Research Topics
Genomes and Genes
| Rong Fu WangSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cellsRong Fu Wang
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Nat Biotechnol 20:149-54. 2002..This CPP-based approach may be generally applicable to enhance the efficacy of DC-based peptide vaccines against cancer and other diseases...- Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell functionGuangyong Peng
Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Science 309:1380-4. 2005..These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases... - Functional control of regulatory T cells and cancer immunotherapyRong Fu Wang
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
Semin Cancer Biol 16:106-14. 2006..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to shift the balance between CD4(+) T-helper and Treg cells, in ways that may improve the outcome of cancer immunotherapy... - Regulatory T cells and toll-like receptors in cancer therapyRong Fu Wang
The 2nd Hospital, Zhejiang University Medical School, Hangzhou, China
Cancer Res 66:4987-90. 2006..Linking TLR signaling to the functional control of Treg cells may offer new opportunities to improve the outcome of cancer immunotherapy by coadminstration of certain TLR ligands... - Regulatory T cells and innate immune regulation in tumor immunityRong Fu Wang
Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120 Houston, TX 77030, USA corrected
Springer Semin Immunopathol 28:17-23. 2006..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to manipulate TLR signaling to control both innate and adaptive immunity against cancer... - CD8+ regulatory T cells, their suppressive mechanisms, and regulation in cancerRong Fu Wang
Center for Cell and Gene Therapy, Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA
Hum Immunol 69:811-4. 2008.... - Toll-like receptors and immune regulation: implications for cancer therapyR F Wang
Center for Cell and Gene Therapy and Department of Pathology and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 27:181-9. 2008..In this review, we focus on the current understanding of TLRs and Treg cells with emphasis on their roles in cancer immunity. Related information on non-TLR immune receptors will be briefly discussed... - Regulatory T cells and Toll-like receptors in tumor immunityRong Fu Wang
Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Semin Immunol 18:136-42. 2006..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to shift the balance between CD4(+) T-helper and Treg cells, in ways that may improve the outcome of cancer immunotherapy... - Immune suppression by tumor-specific CD4+ regulatory T-cells in cancerRong Fu Wang
Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
Semin Cancer Biol 16:73-9. 2006..This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy... - Identification of MHC class II-restricted tumor antigens recognized by CD4+ T cellsRong Fu Wang
Department of Immunology, The Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building N1120, One Baylor Plaza, Houston, TX 77030, USA
Methods 29:227-35. 2003..Helper T peptides are subsequently identified by using synthetic peptides to test their ability to stimulate CD4+ T cells... - Enhancing antitumor immune responses: intracellular peptide delivery and identification of MHC class II-restricted tumor antigensRong Fu Wang
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Immunol Rev 188:65-80. 2002.... - T cell-mediated immune responses in melanoma: implications for immunotherapyRong Fu Wang
Department of Immunology, The Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120, One Baylor Plaza, Houston, TX 77030, USA
Crit Rev Oncol Hematol 43:1-11. 2002..This review will summarize the current status of MHC class I and class II-restricted human tumor antigens, and their potential application to cancer treatment... - The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunityR F Wang
The Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Trends Immunol 22:269-76. 2001..To this end, the identification of MHC class II-restricted tumor antigens that can stimulate CD4+ T cells might provide opportunities for developing effective cancer vaccines... - Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cellsHelen Y Wang
Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 174:2661-70. 2005.... - Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathwayGuangyong Peng
The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Immunity 27:334-48. 2007..These results provide new insights into the regulatory mechanisms of tumor-specific gammadelta T cells and identify a unique TLR8 signaling pathway linking to their functional regulation... - Enhanced TLR-induced NF-?B signaling and type I interferon responses in NLRC5 deficient miceYanzheng Tong
The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Cell Res 22:822-35. 2012.... - CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancerYukiko Kiniwa
Department of Pathology, The Center for Cell and Gene Therapy, Baylor Colleg of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 13:6947-58. 2007..In this study, we investigated prostate tumor-derived CD8(+) Treg cells and their function... - NLRX1 negatively regulates TLR-induced NF-?B signaling by targeting TRAF6 and IKKXiaojun Xia
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Immunity 34:843-53. 2011..Our study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-?B activation by dynamically interacting with TRAF6 and the IKK complex... - NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4Jun Cui
The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
Nat Immunol 13:387-95. 2012..Our results identify a previously unrecognized role for NLRP4 in the regulation of type I interferon signaling and provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation... - Tumor-associated galectin-3 modulates the function of tumor-reactive T cellsWeiyi Peng
The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 68:7228-36. 2008..These findings suggest that Gal-3 may function as an immune regulator to inhibit T-cell immune responses and promote tumor growth, thus providing a new mechanism for tumor immune tolerance... - Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapyHelen Y Wang
