Research Topics
| Jon TysonSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Variations in mortality rates among Canadian neonatal intensive care units: interpretation and implicationsJon Tyson
Center for Clinical Research and Evidence-Based Medicine, University of Texas, Houston Medical School, 77030, USA
CMAJ 166:191-2. 2002
Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns?J E Tyson
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
J Perinatol 32:677-84. 2012..We assessed whether the benefits and hazards for the smallest and sickest infants differed from those for other extremely low-birth-weight (ELBW; ≤ 1000 g) infants in our Neonatal Research Network trial, the only large trial of AgPT...- Intensive care for extreme prematurity--moving beyond gestational ageJon E Tyson
Center for Clinical Research and Evidence Based Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
N Engl J Med 358:1672-81. 2008..Decisions regarding whether to administer intensive care to extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients... - Dilemmas initiating enteral feedings in high risk infants: how can they be resolved?Jon E Tyson
The University of Texas Medical School at Houston, Houston, TX 77030, USA
Semin Perinatol 31:61-73. 2007.... - Effects of prophylactic indomethacin in extremely low-birth-weight infants with and without adequate exposure to antenatal corticosteroidsBarbara Schmidt
Department of Pediatrics, Hospital of the University of Pennsylvania, Ravdin 8, 3400 Spruce St, Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 165:642-6. 2011..To examine whether treatment with antenatal corticosteroids modifies the immediate and long-term effects of prophylactic indomethacin sodium trihydrate in extremely low-birth-weight infants... - Association of physical activity with mortality in the US dialysis populationAustin G Stack
Regional Kidney Center, Department of Internal Medicine, Letterkenny General Hospital, North Western Health Board, Letterkenny, Ireland
Am J Kidney Dis 45:690-701. 2005..It is unclear whether the protective benefits of regular physical activity on mortality extend to patients with end-stage renal disease (ESRD). We tested this hypothesis in a national cohort of new patients with ESRD in the United States... - Postnatal dexamethasone therapy and cerebral tissue volumes in extremely low birth weight infantsNehal A Parikh
Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA
Pediatrics 119:265-72. 2007..Our goal was to relate postnatal dexamethasone therapy in extremely low birth weight infants (birth weight of < or = 1000 g) to their total and regional brain volumes, as measured by volumetric MRI performed at term-equivalent age... - Clinical research methodology I: introduction to randomized trialsLillian S Kao
Department of Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA
J Am Coll Surg 206:361-9. 2008 - Altered fecal microflora and increased fecal calprotectin in infants with colicJ Marc Rhoads
Department of Pediatrics, University of Texas Health Sciences Center at Houston School of Medicine, Houston, TX 77030, USA
J Pediatr 155:823-828.e1. 2009..We explored whether gut inflammation, colonic fermentation, and/or an altered colonic flora could provide a pathophysiological mechanism for colic... - Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurityHelen A Mintz-Hittner
Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, USA
N Engl J Med 364:603-15. 2011..Case series in which patients were treated with vascular endothelial growth factor inhibitors suggest that these agents may be useful in treating retinopathy of prematurity... - Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence?Namasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, 619 South 20th Street, Birmingham, AL 35249, USA
J Pediatr 145:304-7. 2004.... - Aggressive vs. conservative phototherapy for infants with extremely low birth weightBrenda H Morris
University of Texas Medical School, Houston, TX 77030, USA
N Engl J Med 359:1885-96. 2008..It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less)... - Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomesAbbot Laptook
Department of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, Providence, RI 02906, USA
Pediatrics 122:491-9. 2008.... - Evidence-based ethics and the care and outcome of extremely premature infantsJon E Tyson
Center for Clinical Research and Evidence-Based Medicine, The University of Texas-Houston Medical School, 6431 Fannin Street, MSB 2.106, Houston, TX 77030, USA
Clin Perinatol 30:363-87. 2003.... - Car seat or car bed for very low birth weight infants at discharge homeWalid A Salhab
Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
J Pediatr 150:224-8. 2007..To compare the incidence of apnea, bradycardia, or desaturation in a car seat with that in a car bed for preterm very low birth weight (< or = 1500 g) infants... - Trends in neonatal morbidity and mortality for very low birthweight infantsAvroy A Fanaroff
Department of Pediatrics, Case Western Reserve University, Cleveland, OH
Am J Obstet Gynecol 196:147.e1-8. 2007..To document the mortality and morbidity of infants weighing 501-1500 g at birth according to gestational age, birthweight, and sex... - Beware of the weaker sex: don't get too close to your twin brotherDavid K Stevenson
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94306, USA
Pediatrics 120:638-9. 2007 - Risk factors for early death among extremely low-birth-weight infantsSeetha Shankaran
Wayne State University, Detroit, Michigan, USA
Am J Obstet Gynecol 186:796-802. 2002..4; 95% CI, 1.3-1.6), and lower birth weight per 50 g (95% CI, 1.2-1.4). CONCLUSION: Early death (<12 hours of age) among extremely low-birth-weight infants may reflect an assessment of non-viability by obstetricians and neonatologists... - Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhoodSusan R Hintz
