Ming Jer Tsai

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Coup d'Etat: an orphan takes control
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Texas 77030, USA
    Endocr Rev 32:404-21. 2011
  2. pmc Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
  3. ncbi request reprint Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 15:937-49. 2004
  4. pmc COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival
    Cheng Tai Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 139:2330-9. 2012
  5. pmc Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 25:8150-65. 2005
  6. ncbi request reprint SRC-3 is required for prostate cancer cell proliferation and survival
    Hai jun Zhou
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7976-83. 2005
  7. ncbi request reprint BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration
    Mark E Pennesi
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:453-61. 2003
  8. pmc Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:8812-21. 2010
  9. pmc The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development
    Christopher T Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 24:10835-43. 2004
  10. pmc Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 120:1694-707. 2010

Collaborators

Detail Information

Publications73

  1. pmc Coup d'Etat: an orphan takes control
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Texas 77030, USA
    Endocr Rev 32:404-21. 2011
    ..In addition, we will briefly summarize some of the current findings of COUP-TFI...
  2. pmc Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways...
  3. ncbi request reprint Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 15:937-49. 2004
    ..Our results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells...
  4. pmc COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival
    Cheng Tai Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 139:2330-9. 2012
    ....
  5. pmc Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 25:8150-65. 2005
    ....
  6. ncbi request reprint SRC-3 is required for prostate cancer cell proliferation and survival
    Hai jun Zhou
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7976-83. 2005
    ..Taken together, these findings indicate that SRC-3 is an important regulator of prostate cancer proliferation and survival...
  7. ncbi request reprint BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration
    Mark E Pennesi
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:453-61. 2003
    ..Loss of BETA2/NeuroD1 results in an age-related degeneration of both rods and cones...
  8. pmc Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:8812-21. 2010
    ..Taken together, our results implicate COUP-TFII as a critical factor in tumor angiogenesis through regulation of VEGF/VEGFR-2 signaling, suggesting COUP-TFII as a candidate target for antiangiogenic therapy...
  9. pmc The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development
    Christopher T Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 24:10835-43. 2004
    ..Taken together, our results demonstrate that COUP-TFII plays an early role in limb bud outgrowth but not limb bud initiation. Also, COUP-TFII is required for appropriate development of the skeletal musculature of developing limbs...
  10. pmc Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 120:1694-707. 2010
    ..Thus, COUP-TFII is a critical factor that controls lymphangiogenesis in embryonic development and tumorigenesis in adults...
  11. ncbi request reprint Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:45-55. 2006
    ..SRC-3 is the primary coactivator for PR in breast and SRC-1 is the primary coactivator for PR in uterus...
  12. pmc COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 137:725-34. 2010
    ..Taken together, our findings reveal novel and distinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differentiation of progenitor cells, and that COUP-TFs are crucial for dorsalization of the eye...
  13. ncbi request reprint A role for bHLH transcription factors in retinal degeneration and dysfunction
    Mark E Pennesi
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Adv Exp Med Biol 572:155-61. 2006
  14. pmc Role of the steroid receptor coactivator SRC-3 in cell growth
    Ge Zhou
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:7742-55. 2003
    ..Similarly, in SRC-3 null mutant mice, AKT signaling is down-regulated in normally SRC-3-expressing tissues. Taken together, these results suggest that SRC-3 is an important modulator for mammalian cell growth...
  15. pmc ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion
    Weiwen Long
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 122:1869-80. 2012
    ..As such, ERK3 protein kinase may be an attractive target for therapeutic treatment of invasive lung cancer...
  16. ncbi request reprint Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway
    Jun Yan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:11039-46. 2006
    ..Taken together, our results clearly show that SRC-3 and AP-1 can coordinately regulate the transcription of multiple components in the IGF/AKT pathway to ensure ligand-independent cell proliferation and survival of cancer cells...
  17. ncbi request reprint Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
    Li Ru You
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 435:98-104. 2005
    ..Thus, COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway...
  18. ncbi request reprint The expression profiles of nuclear receptors in the developing and adult kidney
    Jae Mi Suh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:3412-20. 2006
    ..Our results suggest that these nuclear receptors are likely to play important physiological roles in the kidney development...
  19. pmc Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion
    Khoi Chu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Diabetes 54:1064-73. 2005
    ..These results suggest for the first time an important role for NNAT in insulin secretion and for proper beta-cell function...
