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Species | J W WhelessSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Using the new antiepilepsy drugs in childrenJames W Wheless
Department of Neurology, University of Texas at Houston, 77030, USA
J Child Neurol 17:S58-64. 2002..All three appear to have advantages over some traditional antiepilepsy drugs and with more clinical experience may replace them in certain seizure types or epilepsy syndromes...- Levetiracetam in refractory pediatric epilepsyJames W Wheless
Department of Neurology, University of Texas Houston, 77030, USA
J Child Neurol 17:413-5. 2002..Its apparent positive effects on cognition in some patients are encouraging. Large, well-controlled studies are needed to fully define levetiracetam's potential in children with refractory epilepsy... - Magnetoencephalography (MEG) and magnetic source imaging (MSI)James W Wheless
Department of Neurology, Texas Comprehensive Epilepsy Program, University of Texas Health Science Center, Houston, Texas, USA
Neurologist 10:138-53. 2004..The magnetic source image (MSI) is created when the MEG data is superimposed on a magnetic resonance image (MRI)... - Vagus nerve stimulation and the ketogenic dietJ W Wheless
Neurology and Pediatrics, University of Texas Houston, Texas Comprehensive Epilepsy Program, 77030, USA
Neurol Clin 19:371-407. 2001..This article discusses the history, mechanism of action, patient selection, efficacy, initiation, complications, and advantages of vagus nerve stimulation and the ketogenic diet... - Acute management of seizures in the syndromes of idiopathic generalized epilepsiesJames W Wheless
Texas Comprehensive Epilepsy Program, Department of Neurology and Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas 77030, U S A
Epilepsia 44:22-6. 2003.... - Treatment strategies for myoclonic seizures and epilepsy syndromes with myoclonic seizuresJames W Wheless
Department of Neurology and Pediatrics, Texas Comprehensive Epilepsy Program, University of Texas Houston, Houston, Texas, U S A
Epilepsia 44:27-37. 2003..Because myoclonic seizures can be difficult to treat, clinicians should be flexible in their approach and tailor therapy to each patient... - Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsyJames W Wheless
Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA
J Child Neurol 19:135-41. 2004..Based on efficacy and tolerability, the recommended target dose for topiramate as first-line therapy in children and adolescents is 100 mg/day... - Choosing antiepileptic drugs for developmentally normal children with specific epilepsy syndromes and behavioral disordersJames W Wheless
Department of Neurology, University of Texas Medical School at Houston, 6431 Fannin, Suite 7 044, Houston, TX 77030, USA
J Child Neurol 19:S39-48. 2004.... - Nonpharmacologic treatment of the catastrophic epilepsies of childhoodJames W Wheless
Department of Neurology and Pediatrics, Texas Comprehensive Epilepsy Program, University of Texas Houston Medical School, 6431 Fannin Street 7044, Houston, TX 77030, U S A
Epilepsia 45:17-22. 2004.... - Vagus nerve stimulation therapyJames W Wheless
Texas Comprehensive Epilepsy Program, University of Texas Houston, Epilepsy Monitoring Unit, Memorial Hermann Hospital, Houston, Texas 77030, USA
Drugs Today (Barc) 40:501-15. 2004..Provided here is an overview of VNS therapy and the VNS therapy system, including the history of vagal nerve stimulation, patient selection guidelines and new indications currently under investigation for this novel therapy... - Adolescent seizures and epilepsy syndromesJames W Wheless
Texas Comprehensive Epilepsy Program, University of Texas Houston, 77030, USA
Epilepsia 43:33-52. 2002..Knowledge of the epilepsy syndromes that remit before adolescence, may persist into adolescence, or begin in adolescence is central to the treatment of this age group... - Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mappingP G Simos
Department of Neurosurgery, The University of Texas, Houston Medical School, 77030, USA
J Neurosurg 91:787-96. 1999..In this paper the authors demonstrate the concordance between magnetic source (MS) imaging and direct cortical stimulation for mapping receptive language cortex... - Language dominance in children as determined by magnetic source imaging and the intracarotid amobarbital procedure: a comparisonJ I Breier
Department of Neurosurgery and the Vivian L Smith Center for Neurologic Research, The University of Texas Health Science Center, Houston, USA
J Child Neurol 16:124-30. 2001..We conclude that magnetic source imaging is a promising method for determination of cerebral dominance for language in children and adults... - Rapid infusion with valproate sodium is well tolerated in patients with epilepsyJ W Wheless
Department of Neurology, University of Texas Health Science Center, Houston, USA
Neurology 63:1507-8. 2004..Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events... - Brain plasticity for sensory and linguistic functions: a functional imaging study using magnetoencephalography with children and young adultsA C Papanicolaou
