Hui Zheng

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons
    Baiping Wang
    Huffington Center on Aging, Department of Molecular and Human Genetics, and
    J Neurosci 34:13314-25. 2014
  2. pmc Molecular neurodegeneration: basic biology and disease pathways
    Robert Vassar
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mol Neurodegener 9:34. 2014
  3. pmc Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Neurodegener 9:28. 2014
  4. pmc Biology and pathophysiology of the amyloid precursor protein
    Hui Zheng
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:27. 2011
  5. pmc Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
    David J Shim
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:42. 2011
  6. pmc Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:30598-605. 2010
  7. pmc Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
    Zilai Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:10788-801. 2009
  8. pmc Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function
    Erica Peethumnongsin
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:13409-18. 2010
  9. pmc Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 5:. 2010
  10. pmc Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:17362-7. 2010

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons
    Baiping Wang
    Huffington Center on Aging, Department of Molecular and Human Genetics, and
    J Neurosci 34:13314-25. 2014
    ....
  2. pmc Molecular neurodegeneration: basic biology and disease pathways
    Robert Vassar
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Mol Neurodegener 9:34. 2014
    ....
  3. pmc Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Neurodegener 9:28. 2014
    ....
  4. pmc Biology and pathophysiology of the amyloid precursor protein
    Hui Zheng
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:27. 2011
    ..This review provides an overview and update on our current understanding of the pathobiology of APP...
  5. pmc Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons
    David J Shim
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 6:42. 2011
    ..abstract:..
  6. pmc Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:30598-605. 2010
    ..Our results establish an essential function of the conserved APP intracellular domain in developmental regulation, and this activity can be genetically uncoupled from APP processing and Aβ pathogenesis...
  7. pmc Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis
    Zilai Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:10788-801. 2009
    ..We postulate that transsynaptic APP interaction modulates its synaptic function and that perturbed APP synaptic adhesion activity may contribute to synaptic dysfunction and AD pathogenesis...
  8. pmc Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function
    Erica Peethumnongsin
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:13409-18. 2010
    ..Our results strongly support a convergent role for PS and tau in axonal transport and neuronal survival and function and implicate their misregulation as a contributor to AD pathogenesis...
  9. pmc Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 5:. 2010
    ..The organism Caenorhabditis elegans is an attractive model as the amyloid precursor-like protein (APL-1) is the single ortholog of APP, and loss of apl-1 leads to a severe molting defect and early larval lethality...
  10. pmc Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
    Hongmei Li
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:17362-7. 2010
    ..This unexpected APP-mediated signaling pathway may play an important role in maintaining TTR and Klotho levels and their respective functions in Aβ sequestration and aging...
  11. pmc Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:2437-45. 2012
    ..Our results clarify several key questions with regard to the fundamental properties of APP and offer critical cellular insights into the pathophysiology of APP...
  12. pmc IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
    Hong Lian
    Huffington Center on Aging Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurodegener 7:47. 2012
    ..Mice deficient in IκBα display deregulated and sustained NFκB activation and early postnatal lethality, highlighting a critical role of IκBα in NFκB regulation...
  13. pmc Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity
    Li Yang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:15660-8. 2009
    ..2. These results provide a direct link between APP and calcium signaling and might help explain how altered APP regulation leads to changes in synaptic function that occur with AD...
  14. pmc Regulation of neuronal APL-1 expression by cholesterol starvation
    Mary Wiese
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e32038. 2012
    ....
  15. pmc APP physiological and pathophysiological functions: insights from animal models
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 22:78-89. 2012
    ..This article will review the current physiological and pathophysiological animal models of APP...
  16. pmc Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death
    Verena Kallhoff-Munoz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:11421-31. 2008
    ..These results support a model whereby the PS gamma-secretase activity is essential in maintaining neuronal viability, and the PS1 loop domain modulates neuronal homeostasis through cell cycle and cytoplasmic p53 control...
  17. pmc NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease
    Hong Lian
    Huffington Center on Aging, Houston, TX 77030, USA Department of Molecular and Human Genetics, Houston, TX 77030, USA
    Neuron 85:101-15. 2015
    ..Therefore, dysregulation of neuron-glia interaction through NFκB/C3/C3aR signaling may contribute to synaptic dysfunction in AD, and C3aR antagonists may be therapeutically beneficial. ..
  18. ncbi request reprint Role of APP and Aβ in synaptic physiology
    Zilai Wang
    Huffington Center on Aging, Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Alzheimer Res 9:217-26. 2012
    ..Here, we review the roles that APP and Aβ play at the synapses, with particular focus on recent findings for the importance of APP in synaptogenesis and synaptic function...
  19. pmc Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e80706. 2013
    ..Although mutations in the tau encoding gene MAPT leads to a subtype of frontotemporal dementia and these mutations have been used to model AD tauopathy, no MAPT mutations have been found to be associated with AD...