  20. ncbi request reprint The transcription factor Bhlhb4 is required for rod bipolar cell maturation
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 43:779-93. 2004
    ..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
  21. ncbi request reprint COUP-TFII is essential for radial and anteroposterior patterning of the stomach
    Norio Takamoto
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2179-89. 2005
    ..Our results are consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital for epithelial-mesenchymal interactions...
  22. ncbi request reprint The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome
    Xiaotao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 124:381-92. 2006
    ..It also highlights the fact that an alternative mode of proteasome-mediated protein degradation, independent of the 19S proteasome regulatory cap, targets the SRC-3 protein for degradation...
  23. pmc Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification
    Xiaotao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 23:3763-73. 2003
    ..This study indicates that differential recruitment of coactivators by nuclear receptors determines the assembly of coactivator complexes on target promoters to mediate specific transcription signals...
  24. pmc COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 493:236-40. 2013
    ....
  25. pmc COUP-TFII is a major regulator of cell cycle and Notch signaling pathways
    Xinpu Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 26:1268-77. 2012
    ....
  26. pmc Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice
    Xiangcang Ye
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:9487-92. 2005
    ..Our results provide unique in vivo insights to the multidimensional cell-type-specific interactions between AR and coregulators...
  27. pmc Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1)
    Ping Yi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:9687-99. 2005
    ....
  28. pmc Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
    Zheng Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:7940-4. 2002
    ....
  29. pmc Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program
    Jean Francois Louet
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17868-73. 2006
    ..Collectively, these data suggest a crucial role for SRC-3 as an integrator of the complex transcriptional network controlling adipogenesis...
  30. pmc Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization
    Dong Kee Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:930-40. 2010
    ..However, COUP-TFII expression is still required in the postimplantation period to facilitate placentation...
  31. pmc Biochemical control of CARM1 enzymatic activity by phosphorylation
    Qin Feng
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:36167-74. 2009
    ..We propose that phosphorylation at Ser(217) serves as a molecular switch for controlling CARM1 enzymatic activity during the cell cycle...
  32. ncbi request reprint Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites
    Ramiro Salas
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 269:317-25. 2002
    ..In addition, COUP-TFI is coexpressed with some ETS factors in the mouse embryo. These results indicate that members of the ETS family can activate COUP-TFI gene expression...
  33. ncbi request reprint Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus
    Kevin Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 38:1204-9. 2006
    ....
  34. pmc Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
    Manuel Mark
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4453-8. 2004
    ....
  35. pmc Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction
    Norio Takamoto
    Department of Molecular and Cellular Biology and Program of Development, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 19:2299-308. 2005
    ....
  36. ncbi request reprint The nuclear orphan receptor COUP-TFI is important for differentiation of oligodendrocytes
    Hideki Yamaguchi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 266:238-51. 2004
    ..Taken together, these results suggest that COUP-TFI is an important regulator of oligodendrocyte differentiation...
  37. pmc Atrial identity is determined by a COUP-TFII regulatory network
    San Pin Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 25:417-26. 2013
    ..Collectively, our results reveal that COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad spectrum of genes that have an impact on atrial development and function...
  38. pmc Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics
    Charles E Foulds
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 51:185-99. 2013
    ..H3K4me3 templates promote specific CoR dynamics in the presence of ATP and AcCoA, as manifested by CBP/p300 and SRC-3 dismissal and SAGA and TFIID stabilization/recruitment...
  39. pmc SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration
    Weiwen Long
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030 USA
    Mol Cell 37:321-32. 2010
    ..Our study also reveals that a nuclear receptor coactivator can act in the periphery of a cell to directly mediate activation of an enzyme...
  40. pmc Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene
    Charles E Foulds
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1090-105. 2010
    ..This study is a valuable resource because it represents the first genome-wide analysis of a mammalian RNA coregulator...
  41. pmc E2/Estrogen receptor/sjogren syndrome-associated autoantigen relieves coactivator activator-induced G1/S arrest to promote breast tumorigenicity
    Yun Kyoung Kang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Mol Cell Biol 34:1670-81. 2014
    ..We propose this as one potential molecular basis for the reduced tumor incidence in autoimmune disease patients and suggest SSA as a potential therapeutic target to treat breast cancer...
  42. ncbi request reprint Neogenesis of beta-cells in adult BETA2/NeuroD-deficient mice
    Hsiang Po Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston Texas 77030, USA
    Mol Endocrinol 16:541-51. 2002
    ..Our results indicate that beta-cell neogenesis in our BETA2/NeuroD-deficient mice contributes to their survival, and these mice may provide a useful model for studying the mechanism of beta-cell regeneration...
