R A Waterland

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi request reprint Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nutrition 20:63-8. 2004
  2. ncbi request reprint Epigenetic epidemiology of the developmental origins hypothesis
    Robert A Waterland
    Department of Pediatrics, USDA Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
    Annu Rev Nutr 27:363-88. 2007
  3. pmc Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS Genet 6:e1001252. 2010
  4. pmc Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
    Hum Mol Genet 18:3026-38. 2009
  5. pmc Methyl donor supplementation prevents transgenerational amplification of obesity
    R A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
    Int J Obes (Lond) 32:1373-9. 2008
  6. ncbi request reprint Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
    FASEB J 21:3380-5. 2007
  7. ncbi request reprint Epigenetic mechanisms and gastrointestinal development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Pediatr 149:S137-42. 2006
  8. ncbi request reprint Maternal methyl supplements increase offspring DNA methylation at Axin Fused
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Texas 77030, USA
    Genesis 44:401-6. 2006
  9. ncbi request reprint Assessing the effects of high methionine intake on DNA methylation
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, U S Department of Agriculture Children s Nutrition Research Center, Houston, TX 77030, USA
    J Nutr 136:1706S-1710S. 2006
  10. ncbi request reprint Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
    Robert A Waterland
    Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030 2600, USA
    Hum Mol Genet 15:705-16. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nutrition 20:63-8. 2004
  2. ncbi request reprint Epigenetic epidemiology of the developmental origins hypothesis
    Robert A Waterland
    Department of Pediatrics, USDA Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
    Annu Rev Nutr 27:363-88. 2007
    ....
  3. pmc Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS Genet 6:e1001252. 2010
    ..MEs should therefore facilitate an improved understanding of the role of interindividual epigenetic variation in human disease...
  4. pmc Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
    Hum Mol Genet 18:3026-38. 2009
    ..These in vivo data clearly indicate a role for DNA methylation in mammalian differentiation, and provide the novel insight that critical windows in mammalian developmental epigenetics extend well beyond early embryonic development...
  5. pmc Methyl donor supplementation prevents transgenerational amplification of obesity
    R A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
    Int J Obes (Lond) 32:1373-9. 2008
    ..The biological mechanisms underlying such processes remain unknown...
  6. ncbi request reprint Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030, USA
    FASEB J 21:3380-5. 2007
    ..These results suggest that, in the female germ line, diet-induced A(vy) hypermethylation occurs in the absence of additional epigenetic modifications that normally confer transgenerational epigenetic inheritance at the locus...
  7. ncbi request reprint Epigenetic mechanisms and gastrointestinal development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Pediatr 149:S137-42. 2006
    ..Data indicating that epigenetic gene regulation plays an important role in GI development and pathology are reviewed, and suggestions for future research in this area are offered...
  8. ncbi request reprint Maternal methyl supplements increase offspring DNA methylation at Axin Fused
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Texas 77030, USA
    Genesis 44:401-6. 2006
    ..Our results indicate that stochastic establishment of epigenotype at metastable epialleles is, in general, labile to methyl donor nutrition, and such influences are not limited to early embryonic development...
  9. ncbi request reprint Assessing the effects of high methionine intake on DNA methylation
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, U S Department of Agriculture Children s Nutrition Research Center, Houston, TX 77030, USA
    J Nutr 136:1706S-1710S. 2006
    ..Recent developments in epigenomic approaches that survey locus-specific DNA methylation on a genome-wide scale offer broader opportunities to assess the effects of high methionine intake on mammalian epigenomes...
  10. ncbi request reprint Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
    Robert A Waterland
    Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030 2600, USA
    Hum Mol Genet 15:705-16. 2006
    ..These results indicate that post-weaning diet can permanently affect expression of Igf2, suggesting that childhood diet could contribute to IGF2 LOI in humans...
  11. pmc Epigenetic maturation in colonic mucosa continues beyond infancy in mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA
    Hum Mol Genet 19:2168-76. 2010
    ..Transcript Profiling: Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/), accession numbers: GSE18031 (DNA methylation arrays), GSE19506 (gene expression arrays)...
  12. pmc Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 17:1306-17. 2008
    ..These results are consistent with normal epigenetic changes during germline development contributing to intergenerational instability of CAG repeats in mice and in humans...
  13. doi request reprint Is epigenetics an important link between early life events and adult disease?
    Robert A Waterland
    Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, Tex, USA
    Horm Res 71:13-6. 2009
    ..Extensive work in animal models is required to develop specific hypotheses that can be practicably tested in humans...
  14. pmc Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 3:2023-36. 2007
    ....
  15. ncbi request reprint Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms?
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX, USA
    Nestle Nutr Workshop Ser Pediatr Program 56:157-71; discussion 171-4. 2005
  16. doi request reprint Individual epigenetic variation: when, why, and so what?
    Marcus V Gomes
    Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX, USA
    Nestle Nutr Workshop Ser Pediatr Program 62:141-50; discussion 151-5. 2008
    ..In this review we will summarize current progress toward answering these questions...
  17. ncbi request reprint Commentary: The global relevance of "biological Freudianism"
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Ste 9070, Houston, TX 77030, USA
    Int J Epidemiol 34:15-7. 2005
  18. ncbi request reprint Methods of DNA methylation analysis
    Lanlan Shen
    Department of Leukemia, University of Texas MD Anderson Cancer Center, USA
    Curr Opin Clin Nutr Metab Care 10:576-81. 2007
    ..To provide guidance for investigators who are new to the field of DNA methylation analysis...
  19. pmc Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:5293-300. 2003
    ..These findings suggest that dietary supplementation, long presumed to be purely beneficial, may have unintended deleterious influences on the establishment of epigenetic gene regulation in humans...
  20. pmc Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Environ Health Perspect 114:567-72. 2006
    ..Thus, we provide the first evidence that in utero dietary genistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome...
  21. pmc Tissue-specific inactivation of murine M6P/IGF2R
    Andrew A Wylie
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Pathol 162:321-8. 2003
    ....
  22. ncbi request reprint M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan
    Yoshihiko Oka
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 35:1153-63. 2002
    ..Loss of heterozygosity in dysplastic liver nodules provides additional evidence that M6P/IGF2R haploid insufficiency is an early event in human hepatocarcinogenesis...
  23. ncbi request reprint Analysis of CpG methylation in the killifish CYP1A promoter
    Alicia R Timme-Laragy
    Nicholas School of the Environment and Earth Sciences Integrated Toxicology Program, Box 90328, Duke University, Durham, NC, USA
    Comp Biochem Physiol C Toxicol Pharmacol 141:406-11. 2005
    ..In fish from both the contaminated and the reference site, cytosine methylation was not detectable at any of the 34 CpG sites examined, including 3 that are part of putative xenobiotic response elements...
  24. pmc Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1454-9. 2007
    ..The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation...
  25. ncbi request reprint Do maternal methyl supplements in mice affect DNA methylation of offspring?
    Robert A Waterland
    J Nutr 133:238; author reply 239. 2003
  26. ncbi request reprint Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation
    Lamia Benbrahim-Tallaa
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, MD F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 206:288-98. 2005
    ..However, overexpression of K-ras occurred without mutations and through a mechanism other than promoter region hypomethylation...
  27. ncbi request reprint Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in rats
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Nutr 132:357-64. 2002
    ..C differential expression at age 26 d, 10 remained differentially expressed at age 110 d. These data indicate that the endocrine pancreas plays a primary role in the putative metabolic imprinting mechanism in SL rats...