Research Topics
Genomes and GenesSpecies | M XiongSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Generalized T2 test for genome association studiesMomiao Xiong
Human Genetics Center, University of Texas Houston, 77225, USA
Am J Hum Genet 70:1257-68. 2002..Finally, examples are given to evaluate the performance of the proposed T2 statistic for association studies using simulated and real data...- Haplotype block linkage disequilibrium mappingMomiao Xiong
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
Front Biosci 8:a85-93. 2003..Our preliminary results of theoretic analysis further demonstrate that the haplotype block LD analysis is a breakthrough in LD mapping and is a promising tool for genome-wide association studies... - Linkage disequilibrium mapping of quantitative trait loci under truncation selectionM Xiong
Human Genetics Center, University of Texas Houston, Houston, Tex 77225, USA
Hum Hered 53:158-72. 2002..Finally, the proposed methods are applied to mapping QTL influencing variation in systolic blood pressure in an isolated Chinese population... - Network-based regulatory pathways analysisMomiao Xiong
Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Bioinformatics 20:2056-66. 2004..The proposed models for network-based regulatory pathway analysis have been applied to apoptosis regulatory network... - Identification of genetic networksMomiao Xiong
Human Genetics Center, University of Texas, Houston Health Science Center, TX 77030, USA
Genetics 166:1037-52. 2004..To illustrate the concepts and methods for reconstruction of genetic networks and identification of association of genetic networks with function, we applied the proposed models and algorithms to three data sets... - The effect that genotyping errors have on the robustness of common linkage-disequilibrium measuresJ M Akey
Human Genetics Center, School of Public Health, University of Texas Houston, Houston, TX, 77030, USA
Am J Hum Genet 68:1447-56. 2001..Finally, through stochastic simulations, we illustrate how genotyping errors can lead to erroneous inferences when measures of LD between two samples are compared... - Population based linkage disequilibrium mapping of QTL: an application to simulated data in an isolated populationJ Zhao
Human Genetics Center, University of Texas-Houston, Houston, Texas, USA
Genet Epidemiol 21:S655-9. 2001..The proposed method is applied to search for polymorphism sites within the candidate genes 2 and 6, which influence quantitative traits Q1 and Q2 or Q5, in a simulated data set in an isolated population... - Combined linkage and linkage disequilibrium mapping for genome screensM Xiong
Human Genetics Center, University of Texas, Houston Health Science Center, Houston, Texas 77225, USA
Genet Epidemiol 19:211-34. 2000..The proposed LLDM is applied to familial hemophagocytic lymphohistiocytosis (FHL) disease... - Haplotypes vs single marker linkage disequilibrium tests: what do we gain?J Akey
Human Genetics Center, University of Texas-Houston, Houston, Texas 77225, USA
Eur J Hum Genet 9:291-300. 2001..Finally, published data from the Hereditary Hemochromatosis disease region is used to illustrate the utility of haplotypes... - Biomarker identification by feature wrappersM Xiong
Human Genetics Center, University of Texas Houston, Houston, TX 77225, USA
Genome Res 11:1878-87. 2001..The preliminary results demonstrate that very high classification accuracy can be attained by identified composite classifiers with several biomarkers... - Feature (gene) selection in gene expression-based tumor classificationM Xiong
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
Mol Genet Metab 73:239-47. 2001..In this report we also show that stepwise Fisher's linear discriminant function is a practicable method for gene expression-based tumor classification... - Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methodsM Xiong
Human Genetics Center, University of Texas Houston Health Science Center, Houston, TX 77225, USA
Am J Hum Genet 64:629-40. 1999..These studies provide not only guidance in selection of the markers and in the design of the sample scheme for positional cloning but also insight into the biological bases of the mapping of human disease genes... - Computational methods for gene expression-based tumor classificationM Xiong
University of Texas Houston Health Science Center, Houston, TX, USA
Biotechniques 29:1264-8, 1270. 2000..0%. The combined approach using principal components and discriminant analysis provided superior sensitivity and specificity compared to an approach using simple differences in the expression levels of individual genes... - Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblastsX Zhou
Division of Rheumatology and Clinical Immunogenetics and Division of Medical Genetics, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
J Immunol 167:7126-33. 2001..Therefore, SSc-associated autoantigen genes are selectively overexpressed in SSc dermal fibroblasts, a major tissue involved in disease pathogenesis... - Interaction between the melanocortin-1 receptor and P genes contributes to inter-individual variation in skin pigmentation phenotypes in a Tibetan populationJ M Akey
Human Genetics Center, School of Public Health, University of Texas Houston, 77030, USA
Hum Genet 108:516-20. 2001..43; P=0.0105). We also discuss the possible mechanisms of how gene interactions arise in signal transduction pathways... - Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalenceXiaodong Zhou
University of Texas-Houston Medical School
Arthritis Rheum 48:2585-92. 2003.... - cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathiesXiaodong Zhou
Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
Med Sci Monit 10:BR191-7. 2004..This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis... - High resolution T association tests of complex diseases based on family dataRuzong Fan
The Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
Ann Hum Genet 69:187-208. 2005..The proposed paired Hotelling's T(2) statistic tests are potentially powerful in mapping complex diseases. A SAS Macro, Hotel_fam.sas, has been written to implement the method for data analysis... - An entropy-based statistic for genomewide association studiesJinying Zhao
Human Genetic Center, University of Texas, Health Science Center at Houston, Houston, TX 77225, USA
Am J Hum Genet 77:27-40. 2005..The results show that the entropy-based statistic obtained smaller P values than did the standard chi2 statistic... - Nonlinear tests for genomewide association studiesJinying Zhao
Human Genetics Center, University of Texas Health Science Center, Houston 77030, USA
Genetics 174:1529-38. 2006..To evaluate their performance, the nonlinear test statistics are also applied to three real data sets. Our study shows that nonlinear test statistics have great potential in association studies of complex diseases... - Test for interaction between two unlinked lociJinying Zhao
