Xiang Yang Zhang

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi request reprint Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Schizophr Res 81:291-300. 2006
  2. doi request reprint Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population
    Xiang Yang Zhang
    Beijing Huilongguan Hospital, Beijing, 100096, People s Republic of China
    Psychopharmacology (Berl) 231:305-14. 2014
  3. doi request reprint Oxidative stress and therapeutic implications in psychiatric disorders
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Michael E DeBakey VA Medical Center, Houston, TX, USA Psychiatry Research Center, Beijing Hui Long Guan Hospital, Peking University, Beijing, China Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:197-9. 2013
  4. doi request reprint Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study
    X Y Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX, USA
    Psychol Med 43:1651-60. 2013
  5. doi request reprint Prevalence, demographic and clinical correlates of suicide attempts in Chinese medicated chronic inpatients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    J Psychiatr Res 47:1370-5. 2013
  6. doi request reprint Clinical symptoms and cognitive impairment associated with male schizophrenia relate to plasma manganese superoxide dismutase activity: a case-control study
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 47:1049-53. 2013
  7. doi request reprint Interleukin 18 and cognitive impairment in first episode and drug naïve schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Brain Behav Immun 32:105-11. 2013
  8. doi request reprint The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population
    Xuan Zhang
    Research Center for Diabetic Complication and Department of Nephrology, Second Hospital, Jilin University, Changchun, China
    J Clin Psychiatry 74:e287-92. 2013
  9. doi request reprint Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 143:301-6. 2013
  10. pmc BDNF Val66Met variant and smoking in a Chinese population
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53295. 2012

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Schizophr Res 81:291-300. 2006
    ..Long-term treatments with typical and atypical antipsychotics may produce the similar effects on the antioxidant enzymes and lipid peroxidation...
  2. doi request reprint Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population
    Xiang Yang Zhang
    Beijing Huilongguan Hospital, Beijing, 100096, People s Republic of China
    Psychopharmacology (Berl) 231:305-14. 2014
    ..Little is known about the association between smoking severity and clinical phenotypes in Chinese patients with schizophrenia...
  3. doi request reprint Oxidative stress and therapeutic implications in psychiatric disorders
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA Michael E DeBakey VA Medical Center, Houston, TX, USA Psychiatry Research Center, Beijing Hui Long Guan Hospital, Peking University, Beijing, China Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:197-9. 2013
    ..The collection of articles in this special section will contribute to providing more efficacious treatments arising from a better appreciation of the roles of oxidative stress in these psychiatric disorders. ..
  4. doi request reprint Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study
    X Y Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX, USA
    Psychol Med 43:1651-60. 2013
    ..This study examined smoking rates, the association between smoking and symptom severity and cognitive function in Chinese first-episode schizophrenia (FES) patients using cross-sectional and case-control designs...
  5. doi request reprint Prevalence, demographic and clinical correlates of suicide attempts in Chinese medicated chronic inpatients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    J Psychiatr Res 47:1370-5. 2013
    ..These results suggest that Chinese inpatients with schizophrenia attempt suicide more often than the general population. Further, some demographic and clinical variables are risk factors for suicide attempts in schizophrenia. ..
  6. doi request reprint Clinical symptoms and cognitive impairment associated with male schizophrenia relate to plasma manganese superoxide dismutase activity: a case-control study
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 47:1049-53. 2013
    ..Our findings add to growing evidence that oxidative stress may be involved in the psychopathology of male schizophrenia, and its associated cognitive impairment...
  7. doi request reprint Interleukin 18 and cognitive impairment in first episode and drug naïve schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Brain Behav Immun 32:105-11. 2013
    ..Our findings suggest that cognitive deficits occur during the acute stage of a schizophrenic episode, and IL-18 may be involved in Visuospatial/Constructional deficits of these patients...
  8. doi request reprint The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population
    Xuan Zhang
    Research Center for Diabetic Complication and Department of Nephrology, Second Hospital, Jilin University, Changchun, China
    J Clin Psychiatry 74:e287-92. 2013
    ..We tested this polymorphism and mRNA expression levels of IGF2BP2 for an association in Han Chinese patients with schizophrenia compared to healthy controls...
