, no MAPT mutations have been found to be associated with AD...
  16. pmc Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease
    Heather A Born
    Department of Neuroscience, Department of Neurology, Department of Molecular and Cellular Biology, Department of Human and Molecular Genetics, Department of Neurosurgery, The Jan and Dan Duncan Neurological Research Institute, and the Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, Texas A and M Health Science Center, College Station, Texas 77843, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, Department of Computational and Applied Mathematics, Rice University, Houston, Texas 77251, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Neuroscience, University of Florida, Gainesville, Florida 32610
    J Neurosci 34:3826-40. 2014
    ..Our results suggest that APP overexpression, and not Aβ overproduction, is responsible for EEG abnormalities in our transgenic mice and can be rescued independently of pathology. ..
  17. pmc Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter
    Bailu Peng
    Departments of Surgical Oncology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:15193-8. 2010
    ....
  18. pmc Central CRF system perturbation in an Alzheimer's disease knockin mouse model
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Neurobiol Aging 33:2678-91. 2012
    ....
  19. pmc Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
    Baiping Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:4487-97. 2011
    ..Our study identifies an essential function for Skor2 as a novel transcriptional regulator in Purkinje cells that acts upstream of Shh during cerebellum development...
  20. pmc Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
    Zilai Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:10788-801. 2009
    ..We postulate that transsynaptic APP interaction modulates its synaptic function and that perturbed APP synaptic adhesion activity may contribute to synaptic dysfunction and AD pathogenesis...
  21. pmc Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion
    Yuying Liu
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Nucleic Acids Res 41:4949-62. 2013
    ..Our results demonstrate for the first time that SPF45 overexpression enhances cell migration and invasion, dependent on biochemical regulation by Clk1...
  22. pmc Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death
    Verena Kallhoff-Munoz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:11421-31. 2008
    ..These results support a model whereby the PS gamma-secretase activity is essential in maintaining neuronal viability, and the PS1 loop domain modulates neuronal homeostasis through cell cycle and cytoplasmic p53 control...
  23. ncbi request reprint Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage
    Yibing Qyang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 43:5352-9. 2004
    ..These results establish a critical role of PS in myelopoiesis. Our finding that this activity can be directly modulated by its gamma-secretase activity has important safety implications concerning these inhibitors...
  24. pmc Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
    Baiping Wang
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:14140-5. 2007
    ..These results identify a physiological activity of APP in cholinergic neurons, and our data indicate that deregulation of APP function may contribute to cholinergic impairment and AD pathogenesis...
  25. pmc Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation
    Runsheng Wang
    Huffington Center on Aging and Departments of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:353-8. 2006
    ..Our results identify Tyr and related proteins as physiological substrates of PS and link gamma-secretase activity with intracellular protein transport...
  26. pmc The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms
    Xuefeng Xia
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:8760-5. 2002
    ..Further, by measuring the levels of endogenous Abeta(X-40) and Abeta(X-42) in primary neuronal cultures, we confirmed the concept that PS1 is indispensable for the production of secreted Abeta...
  27. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    ..Our results suggest that chronic treatment with ghrelin antagonists will have little effect on growth or appetite...
  28. pmc In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease
    Karen Dell Brown Smith
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuroimage 35:1401-8. 2007
    ..After plaque formation, the decline in the transport rate in the Tg2576 mice became even more pronounced. These data indicate that in vivo axonal transport rates decrease prior to plaque formation in the Tg2576 mouse model of AD...
  29. ncbi request reprint Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology
    Yu Deng
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:3845-54. 2006
    ..Our finding supports a protective role of Abeta40 against amyloid pathology and raises the possibility that impaired gamma-secretase activity could be the basis for AD pathogenesis in general...
  30. ncbi request reprint Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...

Research Grants27

  1. PRESENILIN-1 IN DEVELOPMENT AND AGING
    Hui Zheng; Fiscal Year: 2000
    ..We believe that these studies will advance our understanding of the physiological function of PS1 and the pathogenic mechanism of Alzheimer's disease. ..
  2. Developmental and Pathological Effect of Presenilin
    Hui Zheng; Fiscal Year: 2006
    ..The studies proposed will lead to better evaluation of presenilin-based therapy as well as advanced understanding of AD pathogenesis in general. ..
