Research Topics
Genomes and Genes
| Hong WangSummaryAffiliation: Baylor College of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitroYuan Lu Cui
Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, People's Republic of China
J Biomed Mater Res A 66:770-8. 2003..These results implied that gelatin used to modify the PLLA surface through entrapment and coupling could enhance chondrocyte adhesion, proliferation, and function...- Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growthXiao-ming Liu
Michael E. DeBakey VA Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
FASEB J 18:768-70. 2004..The capacity of vascular mitogens to induce LAT1 expression may represent a basic mechanism by which tho acid transport * apoptosis.. - PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cellsMing Zhi Zhang
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 101:2311-6. 2004..Reduced PKHD1 levels in pck rat kidneys and its colocalization with polycystins may underlie the pathogenic basis for cystogenesis in polycystic kidney diseases... - Human urotensin II modulates collagen synthesis and the expression of MMP-1 in human endothelial cellsHong Wang
Renhe Hospital, Shanghai, China
J Cardiovasc Pharmacol 44:577-81. 2004..01 versus hU-II alone). CONCLUSIONS: Our observations provide evidence that hU-II modulates the expression of MMP-1 and collagen-1 in HUVECs, and MAPKp42/44 activation may play a signal transduction role in this process... - Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbationHong Wang
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Blood 101:3901-7. 2003..These results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic and macrophage lipoprotein metabolism, in part, by enhancing uptake of modified LDL... - Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibitionHong Wang
Department of Medicine, Baylor College of Medicine, 2002 Holcombe Ave 109 129, Houston, TX 77030, USA
Blood 99:939-45. 2002..Taken together, these findings indicate that cyclin A is a critical functional target of Hcy-mediated EC growth inhibition... - Hyperhomocysteinemia inhibits post-injury reendothelialization in miceHongmei Tan
Department of Medicine, Baylor College of Medicine, USA
Cardiovasc Res 69:253-62. 2006..In this study, we established a mouse model of endothelial injury and reendothelialization and examined the role and mechanism of HHcy in endothelial repair... - Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearanceDan Liao
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Circ Res 99:598-606. 2006..These findings indicate that HHcy inhibits reverse cholesterol transport by reducing circulating HDL via inhibiting apoA-I protein synthesis and enhancing HDL-C clearance... - Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activationXiaohua Jiang
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Arterioscler Thromb Vasc Biol 25:2515-21. 2005..A risk factor for cardiovascular disease, hyperhomocystinemia (HHcy), is associated with endothelial dysfunction. In this study, we examined the mechanistic role of HHcy in endothelial dysfunction... - Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survivalXiao ming Liu
Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 280:872-7. 2005..The capacity of ER stress to stimulate the HO-1/CO system provides a novel mechanism by which this organelle regulates cell survival... - Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factorsYu Yang
Department of Medicine, Laboratory of Immunopathology, Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, U S A
Biochem J 392:135-43. 2005..These results demonstrate, for the first time, a novel molecular mechanism of T-cell apoptosis that contributes to the SARS-CoV-induced lymphopenia observed in most SARS patients... - Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondriaHong Wang
The Geriatric Research, Education and Clinical Center
J Lipid Res 52:2159-68. 2011..These results suggest that Plin5 regulates oxidative LD hydrolysis and controls local FA flux to protect mitochondria against excessive exposure to FA during physiological stress... - An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activityYu Yang
Department of Medicine, Laboratory of Immunopathology, Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 24:4778-88. 2005..In conclusion, this study has demonstrated that an N-terminal region of a cytosolic protein, TCTP, is required for its binding to Bcl-xL and for its antiapoptotic activity... - Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytesAyako Makino
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, USA
Am J Physiol Regul Integr Comp Physiol 300:R1296-302. 2011.... - Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17Wenjun Wang
Department of Medicine, Division of Hematology Oncology, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 2584, USA
Clin Cancer Res 14:8314-20. 2008..The effects of IFNalpha on STAT signaling in relation to tumor tissue Treg and Th17 have not been documented in humans beyond the observations that IFNalpha2b down-regulates STAT3... - Thyroid hormone receptor-? and vascular functionAyako Makino
Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Am J Physiol Cell Physiol 302:C1346-52. 2012..These data suggest that TR? in SMCs has prominent effects on regulation of vascular tone and TH treatment helps decrease coronary vascular tone by increasing K(+) channel activity through TR? in SMCs... - Single perivascular delivery of mitomycin C stimulates p21 expression and inhibits neointima formation in rat arteriesJuan F Granada
The Methodist Research Institute, Houston, Texas, USA
Arterioscler Thromb Vasc Biol 25:2343-8. 2005.... - Cyclic strain stimulates L-proline transport in vascular smooth muscle cellsSylvia V Reyna
Michael E. DeBakey VA Medical Center, Houston, Texas 77030, USA
Am J Hypertens 17:712-7. 2004.... - Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucoseYong Hu
Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 284:547-55. 2009.... - Insulin signaling stimulates insulin transport by bovine aortic endothelial cellsHong Wang
Department of Medicine, University of Virginia, Box 801410, Charlottesville, VA 22908, USA
Diabetes 57:540-7. 2008..Here, we addressed whether insulin signaling within the endothelial cell is required for the first step of transendothelial insulin transport: its uptake by the endothelial cell... - Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growthKelly J Peyton
Houston VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Blood 99:4443-8. 2002..The capacity of vascular mitogens to induce CO synthesis may provide a novel mechanism by which these agents modulate cell growth... - Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular diseaseDan Liao
Department of Surgery, Baylor College of Medicine, Houston, TX, USA
Clin Chem Lab Med 45:1652-9. 2007..These studies suggest that Hcy-induced HDL-C and apoA-I inhibition represent a novel mechanism by which Hcy induces atherosclerotic CVD... - ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytesHaibing Peng
Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Cell Physiol 215:562-73. 2008..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair... - Physiologic cyclic stretch inhibits apoptosis in vascular endotheliumXiao-ming Liu
VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
FEBS Lett 541:52-6. 2003..The ability of physiologic cyclic stretch to inhibit EC apoptosis may provide a previously unrecognized mechanism by which hemodynamic forces exert an anti-atherogenic effect... - Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated proteinHong Wang
Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 286:15707-15. 2011..Our studies establish perilipin 5 as a novel ATGL partner and provide evidence that the protein composition of perilipins at the LD surface regulates lipolytic activity of ATGL... - Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestrationZheng Sun
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Med 18:934-42. 2012.... - Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistanceMing Bell
Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Gerontology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, USA
Diabetes 57:2037-45. 2008..Our hypothesis is that PAT proteins modulate LD metabolism and therefore insulin resistance... - Oxidative tissue: perilipin 5 links storage with the furnaceHong Wang
The Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, and Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Trends Endocrinol Metab 22:197-203. 2011..This review examines the results of studies on one of the newest members of the perilipin family, perilipin 5, which has emerged as a putative key player in LD function in oxidative tissues... - Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculatureEugene J Barrett
Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 301:E252-63. 2011.... - Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemiaHuaizhu Wu
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Circulation 119:2708-17. 2009.... - Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophyAyako Makino
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0618, USA
Endocrinology 150:2008-15. 2009..These data suggest that TRbeta in the coronary ECs regulates capillary density during cardiac development, and down-regulation of TRbeta results in coronary microvascular rarefaction during pathological hypertrophy... - Adenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cellsXiao-ming Liu
Houston VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
Circulation 105:79-84. 2002..Adenovirus-mediated transfer of the HO-1 gene may provide a novel therapeutic approach in treating occlusive vascular disease... - STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: dose-response effects of systemic IFNalpha therapyWenjun Wang
Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2584, USA
J Invest Dermatol 128:1997-2002. 2008..pSTAT3 is a potential biomarker of melanocytic transformation and progression and is modulated by IFNalpha dose-dependently. STAT3 is a potential target for chemoprevention of melanoma... - Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine modelMichael R Milam