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA
Am J Hum Genet 79:831-45. 2006..Our results showed that the P values of the LD-based statistic were smaller than those obtained by other approaches, including logistic regression models... - An entropy-based genome-wide transmission/disequilibrium testJinying Zhao
Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Hum Genet 121:357-67. 2007..Results show that the entropy-based TDT statistic can reach p-values that are small enough to establish genome-wide linkage or association analyses... - Dissecting linkage disequilibrium in African-American genomes: roles of markers and individualsShuhua Xu
MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
Mol Biol Evol 24:2049-58. 2007.... - Composite measure of linkage disequilibrium for testing interaction between unlinked lociXuesen Wu
School of Life Science, Fudan University, Shanghai, China
Eur J Hum Genet 16:644-51. 2008..The preliminary results demonstrate that the composite LD-based statistic is a strong alternative to the logistic regressions and the intragametic LD-based statistic for the detection of interaction between two unlinked loci... - Linkage and association studies of QTL for nuclear families by mixed modelsRuzong Fan
Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
Biostatistics 4:75-95. 2003..1999) under moderate disequilibrium for nuclear families. Moreover, it has higher power than the TDT statistic which is constructed by randomly choosing a single offspring from each nuclear family... - High resolution mapping of quantitative trait loci by linkage disequilibrium analysisRuzong Fan
Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas, TX 77843 3143, USA
Eur J Hum Genet 10:607-15. 2002..For a complex disease with heritability h(2)> or =0.15, a study with sample size of 250 can provide high power for QTL detection under moderate linkage disequilibria... - The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibriumJoshua M Akey
Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
Mol Biol Evol 20:232-42. 2003..Finally, we validate our theoretical predictions by comparing our results to publicly available data from ten genes sequenced in 24 African American and 23 European American individuals... - A mathematical programming approach for gene selection and tissue classificationMinghe Sun
Department of Management Science and Statistics, College of Business, The University of Texas at San Antonio, San Antonio, TX 78249 0632, USA
Bioinformatics 19:1243-51. 2003..Very encouraging results were obtained with two data sets from the literature as examples. These results show that the mathematical programming approach can rival or outperform traditional classification methods... - SamCluster: an integrated scheme for automatic discovery of sample classes using gene expression profileWuju Li
Beijing Institute of Basic Medical Sciences, PO Box 130 3, People s Republic of China
Bioinformatics 19:811-7. 2003..In contrast to class prediction, few statistical and computational methods for feature selection have been applied to clustering algorithms for pattern discovery... - Combined high resolution linkage and association mapping of quantitative trait lociRuzong Fan
Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas 77843 3143, USA
Eur J Hum Genet 11:125-37. 2003.... - Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic driftKun Zhang
Center for Genome Information, 130 Kettering, Department of Environmental Health, University of Cincinnati, OH 45215, Cincinnati, USA
Hum Genet 113:51-9. 2003..Our findings highlight the necessity of characterizing haplotype blocks in world-wide populations... - Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosisEun Bong Lee
Seoul National University, Seoul, Republic of Korea
Arthritis Rheum 56:2443-8. 2007..To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc)... - Multiple transporters associated with malaria parasite responses to chloroquine and quinineJianbing Mu
Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA
Mol Microbiol 49:977-89. 2003..This study provides specific leads for better understanding of complex drug resistances in malaria parasites... - [Linkage analysis of 13 vasoactivity-regulating short tandem genes loci in essential hypertension in Chinese]Shaoli Chu
Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Zhonghua Nei Ke Za Zhi 41:295-7. 2002..It is worthwhile to pay attention to chromosomal regions near the loci with small P values... - [Linkage analysis of cytokine and cytokine-related receptor gene loci and essential hypertension in Chinese]Shaoli Chu
Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:221-4. 2002..To investigate the genetic linkage between several cytokine and cytokine-related receptor gene loci and essential hypertension (EH) in Chinese... - Linkage analysis of a region on chromosome 2 with essential hypertension in Chinese familiesDingliang Zhu
Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Chin Med J (Engl) 115:654-7. 2002..To verify the linkage of the candidate regions identified in a previous study (markers D2S168, D2S151, D2S142 on chromosome 2) with hypertension in Chinese families... - Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profilesJieruo Gu
University of California Los Angeles, 90095, USA
J Rheumatol 29:2159-64. 2002..CONCLUSION: Previous data postulating UPR in SpA are based on in vitro experiments with transfected cell lines. Our patient derived data suggest that it also occurs in vivo in the macrophages of SpA joints... - Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profilesXiaodong Zhou
University of Texas Medical School at Houston, USA
Arthritis Rheum 52:3305-14. 2005..Thus, a stronger genetic predisposition to SSc (than can be detected clinically) is apparent at the molecular level in skin fibroblasts... - Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarrayAiping Luo
National Lab of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P R China
Oncogene 23:1291-9. 2004..This study provides new insights into the role of squamous cell differentiation-associated genes in ESCC initiation and progression... - Comparison of gene expression between metastatic derivatives and their poorly metastatic parental cells implicates crucial tumor-environment interaction in metastasis of head and neck squamous cell carcinomaZhuo Chen
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Clin Exp Metastasis 20:335-42. 2003.... - Differential dynamic properties of scleroderma fibroblasts in response to perturbation of environmental stimuliMomiao Xiong
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston UTHSC H, Houston, Texas, USA
PLoS ONE 3:e1693. 2008..Our findings may open a new avenue in exploring the functions of cells and mechanism operative in disease development...