Francesco Vetrini

Summary

Affiliation: Baylor College of Medicine
Location: Houston, USA
Publications:
1.TFEB links autophagy to lysosomal biogenesis.

Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A.

Science. 2011 Jun 17;332(6036):1429-33. Epub 2011 May 26.

PMID: [PubMed - in process]
Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives
Francesco Vetrini and Philip Ng *
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston , TX, USA
* Author to whom correspondence should be addressed.
Received: 21 June 2010; in revised form: 26 August 2010 / Accepted: 30 August 2010 / Published: 3 September 2010
(This article belongs to the Special Issue Adenoviral Vectors)

Related citations

2.Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer.

Khare R, May SM, Vetrini F, Weaver EA, Palmer D, Rosewell A, Grove N, Ng P, Barry MA.

Mol Ther. 2011 Apr 19. [Epub ahead of print]

PMID: [PubMed - as supplied by publisher]
Related citations

3.Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells.

Prill JM, Espenlaub S, Samen U, Engler T, Schmidt E, Vetrini F, Rosewell A, Grove N, Palmer D, Ng P, Kochanek S, Kreppel F.

Mol Ther. 2011 Jan;19(1):83-92. Epub 2010 Oct 19.

PMID: [PubMed - indexed for MEDLINE]
Related citations

4.Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad.

Vetrini F, Brunetti-Pierri N, Palmer DJ, Bertin T, Grove NC, Finegold MJ, Ng P.

Mol Ther. 2010 Jul;18(7):1339-45. Epub 2010 May 11.

PMID: [PubMed - indexed for MEDLINE]
Related citations

5.Fibroblast growth factor and epidermal growth factor differently affect differentiation of murine retinal stem cells in vitro.

Giordano F, De Marzo A, Vetrini F, Marigo V.

Mol Vis. 2007 Oct 2;13:1842-50.

PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations

6.Aberrant splicing in the ocular albinism type 1 gene (OA1/GPR143) is corrected in vitro by morpholino antisense oligonucleotides.

Vetrini F, Tammaro R, Bondanza S, Surace EM, Auricchio A, De Luca M, Ballabio A, Marigo V.

Hum Mutat. 2006 May;27(5):420-6.

PMID: [PubMed - indexed for MEDLINE]
Related citations

7.The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis.

Vetrini F, Auricchio A, Du J, Angeletti B, Fisher DE, Ballabio A, Marigo V.

Mol Cell Biol. 2004 Aug;24(15):6550-9.

PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations

Publications

  1. pmc The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 24:6550-9. 2004
  2. ncbi request reprint Aberrant splicing in the ocular albinism type 1 gene (OA1/GPR143) is corrected in vitro by morpholino antisense oligonucleotides
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Hum Mutat 27:420-6. 2006
  3. ncbi request reprint Fibroblast growth factor and epidermal growth factor differently affect differentiation of murine retinal stem cells in vitro
    Francesca Giordano
    Telethon Institute of Genetics and Medicine, Naples, Italy
    Mol Vis 13:1842-50. 2007
  4. pmc Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad
    Francesco Vetrini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 18:1339-45. 2010
  5. pmc Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells
    Jan Michael Prill
    Department of Gene Therapy, University of Ulm, Ulm, Germany
    Mol Ther 19:83-92. 2011
  6. pmc Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer
    Reeti Khare
    Virology and Gene Therapy Program, Mayo Graduate School, Rochester, Minnesota, USA
    Mol Ther 19:1254-62. 2011
  7. pmc TFEB links autophagy to lysosomal biogenesis
    Carmine Settembre
    Telethon Institute of Genetics and Medicine TIGEM, Via Pietro Castellino 111, 80131 Naples, Italy
    Science 332:1429-33. 2011
  8. pmc Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives
    Francesco Vetrini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA E mail
    Viruses 2:1886-917. 2010

Collaborators

Detail Information

Publications8

  1. pmc The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 24:6550-9. 2004
    ..The results obtained with this viral system are a preamble to the development of new gene delivery approaches for the treatment of retinal pigment epithelium defects...
  2. ncbi request reprint Aberrant splicing in the ocular albinism type 1 gene (OA1/GPR143) is corrected in vitro by morpholino antisense oligonucleotides
    Francesco Vetrini
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Hum Mutat 27:420-6. 2006
    ..The use of MO demonstrated that the lack of OA1 was caused by the generation of a new splice site. Furthermore, this technique will lead to new approaches to correct splice site mutations that cause human diseases...
  3. ncbi request reprint Fibroblast growth factor and epidermal growth factor differently affect differentiation of murine retinal stem cells in vitro
    Francesca Giordano
    Telethon Institute of Genetics and Medicine, Naples, Italy
    Mol Vis 13:1842-50. 2007
    ..Similarly, RSC in culture may exhibit alternative molecular characteristics in response to different GF stimuli...
  4. pmc Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad
    Francesco Vetrini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 18:1339-45. 2010
    ..These results suggest that VIP can improve the therapeutic index of HDAd by increasing hepatocyte transduction efficiency while reducing cytokine and chemokine expression following intravascular delivery of HDAd...
  5. pmc Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells
    Jan Michael Prill
    Department of Gene Therapy, University of Ulm, Ulm, Germany
    Mol Ther 19:83-92. 2011
    ..Our approach may lead to a detailed understanding of the interactions between adenovirus vectors and Kupffer cells, one of the most important barriers for adenovirus-mediated gene delivery...
  6. pmc Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer
    Reeti Khare
    Virology and Gene Therapy Program, Mayo Graduate School, Rochester, Minnesota, USA
    Mol Ther 19:1254-62. 2011
    ..These data suggest that the Ad5/6 hexon-chimera evades Kupffer cells and may have utility for systemic and liver-directed therapies...
  7. pmc TFEB links autophagy to lysosomal biogenesis
    Carmine Settembre
    Telethon Institute of Genetics and Medicine TIGEM, Via Pietro Castellino 111, 80131 Naples, Italy
    Science 332:1429-33. 2011
    ..Thus, a mitogen-activated protein kinase-dependent mechanism regulates autophagy by controlling the biogenesis and partnership of two distinct cellular organelles...
  8. pmc Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives
    Francesco Vetrini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA E mail
    Viruses 2:1886-917. 2010
    ..This review summarizes the many aspects of HDAd biology and structure with a major focus on in vivo gene therapy application and with an emphasis on the unsolved issues that these vectors still presents toward clinical application...