  9. doi request reprint Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 143:301-6. 2013
    ..The differential association of TRX and cognitive performance in schizophrenia and controls may be related to the impaired oxidative stress status of schizophrenia patients...
  10. pmc BDNF Val66Met variant and smoking in a Chinese population
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53295. 2012
    ..However, the findings must be interpreted with caution because of the relatively small sample size for an association study. Results should be confirmed in a larger cohort...
  11. doi request reprint Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    Schizophr Res 141:48-53. 2012
    ..These results suggest that the DBH 5'-Ins/Del polymorphism may influence smoking severity among schizophrenic smokers...
  12. doi request reprint Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, USA
    Am J Psychiatry 169:974-81. 2012
    ..The authors examined multiple dosages of tropisetron, a partial agonist at the nAChR, for short-term effects on cognition and P50 deficits in schizophrenia...
  13. doi request reprint Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Biol Psychiatry 72:700-6. 2012
    ..We hypothesized that treatment with EGb-761 would increase serum BDNF levels and reduce TD, particularly among schizophrenia patients who have the BDNF valine 66 to methionine (Val66Met) genotype (Val/Val)...
  14. doi request reprint Plasma total antioxidant status and cognitive impairments in schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 139:66-72. 2012
    ..Our findings suggest that oxidative stress may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment...
  15. doi request reprint Gender differences in never-medicated first-episode schizophrenia and medicated chronic schizophrenia patients
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texasm, USA
    J Clin Psychiatry 73:1025-33. 2012
    ..The aims of this study were to compare gender differences in clinical features and cognitive functioning in first-episode and chronic schizophrenia among Han Chinese inpatients...
  16. doi request reprint Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Psychopharmacology (Berl) 222:277-84. 2012
    ..Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this association of BDNF with cognitive deficits in schizophrenia...
  17. pmc Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Hum Genet 131:1187-95. 2012
    ..The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism...
  18. doi request reprint Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropharmacology 62:1928-34. 2012
    ....
  19. pmc Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e30937. 2012
    ..Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia...
  20. doi request reprint Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 204:177-84. 2009
    ..These abnormalities may improve during antipsychotic drug treatment that reduces symptoms in schizophrenic patients...
  21. doi request reprint Smoking and tardive dyskinesia in male patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1765-9. 2011
    ..Thus, smoking was not associated with TD in male Chinese schizophrenics, but consistent with previous reports, older patients with a longer duration of illness and more hospitalizations showed greater severity of TD...
  22. ncbi request reprint Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Neuropsychopharmacology 32:2020-4. 2007
    ....
  23. doi request reprint The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Schizophr Res 113:151-7. 2009
    ..Lower TRX levels in chronic patients treated with antipsychotics may have implications for treatment outcome...
  24. ncbi request reprint Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex, USA
    J Clin Psychiatry 68:754-60. 2007
    ..However, the relationship between antioxidant enzymes, lipid peroxidation products, and the severity of TD symptoms has not been determined within a single patient group...
  25. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  26. ncbi request reprint Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 41:997-1004. 2007
    ..Antipsychotic class exerted differential effects over BDNF levels and BMI gain. Our findings suggest that decreased BDNF levels may be associated with weight gain in female schizophrenic patients on long-term antipsychotic treatment...
  27. ncbi request reprint The effects of Ginkgo biloba extract added to haloperidol on peripheral T cell subsets in drug-free schizophrenia: a double-blind, placebo-controlled trial
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, 100083, People s Republic of China
    Psychopharmacology (Berl) 188:12-7. 2006
    ..To investigate the effects of Ginkgo biloba extract (EGb) administration on T lymphocyte subsets and superoxide dismutase (SOD) levels in schizophrenia...
  28. doi request reprint Smoking initiation and schizophrenia: a replication study in a Chinese Han population
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Schizophr Res 119:110-4. 2010
    ..001). These findings suggest that schizophrenic patients have a higher risk of starting daily smoking suggesting that vulnerability to schizophrenia may be associated with a higher risk of becoming a daily smoker...
  29. doi request reprint Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    Psychopharmacology (Berl) 201:383-9. 2008
    ..The purpose of this study was to determine any differences in cytokine profiles in smokers and nonsmokers with schizophrenia and whether there were any relationships among altered cytokine profiles and psychopathological symptoms...