  43. ncbi request reprint Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions
    Joo In Park
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Keio J Med 52:174-81. 2003
    ..Here we will review the molecular mechanism of COUP-TFs as repressors and activators. Also, we will review the known biological function of COUP-TFI during development and differentiation...
  44. ncbi request reprint The regulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co-activators
    Fabrice G Petit
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Ageing Dev 125:719-32. 2004
    ..These results indicate that COUP-TFII is a potential downstream target of Ets-1 and it may partially mediate the Ets-1 function in angiogenesis...
  45. pmc Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover
    Chao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 31:835-49. 2008
    ..These two sites are located within a degron of SRC-3 and are primary determinants of SRC-3 turnover. Moreover, PP1 regulates the oncogenic cell proliferation and invasion functions of SRC-3 in breast cancer cells...
  46. pmc Endocardial cushion morphogenesis and coronary vessel development require chicken ovalbumin upstream promoter-transcription factor II
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 32:e135-46. 2012
    ..Here, we investigated the role of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII, NR2F2) in cardiac organogenesis...
  47. pmc COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:3687-92. 2010
    ..Because COUP-TFII has little impact on normal adult physiological function, our results raise an interesting possibility that inhibition of COUP-TFII may offer a therapeutic approach for anticancer intervention...
  48. ncbi request reprint The expression pattern of nuclear receptors during cerebellar development
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Dyn 236:810-20. 2007
    ..Taken together, our results suggest that members of the nuclear receptor superfamily might play importantly physiological roles in the cerebellum...
  49. pmc Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover
    Chao Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:1296-308. 2007
    ....
  50. pmc Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression
    Jun Yan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:5460-8. 2008
    ..Taken together, these data suggest that SRC-3/AIB1 plays an essential role in prostate cancer cell invasion and metastasis...
  51. ncbi request reprint SRC-3/AIB1: transcriptional coactivator in oncogenesis
    Jun Yan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Acta Pharmacol Sin 27:387-94. 2006
    ..Here, we summarize recent evidence that indicates aberrant SRC-3 expression is important in hormone-sensitive and -insensitive human cancers...
  52. pmc Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia
    Li Ru You
    Department of Molecular and Cellular Biology and Developmental Biological Program, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:16351-6. 2005
    ..Our finding suggests that COUP-TFII is a likely contributor to the formation of CDH in individuals with 15q deletions, and it may also be a potential contributor to some other Bochdalek-type of CDH...
  53. pmc Generation of ES cells for conditional expression of nuclear receptors and coregulators in vivo
    San Pin Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1297-304. 2010
    ..Upon completion, it will be a very valuable resource for the scientific community. Several ES cells are currently available for distribution...
  54. pmc Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation
    Xin Xie
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:14843-8. 2011
    ..Together, our results provide insight into the mechanisms whereby a single nuclear receptor can fine-tune the lineage-specific differentiation of a progenitor cell...
  55. ncbi request reprint Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer
    Elly S W Ngan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 22:734-9. 2003
    ..Therefore, upregulation of Cdc25B in human prostate cancer and its interplay with AR may contribute to prostate cancer development...
  56. pmc Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency
    Fabrice G Petit
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA corrected
    Proc Natl Acad Sci U S A 104:6293-8. 2007
    ..The endometrial COUP-TFII might modulate the signaling between the uterus and the extraembryonic tissue for the proper formation of the placenta...
  57. ncbi request reprint BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells
    J Michael Moates
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Diabetes 52:403-8. 2003
    ..We propose that BETA2 (also termed NeuroD1) regulates betaGK promoter activity...
  58. ncbi request reprint Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior-posterior axis
    Jang Hyeon Cho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 290:125-38. 2006
    ..Thus, our data indicate that preferential expression of BETA2/NeuroD1 and TrkC in posterior lobes explains the earlier start of cell apoptosis and preferential loss of granule cells in the posterior lobes...
  59. ncbi request reprint The role of BETA2/NeuroD1 in the development of the nervous system
    Jang Hyeon Cho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Neurobiol 30:35-47. 2004
    ..The focus of this article is on the recent progress in understanding the role of BETA2/NeuroD1 in the development of the nervous system...
  60. pmc The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism
    Luoping Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 9:77-87. 2009
    ..Thus, COUP-TFII regulates adipogenesis by regulating the key molecules in adipocyte development and can serve as a target for regulating energy metabolism...
