Genomes and Genes
Affiliation: Baylor College of Medicine
- A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in DrosophilaSheng Zhang
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genetics 184:1165-79. 2010..Thus, other aggregates regulators isolated in our screen may identify additional genes involved in the protein-folding pathway and neurotoxicity...
- Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease modelSheng Zhang
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Dis Model Mech 2:247-66. 2009....
- Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processesSheng Zhang
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
Cell 108:45-56. 2002..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...