Research Topics
Genomes and GenesSpecies | Kelly VolcikSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC studyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Ann Epidemiol 18:101-7. 2008..The influence of different types of alcoholic beverages on plasma lipid levels has been investigated to a lesser extent and in limited populations...- A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery diseaseThemistocles L Assimes
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
Atherosclerosis 198:136-44. 2008..We tested the hypothesis that exonic and/or promoter single nucleotide polymorphisms (SNPs) in the human 12/15-LOX gene (ALOX15) alter the risk of symptomatic coronary artery disease (CAD)... - Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC studyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, Texas, USA
Am J Hypertens 21:533-8. 2008.... 
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery diseaseThemistocles L Assimes
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
Hum Genet 123:399-408. 2008..However, additional studies are needed to exclude modest effects of promoter variation in ALOX5 on the risk of CAD assuming a recessive mode of inheritance...- Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities StudyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Am J Clin Nutr 87:1926-31. 2008..The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA... - Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CADJoshua W Knowles
Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
BMC Med Genet 9:23. 2008..We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study... - Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) studyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, United States
Atherosclerosis 195:e76-82. 2007..We also tested common haplotypes in the PSEL and PSGL-1 genes to assess associations with incident CHD and ischemic stroke... - SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI StudyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center School of Public Health, Houston, TX 77030, USA
Clin Chem 55:1076-82. 2009.... - MMP2 genetic variation is associated with measures of fibrous cap thickness: The Atherosclerosis Risk in Communities Carotid MRI StudyKelly A Volcik
University of Texas Health Science Center School of Public Health, Human Genetics Center, 1200 Hermann Pressler, Houston, TX 77030, United States
Atherosclerosis 210:188-93. 2010..We examined the association of MMP promoter variation with multiple plaque characteristics measured by gadolinium-enhanced MRI among 1700 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study... - Intercellular Adhesion Molecule-1 G241R Polymorphism Predicts Risk of Incident Ischemic Stroke: Atherosclerosis Risk in Communities StudyKelly A Volcik
Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr, Houston, TX 77030
Stroke 41:1038-40. 2010..05) and blacks (hazard rate ratio=7.04; 95% CI, 3.72 to 13.3; P<0.001). CONCLUSIONS: The intercellular adhesion molecule-1 241RR genotype is associated with an increased risk of incident ischemic stroke in both whites and blacks... - Interaction effects of high-density lipoprotein metabolism gene variation and alcohol consumption on coronary heart disease risk: the atherosclerosis risk in communities studyKelly Volcik
University of Texas Health Science Center, School of Public Health, Human Genetics Center, 1200 Hermann Pressler, Houston, Texas 77030, USA
J Stud Alcohol Drugs 68:485-92. 2007..Genes of interest included cholesterol ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (HL), and paraoxonase-1 (PON1)... - Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities studyJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, P O Box 20334, Houston, TX 77225 0334, USA
Am J Epidemiol 171:14-23. 2010..This study demonstrates that genetic variants revealed in a case-control genome-wide association study enriched for early disease onset may play a role in the genetic etiology of CHD in the general population... - P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities StudyKelly A Volcik
Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr, Houston, TX 77030, USA
Atherosclerosis 186:74-9. 2006.... - Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participantsKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Am J Epidemiol 164:342-8. 2006..The ApoE epsilon2 and epsilon4 alleles were associated with carotid IMT measures in both racial groups, but, after adjusting for lipid parameters, only the epsilon4 allele was associated with carotid IMT measures in African Americans... - Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities StudyShun Kohsaka
Texas Heart Institute, Baylor College of Medicine, Houston, TX, United States
Atherosclerosis 196:926-30. 2008..The present study explored whether the COX-2 G-765C polymorphism contributes to increased incidence of coronary heart disease (CHD) or stroke in the large prospective Atherosclerosis Risk in Communities (ARIC) Study... - Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) studyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Coll Cardiol 55:1600-7. 2010..We evaluated whether carotid intima-media thickness (CIMT) and the presence or absence of plaque improved coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF)... - Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities studyJennifer A Nettleton
Division of Epidemiology and Disease Control, University of Texas Health Science Center, Houston, TX 77030, USA
Ann Epidemiol 18:842-6. 2008.... - Carbohydrate intake modifies associations between ANGPTL4[E40K] genotype and HDL-cholesterol concentrations in White men from the Atherosclerosis Risk in Communities (ARIC) studyJennifer A Nettleton
Division of Epidemiology and Disease Control, University of Texas Health Science Center, Houston 1200 Herman Pressler Dr, Houston, TX 77030, United States
Atherosclerosis 203:214-20. 2009..Common allelic variation in the angiopoietin-like 4 gene (ANGPTL4[E40K]) has been associated with low triglyceride (TG) and high HDL-C... - Apolipoprotein E and apolipoprotein B genotypes and risk for spina bifidaKelly A Volcik
Institute of BioScience and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
Teratology 66:257-9. 2002..The purpose of our study was to explore the possible association between infant genetic variations in the apoE and apoB genes and spina bifida (SB) risk... - Genetic variation in the proto-oncogene SKI and risk for orofacial cleftingWei Lu
Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
Mol Genet Metab 86:412-6. 2005..To identify genetic variants within the SKI gene and investigate the potential association between SKI polymorphisms and risk for orofacial defects, we initially re-sequenced the gene... - Associations between polymorphisms within the thymidylate synthase gene and spina bifidaKelly A Volcik
Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
Birth Defects Res A Clin Mol Teratol 67:924-8. 2003..We investigated whether TS polymorphisms contribute to spina bifida (SB) risk, given that a reduction in the risk of SB has been linked to folate metabolism... - Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifidaKelly A Volcik
Institute of BioScience and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
Birth Defects Res A Clin Mol Teratol 67:158-61. 2003.... - Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defectsKelly A Volcik
Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 0330, USA
Birth Defects Res A Clin Mol Teratol 67:154-7. 2003..It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme... - Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities studyTamra E Meyer
Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 19:558-65. 2010..02; blacks only). The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR, 0.79; 95% CI, 0.65-0.97). Further knowledge of T2D gene-PrCa mechanisms may improve understanding of PrCa etiology... - Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?Richard H Finnell
Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
Genet Test 6:47-52. 2002.... - Evaluation of the Cited2 gene and risk for spina bifida and congenital heart defectsKelly A Volcik
Am J Med Genet A 126:324-5. 2004 - Evaluation of the jumonji gene and risk for spina bifida and congenital heart defectsKelly A Volcik
Am J Med Genet A 126:215-7. 2004
Research Grants
- Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVDKelly Volcik; Fiscal Year: 2007....