  61. pmc Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function
    Maria M Szwarc
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 9:e98664. 2014
    ..We believe such mechanistic insight may provide new molecular descriptors for diagnosis, prognosis, and/or therapy in the clinical management of female infertility. ..
  62. ncbi request reprint BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 79:402-12. 2002
    ..Together, these data suggest that BHLHB4 may modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types...
  63. ncbi request reprint Distinct temporal and spatial activities of RU486 on progesterone receptor function in reproductive organs of ovariectomized mice
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 148:2471-86. 2007
    ..This report suggests that in comparison with chronic natural hormone (P4), a mixed antagonist/agonist (RU486) induces a distinct temporal and spatial pattern of cellular genetic regulators that accompany ligand-specific gene expression...
  64. pmc COUP-TFII controls amygdala patterning by regulating neuropilin expression
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 139:1630-9. 2012
    ..Our study presented novel genetic evidence that the caudal ganglionic eminence, a distinct subpallial progenitor zone, contributes cells to the basal telencephalon, such as the BMA nucleus...
  65. pmc Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice
    Cedric Le May
    Division of Diabetes, Endocrinology and Metabolism, Department of, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:9232-7. 2006
    ..This study demonstrates that estradiol, acting, at least in part, through ERalpha, protects beta-cells from oxidative injury and prevents diabetes in mice of both genders...
  66. pmc COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity
    Isao Kurihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 3:e102. 2007
    ....
  67. pmc Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis
    Yun Kyoung Kang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7887-96. 2008
    ..This is, thus far, the only example of a nuclear receptor coregulator involved in suppression of kidney cancer and suggests potentially significant new roles for coregulators in renal cancer biology...
  68. pmc Artery and vein formation: a tug of war between different forces
    Fu Jung Lin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    EMBO Rep 8:920-4. 2007
    ....
  69. pmc Altered traveling wave propagation and reduced endocochlear potential associated with cochlear dysplasia in the BETA2/NeuroD1 null mouse
    Anping Xia
    The Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, One Baylor Plaza, NA102, Houston, TX 77030, USA
    J Assoc Res Otolaryngol 8:447-63. 2007
    ..Additionally, the presence of electrically evoked otoacoustic emissions suggests that outer hair cell reverse transduction is present, although the acoustic response is shaped by the alterations in cochlear mechanics...
  70. pmc Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum
    Bum Jun Kim
    Department of Molecular and Cellular Biology and Development Program, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 326:378-91. 2009
    ..In addition, dendritic branching of Purkinje cells was decreased in the mutant mice. Thus, our results indicate that COUP-TFII regulates growth and maturation of the mouse postnatal cerebellum through modulation of IGF-1 expression...
  71. pmc Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt
    Gustavo Ayala
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 14:7511-8. 2008
    ....
  72. pmc Essential roles of COUP-TFII in Leydig cell differentiation and male fertility
    Jun Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    PLoS ONE 3:e3285. 2008
    ..Taken together, these results indicate that COUP-TFII plays a major role in differentiation, but not the maintenance of Leydig cells...
  73. pmc Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1
    Ping Yi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 29:465-76. 2008
    ..Our results demonstrate a potent signaling mechanism for regulating SRC-3 levels in cells by coordinate enzymatic inhibition of both ubiquitin-dependent and ubiquitin-independent proteolytic pathways...

Research Grants41

  1. In vitro Expression of Hormone Regulated Genes: COUP-TFII in CDH
    Ming Jer Tsai; Fiscal Year: 2009
    ..And eventually, by screening CDH patients for the mutations in COUP-TFII, it will certainly improve the translational prospect in setting up a diagnostic kit and devise an intervention for some CDH patients. ..
  2. Steroid Receptor Coactivators (SRC-3) in Prostate Cancer
    Ming Jer Tsai; Fiscal Year: 2003
    ..abstract_text> ..
  3. Steroid Receptor Coactivators (SRC-3) in Prostate Cancer
    Ming Jer Tsai; Fiscal Year: 2002
    ..abstract_text> ..
  4. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 2002
    ..Results from this study, together with what we already know, should help us in defining the interplay between various basic helix-loop- helix and other transcription factors in pancreatic islet development. ..
  5. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 2001
    ..Results from this study, together with what we already know, should help us in defining the interplay between various basic helix-loop- helix and other transcription factors in pancreatic islet development. ..
  6. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 2001
    ..Results from this study, together with what we already know, should help us in defining the interplay between various basic helix-loop- helix and other transcription factors in pancreatic islet development. ..
