Morihito Takita

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. doi request reprint Effect of the Duration of Chronic Pancreatitis on Pancreas Islet Yield and Metabolic Outcome Following Islet Autotransplantation
    Morihito Takita
    Islet Cell Laboratory, Islet Cell Laboratory, Baylor Research Institute, 3410 Worth St 950, Dallas, TX, 75246, USA
    J Gastrointest Surg 19:1236-46. 2015
  2. doi request reprint Adverse events in clinical islet transplantation: one institutional experience
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 21:547-51. 2012
  3. pmc SUITO index for evaluation of clinical islet transplantation
    Morihito Takita
    Baylor Research Institute, 1400 8th Ave, Fort Worth, TX 76104, USA
    Cell Transplant 21:1341-7. 2012
  4. doi request reprint Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:509-16. 2012
  5. doi request reprint Islet purification method using large bottles effectively achieves high islet yield from pig pancreas
    Masayuki Shimoda
    Baylor University Medical Center, Dallas, TX, USA
    Cell Transplant 21:501-8. 2012
  6. ncbi request reprint Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1371-81. 2012
  7. doi request reprint Improved pancreatic islet isolation outcome in autologous transplantation for chronic pancreatitis
    Bashoo Naziruddin
    Baylor Simmons Transplant Institute, Dallas, TX 75246, USA
    Cell Transplant 21:553-8. 2012
  8. doi request reprint Fresh islets are more effective for islet transplantation than cultured islets
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:517-23. 2012
  9. doi request reprint Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 20:313-22. 2011
  10. doi request reprint Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 89:47-54. 2010