  30. doi request reprint Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 205:647-54. 2009
    ..This study examined gender-specific relationships between TD and symptom levels in schizophrenia among Han Chinese, which have previously received little systematic study...
  31. doi request reprint Increased serum S100B in never-medicated and medicated schizophrenic patients
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    J Psychiatr Res 44:1236-40. 2010
    ..The lower S100B levels in chronic than early-stage patients further suggest that antipsychotic treatment may reduce this neurodegeneration...
  32. doi request reprint Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    J Psychiatr Res 44:429-33. 2010
    ..Serum S100B levels were positively correlated with AIMS scores in patients with TD. These data suggest that increased S100B levels may be related to neuro-degeneration, associated with TD pathophysiology...
  33. doi request reprint Nicotine dependence and serum BDNF levels in male patients with schizophrenia
    Xiang Yang Zhang
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, 100096, China
    Psychopharmacology (Berl) 212:301-7. 2010
    ..The purposes of this study were to compare BDNF levels in smokers to nonsmokers with schizophrenia and examine the association between BDNF levels and psychopathological symptoms...
  34. doi request reprint Sex difference in the prevalence of smoking in Chinese schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    J Psychiatr Res 44:986-8. 2010
    ..05). Smoking was associated with a family history of smoking, a personal history of alcohol use and age in men with schizophrenia. Our present findings suggest a significant gender difference in the prevalence of smoking in schizophrenia...
  35. ncbi request reprint Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, People s Republic of China
    J Clin Psychopharmacol 27:246-51. 2007
    ..004, r(2) = 0.16), but not in female patients (P > 0.05). Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment...
  36. doi request reprint Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics
    Mei Hong Xiu
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 33:1508-12. 2009
    ..Our findings indicated decreased BDNF serum levels in chronic patients with schizophrenia, which may be related to clinical phenotypes, including gender, antipsychotic treatment and the severity of psychotic symptoms...
  37. ncbi request reprint Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers
    Song Guo
    Institute of Mental Health, Peking University, Beijing, 100083, China
    Psychopharmacology (Berl) 190:449-56. 2007
    ..Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence...
  38. doi request reprint Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:267-72. 2009
    ..Heroin use and withdrawal cause abnormality in the endocrine system. However, the time course of neuroendocrine alterations in heroin addicts during pharmacologically unassisted withdrawal is still unclear...
  39. doi request reprint The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia
    Li Hui
    Research Center for Diabetic Complication, The Second Hospital, Jilin University, Changchun, China
    J Psychiatr Res 46:733-7. 2012
    ..The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH5'-Ins/Del) and schizophrenia in a Han Chinese population...
  40. ncbi request reprint Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, China
    J Clin Psychiatry 65:940-7. 2004
    ....
  41. doi request reprint Diurnal variation in cue-induced responses among protracted abstinent heroin users
    Zhen Yu Ren
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Pharmacol Biochem Behav 91:468-72. 2009
    ..The present study was to examine whether there was a variation in drug-related cue reactivity across the diurnal cycle among recently abstinent opiate addicts...
  42. ncbi request reprint Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropsychopharmacology 30:1532-8. 2005
    ..Our results suggest that the imbalance in the HPA axis and cytokine system in patients with SCH is implicated in clinical symptoms, and is improved with atypical antipsychotic treatment...
  43. doi request reprint No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population
    Xuan Zhang
    Research Center for Diabetic Complication and Department of Nephrology, The Second Hospital, Jilin University, Changchun, China
    Hum Psychopharmacol 27:392-6. 2012
    ..We examined the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han Chinese population...
  44. pmc Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e36563. 2012
    ....
  45. doi request reprint Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics
    Ling Yan Qi
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Neurosci Lett 462:113-7. 2009
    ....
  46. doi request reprint Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population
    Shilong Sun
    Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin University, Changchun, PR China
    Neurosci Lett 440:35-7. 2008
    ..07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia...
  47. doi request reprint Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers
    Hong Qiang Sun
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:183-8. 2009
    ..The purpose of this study is to assess social support and demographic factors that influence the success of smoking cessation aided with sublingual nicotine tablets in a Han Chinese population...
  48. pmc Stress enhances retrieval of drug-related memories in abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, Beijing, China
    Neuropsychopharmacology 35:720-6. 2010
    ..The potential of beta-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts...