  20. pmc Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
    Vinicia A Polito
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA
    EMBO Mol Med 6:1142-60. 2014
    ..The specificity and efficacy of TFEB in mediating the clearance of toxic Tau species makes it an attractive therapeutic target for treating diseases of tauopathy including AD. ..
  21. ncbi request reprint Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2
    Pei Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:1219-25. 2005
    ..Our results identify APP/APLP2 as key regulators of structure and function of developing neuromuscular synapses...
  22. pmc Posttraumatic Stress Disorder-Like Induction Elevates β-Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses
    Nicholas J Justice
    Institute of Molecular Medicine, Program in Neuroscience, and Huffington Center on Aging and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, and
    J Neurosci 35:2612-23. 2015
    ..Together, these data demonstrate that exposure to PTSD-like trauma can drive AD pathogenesis, which directly perturbs CRF signaling, thereby enhancing chronic PTSD symptoms while increasing risk for AD-related dementia. ..
  23. pmc Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
    Baiping Wang
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:14140-5. 2007
    ..These results identify a physiological activity of APP in cholinergic neurons, and our data indicate that deregulation of APP function may contribute to cholinergic impairment and AD pathogenesis...
  24. pmc Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease
    Heather A Born
    Department of Neuroscience, Department of Neurology, Department of Molecular and Cellular Biology, Department of Human and Molecular Genetics, Department of Neurosurgery, The Jan and Dan Duncan Neurological Research Institute, and the Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, Texas A and M Health Science Center, College Station, Texas 77843, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, Department of Computational and Applied Mathematics, Rice University, Houston, Texas 77251, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Neuroscience, University of Florida, Gainesville, Florida 32610
    J Neurosci 34:3826-40. 2014
    ..Our results suggest that APP overexpression, and not Aβ overproduction, is responsible for EEG abnormalities in our transgenic mice and can be rescued independently of pathology. ..
  25. pmc Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
    Baiping Wang
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Development 138:4487-97. 2011
    ..Our study identifies an essential function for Skor2 as a novel transcriptional regulator in Purkinje cells that acts upstream of Shh during cerebellum development...
  26. pmc Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter
    Bailu Peng
    Departments of Surgical Oncology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:15193-8. 2010
    ....
  27. pmc Central CRF system perturbation in an Alzheimer's disease knockin mouse model
    Qinxi Guo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Neurobiol Aging 33:2678-91. 2012
    ....
  28. pmc Dimorphic effects of Notch signaling in bone homeostasis
    Feyza Engin
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 7703, USA
    Nat Med 14:299-305. 2008
    ..Together, these findings highlight the potential dimorphic effects of Notch signaling in bone homeostasis and may provide direction for novel therapeutic applications...
  29. pmc Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion
    Yuying Liu
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Nucleic Acids Res 41:4949-62. 2013
    ..Our results demonstrate for the first time that SPF45 overexpression enhances cell migration and invasion, dependent on biochemical regulation by Clk1...
  30. pmc Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation
    Runsheng Wang
    Huffington Center on Aging and Departments of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:353-8. 2006
    ..Our results identify Tyr and related proteins as physiological substrates of PS and link gamma-secretase activity with intracellular protein transport...
  31. ncbi request reprint Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage
    Yibing Qyang
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 43:5352-9. 2004
    ..These results establish a critical role of PS in myelopoiesis. Our finding that this activity can be directly modulated by its gamma-secretase activity has important safety implications concerning these inhibitors...
  32. pmc The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms
    Xuefeng Xia
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:8760-5. 2002
    ..Further, by measuring the levels of endogenous Abeta(X-40) and Abeta(X-42) in primary neuronal cultures, we confirmed the concept that PS1 is indispensable for the production of secreted Abeta...
  33. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    ..Our results suggest that chronic treatment with ghrelin antagonists will have little effect on growth or appetite...
  34. ncbi request reprint Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology
    Yu Deng
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:3845-54. 2006
    ..Our finding supports a protective role of Abeta40 against amyloid pathology and raises the possibility that impaired gamma-secretase activity could be the basis for AD pathogenesis in general...
  35. pmc In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease
    Karen Dell Brown Smith
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuroimage 35:1401-8. 2007
    ..After plaque formation, the decline in the transport rate in the Tg2576 mice became even more pronounced. These data indicate that in vivo axonal transport rates decrease prior to plaque formation in the Tg2576 mouse model of AD...
  36. ncbi request reprint Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...

Research Grants2

  1. Defining presenilin-beta-catenin pathway in vivo
    Hui Zheng; Fiscal Year: 2006
    ..The proposed study will lead to a comprehensive understanding of the molecular mechanisms of presenilin and the effect of FAD mutation on b-catenin regulation, tumorigenesis and synaptic formation and maintenance. ..
  2. Presenilins in tumorigenesis and neurodegeneration
    Hui Zheng; Fiscal Year: 2007
    ..The studies combined will significantly advance our understanding of the molecular mechanisms underlying presenilin activities in tumorigenesis, neurodegeneration and AD pathogenesis. ..