Jue D Wang

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies
    Anjana Srivatsan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 4:e1000139. 2008
  2. pmc Metabolism, cell growth and the bacterial cell cycle
    Jue D Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Rev Microbiol 7:822-7. 2009
  3. doi request reprint GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes
    Allison Kriel
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Bacteriol 196:189-201. 2014
  4. pmc Dose-dependent reduction of replication elongation rate by (p)ppGpp in Escherichia coli and Bacillus subtilis
    Jessica Denapoli
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Microbiol 88:93-104. 2013
  5. pmc Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance
    Allison Kriel
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 48:231-41. 2012
  6. pmc Co-orientation of replication and transcription preserves genome integrity
    Anjana Srivatsan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 6:e1000810. 2010
  7. pmc The transcription factor DksA prevents conflicts between DNA replication and transcription machinery
    Ashley K Tehranchi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 141:595-605. 2010
  8. doi request reprint Control of bacterial transcription, translation and replication by (p)ppGpp
    Anjana Srivatsan
    Department of Molecular and Human Genetics, One Baylor Plaza, Room S 911, Mail Stop 225, Baylor College of Medicine, Houston, TX 77030, United States
    Curr Opin Microbiol 11:100-5. 2008
  9. doi request reprint DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest
    Yan Zhang
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 53:766-78. 2014

Research Grants

  1. Control of elongation of DNA replication
    Jue Wang; Fiscal Year: 2009
  2. Control of elongation of DNA replication
    Jue D Wang; Fiscal Year: 2010

Collaborators

  • Yan Zhang
  • Benjamin P Tu
  • Anjana Srivatsan
  • Ashley K Tehranchi
  • Allison Kriel
  • Jessica Denapoli
  • Alycia N Bittner
  • Rui Chen
  • Jessica L Tse
  • Abraham L Sonenshein
  • Shaun R Brinsmade
  • Winnie Y Zou
  • Kuanqing Liu
  • Sok Ho Kim
  • Samantha Rendon
  • Jennifer A Halliday
  • Jia Peng
  • David M MacAlpine
  • Ashley Tehranchi
  • Matthew D Blankschien
  • Christophe Herman
  • Yi Han
  • Jianlan Peng
  • Richard Gibbs

Detail Information

Publications9

  1. pmc High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies
    Anjana Srivatsan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 4:e1000139. 2008
    ....
  2. pmc Metabolism, cell growth and the bacterial cell cycle
    Jue D Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Rev Microbiol 7:822-7. 2009
    ..In this Opinion article we summarize recent groundbreaking work in this area and discuss potential mechanisms by which nutrient availability and metabolic status are coordinated with cell growth, chromosome replication and cell division...
  3. doi request reprint GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes
    Allison Kriel
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Bacteriol 196:189-201. 2014
    ..This ability of (p)ppGpp to integrate a general stress response with a targeted reprogramming of gene regulation allows appropriate adaptation and is likely conserved among diverse bacteria. ..
  4. pmc Dose-dependent reduction of replication elongation rate by (p)ppGpp in Escherichia coli and Bacillus subtilis
    Jessica Denapoli
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Microbiol 88:93-104. 2013
    ..subtilis. This supports a model where replication elongation rates are regulated by (p)ppGpp to allow rapid and tunable response to multiple abrupt stresses in evolutionarily diverse bacteria...
  5. pmc Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance
    Allison Kriel
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 48:231-41. 2012
    ....
  6. pmc Co-orientation of replication and transcription preserves genome integrity
    Anjana Srivatsan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 6:e1000810. 2010
    ..Our results strongly suggest that preservation of genome integrity drives the evolution of co-orientation of replication and transcription, a conserved feature of genome organization...
  7. pmc The transcription factor DksA prevents conflicts between DNA replication and transcription machinery
    Ashley K Tehranchi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 141:595-605. 2010
    ..We conclude that transcription elongation factors alleviate fundamental conflicts between replication and transcription, thereby protecting replication fork progression and DNA integrity...
  8. doi request reprint Control of bacterial transcription, translation and replication by (p)ppGpp
    Anjana Srivatsan
    Department of Molecular and Human Genetics, One Baylor Plaza, Room S 911, Mail Stop 225, Baylor College of Medicine, Houston, TX 77030, United States
    Curr Opin Microbiol 11:100-5. 2008
    ..These studies highlight (p)ppGpp as a key factor in bacterial physiology that responds rapidly to diverse stresses, by shutting down growth and priming cellular defensive and adaptive processes...
  9. doi request reprint DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest
    Yan Zhang
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 53:766-78. 2014
    ..We propose that inactive ribosomes prevent formation of backtrack-blocking mRNA structures and that, in this circumstance, DksA acts as a transcription elongation factor in vivo...

Research Grants2

  1. Control of elongation of DNA replication
    Jue Wang; Fiscal Year: 2009
    ..Understand this pathway is also important for understanding microbial development of antibiotic resistance. ..
  2. Control of elongation of DNA replication
    Jue D Wang; Fiscal Year: 2010
    ..Understand this pathway is also important for understanding microbial development of antibiotic resistance. ..