Department of Gynecologic Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Obstet Gynecol 196:247.e1-5. 2007..The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model... - ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammationCourtney Brown
Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
J Biol Chem 279:12794-803. 2004..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation... - Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nucleaseLaura A Christensen
Department of Carcinogenesis, Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX, USA
Nucleic Acids Res 36:7136-45. 2008..As mutagenesis by TFO-directed ICLs requires nucleotide excision repair, the efficient processing of these lesions supports the use of triplex technology to direct DNA damage for genome modification... - Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopesBernard Ng
Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA
J Allergy Clin Immunol 114:1463-70. 2004..Furthermore, the product of a transcript that does not undergo alternative splicing is unlikely to be a target antigen in autoimmunity... - Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemiaVictor Vitvitsky
Biochemistry Dept, Univ of Nebraska, Lincoln, NE 68588 0664, USA
Am J Physiol Regul Integr Comp Physiol 287:R39-46. 2004.... - Hyperhomocysteinemia, DNA methylation and vascular diseaseMd S Jamaluddin
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Clin Chem Lab Med 45:1660-6. 2007..We hypothesize that DNA hypomethylation is a key biochemical mechanism responsible for Hcy-induced cyclin A suppression and growth inhibition in EC and contributes to CVD... - Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndromeMichael Ogier
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 27:10912-7. 2007..These data demonstrate that BDNF expression remains plastic in Mecp2 null mice and raise the possibility that ampakine compounds could be of therapeutic value in the treatment of RTT... - Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylationZong Chun Yi
Department of Biological Engineering, Beijing University of Aeronautics and Astronautics, 37 Xueyuan Road, Beijing 100083, PR China
Oral Oncol 43:898-904. 2007..These results indicate the promoter methylation as an important role in inactivation of Cx43 in CNE-1 cells... - IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanismBeatriz Rendon-Mitchell
Center of Immunology and Inflammation, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
J Immunol 170:3890-7. 2003..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism... - Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repairMark P Marriott
Howard Florey Institute, The University of Melbourne, Victoria, Australia
Glia 56:686-98. 2008..Thus endogenous LIF receptor signaling is not only protective of oligodendrocytes but can also enhance remyelination, and exogenous LIF has therapeutic potential in limiting the consequences of oligodendrocyte damage... - Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survivalXiao ming Liu
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Cardiovasc Res 75:381-9. 2007..In the present study, we determined the signaling pathway responsible for the induction of HO-1 and its biological significance... - PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiationYaxu Wu
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
J Mol Cell Cardiol 44:47-58. 2008.... - Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A geneM D S Jamaluddin
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Blood 110:3648-55. 2007..In conclusion, Hcy inhibits cyclin A transcription and cell growth by inhibiting DNA methylation through suppression of DNMT1 in ECs... - Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of K(ATP) channelYuming Zhu
Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
Vascul Pharmacol 48:92-9. 2008..This study provides further evidence that iptakalim may serve as another candidate drug to treat pulmonary hypertension... - Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cellsXiaohua Jiang
Temple University School of Medicine, Department of Pharmacology, 3420 North Broad Street, Philadelphia, PA 19140, USA
Arterioscler Thromb Vasc Biol 27:1976-83. 2007..This study characterized and directly compared Hcy transport in cultured human aortic ECs (HAECs) and smooth muscle cells (HASMCs)... - Angiotensin II induces matrix metalloproteinase-9 expression via a nuclear factor-kappaB-dependent pathway in vascular smooth muscle cellsRui wei Guo
Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan, 650032, China
Regul Pept 147:37-44. 2008..In summary, this study demonstrates that AngII stimulates NF-kappaB nuclear translocation in VSMC via AT1 and AT2. AngII increases the expression of MMP-9 in VSMC, and AT1 and NF-kappaB pathways have an important role in this response... - Resistin, an adipocytokine, offers protection against acute myocardial infarctionJinping Gao
Cecile Cox Quillen Laboratory of Geriatrics, James H Quillen College of Medicine East Tennessee State University, and James H Quillen Veterans Affairs Medical Center, Johnson City, TN 37614, USA
