Research Topics
Species | R A WaterlandSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseasesRobert A Waterland
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nutrition 20:63-8. 2004- Epigenetic epidemiology of the developmental origins hypothesisRobert A Waterland
Department of Pediatrics, USDA Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
Annu Rev Nutr 27:363-88. 2007.... 
Season of conception in rural gambia affects DNA methylation at putative human metastable epiallelesRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, United States of America
PLoS Genet 6:e1001252. 2010..MEs should therefore facilitate an improved understanding of the role of interindividual epigenetic variation in human disease...- Epigenomic profiling indicates a role for DNA methylation in early postnatal liver developmentRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
Hum Mol Genet 18:3026-38. 2009..These in vivo data clearly indicate a role for DNA methylation in mammalian differentiation, and provide the novel insight that critical windows in mammalian developmental epigenetics extend well beyond early embryonic development... - Methyl donor supplementation prevents transgenerational amplification of obesityR A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
Int J Obes (Lond) 32:1373-9. 2008..The biological mechanisms underlying such processes remain unknown... - Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the femaleRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
FASEB J 21:3380-5. 2007..These results suggest that, in the female germ line, diet-induced A(vy) hypermethylation occurs in the absence of additional epigenetic modifications that normally confer transgenerational epigenetic inheritance at the locus... - Epigenetic mechanisms and gastrointestinal developmentRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Pediatr 149:S137-42. 2006..Data indicating that epigenetic gene regulation plays an important role in GI development and pathology are reviewed, and suggestions for future research in this area are offered... - Maternal methyl supplements increase offspring DNA methylation at Axin FusedRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Texas 77030, USA
Genesis 44:401-6. 2006..Our results indicate that stochastic establishment of epigenotype at metastable epialleles is, in general, labile to methyl donor nutrition, and such influences are not limited to early embryonic development... - Assessing the effects of high methionine intake on DNA methylationRobert A Waterland
Department of Pediatrics, Baylor College of Medicine, U S Department of Agriculture Children s Nutrition Research Center, Houston, TX 77030, USA
J Nutr 136:1706S-1710S. 2006..Recent developments in epigenomic approaches that survey locus-specific DNA methylation on a genome-wide scale offer broader opportunities to assess the effects of high methionine intake on mammalian epigenomes... - Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locusRobert A Waterland
Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030 2600, USA
Hum Mol Genet 15:705-16. 2006..These results indicate that post-weaning diet can permanently affect expression of Igf2, suggesting that childhood diet could contribute to IGF2 LOI in humans... - Epigenetic maturation in colonic mucosa continues beyond infancy in miceRichard Kellermayer
Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA
Hum Mol Genet 19:2168-76. 2010..Transcript Profiling: Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/), accession numbers: GSE18031 (DNA methylation arrays), GSE19506 (gene expression arrays)... 
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germlineVincent Dion
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Hum Mol Genet 17:1306-17. 2008..These results are consistent with normal epigenetic changes during germline development contributing to intergenerational instability of CAG repeats in mice and in humans...- Is epigenetics an important link between early life events and adult disease?Robert A Waterland
Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Tex, USA
Horm Res 71:13-6. 2009..CONCLUSIONS: Coupling such models with recently developed epigenomic technologies should ultimately enable us to determine if epigenetics is an important link between early life events and adult disease... - Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promotersLanlan Shen
Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
PLoS Genet 3:2023-36. 2007.... - Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms?Robert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX, USA
Nestle Nutr Workshop Ser Pediatr Program 56:157-71; discussion 171-4. 2005 - Individual epigenetic variation: when, why, and so what?Marcus V Gomes
Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX, USA
Nestle Nutr Workshop Ser Pediatr Program 62:141-50; discussion 151-5. 2008..In this review we will summarize current progress toward answering these questions... - Commentary: The global relevance of "biological Freudianism"Robert A Waterland
Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Ste. 9070, Houston, TX 77030, USA
Int J Epidemiol 34:15-7. 2005 - Methods of DNA methylation analysisLanlan Shen
Department of Leukemia, University of Texas MD Anderson Cancer Center, USA
Curr Opin Clin Nutr Metab Care 10:576-81. 2007..To provide guidance for investigators who are new to the field of DNA methylation analysis... - Transposable elements: targets for early nutritional effects on epigenetic gene regulationRobert A Waterland
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Mol Cell Biol 23:5293-300. 2003..These findings suggest that dietary supplementation, long presumed to be purely beneficial, may have unintended deleterious influences on the establishment of epigenetic gene regulation in humans... - Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenomeDana C Dolinoy
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Environ Health Perspect 114:567-72. 2006..Thus, we provide the first evidence that in utero dietary genistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome... - Tissue-specific inactivation of murine M6P/IGF2RAndrew A Wylie
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Pathol 162:321-8. 2003.... - M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in JapanYoshihiko Oka
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Hepatology 35:1153-63. 2002..Loss of heterozygosity in dysplastic liver nodules provides additional evidence that M6P/IGF2R haploid insufficiency is an early event in human hepatocarcinogenesis... - Analysis of CpG methylation in the killifish CYP1A promoterAlicia R Timme-Laragy
Nicholas School of the Environment and Earth Sciences Integrated Toxicology Program, Box 90328, Duke University, Durham, NC, USA
Comp Biochem Physiol C Toxicol Pharmacol 141:406-11. 2005..In fish from both the contaminated and the reference site, cytosine methylation was not detectable at any of the 34 CpG sites examined, including 3 that are part of putative xenobiotic response elements... - Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferaseLamia Benbrahim Tallaa
Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 115:1454-9. 2007..The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation... - Do maternal methyl supplements in mice affect DNA methylation of offspring?Robert A Waterland
J Nutr 133:238; author reply 239. 2003 - Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activationLamia Benbrahim-Tallaa
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, MD F0-09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 206:288-98. 2005..However, overexpression of K-ras occurred without mutations and through a mechanism other than promoter region hypomethylation... - Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in ratsRobert A Waterland
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
J Nutr 132:357-64. 2002..C differential expression at age 26 d, 10 remained differentially expressed at age 110 d. These data indicate that the endocrine pancreas plays a primary role in the putative metabolic imprinting mechanism in SL rats...