Benigno Valdez

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Cloning and characterization of Gu/RH-II binding protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 234:335-40. 1997
  2. ncbi Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family
    L Zhu
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Mol Biol Int 42:927-35. 1997
  3. ncbi RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two activities in separate domains of the same protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 250:800-7. 1997
  4. ncbi Green fluorescent protein tag for studies of drug-induced translocation of nucleolar protein RH-II/Gu
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biotechniques 24:1032-6. 1998
  5. ncbi Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Genomics 66:184-94. 2000
  6. ncbi Structural domains involved in the RNA folding activity of RNA helicase II/Gu protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, USA
    Eur J Biochem 267:6395-402. 2000
  7. ncbi The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:10709-14. 2004
  8. ncbi Expression, cellular localization, and enzymatic activities of RNA helicase II/Gu(beta)
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Exp Cell Res 276:249-63. 2002
  9. ncbi The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation
    Bianca Gonzales
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:2035-43. 2005
  10. ncbi Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4
    Hushan Yang
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS J 272:3788-802. 2005

Research Grants

  1. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003

Collaborators

  • W Wang
  • A Battistini
  • Dale Henning
  • Bianca Gonzales
  • Hushan Yang
  • Rolando B So
  • Jukka Westermarck
  • Tim H Holmström
  • Jill Dixon
  • Michael J Dixon
  • Runyan Jin
  • Eliana M Coccia
  • Marko Kallio
  • Leni Mannermaa
  • Henrik Johansson
  • Tiina A Salminen
  • David Gillespie
  • Tina Holm
  • Elizabeth Black
  • Yvonne Nymalm
  • Antoine Mialon
  • Ulo Langel
  • L Zhu
  • Juhua Zhou
  • Lester F Lau
  • Robert L Ochs
  • Anna-Maria Musti
  • Bertrand Seraphin
  • Roberto Orsatti
  • Anna Maria Musti
  • Matthias Wessely
  • Rainer Saffrich
  • Dirk Bohmann
  • Giovanna Marziali
  • Emilia Stellacci
  • Elena Giacomini
  • Wilhelm Ansorge
  • Jürgen Kast
  • Matthias Wilm
  • Eleonora Benedetti
  • Carsten Weiss
  • L Perlaky
  • D Henning