  49. ncbi request reprint The effect of risperidone treatment on superoxide dismutase in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, and dagger Beijing Huilongguan Hospital, Beijing, China
    J Clin Psychopharmacol 23:128-31. 2003
    ..The limitations of this study are the measurement of SOD levels by RIA rather than biochemical assay; the 2-week washout, which may not be adequate; and the measurement of only SOD enzyme and not the other antioxidant enzymes...
  50. doi request reprint Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats
    Yan qin Li
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, China
    Psychopharmacology (Berl) 199:245-53. 2008
    ..While many manipulations used to study these consequences alter mother-infant interactions, the effects of sibling interactions are less well characterized...
  51. ncbi request reprint Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, People s Republic of China corrected
    Schizophr Res 57:247-58. 2002
    ..This immune disturbance is related to the subgroup of schizophrenic patients with characteristic clinical variables. The dysfunction of interaction or inter-adjustment between different cytokines may exist in schizophrenic patients...
  52. ncbi request reprint Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, People s Republic of China
    Psychopharmacology (Berl) 178:35-40. 2005
    ..There are few data from systematic, double-blind clinical trials that have compared the effect of the typical and the atypical antipsychotics on serum prolactin (PRL) levels in patients with schizophrenia...
  53. doi request reprint Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population
    Wen Jun Li
    Department of Social Medicine and Health Management, Jilin University, Changchun, China
    Am J Med Genet B Neuropsychiatr Genet 159:370-5. 2012
    ..Thus, the COMT gene polymorphisms may not contribute to the susceptibility to schizophrenia, but may contribute to the negative symptoms of schizophrenia among Han Chinese...
  54. ncbi request reprint Blood superoxide dismutase level in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, 100083 Beijing, China
    Schizophr Res 62:245-50. 2003
    ..Our data support the view that free radicals may be involved in the pathophysiology of TD. There may exist a relationship between the free radical metabolism and the severity of dyskinesia of TD patients...
  55. ncbi request reprint The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, 100083 Beijing, China dagger Beijing Hui Long Guan Hospital, 100096 Beijing, China
    J Clin Psychopharmacol 24:83-6. 2004
    ..05). These results support earlier findings of the efficacy of vitamin E in the treatment of TD. Moreover, the efficacy of vitamin E may be due to its ability to increase SOD level, which may reduce oxidative injure in tardive dyskinesia...
  56. ncbi request reprint Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing 100083, PR China
    Psychiatry Res 117:85-8. 2003
    ..Blood SOD levels were significantly elevated in schizophrenia compared with control values. SOD levels showed a positive relationship with the BRPS and the SAPS total score in patients...
  57. doi request reprint Circadian alteration in neurobiology during 30 days of abstinence in heroin users
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Biol Psychiatry 65:905-12. 2009
    ..However, there are no published studies of changes in expression of clock genes or of other neuropeptides related to circadian-rhythm regulation, which may influence relapse susceptibility...
  58. ncbi request reprint Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Yun Long Tan
    Institute of Mental Health, Peking University, Beijing 100083, China
    Schizophr Res 74:263-70. 2005
    ..Our results suggest that decreased BDNF may play an important role in the pathophysiology of TD. There may be a relationship between decreased BDNF levels and dyskinetic movements associated with TD...
  59. doi request reprint A family-based study of the IL3RA gene on susceptibility to schizophrenia in a Chinese Han population
    Shilong Sun
    Research Center for Neuroscience and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun 130021, China
    Brain Res 1268:13-6. 2009
    ..66; 95% CI=1.08-2.55). In conclusion, our family-based association study also revealed a small but significant contribution of the IL3RA variants to susceptibility to schizophrenia in a Chinese population...
  60. ncbi request reprint Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
    Yun Long Tan
    Institute of Mental Health, Peking University, Beijing 100083, PR China
    Neurosci Lett 382:27-32. 2005
    ..These findings suggest that serum BDNF levels in chronic schizophrenia under antipsychotic medication may be decreased. However, long-term effects of antipsychotics remain to be characterized...
  61. doi request reprint Circadian alteration in neurobiology during protracted opiate withdrawal in rats
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 115:353-62. 2010
    ....