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Immunity 20:107-18. 2004..These findings suggest that the presence of tumor-specific CD4(+) Treg cells at tumor sites may have a profound effect on the inhibition of T cell responses against cancer... - Identification of prostate-specific g-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapySatoko Matsueda
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 7:e45756. 2012..In this study, we describe the identification of PSGR-derived peptide epitopes recognized by CD8(+) T cells in an HLA-A2 dependent manner... - Enhancing cancer immunotherapy by intracellular delivery of cell-penetrating peptides and stimulation of pattern-recognition receptor signalingHelen Y Wang
Department of Pathology and Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
Adv Immunol 114:151-76. 2012..We will discuss the recent progress and novel strategies in cancer immunotherapy... - TAK1 negatively regulates NF-?B and p38 MAP kinase activation in Gr-1+CD11b+ neutrophilsAdebusola Alagbala Ajibade
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Immunity 36:43-54. 2012..Our findings identify a previously unrecognized role of TAK1 as a negative regulator of p38 and IKK activation in a cell type-specific manner... - Molecular cloning and characterization of MHC class I- and II-restricted tumor antigens recognized by T cellsRong Fu Wang
The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
Curr Protoc Immunol . 2009..This unit describes a cDNA expression system and a genetic targeting expression system for the cloning of genes encoding for MHC class I- and II-restricted antigens recognized by antigen-specific CD8(+) and CD4(+) T cells... - Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cellsKui Shin Voo
The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 62:7195-9. 2002.... - Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cellsHelen Y Wang
Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 109:1463-70. 2002..These results suggest that a TAT-mediated antigen delivery system may have important clinical applications for cancer therapy... - Regulatory T cells and cancerHelen Y Wang
Center for Cell and Gene Therapy, Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Curr Opin Immunol 19:217-23. 2007.... - Identification of a mutated fibronectin as a tumor antigen recognized by CD4+ T cells: its role in extracellular matrix formation and tumor metastasisHelen Y Wang
The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Exp Med 195:1397-406. 2002.... - Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapyHelen Y Wang
ALKEK Building, N1120, Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
Microbes Infect 7:1056-62. 2005..This review discusses the natural ligands and their potential roles of tumor-specific CD4(+) regulatory T cells in cancer therapy... - Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancerYoshihiro Miyahara
Department of Pathology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:15505-10. 2008..These findings should accelerate efforts to define the function of this important subset of CD4(+) T cells in the human immune response to cancer... - NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathwaysJun Cui
Center for Cell and Gene Therapy, and Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 141:483-96. 2010..Our findings identify NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity... - CD4+ T-cell response to mitochondrial cytochrome B in human melanomaKui Shin Voo
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
Cancer Res 66:5919-26. 2006..These findings provide the first example of a mitochondrial immune target for CD4(+) T cells and therefore have implications for the immunosurveillance of mitochondrial aberrations in cancer patients... - Critical role of EBNA1-specific CD4+ T cells in the control of mouse Burkitt lymphoma in vivoTihui Fu
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Invest 114:542-50. 2004.... - Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulationKui Shin Voo
The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
Cancer Res 65:1577-86. 2005.... - Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytesKui Shin Voo
Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
J Exp Med 199:459-70. 2004.... - Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzymeSuzanne L Topalian
Surgery Branch, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892 1502, USA
Cancer Res 62:5505-9. 2002..Genetic aberrations such as the described point mutation can have unexpected immunological consequences, in this case leading to immune recognition of a distant normal self epitope... - Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine designGang Zeng
Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 62:3630-5. 2002..Dual-specific peptides containing both cytotoxic T-cell and helper T-cell epitopes may represent an attractive strategy of vaccine design aimed at generating tumor-reactive CD4+ and CD8+ T cells... - Microarray method to monitor 40 intestinal bacterial species in the study of azo dye reductionRong Fu Wang
Microbiology Division, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
Biosens Bioelectron 20:699-705. 2004..Results from this study showed 26-30 species are present in the cultured fecal samples. The representative bacteria were then examined for the azo dye reduction activity... - [Study of clinical value of dual-phase imaging using single photon emission computed tomography with coincidence detection for differentiating benign from malignant lesions]Rong Fu Wang
Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
Beijing Da Xue Xue Bao 37:287-91. 2005.... - [Prospect of hypoxia imaging of nuclear medicine in tumors]Gang Chen
Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
Beijing Da Xue Xue Bao 38:335-inside back cover. 2006..Presenting a noninvasive approach in detecting hypoxic state in tumors, hypoxia imaging of nuclear medicine can be used in the differential diagnosis, prognosis evaluation and guiding therapy of malignant tumors...