Department of Neurosurgery, Vivian L Smith Center for Neurologic Research, The University of Texas Houston Medical School, 77030, USA
J Child Neurol 16:241-52. 2001.... - Mapping of expressive language cortex using magnetic source imagingE M Castillo
Departments of Neurosurgery, Vivian L Smith Center for Neurologic Research, The University of Texas Medical School, Houston, Texas 77030, USA
Neurocase 7:419-22. 2001.... - Use of topiramate in childhood generalized seizure disordersJ W Wheless
Department of Neurology, University of Texas Houston, 77030, USA
J Child Neurol 15:S7-13. 2000..Moreover, life-threatening organ toxicity has not been attributed to topiramate. Topiramate is an effective treatment for refractory generalized seizure types and epilepsy syndromes encountered in children... - Profiles of cognitive performance associated with reading disability in temporal lobe epilepsyJ I Breier
Department of Neurosurgery, The University of Texas, Health Science Center, Houston 77030, USA
J Clin Exp Neuropsychol 22:804-16. 2000.... - On the surgical treatment of refractory epilepsy in tuberous sclerosis complexJ E Baumgartner
Division of Pediatric Surgery Neurosurgery, The University of Texas Medical School, Houston 77030, USA
Pediatr Neurosurg 27:311-8. 1997..Temporal lobectomy and focal cortical resection can result in improved seizure control in patients with TSC and RE... - [Insights into brain function though magnetic source imaging: A review of research and clinical applications]P G Simos
Dpt of Neurosurgery University of Texas Houston Health Science Center, Houston Texas, TX77030, EE UU
Rev Neurol 34:871-6. 2002.... - Magnetoencephalographic mapping of the language-specific cortexA C Papanicolaou
Department of Neurosurgery, The University of Texas Houston Medical School, USA
J Neurosurg 90:85-93. 1999..In this paper the authors introduce a novel use of magnetoencephalography (MEG) for noninvasive mapping of language-specific cortex in individual patients and in healthy volunteers... - Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective studyS L Helmers
Department of Neurology, Division of Epilepsy and Clinical Neurophysiology, Children s Hospital, Boston, MA, USA
J Child Neurol 16:843-8. 2001..We concluded that vagus nerve stimulation is an effective treatment for medically refractory epilepsy in children... - Idiopathic cardiac asystole presenting as an intractable adult onset partial seizure disorderV Venkataraman
Texas Comprehensive Epilepsy Program, Department of Neurology, University of Texas Houston, 77030, USA
Seizure 10:359-64. 2001..Early video-EEG and ECG monitoring is essential in adults with intractable seizure disorders... - New formulations of drugs in epilepsyJ W Wheless
Texas Comprehensive Epilepsy Program, University of Texas Houston, Department of Neurology, 6431 Fannin Street, Suite 7 044, Houston, Texas 77030, USA
Expert Opin Pharmacother 1:49-60. 1999..All of these new formulations expand treatment options for patients with epilepsy, who will benefit from them... - Does magnetoencephalography add to scalp video-EEG as a diagnostic tool in epilepsy surgery?E Pataraia
Department of Neurosurgery, Vivian L Smith Center for Neurologic Research, University of Texas Health Science Center at Houston, USA
Neurology 62:943-8. 2004.... - Clinical experience with topiramate dosing and serum levels in children 12 years or under with epilepsyM J Schwabe
Texas Comprehensive Epilepsy Program, Department of Neurology, University of Texas-Houston, 77030, USA
J Child Neurol 16:806-8. 2001..This study supports a wider dosing range (7-22 mg/kg/day) of topiramate and dosage escalation beyond the approved range. Serum levels are useful in guiding topiramate dosing, especially in young children... - Characterization of mutations in the gene doublecortin in patients with double cortex syndromeJ G Gleeson
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Ann Neurol 45:146-53. 1999..Single amino acid substitution mutations were tightly clustered in two regions of the open reading frame, suggesting that these two regions are critical for the function of the Doublecortin protein... - Periventricular heterotopia associated with chromosome 5p anomaliesV L Sheen
Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
Neurology 60:1033-6. 2003..FISH identified a duplication of 5p15.1 [46,XX,dup(5)(p15.1p15.1)] and a trisomy of 5p15.33 [46,XY,der(14)t(5;14)(p15.33;p11.2) mat]. These findings suggest a new PH locus along the telomeric end of chromosome 5p... - Intractable epilepsy: A survey of patients and caregiversJames W Wheless
Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Epilepsy Behav 8:756-64. 2006..Physicians must take into account medication side effects and quality-of-life issues when treating patients with epilepsy... - Pediatric extratemporal epilepsy presenting with a complex auditory auraDave F Clarke
Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Epileptic Disord 10:181-6. 2008..We report on one child, whose aura was a more complex auditory phenomenon, consisting of a door opening and closing, getting louder as the ictus persisted... - Treatment of pediatric epilepsy: European expert opinion, 2007James W Wheless
Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Epileptic Disord 9:353-412. 2007..In such clinical situations, expert opinion can be especially helpful... - Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United StatesKit Sing Au
Department of Pediatrics, The University of Texas Medical School at Houston, 77030, USA
Genet Med 9:88-100. 2007..Male patients showed more frequent neurologic and eye symptoms, renal cysts, and ungual fibromas. Correlating genotypes with phenotypes should facilitate the disease management of tuberous sclerosis complex... - Combined ketogenic diet and vagus nerve stimulation: rational polytherapy?Eric H Kossoff
The Johns Hopkins Hospital, Baltimore, Maryland 21287 1000, USA
Epilepsia 48:77-81. 2007..The concept of "rational polypharmacy" has been associated with anticonvulsant management for decades, but the term has not been applied to nonpharmacologic therapies... - VigabatrinJames W Wheless
University of Tennessee Health Science Center, Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
Neurotherapeutics 4:163-72. 2007.... - Frequency of panic symptoms in psychogenic nonepileptic seizuresMariana E Witgert
Department of Psychology, University of Houston, Houston, TX, USA
Epilepsy Behav 6:174-8. 2005..Implications of results are discussed in terms of the diagnosis and treatment of PNES in the different age groups... - Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalographyJoshua I Breier
Vivian L Smith Center for Neurologic Research, Department of Neurosurgery, Division of Clinical Neurosciences, The University of Texas Health Science Center at Houston, Texas 77030, USA
Epilepsia 46:540-8. 2005..To characterize the relation between hemispheric asymmetries in language-specific brain activity and reading/spelling achievement by using magnetoencephalography (MEG)... - Childhood mesial temporal sclerosisYu tze Ng
Division of Child Neurology, St Joseph s Hospital and Children s Health Center at Barrow Neurological Institute, 500 West Thomas Road, Phoenix, AZ 85013, USA
J Child Neurol 21:512-7. 2006..Asymptomatic mesial temporal sclerosis or mesial temporal sclerosis not associated with a seizure disorder did not occur in our series. Febrile seizures can occur in association with mesial temporal sclerosis presenting in childhood... - Toward the substitution of invasive electroencephalography in epilepsy surgeryAndrew C Papanicolaou
Division of Clinical Neurosciences in the Department of Neurosurgery, University of Texas - Houston Health Science Center, Houston, Texas 77030, USA
J Clin Neurophysiol 22:231-7. 2005..The authors predict the replacement of the more invasive procedure with MEG in the near future for TLE cases, subsequent to the optimization of the conditions under which preoperative MEG is performed... - Treatment of pediatric epilepsy: expert opinion, 2005James W Wheless
Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
J Child Neurol 20:S1-56; quiz S59-60. 2005..In such clinical situations, expert opinion can be especially helpful... - Corpus callosotomy: a palliative therapeutic technique may help identify resectable epileptogenic fociDave F Clarke
Department of Pediatrics, Division of Pediatric Neurology, Le Bonheur Comprehensive Epilepsy Program, University of Tennessee Health Science Center, Memphis, TN 38105, USA
Seizure 16:545-53. 2007..Study limitations include its retrospective nature and cohort size. The findings, however, suggest the need for prospective, systematic, well-controlled studies of the use of corpus callostomy in this intractable patient population... - Treatment of myoclonic epilepsies in infancy and early childhoodRaman Sankar
Department of Neurology, David Geffen School of Medicine at UCLA and Mattel Children's Hospital at UCLA, Los Angeles, California, USA
Adv Neurol 95:289-98. 2005 - Vagus nerve stimulation therapy in patients younger than 18 yearsJames W Wheless
Texas Comprehensive Epilepsy Program, Medical School, University of Texas-Houston, MSB 7.044, 6431 Fannin, Houston, TX 77030, USA
Neurology 59:S21-5. 2002..One such treatment, vagus nerve stimulation (VNS) therapy, appears to be particularly effective among pediatric patients with refractory seizures. Seizure severity and frequency, as well as quality of life, are improved with VNS therapy... - Multimodality functional imaging evaluation in a patient with Rasmussen's encephalitisHideaki Ishibashi
Department of Neurosurgery, Vivian L Smith Center for Neurologic Research, Division of Clinical Neurosciences, The University of Texas Health Science Center at Houston, USA
Brain Dev 24:239-44. 2002..In addition, MEG may provide insights about the cortical reorganization of somatosensory cortex following hemispherectomy... - Localization of ictal and interictal bursting epileptogenic activity in focal cortical dysplasia: agreement of magnetoencephalography and electrocorticographyHideaki Ishibashi
Department of Neurosurgery, Vivian L Smith Center for Neurologic Research, The University of Texas Health Science Center at Houston, 77030, USA
Neurol Res 24:525-30. 2002..This was critical for pre-surgical planning regarding placement of intracranial electrodes and for risk-benefit evaluation... - The evolving place of vagus nerve stimulation therapySteven C Schachter
Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 457, Boston, MA 02215, USA
Neurology 59:S1-2. 2002..This supplement updates developments with VNS therapy since its approval and suggests future directions for this still-evolving treatment... - Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsyJ Ben Renfroe
Child Neurology Center of Northwest Florida, 5153 North 9th Avenue, Suite 300, Pensacola, FL 32504, USA
Neurology 59:S26-30. 2002..We suggest future prospective studies evaluating VNS therapy versus best medical therapy after the first two to three AEDs have failed, which typically occurs within 2 years of seizure onset... - Language dysfunction in epileptic conditionsJames W Wheless
Department of Neurology, University of Texas-Houston, 77030, USA
Semin Pediatr Neurol 9:218-28. 2002..We demonstrate how magnetoencephalography (MEG) offers the ability to analyze the relationship of language, EEG abnormalities, and epilepsy... - Multimodality neuroimaging evaluation improves the detection of subtle cortical dysplasia in seizure patientsWenbo Zhang
Department of Neurosurgery, Vivian L Smith Center for Neurologic Research, Texas Comprehensive Epilepsy Program, University of Texas Health Science Center at Houston, 1333 Moursund Street, Ste H114, Houston, TX 77030, USA
Neurol Res 25:53-7. 2003..Normal magnetic resonance images should be re-evaluated for subtle signs of focal cortical dysplasia especially when magnetoencephalography recording demonstrate focal epileptic discharges... - Successful neurosurgical treatment of childhood complex partial status epilepticus with focal resectionYu tze Ng
Texas Comprehensive Epilepsy Program, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, USA
Epilepsia 44:468-71. 2003.... - Integrating sensory and motor mapping in a comprehensive MEG protocol: clinical validity and replicabilityEduardo M Castillo
Vivian L Smith Center for Neurologic Research, Department of Neurosurgery, University of Texas Houston Medical School, Houston, TX 77030, USA
Neuroimage 21:973-83. 2004..This method minimizes methodological problems and improves our knowledge of the spatiotemporal organization of the sensorimotor cortical network and helps to optimize the surgical management of patients with perirolandic lesions... - Detection and significance of focal, interictal, slow-wave activity visualized by magnetoencephalography for localization of a primary epileptogenic regionHideaki Ishibashi
Vivian L Smith Foundation for Neurological Research, Department of Neurosurgery, The University of Texas Houston Health Science Center, Houston 77030, USA
J Neurosurg 96:724-30. 2002..In the present study the authors examined the significance of focal, slow-wave and interictal spike activity detected using MEG in 29 patients who suffered from MTLE that was not associated with structural brain lesions... - The ketogenic diet: adolescents can do it, tooMackenzie A Mady
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Epilepsia 44:847-51. 2003..CONCLUSIONS: The ketogenic diet is as well tolerated and efficacious for adolescents with epilepsy as for the general childhood population... - Magnetic resonance imaging detection of mesial temporal sclerosis in childrenYu-tze Ng
Department of Neurology, Texas Comprehensive Epilepsy Program, The University of Texas-Houston Medical School, Houston, Texas, USA
Pediatr Neurol 30:81-5. 2004..Children with mesial temporal sclerosis often had comorbid conditions, and the diagnosis of mesial temporal sclerosis made by magnetic resonance imaging was accurate when compared with the available histopathology... - The personal and financial impact of repetitive or prolonged seizures on the patient and familyChristine O'Dell
Comprehensive Epilepsy Management Center, Montefiore Medical Center, Bronx, New York 10467, USA
J Child Neurol 22:61S-70S. 2007..This article discusses factors that contribute to the personal and financial impact of prolonged seizures on adult and pediatric patients, their families, and caregivers... - Neuroimaging features of epidermal nevus syndromeWenbo Zhang
Department of Neurosurgery, Vivian L. Smith Center for Neurologic Research, Texas Comprehensive Epilepsy Program, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
AJNR Am J Neuroradiol 24:1468-70. 2003..One patient underwent hemispherectomy because of the medically intractable seizure. He remained seizure free with topiramate monotherapy... - Evidence-based versus reported epilepsy management practicesKatherine S Mastriani
Division of Pediatric Epidemiology, Medical University of South Carolina, Charleston, SC, USA
J Child Neurol 23:507-14. 2008..Safety and efficacy data suggest that the ketogenic diet should be more widely adopted as a management strategy in pediatric epilepsy... - Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physiciansCollin A Hovinga
University of Tennessee Health Science Center, Memphis, TN 38103, USA
Epilepsy Behav 13:316-22. 2008.... - Children with epilepsy: are they the same on both sides of the Atlantic, and do the same treatments work?Alexis Arzimanoglou
Epileptic Disord 9:351-2. 2007