J Mol Cell Cardiol 43:601-9. 2007..There were significantly fewer in situ oligo ligation-positive myocyte nuclei in mice treated with resistin. Our results show that resistin can dramatically reduce apoptosis and infarct size, thus protecting the heart against I/R injury... - Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1Chih Ching Lin
Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
Arterioscler Thromb Vasc Biol 28:739-45. 2008..In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation... - [Association of paraoxonase polymorphisms and serum homocysteine thiolactone complex with coronary heart disease]Qin Qin
Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin 300051, China
Zhonghua Xin Xue Guan Bing Za Zhi 34:803-7. 2006..005). CONCLUSIONS: The elevation of serum Hcy and the complex of HTL were associated with increased risk of coronary heart disease. The allele PON1/(-107)T and PON2/311S might be protective for the development of atherosclerosis... - [Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]Yu-jin Qu
Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, P. R. China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:680-2. 2006..2)The PTPS gene analysis is very important for all patients with hyperphenylalaninemia, which would be useful for early clinical diagnosis and correct treatment of BH4D patients... - Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric miceMichael W Epperly
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
In Vivo 20:573-82. 2006..The data show that the reduced in vitro and in vivo migratory capacity of Smad3-/- bone marrow stromal cells correlates with decreased radiation pulmonary fibrosis observed in mice chimeric for Smad3-/- marrow... - Distribution of variant genotypes of Fc gamma receptor IIIa in healthy Chinese population of Zhengzhou CityJun Wang
Department of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
J Huazhong Univ Sci Technolog Med Sci 23:239-41. 2003..3%, 48.9% and 8.8% respectively. The distribution of Fc gamma R IIIa-158 in healthy Chinese population of Zhengzhou city was polymorphic and different from that of African Americans (AA) and Caucasian Americans (CA)... - Temporal progression of gene expression responses to salt shock in maize rootsHong Wang
Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
Plant Mol Biol 52:873-91. 2003..Within this framework, 16 signaling molecules, including six protein kinases, two protein phosphatases and eight transcription factors, were regulated with distinct expression patterns by high salinity... - Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomasCharles T Miller
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Oncogene 22:7950-7. 2003..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers... - Neurokinin-1 receptor-expressing cells regulate depressor region of rat ventrolateral medullaHong Wang
Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 285:H2757-69. 2003.... - The effects of different donor cells and passages on development of reconstructed embryosLei Lei
State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China
Yi Chuan Xue Bao 30:215-20. 2003..We could conclude that culture and passage of donor cells might be benefit to nucleus reprogramming... - Structural basis for the proinflammatory cytokine activity of high mobility group box 1Jianhua Li
Laboratory of Biomedical Science, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
Mol Med 9:37-45. 2003..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics... - Thrombin signaling in the brain: the role of protease-activated receptorsHong Wang
, , Leipziger Strasse 44, D-39120 Magdeburg, Germany
Biol Chem 384:193-202. 2003.... - Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomasGuoan Chen
Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 2:107-16. 2003.... - The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytesHong Wang
Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Institut fur Neurobiochemie, Magdeburg, Germany
J Neurochem 84:1349-57. 2003..From these data we conclude that PAR-1 uses Ca2+- and PKC-dependent Pyk2 to activate Src, thereby leading to ERK1/2 activation, which predominantly recruits Grb2 in rat astrocytes... - Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathwaysHong Wang
Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, 39120 Magdeburg, Germany
Am J Physiol Cell Physiol 283:C1351-64. 2002..EGF receptor activation was detected by the receptor autophosphorylation site, tyrosine 1068. Our data suggest that thrombin-induced mitogenic action in astrocytes occurs independently of EGF receptor transphosphorylation... - Globin attenuates the innate immune response to endotoxinHuan Yang
Laboratory of Biomedical Science, North Shore University Hospital-New York University School of Medicine, New York 11030, USA
Shock 17:485-90. 2002..Thus, the heme-iron moiety of hemoglobin, and not the binding of LPS to globin, enhanced macrophage responses to LPS... - Control of petal and pollen development by the plant cyclin-dependent kinase inhibitor ICK1 in transgenic Brassica plantsYongming Zhou
Saskatoon Reseach Centre, 107 Science Place, Saskatoon, SK S7N 0X2, Canada