  7. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 2000
    ..Results from this study, together with what we already know, should help us in defining the interplay between various basic helix-loop- helix and other transcription factors in pancreatic islet development. ..
  8. Steroid Receptor Coactivators (SRC-3) in Prostate Cancer
    Ming Jer Tsai; Fiscal Year: 2004
    ..abstract_text> ..
  9. Steroid Receptor Coactivators (SRC-3) in Prostate Cancer
    Ming Jer Tsai; Fiscal Year: 2005
    ..abstract_text> ..
  10. MECHANISM OF ACTION OF COUP-TRANSCRIPTION FACTORS
    Ming Jer Tsai; Fiscal Year: 2010
    ..Understanding COUP-TFII's mechanism of action will provide new avenues for the treatment of kidney diseases and diabetic complications. ..
  11. In vitro Expression of Hormone Regulated Genes: COUP-TFII in CDH
    Ming Jer Tsai; Fiscal Year: 2010
    ..And eventually, by screening CDH patients for the mutations in COUP-TFII, it will certainly improve the translational prospect in setting up a diagnostic kit and devise an intervention for some CDH patients. ..
  12. In vitro Expression of Hormone Regulated Genes: COUP-TFII in CDH
    Ming Jer Tsai; Fiscal Year: 2009
    ..And eventually, by screening CDH patients for the mutations in COUP-TFII, it will certainly improve the translational prospect in setting up a diagnostic kit and devise an intervention for some CDH patients. ..
  13. MECHANISM OF ACTION OF COUP TRANSCRIPTION FACTORS
    Ming Jer Tsai; Fiscal Year: 2007
    ..The proposed studies will also be pertinent to the development of more precise theories for the biochemical mechanism of action of hormones and their receptors. ..
  14. In vitro Expression of Hormone Regulated Genes: COUP-TFII in CDH
    Ming Jer Tsai; Fiscal Year: 2007
    ..And eventually, by screening CDH patients for the mutations in COUP-TFII, it will certainly improve the translational prospect in setting up a diagnostic kit and devise an intervention for some CDH patients. ..
  15. Steroid Receptor Coactivators (SRC-3) in Prostate Cancer
    Ming Jer Tsai; Fiscal Year: 2004
    ..abstract_text> ..
  16. IN VITRO EXPRESSION OF HORMONE-REGULATED GENES
    Ming Jer Tsai; Fiscal Year: 1993
    ..In addition, the following proposal should also be pertinent in elucidating a more precise hypothesis for the regulation of gene expression during differentiation, development and cancer metastasis...
  17. IN VITRO EXPRESSION OF HORMONE-REGULATED GENES
    Ming Jer Tsai; Fiscal Year: 1992
    ..In addition, the following proposal should also be pertinent in elucidating a more precise hypothesis for the regulation of gene expression during differentiation, development and cancer metastasis...
  18. IN VITRO EXPRESSION OF HORMONE-REGULATED GENES
    Ming Jer Tsai; Fiscal Year: 1991
    ..In addition, the following proposal should also be pertinent in elucidating a more precise hypothesis for the regulation of gene expression during differentiation, development and cancer metastasis...
  19. TRANSCRIP FACTORS IN THE FORMATION OF PANCREATIC ISLETS
    Ming Jer Tsai; Fiscal Year: 1999
    ..Results from this study, together with what we already know, should help us in defining the interplay between various basic helix-loop- helix and other transcription factors in pancreatic islet development. ..
  20. MECHANISM OF ACTION OF COUP-TRANSCRIPTION FACTORS
    Ming Jer Tsai; Fiscal Year: 1992
    ..The proposed studies should also be pertinent to development of more precise theories for the biochemical mechanism of action of hormone in general and more specifically, thyroid, retinoic acid and vitamin D...
  21. MECHANISM OF ACTION OF COUP-TRANSCRIPTION FACTORS
    Ming Jer Tsai; Fiscal Year: 1993
    ..The proposed studies should also be pertinent to development of more precise theories for the biochemical mechanism of action of hormone in general and more specifically, thyroid, retinoic acid and vitamin D...
  22. IN VITRO EXPRESSION OF HORMONE-REGULATED GENES
    Ming Jer Tsai; Fiscal Year: 1990
    ..In addition, the following proposal should also be pertinent in elucidating a more precise hypothesis for the regulation of gene expression during differentiation, development and cancer metastasis...