Research Topics
| Regis A VilchezSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Detection of polyomavirus simian virus 40 tumor antigen DNA in AIDS-related systemic non-Hodgkin lymphomaRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Acquir Immune Defic Syndr 29:109-16. 2002..None of the S-NHL samples were positive for both Epstein-Barr virus DNA and SV40 DNA. Further studies of the possible role of SV40 in the pathogenesis of S-NHL are warranted...
Conventional epidemiology and the link between SV40 and human cancersRegis A Vilchez
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Lancet Oncol 4:188-91. 2003..In this essay, we consider the unique features of SV40 infection in humans and examine the limitations of conventional studies that seek to disprove the aetiological link with human cancer...
Simian virus 40 in human cancersRegis A Vilchez
Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, BCM 286, Room N1319, One Baylor Plaza, Houston, TX 77030, USA
Am J Med 114:675-84. 2003..However, the small samples and lack of control groups in some reports have made it difficult to assess their reliability...
Standardized detection of SV40 by real time quantitative polymerase chain reactionRegis A Vilchez
Department of Medicine, Baylor Center for AIDS Research, Baylor College of Medicine, USA
Haematologica 90:6. 2005
Association between simian virus 40 and non-Hodgkin lymphomaRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Lancet 359:817-23. 2002..We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma...
AIDS-related systemic non-Hodgkin's lymphoma at a large community programRegis A Vilchez
Department of Medicine, Baylor Center for AIDS Research, Baylor College of Medicine, Houston, Texas 77030, USA
AIDS Res Hum Retroviruses 18:237-42. 2002..In addition, this opportunistic malignancy is associated with significant mortality. Therefore, it is necessary to develop a better understanding of the pathogenesis of this disease...
The clinical epidemiology of Hodgkin lymphoma in HIV-infected patients in the highly active antiretroviral therapy (HAART) eraRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Medicine (Baltimore) 82:77-81. 2003..These results suggest that Hodgkin lymphoma has a low incidence in HIV-infected patients receiving HAART, but the malignancy is an aggressive disease with unfavorable clinical outcome in these patients...
Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamstersNiraj C Patel
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM385, Houston, TX 77030 3411, USA
Virology 386:94-101. 2009..These results indicate that SV40 replicates in hamsters, vertical transmission of SV40 can occur, and the viral regulatory region influences transmission...
Simian virus 40 tumor antigen expression and immunophenotypic profile of AIDS-related non-Hodgkin's lymphomaRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Virology 342:38-46. 2005..2/12, 17%; P = 0.05). This study shows that SV40 gene expression occurs in a fraction of cells in some B-cell lymphomas among patients with HIV/AIDS...
Detection of polyomavirus SV40 in tonsils from immunocompetent childrenNiraj C Patel
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, United States
J Clin Virol 43:66-72. 2008..BK and JC viruses establish persistent infections in humans, and evidence suggests that SV40 can infect humans, as well. Whether persistence occurs in the lymphoid system is unknown...
Polyomavirus infection and its impact on renal function and long-term outcomes after lung transplantationLora D Thomas
Department of Medicine, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, USA
Transplantation 88:360-6. 2009..Polyomavirus infection causes nephropathy after kidney transplantation but has not been thoroughly investigated in nonrenal organ transplantation...
SV40 lymphomagenesis in Syrian golden hamstersAdrienne L McNees
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Virology 384:114-24. 2009....
Association between SV40 and non-Hodgkin's lymphomaJanet S Butel
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM385, One Baylor Plaza, Houston, TX 77030, USA
Leuk Lymphoma 44:S33-9. 2003..We conclude that SV40 is significantly associated with some types of NHL and that lymphomas should be added to the types of human cancers associated with SV40...
A prospective longitudinal study of polyomavirus shedding in lung-transplant recipientsLora D Thomas
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Infect Dis 195:442-9. 2007..Polyomavirus infection causes renal dysfunction after kidney transplantation, but it has not been thoroughly investigated in nonrenal solid-organ transplantation...
Polyomavirus SV40 infections in KazakhstanZhannat Z Nurgalieva
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Infect 50:142-8. 2005..As increasing evidence indicates an association of SV40 with selected types of human malignancies, prospective studies are needed to examine the risk of SV40 infection with the development of neoplasias...
Specific and quantitative detection of human polyomaviruses BKV, JCV, and SV40 by real time PCRAdrienne L McNees
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM-385, Houston, TX 77030, USA
J Clin Virol 34:52-62. 2005..CONCLUSION: These assays provide a technique for rapid and specific quantification of polyomavirus genomes per cell in human samples...
Molecular and clinical perspectives of polyomaviruses: emerging evidence of importance in non-kidney transplant populationsRegis A Vilchez
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
Liver Transpl 12:1457-63. 2006....
Influence of the viral regulatory region on tumor induction by simian virus 40 in hamstersVojtech Sroller
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM385, One Baylor Plaza, Houston, TX 77030, USA
J Virol 82:871-9. 2008..This study shows that SV40 strains differ in their biological properties, suggests that SV40 replicates to some level in hamsters, and indicates that the outcome of an SV40 infection may depend on the viral strain present...
Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipientAaron Milstone
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Transplantation 77:1019-24. 2004..No serum or tissue samples were available from his 27-year-old donor. DISCUSSION: This report shows that SV40 is circulating in the community and can cause nephropathy in transplant patients...