  62. doi request reprint Gender differences in the prevalence of diabetes mellitus in chronic hospitalized patients with schizophrenia on long-term antipsychotics
    Da Chun Chen
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, China
    Psychiatry Res 186:451-3. 2011
    ..01). Furthermore, increased body mass index (BMI), abdominal obesity and antipsychotic types were predictors of diabetes in these chronic schizophrenic patients...
  63. doi request reprint Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy
    Hongqiang Sun
    Beijing Hui Long Guan Hospital, Beijing, China
    J Neural Transm 119:1491-8. 2012
    ..25 %). We found that SNT significantly increased smoking abstinence, reduced craving and was well tolerated, and the COMT Val/Val genotype was associated with a greater improvement in smoking cessation...
  64. doi request reprint Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial
    Wu Fang Zhang
    Key laboratory for Mental Health, Ministry of Health, Institute of Mental Health, Peking University, China
    J Clin Psychiatry 72:615-21. 2011
    ..The aim of the study was to evaluate the efficacy of EGb-761, a standardized extract given in capsule form, in treating TD in schizophrenia patients...
  65. doi request reprint Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology
    Mei Hong Xiu
    Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University, Beijing, China
    J Psychiatr Res 46:1093-8. 2012
    ..The aim of this study was to assess the clinical significance of serum IL-18 levels in various stages of schizophrenia...
  66. doi request reprint Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes
    Da Chun Chen
    Beijing Huilongguan Hospital, Beijing, People s Republic of China
    Psychopharmacology (Berl) 207:375-80. 2009
    ..However, there have been few systematic studies to examine the relationship between BDNF levels and psychopathology in first-episode and drug-naïve patients with schizophrenia...
  67. doi request reprint Association between DBH 19 bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients
    Li Hui
    Research Center for Genomic Medicine and MH Radiobiology Research Unit, School of Public Health, Jilin University, Changchun, PR China
    Schizophr Res 147:236-40. 2013
    ..The DBH5'-Ins/Del polymorphism may also influence immediate memory in FEP. Moreover, FEP had poorer cognitive function than healthy controls in all examined cognitive domains except for the visuospatial/constructional index...
  68. doi request reprint Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesian Chinese Han patients with schizophrenia
    Fan Wang
    National Institute on Drug Dependence, Peking University, Beijing, 100191, China
    Prog Neuropsychopharmacol Biol Psychiatry 37:106-10. 2012
    ..The present study investigated whether this variation is associated with clinical phenotypes and TD in schizophrenia in a genetically homogeneous northern Chinese Han population...
  69. ncbi request reprint Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, School of Medicine, Peking University, Beijing 100083, PR China
    Psychiatry Res 109:297-302. 2002
    ..The serum PRL levels at baseline could be used to predict the responses of schizophrenic patients to risperidone...
  70. doi request reprint Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics
    Fu De Yang
    Beijing Huilongguan Hospital, Beijing, 100096, People s Republic of China
    Psychopharmacology (Berl) 216:9-16. 2011
    ....
  71. ncbi request reprint Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+ cells in medication-free patients with schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, School of Medicine, Peking University, Beijing, China
    J Psychiatr Res 36:331-6. 2002
    ..The lower in vitro IL-2 production is probably related to the decreased number of T-cells that secret IL-2, as well as to the intrinsic disorder of the patients' T cells...
  72. doi request reprint Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Eur J Pharmacol 615:108-12. 2009
    ..Our findings suggested that rapamycin merits outpatient clinical trials as a potential pharmacotherapy for relapse prevention from drug-related cue induced craving...
  73. pmc Rater evaluations for psychiatric instruments and cultural differences: the positive and negative syndrome scale in China and the United States
    Neil Krishan Aggarwal
    Department of Psychiatry, Yale University, New Haven, CT, USA
    J Nerv Ment Dis 200:814-20. 2012
    ..Differences seem to be best explained by both cultural differences in patient clinical presentations and varying American and Chinese cultural values affecting rater judgment...
  74. pmc Serum cortisol secretion during heroin abstinence is elevated only nocturnally
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 34:321-8. 2008
    ..The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects...
  75. doi request reprint Sex differences in non-reinforced responding for cocaine
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 34:473-88. 2008
    ..In contrast, responding for cocaine in males appears driven by drug delivery...