Collaborators

Detail Information

Publications37

  1. doi request reprint Effect of the Duration of Chronic Pancreatitis on Pancreas Islet Yield and Metabolic Outcome Following Islet Autotransplantation
    Morihito Takita
    Islet Cell Laboratory, Islet Cell Laboratory, Baylor Research Institute, 3410 Worth St 950, Dallas, TX, 75246, USA
    J Gastrointest Surg 19:1236-46. 2015
    ..The effect of duration of CP on TP-IAT has not been clarified...
  2. doi request reprint Adverse events in clinical islet transplantation: one institutional experience
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 21:547-51. 2012
    ..All SAEs resolved with no sequelae. Neoplasms and deaths were not observed in our study. The present study suggests need to improve both infusion procedure and immunosuppressive strategy from the view of preventing SAEs...
  3. pmc SUITO index for evaluation of clinical islet transplantation
    Morihito Takita
    Baylor Research Institute, 1400 8th Ave, Fort Worth, TX 76104, USA
    Cell Transplant 21:1341-7. 2012
    ..Thus, the SUITO index is excellent for assessing important endpoints (insulin independence, reduction of hypoglycemia, improved quality of life) after allogeneic islet transplantation...
  4. doi request reprint Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:509-16. 2012
    ..In summary, there are no other trypsin inhibitors that are more effective than ulinastatin. Based on these data, we now use ET-Kyoto solution with ulinastatin for clinical islet transplantation...
  5. doi request reprint Islet purification method using large bottles effectively achieves high islet yield from pig pancreas
    Masayuki Shimoda
    Baylor University Medical Center, Dallas, TX, USA
    Cell Transplant 21:501-8. 2012
    ..COBE), which indicated that bottle method can reduce shear force during purification. Our new purification using top loading bottle method enabled us to obtain a high yield of porcine islets from marginal pancreata...
  6. ncbi request reprint Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1371-81. 2012
    ..Hence, released HMGB1 levels from islets should be a useful marker to evaluate the potency of isolated islets...
  7. doi request reprint Improved pancreatic islet isolation outcome in autologous transplantation for chronic pancreatitis
    Bashoo Naziruddin
    Baylor Simmons Transplant Institute, Dallas, TX 75246, USA
    Cell Transplant 21:553-8. 2012
    ..The techniques applied for islet isolations from normal pancreata are showing promise for fibrotic pancreata from CP patients...
  8. doi request reprint Fresh islets are more effective for islet transplantation than cultured islets
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:517-23. 2012
    ..Based on these data, we have transplanted fresh islets without culture for our current clinical islet transplantation protocol...
  9. doi request reprint Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 20:313-22. 2011
    ..Pancreata from patients with higher BMI could obtain higher islet yield in the setting of autologous islet cell transplantation for chronic pancreatitis...
  10. doi request reprint Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 89:47-54. 2010
    ..In this study, we evaluated optimal temperature for culture/preservation of isolated human islets before transplantation...
  11. doi request reprint Evaluation of osmolality of density gradient for human islet purification
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:493-500. 2012
    ..Since the density of islet and acinar tissue is changed according to osmolality, the density adjustment is important when using several osmolality solutions...
  12. pmc An effective purification method using large bottles for human pancreatic islet isolation
    Masayuki Shimoda
    Baylor University Medical Center, Dallas, TX
    Islets 4:398-404. 2012
    ..In vivo viability was also significantly higher in the top group compared with the COBE group. In conclusion, the top-loading bottle method could improve the quality and quantity of human islets after purification...
  13. doi request reprint Improvement of porcine islet isolation by inhibition of trypsin activity during pancreas preservation and digestion using α1-antitrypsin
    Masayuki Shimoda
    Baylor University Medical Center, Dallas, TX, USA
    Cell Transplant 21:465-71. 2012
    ..Inhibition of trypsin activity by Aralast could improve porcine islet isolation...
  14. ncbi request reprint Large human islets secrete less insulin per islet equivalent than smaller islets in vitro
    Yasutaka Fujita
    Baylor All Saints Islet Cell Laboratory, Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Islets 3:1-5. 2011
    ..This method revealed that large human islets secrete less insulin per IEQ. Thus the distribution of islet size must be monitored when the glucose stimulation test is conducted...
  15. pmc Low temperature condition prevents hypoxia-induced islet cell damage and HMGB1 release in a mouse model
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1361-70. 2012
    ..05). In conclusion, low temperature conditions could prevent hypoxia-induced islet cell damage, inflammatory reactions in islets, and HMGB1 release and expression. Low temperature conditions should improve the efficacy of isolated islets...
  16. doi request reprint Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1β and TNF-α
    Shinichi Matsumoto
    Baylor All Saints Islet Cell Laboratory, Fort Worth, TX 76104, USA
    Cell Transplant 20:1641-7. 2011
    ..This protocol enabled us to perform successful single-donor islet transplantations. Further large-scale studies are necessary to confirm these results and clarify the mechanism of each component...
  17. doi request reprint Secretory unit of islet transplant objects (SUITO) index can predict severity of hypoglycemic episodes in clinical islet cell transplantation
    Morihito Takita
    Islet Cell Laboratory, Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Cell Transplant 21:91-8. 2012
    ..521 (p < 0.001) between that of severe events and the SUITO index. The SUITO index could predict the severity of hypoglycemic episodes in type 1 diabetic patients who received islet cell transplantations...
  18. doi request reprint New stepwise cooling system for short-term porcine islet preservation
    Tetsuya Ikemoto
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, USA
    Pancreas 39:960-3. 2010
    ..Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of hepatocyte. In this study, we examined the KFC for porcine islet preservation...
  19. pmc Safety and tolerability of the T-cell depletion protocol coupled with anakinra and etanercept for clinical islet cell transplantation
    Morihito Takita
    Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA
    Clin Transplant 26:E471-84. 2012
    ....
  20. doi request reprint Characterization of human pancreatic progenitor cells
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Cell Transplant 19:879-86. 2010
    ..Although the duplications of these cells were limited, this approach could provide a potential new source of insulin-producing cells for transplantation...
  21. ncbi request reprint Japanese herbal medicine TJ-48 prevents autoimmune diabetes in NOD mice
    Tetsuya Ikemoto
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Am J Chin Med 39:743-56. 2011
    ..The effect of TJ-48 on decreasing Tregs was less apparent in the NOD mice model. TJ-48 inhibited lymphocyte infiltrations into islets, which led to preventing the onset of T1DM in NOD mice...
