Research Topics
| John H WilsonSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Activation of gene expression by triplex-directed psoralen crosslinksJie Song
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Gene 324:183-90. 2004..Collectively, these results demonstrate that TFOs can be used to direct psoralen crosslinks adjacent to a gene as a way of activating gene expression...- Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapyFung Chan
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:9109-14. 2004.... - The nature of dominant mutations of rhodopsin and implications for gene therapyJohn H Wilson
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Neurobiol 28:149-58. 2003..If added wild-type rhodopsin could slow retinal degeneration in human patients, as it does in mice, it would represent a valuable new strategy for gene therapy of RP caused by dominant rhodopsin mutations... - Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosaBrandee A Price
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 52:9728-36. 2011..The goal was to introduce a gene that expressed rhodopsin at low levels to avoid rapid retinal degeneration, and with a readily visible tag to make it easy to distinguish from wild type rhodopsin... - Rhodopsin-EGFP knock-ins for imaging quantal gene alterationsTheodore G Wensel
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Vision Res 45:3445-53. 2005..They represent tools for studying molecular triggers of photoreceptor development, for following stem cell populations, and for evaluating retinal transplantation experiments... - Defective development of photoreceptor membranes in a mouse model of recessive retinal degenerationAlecia K Gross
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Vision Res 46:4510-8. 2006..These results reveal that in addition to its role in transport and sorting of rhodopsin to disk membranes, rhodopsin is also essential for formation of disks... - Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cellsLeroy Hubert
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Cell Biol 31:3105-12. 2011..These studies broaden the scope of pathways involved in transcription-induced CAG repeat instability and begin to define their interrelationships... - Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1Leroy Hubert
Present address Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Hum Mol Genet 20:4822-30. 2011..These results validate our original findings in cultured human cells and suggest that transcription may induce NER-dependent TNR instability in neuronal tissues in humans... - Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in miceFung Chan
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Nucleic Acids Res 39:5955-66. 2011..These studies establish that the genomes of terminally differentiated rod cells can be efficiently edited in living organisms... - Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is troubleYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX USA
Cell Cycle 10:611-8. 2011..Transcription-induced DNA toxicity may have profound biological consequences, with particular relevance to repeat-associated neurodegenerative diseases... - R loops stimulate genetic instability of CTG.CAG repeatsYunfu Lin
Baylor College of Medicine, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:692-7. 2010..DNA hybrid. These studies demonstrate that persistent hybrids between the nascent RNA transcript and the template DNA strand at CTG.CAG tracts promote instability of DNA trinucleotide repeats... - Impaired photoreceptor protein transport and synaptic transmission in a mouse model of Bardet-Biedl syndromeMuhammad M Abd-El-Barr
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Vision Res 47:3394-407. 2007..Additionally, we show defects in synaptic transmission from the photoreceptors to secondary neurons of the visual system, demonstrating multiple functions for BBS4 in photoreceptors... - Hsp90 modulates CAG repeat instability in human cellsDavid Mittelman
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cell Stress Chaperones 15:753-9. 2010..The capacity of Hsp90 to modulate repeat-tract lengths suggests that the chaperone, in addition to exposing cryptic variation, might facilitate the expression of new phenotypes through induction of novel genetic variation... - Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosisYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Biol 30:4435-51. 2010..Convergent transcription through a CAG repeat represents a novel mechanism for triggering a cellular stress response, one that is initiated by events at a single locus in the genome and resembles the response to DNA damage... - Transcription destabilizes triplet repeatsYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Carcinog 48:350-61. 2009.... - Evaluating retinal toxicity of intravitreal caspofungin in the mouse eyeDeb K Mojumder
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Invest Ophthalmol Vis Sci 51:5796-803. 2010..In this study, retinal toxicity was determined after intravitreal injection of caspofungin in a mouse model to assess its safety profile for the treatment of fungal endophthalmitis... - Stress, genomes, and evolutionDavid Mittelman
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cell Stress Chaperones 15:463-6. 2010..We discuss key findings that suggest a rich set of pathways by which Hsp90 can mediate the influences of the environment on the genome... - Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cellsDavid Mittelman
Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 106:9607-12. 2009..These studies identify a ZFN as a useful reagent for characterizing the effects of DSBs on CAG repeats in cells... - Neural reprogramming in retinal degenerationRobert E Marc
Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132
Invest Ophthalmol Vis Sci 48:3364-71. 2007..The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration... - [Triple helix: a new promise for gene therapy]Zsofia Intody
Semmelweis Egyetem, Általános Orvostudományi Kar, I Sz Szemészeti Klinika, Budapest
Orv Hetil 144:757-63. 2003..The most common cause for autosomal dominant retinitis pigmentosa is a mutation in the rhodopsin gene...