Simian virus 40 in posttransplant lymphoproliferative disordersRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Hum Pathol 37:1130-6. 2006..These results suggest that SV40 may be associated with a small subset of PTLD cases. Additional studies are needed to determine the role of SV40 in EBV-negative PTLD...
Emergent human pathogen simian virus 40 and its role in cancerRegis A Vilchez
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Mail Stop BCM-385, One Baylor Plaza, Houston, TX 77030, USA
Clin Microbiol Rev 17:495-508, table of contents. 2004..quot; This review analyzes the accumulating data that indicate that SV40 is a pathogen which has a possible etiologic role in human malignancies. Future research directions are considered...
SV40 in human brain cancers and non-Hodgkin's lymphomaRegis A Vilchez
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Oncogene 22:5164-72. 2003....
Polyomavirus SV40 and AIDS-related systemic non-Hodgkin's lymphomaRegis A Vilchez
Department of Molecular Virology and Microbiology and Baylor-UTHouston Center for AIDS Research, Baylor College of Medicine, Houston, TX, USA
Cancer Treat Res 133:215-40. 2007
Polyomavirus JC urinary shedding in kidney and liver transplant recipients associated with reduced creatinine clearanceShimon Kusne
Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA
J Infect Dis 206:875-80. 2012..Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients...
Differential ability of two simian virus 40 strains to induce malignancies in weanling hamstersRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Virology 330:168-77. 2004....
Parainfluenza virus infection in adult lung transplant recipients: an emergent clinical syndrome with implications on allograft functionRegis A Vilchez
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Transplant 3:116-20. 2003..In addition, controlled studies are needed to evaluate the efficacy of aerosolized ribavarin in the treatment of parainfluenza virus infection and to determine whether vaccines may be effective in these high-risk patients...
Simian virus 40 and its association with human lymphomasRegis A Vilchez
Department of Medicine, Baylor College of Medicine, Mail Stop BCM-385, One Baylor Plaza, Houston, TX 77030, USA
Curr Oncol Rep 5:372-9. 2003..This review examines the data implicating SV40 in the pathogenesis of human lymphomas and discusses future directions to define the causative role for SV40 in these malignancies...
Pathogenesis and management of polyomavirus infection in transplant recipientsEun Jeong Kwak
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 35:1081-7. 2002..Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed...
Viruses from nonhuman primatesRegis A Vilchez
Emerg Infect Dis 12:1802-3; author reply 1803. 2006
Limitations of epidemiological and serologic studies addressing simian virus 40 and non-Hodgkin's lymphomaRegis A Vilchez
Cancer Invest 24:333-6. 2006
Polyomaviruses in solid-organ transplant recipientsRegis A Vilchez
Transplantation 74:579-80; author reply 580-1. 2002
Lymphoproliferative disorders in Costa Rica and simian virus 40Armando Meneses
Department of Pathology, Hospital San Juan de Dios, San Jose, Costa Rica
Haematologica 90:1635-42. 2005..Of note, 20% of patients with SV40-related lymphomas were born in the 1970s and 1980s. INTERPRETATION AND CONCLUSIONS. These results indicate that SV40 is significantly associated with some B-cell neoplasms in Costa Rica today...
Re: Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40Regis A Vilchez
J Natl Cancer Inst 95:1249; author reply 1250. 2003
Polyomavirus JCV excretion and genotype analysis in HIV-infected patients receiving highly active antiretroviral therapyJohn A Lednicky
Baylor Coll Med, Houston, TX
AIDS 17:801-7. 2003..As the common types of JCV excreted varied among ethnic groups, JCV genotypes associated with progressive multifocal leukoencephalopathy may reflect demographics of those infected patient populations...
The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal studyPaul D Ling
Baylor Coll Med, Houston, TX
J Infect Dis 187:1571-80. 2003..50). Thus, adults independently control persistent viruses, which display discordant, sporadic reactivations...
Re: Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccinesRegis A Vilchez
J Natl Cancer Inst 95:687; author reply 689. 2003
Systemic non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapyRegis A Vilchez
Blood 99:4250-1. 2002
Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapyPaul D Ling
Baylor Coll Med, Houston, TX
Clin Infect Dis 37:1244-9. 2003..Additional studies are needed to determine whether EBV-specific CD4+ and CD8+ cells play a role in the pathogenesis of EBV in HIV-1-infected patients receiving HAART...
Re: Lack of serologic evidence for prevalent simian virus 40 infection in humansRegis A Vilchez
J Natl Cancer Inst 96:633; author reply 633-4. 2004
Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profilesFrancisco Vega
Department of Pathology, Baylor College of Medicine [corrected] Houston, TX [corrected] USA
Mod Pathol 18:806-15. 2005..These results do not support the suggestion in the WHO classification that plasmablastic lymphoma is a variant of diffuse large B-cell lymphoma...
Polyomavirus SV40 infection and lymphomas in SpainRegis A Vilchez
Int J Cancer 107:505-6; author reply 507-8. 2003
An overview of the biology and viral pathogenesis of lymphoproliferative disorders in HIV-infected patientsRegis A Vilchez
Res Initiat Treat Action 9:14-8. 2003
Polyomaviruses in kidney transplant recipientsRegis A Vilchez
Am J Transplant 2:481. 2002
Simian virus 40 infection in lymphoproliferative disordersRegis A Vilchez
Lancet 361:1565; author reply 1565-6. 2003