  22. pmc Impact of tissue volume and purification on clinical autologous islet transplantation for the treatment of chronic pancreatitis
    Shinichi Matsumoto
    Baylor All Saints Islet Cell Laboratory, Fort Worth, TX 76104, USA
    Cell Transplant 21:625-32. 2012
    ..Therefore, islet purification can reduce the risk of complications and may improve clinical outcome for autologous islet transplantation when tissue volume is large...
  23. pmc Establishment of a prolonged pancreas preservation model for islet isolation research in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Islets 3:376-80. 2011
    ..Thus, this model might be useful for prehuman islet isolation screening research, reserving research using human pancreata for the most promising approaches...
  24. pmc Cluster analysis of self-monitoring blood glucose assessments in clinical islet cell transplantation for type 1 diabetes
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Diabetes Care 34:1799-803. 2011
    ..Cluster analysis was performed on the results of self-monitoring of blood glucose (SMBG) to discriminate islet graft function after islet cell transplantation (ICT) in patients with type 1 diabetes...
  25. doi request reprint Seven consecutive successful clinical islet isolations with pancreatic ductal injection
    Shinichi Matsumoto
    Baylor Research Institute, Fort Worth, TX 76104, USA
    Cell Transplant 19:291-7. 2010
    ..Ductal injection significantly improved quantity and quality of isolated islets and resulted in high success rate of clinical islet transplantation. This simple modification will reduce the risk of failure of clinical islet isolation...
  26. doi request reprint Emergence of a broad repertoire of GAD65-specific T-cells in type 1 diabetes patients with graft dysfunction after allogeneic islet transplantation
    Daisuke Chujo
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Cell Transplant 21:2783-95. 2012
    ..Thus, our observations support the hypothesis that these islet-specific T-cells contribute to the development of chronic islet graft dysfunction...
  27. pmc One hundred human pancreatic islet isolations at Baylor Research Institute
    Morihito Takita
    Baylor Research Institute, Fort Worth Campus, Fort Worth, Texas Takita, Matsumoto, Noguchi, Sugimoto, Itoh the Department of Internal Medicine Shimoda, Department of Surgery Lamont, and Division of Gastroenterology Lara, Baylor University Medical Center at Dallas Baylor Institute for Immunology Research, Dallas, Texas Chujo and Baylor Regional Transplant Institute, Dallas, Texas Onaca, Naziruddin, Klintmalm, Levy
    Proc (Bayl Univ Med Cent) 23:341-8. 2010
    ..576 ± 49 × 10(3) IE in autologous ICT (P = 0.59). This retrospective study revealed that the BIIM provided favorable outcomes for both autologous and allogeneic ICT...
  28. doi request reprint Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors
    Koji Sugimoto
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA The Departments of Surgery, Tokushima University, Tokushima, Japan
    Transpl Int 27:408-15. 2014
    ..Moreover, DST treated with HDACi prolonged graft survival relative to controls in mice islet transplantation. DST with HDACi may therefore have utility in islet transplantation. ..
  29. doi request reprint Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Pancreas 40:103-8. 2011
    ....
  30. pmc Elevation of high-mobility group box 1 after clinical autologous islet transplantation and its inverse correlation with outcomes
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 23:153-65. 2014
    ..Therefore, anti-HMGB1 therapy might be a candidate for further improving the outcomes of clinical AIT. ..
  31. pmc Pancreatic ductal perfusion at organ procurement enhances islet yield in human islet isolation
    Morihito Takita
    From the Islet Cell Laboratory, Baylor Research Institute, Dallas, Institute for Biomedical Studies, Baylor University, Waco, and Baylor Annette C and Harold C Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
    Pancreas 43:1249-55. 2014
    ..Pancreas preservation is a major factor influencing the results of islet cell transplantation. This study evaluated the effects of 2 different solutions for pancreatic ductal perfusion (PDP) at organ procurement...
  32. pmc Alleviation of instant blood-mediated inflammatory reaction in autologous conditions through treatment of human islets with NF-κB inhibitors
    Mazhar A Kanak
    1 The Institute of Biomedical Studies, Baylor University, Waco, TX 2 Islet Cell Laboratory, Baylor Research Institute, Dallas, TX 3 Baylor Annette C and Harold C Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX 4 Address correspondence to Bashoo Naziruddin, Ph D, 3410 Worth Street, Suite 950, Dallas, TX 75246
    Transplantation 98:578-84. 2014
    ..We investigated how treating islets with NF-κB inhibitors affected IBMIR using an in vitro human autologous blood islet model...
  33. pmc NFAT targets signaling molecules to gene promoters in pancreatic β-cells
    Michael C Lawrence
    Islet Cell Laboratory M C L, N B A, F K, R S, I S, M T, Baylor Research Institute, Dallas, Texas 75226 Department of Pharmacology K M, University of Texas Southwestern Medical Center, Dallas, Texas 75390 Institute of Biomedical Studies M K, Baylor University, Waco, Texas 76798 and Annette C and Harold C Simmons Transplant Institute M F L, B N, Baylor University Medical Center, Dallas, Texas 75246
    Mol Endocrinol 29:274-88. 2015
    ..These findings have therapeutic potential for suppressing islet inflammation while preserving islet function in diabetes and islet transplantation. ..
  34. doi request reprint Iodixanol-controlled density gradient during islet purification improves recovery rate in human islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 87:1629-35. 2009
    ..In this study, we evaluated the effectiveness of iodixanol-controlled density gradients on the islet purification step...
  35. pmc Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis
    Morihito Takita
    Baylor Research Institute, Fort Worth Campus, Fort Worth, Texas Takita, Matsumoto, Noguchi, Itoh, Sugimoto Baylor Regional Transplant Institute, Dallas, Texas Naziruddin, Onaca, Levy Department of Internal Medicine Shimoda, Department of Surgery Lamont, and Division of Gastroenterology Lara, Baylor University Medical Center, Dallas, Texas and Baylor Institute for Immunology Research, Dallas, Texas Chujo
    Proc (Bayl Univ Med Cent) 23:115-20. 2010
    ....
  36. doi request reprint CD11b(+) cells in donor-specific transfusion prolonged allogenic skin graft survival through indoleamine 2,3-dioxygenase
    Tetsuya Ikemoto
    Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
    Cell Immunol 283:81-90. 2013
    ..Graft survival with DST using IDO antagonist (1MT) were not prolonged. In conclusion, DST allows induction of donor-specific tolerance which involves Foxp3(+)CD4(+)CD25(+) T cells and IDO expression. ..
  37. doi request reprint Evaluation of MicroRNA375 as a Novel Biomarker for Graft Damage in Clinical Islet Transplantation
    Mazhar A Kanak
    1 Institute of Biomedical Studies, Baylor University, Waco, TX 2 Islet Cell Laboratory, Baylor Research Institute, Dallas, TX 3 Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester, UK 4 Baylor Annette C and Harold C Simmons Transplant Institute, Dallas, TX
    Transplantation 99:1568-73. 2015
    ..Early and sensitive detection of islet graft damage is essential for improving posttransplant outcomes. MicroRNA 375 (miR375) has been reported as a biomarker of pancreatic β-cell death in small animal models...