Detail Information

Publications20

  1. ncbi Cloning and characterization of Gu/RH-II binding protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 234:335-40. 1997
    ..The GBP mRNA level is highest in testis, 9- to 49-fold greater than other tissues. When GBP interacts with Gu/RH-II, proteolytic cleavage of Gu/RH-II occurs; the amino-terminal portion of Gu/RH-II is critical for this proteolysis...
  2. ncbi Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family
    L Zhu
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Mol Biol Int 42:927-35. 1997
    ..Its interaction with RNA polymerase I suggests that SSP29 may participate in signal transduction that directs nucleolar activities by regulating ribosomal RNA biosynthesis...
  3. ncbi RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two activities in separate domains of the same protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 250:800-7. 1997
    ..Amino acids 646-801 fold single-stranded RNA but lack helicase activity. This report shows distinct RNA-unwinding and RNA-folding activities residing in separate domains within the same protein...
  4. ncbi Green fluorescent protein tag for studies of drug-induced translocation of nucleolar protein RH-II/Gu
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biotechniques 24:1032-6. 1998
    ..Real-time results are obtained more quickly without the disadvantages associated with cell fixation and immunofluorescence-based staining...
  5. ncbi Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Genomics 66:184-94. 2000
    ..Both mouse and human RH II/Gu genes are localized on chromosome 10. The availability of the mouse RH II/Gu gene will facilitate its functional analysis including creation of a mouse deficient in RH II/Gu protein...
  6. ncbi Structural domains involved in the RNA folding activity of RNA helicase II/Gu protein
    B C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, USA
    Eur J Biochem 267:6395-402. 2000
    ..The last 17 amino acids of RH II/Gu can be replaced by an RNA binding motif from nucleolar protein p120 without a deleterious effect on its foldase activity. A model is proposed to explain how RH II/Gu binds and folds an RNA substrate...
  7. ncbi The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:10709-14. 2004
    ..The elucidation of a physiological function of treacle provides important information of relevance to the molecular dissection of the biochemical pathology of TCS...
  8. ncbi Expression, cellular localization, and enzymatic activities of RNA helicase II/Gu(beta)
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Exp Cell Res 276:249-63. 2002
    ..Instead, the presence of RH-II/Gu(beta) stimulates RH-II/Gu(alpha) unwinding activity. Our data suggest distinct and complex regulation of expression of the two paralogues with nonredundant gene products...
  9. ncbi The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation
    Bianca Gonzales
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:2035-43. 2005
    ....
  10. ncbi Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4
    Hushan Yang
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS J 272:3788-802. 2005
    ..These observations have suggested that the function of Gu(alpha) in rRNA processing is at least partially dependent on its ability to interact with RPL4...
  11. ncbi Cloning and functional characterization of the Xenopus orthologue of the Treacher Collins syndrome (TCOF1) gene product
    Bianca Gonzales
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA
    Gene 359:73-80. 2005
    ..laevis oocytes resulted in inhibition of rDNA gene transcription. The results suggest evolutionary conservation of the function of treacle in ribosomal RNA biogenesis in higher eukaryotes...
  12. ncbi c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21
    Tim H Holmström
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    J Biol Chem 283:7046-53. 2008
    ..Moreover, these results suggest that the phenotypes observed previously in c-Jun-depleted mouse models and cell lines could be partly due to the effects of c-Jun on rRNA processing...
  13. ncbi Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons
    Rolando B So
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Gene 328:49-57. 2004
    ..The discovery of exons 6A and 16A is relevant to mutational analysis of the TCOF1 gene in TCS patients, and to functional analysis of its gene product...
  14. ncbi Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production
    Dale Henning
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:52307-14. 2003
    ..Both down-regulation of RH-II/Gualpha and overexpression of RH-II/Gubeta slowed cell proliferation. The opposite effects of the two paralogues suggest antagonistic functions...
  15. ncbi Down-regulation of RNA helicase II/Gu results in the depletion of 18 and 28 S rRNAs in Xenopus oocyte
    Hushan Yang
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:38847-59. 2003
    ..Our results show that xGu is involved in the processing of 20 to 18 S rRNA and contributes to the stability of 28 S rRNA in Xenopus oocytes...
  16. ncbi Drug-induced translocation of nucleolar proteins fused to green fluorescent protein
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 183:151-61. 2002
  17. ncbi Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Gene 284:53-61. 2002
    ..No alternative splicing was identified for RH-II/Gualpha. Overall, the results suggest that the two paralogues of RH-II/Gu arose by gene duplication but the resulting genes are differentially regulated...
  18. ncbi The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription
    Jukka Westermarck
    EMBL, D 69117 Heidelberg, Germany
    EMBO J 21:451-60. 2002
    ..These findings clarify the mechanism of c-Jun-mediated transcriptional regulation, and provide evidence for an involvement of RHII/Gu in stress response and in RNA polymerase II-catalyzed transcription in mammalian cells...
  19. ncbi Protein inhibitor of activated signal transducer and activator of transcription (STAT)-1 (PIAS-1) regulates the IFN-gamma response in macrophage cell lines
    Eliana M Coccia
    Laboratory of Immunology, Viale Regina Elena 299, 00161 Rome, Italy
    Cell Signal 14:537-45. 2002
    ..D1. Thus, our results indicate that PIAS-1 may account for the differential IFN-gamma responsiveness in macrophage cell lines at different stages of maturation...
  20. ncbi Altered gene expression in busulfan-resistant human myeloid leukemia
    Benigno C Valdez
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States
    Leuk Res 32:1684-97. 2008
    ....

Research Grants5

  1. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003
    ..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..