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
Arch Pediatr Adolesc Med 162:748-55. 2008..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age... - Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 monthsConrad R Cole
Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
Pediatrics 122:e573-82. 2008.... - Minimal ventilation to prevent bronchopulmonary dysplasia in extremely-low-birth-weight infantsWaldemar A Carlo
University of Alabama at Birmingham, Division of Neonatology, 35233, USA
J Pediatr 141:370-4. 2002..CONCLUSIONS: With the sample size studied, minimal ventilation did not reduce the incidence of death or BPD. The reduced ventilator support at 36 weeks in the minimal ventilation group warrants further study of this intervention... - Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 monthsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama, Birmingham, Alabama 35249, USA
Pediatrics 115:e249-54. 2005..89). As with postnatal steroids or other interventions, it is important to ensure that there are no longer-term adverse effects that outweigh neonatal benefits... - Center differences and outcomes of extremely low birth weight infantsBetty R Vohr
Women and Infants Hospital, Providence, Rhode Island 02905, USA
Pediatrics 113:781-9. 2004.... - Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomesMichele C Walsh
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
J Pediatr 146:798-804. 2005..To compare duration of ventilation to mortality and adverse neurodevelopmental outcomes among extremely low birth weight (ELBW; 501-1000 g) infants... - Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infantsBrenda B Poindexter
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Pediatrics 113:1209-15. 2004..Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known... - Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infantsWilliam Oh
Women and Infants Hospital of Rhode Island Brown University, Providence, Rhode Island 02905, USA
Pediatrics 112:773-9. 2003..To assess the association between peak total serum bilirubin (PSB) levels during the first 2 weeks of life and neurodevelopmental outcomes of extremely low birth weight (ELBW) infants at 18 to 22 months' postmenstrual age... - Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research NetworkBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Pediatrics 110:285-91. 2002..Strategies to reduce late-onset sepsis and its medical, social, and economic toll need to be addressed urgently... - A comparison of three vitamin A dosing regimens in extremely-low-birth-weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
J Pediatr 142:656-61. 2003.... - Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infantsBrenda B Poindexter
Indiana University, Indianapolis, USA
Am J Clin Nutr 77:737-43. 2003..Currently available amino acid solutions are likely to be suboptimal in their supply of phenylalanine, tyrosine, or both for these infants... - To tap or not to tap: high likelihood of meningitis without sepsis among very low birth weight infantsBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatrics 113:1181-6. 2004..Because CSF cultures were performed only half as often as BCs, this discordance in blood and CSF culture results suggests that meningitis may be underdiagnosed among VLBW infants... - Hope for perinatal prevention of cerebral palsyJon E Tyson
JAMA 290:2730-2. 2003 - Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathyNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 118:2084-93. 2006..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy... - Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertionIra Adams-Chapman
Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Pediatrics 121:e1167-77. 2008..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion... - Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failureN Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
J Perinatol 28:420-6. 2008..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure... - Outcomes for extremely low-birth-weight infants: disappointing newsJon E Tyson
JAMA 294:371-3. 2005 - Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxideSusan R Hintz
NICHD Neonatal Research Network
J Pediatr 151:16-22, 22.e1-3. 2007.... - Changes in pathogens causing early-onset sepsis in very-low-birth-weight infantsBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
N Engl J Med 347:240-7. 2002..The change in pathogens over time from predominantly gram-positive to predominantly gram-negative requires confirmation by ongoing surveillance... - Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathySeetha Shankaran
Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
N Engl J Med 353:1574-84. 2005..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain... - Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted ageMartin L Blakely
University of Tennessee Health Science Center, Memphis, Tennessee, USA
Pediatrics 117:e680-7. 2006....
Research Grants
- MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITSJon Tyson; Fiscal Year: 2003The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and ..
- CLINICAL RESEARCH CURRICULUM AND MENTORSHIP PROGRAMJon Tyson; Fiscal Year: 2004..This program is likely to be cost-effective in developing productive clinical investigators "who are competitive in seeking research support and knowledgeable about the complex issues associated with ... sound clinical research." ..
- NICHD Cooperative Multicenter Neonatal Research NetworkJon Tyson; Fiscal Year: 2006..A PI & CoPI skilled in clinical research & committed to the Network. The PI is Jon Tyson, MD, MPH, Director of the Center for Clinical Research and Evidence Based Medicine & recipient of the ..