  76. ncbi request reprint Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats
    Yan qin Li
    National Institute on Drug Dependence, Peking University, Beijing 100083, China
    Behav Brain Res 186:138-42. 2008
    ..EPSD on PN1 improved, but on PN7 impaired performance of the spatial learning task in adult female rats. However, EPSD did not have any effect on the spatial learning ability in adult male rats...
  77. ncbi request reprint Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses
    Therese A Kosten
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Behav Neurosci 121:380-8. 2007
    ..Maintenance studies of cocaine self-administration rather than acquisition may better reflect vulnerability to addiction...
  78. ncbi request reprint Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Behav Brain Res 151:137-49. 2004
    ..These data confirm and extend our previous findings demonstrating the enduring effects of ISO on adult self-administration behavior and emphasize the importance of measuring behavioral patterns versus intake in acquisition studies...
  79. ncbi request reprint Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia
    Zhi Ren Wang
    Schizophr Res 97:299-301. 2007
  80. ncbi request reprint Heightened cocaine and food self-administration in female rats with neonatal isolation experience
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, West Haven, CT, USA
    Neuropsychopharmacology 31:70-6. 2006
    ..Neuropsychopharmacology (2006) 31, 70-76. doi:10.1038/sj.npp.1300779; published online 1 June 2005...
  81. ncbi request reprint Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Dev Brain Res 141:109-16. 2003
    ....
  82. doi request reprint Association between interleukin-6 receptor polymorphism and patients with schizophrenia
    Shilong Sun
    Schizophr Res 102:346-7. 2008
  83. ncbi request reprint Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
    Xiang Yang Zhang
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 177:391-9. 2005
    ..Previously, we demonstrated that neonatal isolation increases acquisition of cocaine self-administration in adult male rats...
  84. ncbi request reprint Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter
    Colin N Haile
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, 950 Campbell Avenue, Building 5 3rd Floor, West Haven CT 06516, USA
    Brain Res 1055:186-95. 2005
    ..Results show that a DAT inhibitor alters cocaine-induced behaviors in a strain-dependent manner. These effects may relate to inherent differences in NAc DAT levels between Lewis and F344 rats...
  85. ncbi request reprint Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population
    Wenjun Li
    Schizophr Res 97:297-8. 2007
  86. ncbi request reprint Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA Connecticut Hospital System, 950 Campbell Avenue, Bldg 5, 3rd Floor, West Haven, CT 06516, USA
    J Pharmacol Exp Ther 314:661-7. 2005
    ..Moreover, that ISO rats are more sensitive to a D(2) antagonist may reflect decreased levels of this receptor type as we showed previously in infant rats...
  87. ncbi request reprint Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking
    Xiang Yang Zhang
    Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1202-4. 2005
    ..Norepinephrine is implicated in cocaine's behavioral effects. In this study, we tested the effect of prazosin, an alpha1-adrenergic receptor antagonist, on cocaine-induced reinstatement of drug-seeking behavior...
  88. ncbi request reprint The interaction between superoxide dismutase and prolactin is involved in response to haloperidol and risperidone treatment in schizophrenia: a double-blind and randomized study
    Xiang Yang Zhang
    J Clin Psychopharmacol 26:103-5. 2006
  89. ncbi request reprint Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia
    Yun Long Tan
    Schizophr Res 77:355-6. 2005
  90. ncbi request reprint Neonatal isolation alters estrous cycle effects on ventral striatal extracellular monoamine levels
    Xiang Yang Zhang
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:504-11. 2006
    ..Because 5-HT modulates DA and levels of both transmitters are increased by cocaine, this neurochemical effect of ISO may contribute to the ability of ISO to alter the behavioral responses to cocaine as we showed previously...
  91. doi request reprint The CCR5 32-bp deletion allele is rare in a Chinese population
    Fan Wang
    Schizophr Res 101:341-3. 2008
  92. ncbi request reprint Infant rats with chronic neonatal isolation experience show decreased extracellular serotonin levels in ventral striatum at baseline and in response to cocaine
    Therese A Kosten
    Yale University School of Medicine, Ribicoff Research Facilities, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Dev Brain Res 152:19-24. 2004
    ....