  3. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2006
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  4. Presenilins in tumorigenesis and neurodegeneration
    Hui Zheng; Fiscal Year: 2007
    ..The studies combined will significantly advance our understanding of the molecular mechanisms underlying presenilin activities in tumorigenesis, neurodegeneration and AD pathogenesis. ..
  5. Developmental and Pathological Effects of Presenilin
    Hui Zheng; Fiscal Year: 2007
    ....
  6. Pathophysiology of APP in vivo.
    Hui Zheng; Fiscal Year: 2009
    ..Our studies will provide a comprehensive understanding of the role of APP in various neuronal circuitry and reveal novel pathogenic insights into Alzheimer's disease. ..
  7. Developmental and Pathological Effects of Presenilin
    Hui Zheng; Fiscal Year: 2009
    ....
  8. Role of APP in Synaptic Regulation
    Hui Zheng; Fiscal Year: 2009
    ..Our studies will provide a comprehensive understanding of the role of APP in synaptic regulation and reveal new pathogenic insights into Alzheimer's disease. ..
  9. Role of APP in Synaptic Regulation
    Hui Zheng; Fiscal Year: 2010
    ..Our studies will provide a comprehensive understanding of the role of APP in synaptic regulation and reveal new pathogenic insights into Alzheimer's disease. ..
  10. Pathophysiology of APP in vivo.
    Hui Zheng; Fiscal Year: 2010
    ..Our studies will provide a comprehensive understanding of the role of APP in various neuronal circuitry and reveal novel pathogenic insights into Alzheimer's disease. ..
  11. Presenilins in tumorigenesis and neurodegeneration
    Hui Zheng; Fiscal Year: 2006
    ..The studies combined will significantly advance our understanding of the molecular mechanisms underlying presenilin activities in tumorigenesis, neurodegeneration and AD pathogenesis. ..
  12. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2005
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  13. Developmental and Pathological Effect of Presenilin
    Hui Zheng; Fiscal Year: 2005
    ..The studies proposed will lead to better evaluation of presenilin-based therapy as well as advanced understanding of AD pathogenesis in general. ..
  14. PRESENILIN-1 IN DEVELOPMENT AND AGING
    Hui Zheng; Fiscal Year: 2001
    ..We believe that these studies will advance our understanding of the physiological function of PS1 and the pathogenic mechanism of Alzheimer's disease. ..
  15. Developmental and Pathological Effect of Presenilin
    Hui Zheng; Fiscal Year: 2002
    ..The studies proposed will lead to better evaluation of presenilin-based therapy as well as advanced understanding of AD pathogenesis in general. ..
  16. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2002
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  17. PRESENILIN-1 IN DEVELOPMENT AND AGING
    Hui Zheng; Fiscal Year: 2002
    ..We believe that these studies will advance our understanding of the physiological function of PS1 and the pathogenic mechanism of Alzheimer's disease. ..
  18. Developmental and Pathological Effect of Presenilin
    Hui Zheng; Fiscal Year: 2003
    ..The studies proposed will lead to better evaluation of presenilin-based therapy as well as advanced understanding of AD pathogenesis in general. ..
  19. PRESENILIN-1 IN DEVELOPMENT AND AGING
    Hui Zheng; Fiscal Year: 2003
    ..We believe that these studies will advance our understanding of the physiological function of PS1 and the pathogenic mechanism of Alzheimer's disease. ..
  20. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2003
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  21. Developmental and Pathological Effect of Presenilin
    Hui Zheng; Fiscal Year: 2004
    ..The studies proposed will lead to better evaluation of presenilin-based therapy as well as advanced understanding of AD pathogenesis in general. ..
  22. Presenilins in tumorigenesis and neurodegeneration
    Hui Zheng; Fiscal Year: 2004
    ..The studies combined will significantly advance our understanding of the molecular mechanisms underlying presenilin activities in tumorigenesis, neurodegeneration and AD pathogenesis. ..
  23. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2004
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  24. Presenilins in tumorigenesis and neurodegeneration
    Hui Zheng; Fiscal Year: 2005
    ..The studies combined will significantly advance our understanding of the molecular mechanisms underlying presenilin activities in tumorigenesis, neurodegeneration and AD pathogenesis. ..
  25. Developmental and Pathological Effects of Presenilin
    Hui Zheng; Fiscal Year: 2010
    ....