Research Grants
- Instability of Triplet Repeats in Mammalian CellsJohn H Wilson; Fiscal Year: 2010..These studies will define basic mechanisms of repeat instability in germline and somatic tissues, test a novel mechanism of disease pathogenesis, and develop a reagent with potential therapeutic applications. ..
- Rhodopsin Gene Correction and Gene Knockout in Rod CellsJohn Wilson; Fiscal Year: 2007..Assays for rhodopsin gene correction and knockout will utilize the fluorescent properties of the human rhodopsin-GFP target gene. ..
- Instability of Triplet Repeats in Mammalian CellsJohn Wilson; Fiscal Year: 2006..abstract_text> ..
- RHODOSPIN GENE CORRECTION BY OLIGONUCLEOTIDE TARGETINGJohn Wilson; Fiscal Year: 2005..These results will be used as the basis for developing treatment protocols in mice. ..
- Instability of Triplet Repeats in Mammalian CellsJohn Wilson; Fiscal Year: 2007..Our goal is to delineate those processes that are responsible for both the germline and somatic CTG/CAG repeat instability that characterizes myotonic dystrophy and other neurological diseases. ..
- Instability of Triplet Repeats in Mammalian CellsJohn Wilson; Fiscal Year: 2006..Our goal is to delineate those processes that are responsible for both the germline and somatic CTG/CAG repeat instability that characterizes myotonic dystrophy and other neurological diseases. ..
- Instability of Triplet Repeats in Mammalian CellsJohn Wilson; Fiscal Year: 2009..Our goal is to delineate those processes that are responsible for both the germline and somatic CTG/CAG repeat instability that characterizes myotonic dystrophy and other neurological diseases. ..
- Rhodopsin Gene Correction and Gene Knockout in Rod CellsJohn H Wilson; Fiscal Year: 2010..Assays for rhodopsin gene correction and knockout will utilize the fluorescent properties of the humanrhodopsin-GFPtarget gene. ..
- Rhodopsin Gene Correction and Gene Knockout in Rod CellsJohn Wilson; Fiscal Year: 2009..Assays for rhodopsin gene correction and knockout will utilize the fluorescent properties of the humanrhodopsin-GFPtarget gene. ..
- Rhodopsin Gene Correction and Gene Knockout in Rod CellsJohn Wilson; Fiscal Year: 2007..Assays for rhodopsin gene correction and knockout will utilize the fluorescent properties of the humanrhodopsin-GFPtarget gene. ..
- RHODOPSIN GENE CORRECTION BY OLIGONUCLEOTIDE TARGETINGJohn Wilson; Fiscal Year: 1999..This will be done by fusing the Green fluorescent Protein (GFP) to the rhodopsin gene. This construct will allow fluorescent-activated cell sorting to be used to collect altered cells. ..
- TARGETED RECOMBINATION IN CELLSJohn Wilson; Fiscal Year: 2000..Considering what is known about ERCC-1 function, a number of questions can be put forth. For example, the effect of nonhomologous tails could be quite interesting as could be triplex formation under repair-defective states. ..
- TARGETED RECOMBINATION IN MAMMALIAN CELLSJohn Wilson; Fiscal Year: 1993..Collectively, these studies will advance understanding of mammalian gene targeting and may lead to improved targeting frequencies...
- TARGETED RECOMBINATION IN MAMMALIAN CELLSJohn Wilson; Fiscal Year: 1991....