Planta 215:248-57. 2002..In those plants, the ability of pollen to germinate and pollen nuclear number were affected. These results are discussed in relation to the cell cycle and plant development... - Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonatesJohn M Sanders
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
J Med Chem 47:375-84. 2004.... - [Neuronal differentiation and TrkA expression of neuroblastoma induced by the combination treatment of interferon-gamma and NGF]Hong Wang
Department of Pediatrics, The Second Affiliated Hospital of China Medical University, Shenyang 110004, China
Zhonghua Er Ke Za Zhi 42:180-3. 2004..These data suggest that using IFN-gamma and NGF together may be an appropriate strategy in the treatment of children with advanced neuroblastoma... - Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery diseaseXi long Zhang
Department of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Chin Med J (Engl) 117:844-7. 2004..This research was carried out to investigate the effects of CPAP treatment on vascular endothelial function in patients with OSAHS and CHD... - [Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment]Yu Yuan Li
Department of Gastroenterology, First People s Hospital of Guangzhou, 510180, China
Zhonghua Nei Ke Za Zhi 45:552-5. 2006.... - Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null miceHong Wang
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
J Neurosci 26:10911-5. 2006..These findings are the first examples of abnormal neuropeptide and catecholamine secretion in a mouse model of RTT... - Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigensFan Yang
Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Medical Research Building, Suite 300, Philadelphia, PA 19140, USA
Clin Immunol 121:121-33. 2006.... - Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late lifeJoseph John Bianco
Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
Am J Pathol 168:1869-78. 2006..Finally, this study establishes the ArKO mouse model of estrogen deficiency as a unique approach to study the effects of estrogens, estrogenic factors, and endocrine disruptors on prostate development... - Phenylketonuria mutations in Northern ChinaFang Song
Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, PR China
Mol Genet Metab 86:S107-18. 2005..The study enables us to construct a national database in China serving as a valuable tool for genetic counseling and prognostic evaluation of future cases of PKU... - The relaxin gene knockout mouse: a model of progressive sclerodermaChrishan S Samuel
Relaxin Group, Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria, Australia
J Invest Dermatol 125:692-9. 2005.... - Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cellsGuolian Li
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P.O. Box 801410, Charlottesville, Virginia 22908-1410, USA
Endocrinology 146:4690-6. 2005.... - Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase CHelena Frecker
Institute of Medical Science, University Health Network, University of Toronto, ON, Canada M5S 1A8
Am J Physiol Renal Physiol 289:F1078-87. 2005..We conclude that reduced Ca(2+) signaling in HG cannot be explained by reduced Ca(2+) stores but is due to conventional PKC-dependent phosphorylation and inactivation of PLC-beta(3)... - Tanshinone: an inhibitor of proliferation of vascular smooth muscle cellsHong Wang
Research Center of Traditional Chinese Medicine, Tianjin College of Traditional Chinese Medicine, Tianjin 300193, PR China
J Ethnopharmacol 99:93-8. 2005..The data suggest that the anti-proliferative effect of Tan on VSMCs proliferation was associated with ERK1/2 signaling pathway... - Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cellsWeiping Xie
Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China
Eur J Pharmacol 511:81-7. 2005..These findings suggest that iptakalim might be a promising candidate for the treatment of pulmonary arterial remodeling in pulmonary hypertension... - Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase componentsYun Wu Zhang
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 280:17020-6. 2005.... - [Effects of iptakalim on the proliferation of cultured rabbit pulmonary arterial smooth muscle cells induced by endothelin-1]Wei-ping Xie
Department of Respiratory Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
Zhonghua Jie He He Hu Xi Za Zhi 27:752-5. 2004..01). Glibenclimide abolished the effect of iptakalim on [(3)H]-TdR incorporation. CONCLUSION: Iptakalim has an inhibitory effect on PASMC proliferation induced by ET-1 through activating ATP sensitive potassium (K(ATP)) channels... - Genetic polymorphisms analysis of glutathione S-transferase M1 and T1 in children with acute lymphoblastic leukemiaJun Wang
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 24:243-4. 2004..19% versus 49.32%, OR=1.621, P>0.05). It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL, while there as no correlation between GSTT1 null genotype and childhood ALL... - The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteinsChuan Ju Liu
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
Mol Cell Biol 22:2893-905. 2002....