Morihito Takita

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. doi request reprint Adverse events in clinical islet transplantation: one institutional experience
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 21:547-51. 2012
  2. ncbi request reprint SUITO index for evaluation of clinical islet transplantation
    Morihito Takita
    Baylor Research Institute, 1400 8th Ave, Fort Worth, TX 76104, USA
    Cell Transplant 21:1341-7. 2012
  3. ncbi request reprint Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1371-81. 2012
  4. doi request reprint Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:509-16. 2012
  5. doi request reprint Fresh islets are more effective for islet transplantation than cultured islets
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:517-23. 2012
  6. doi request reprint Evaluation of osmolality of density gradient for human islet purification
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:493-500. 2012
  7. doi request reprint Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 89:47-54. 2010
  8. doi request reprint Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 20:313-22. 2011
  9. ncbi request reprint Low temperature condition prevents hypoxia-induced islet cell damage and HMGB1 release in a mouse model
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1361-70. 2012
  10. ncbi request reprint Large human islets secrete less insulin per islet equivalent than smaller islets in vitro
    Yasutaka Fujita
    Baylor All Saints Islet Cell Laboratory, Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Islets 3:1-5. 2011

Detail Information

Publications25

  1. doi request reprint Adverse events in clinical islet transplantation: one institutional experience
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 21:547-51. 2012
    ..All SAEs resolved with no sequelae. Neoplasms and deaths were not observed in our study. The present study suggests need to improve both infusion procedure and immunosuppressive strategy from the view of preventing SAEs...
  2. ncbi request reprint SUITO index for evaluation of clinical islet transplantation
    Morihito Takita
    Baylor Research Institute, 1400 8th Ave, Fort Worth, TX 76104, USA
    Cell Transplant 21:1341-7. 2012
    ..Thus, the SUITO index is excellent for assessing important endpoints (insulin independence, reduction of hypoglycemia, improved quality of life) after allogeneic islet transplantation...
  3. ncbi request reprint Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1371-81. 2012
    ..Hence, released HMGB1 levels from islets should be a useful marker to evaluate the potency of isolated islets...
  4. doi request reprint Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:509-16. 2012
    ..In summary, there are no other trypsin inhibitors that are more effective than ulinastatin. Based on these data, we now use ET-Kyoto solution with ulinastatin for clinical islet transplantation...
  5. doi request reprint Fresh islets are more effective for islet transplantation than cultured islets
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:517-23. 2012
    ..Based on these data, we have transplanted fresh islets without culture for our current clinical islet transplantation protocol...
  6. doi request reprint Evaluation of osmolality of density gradient for human islet purification
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX, USA
    Cell Transplant 21:493-500. 2012
    ..Since the density of islet and acinar tissue is changed according to osmolality, the density adjustment is important when using several osmolality solutions...
  7. doi request reprint Low-temperature preservation of isolated islets is superior to conventional islet culture before islet transplantation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 89:47-54. 2010
    ..In this study, we evaluated optimal temperature for culture/preservation of isolated human islets before transplantation...
  8. doi request reprint Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Cell Transplant 20:313-22. 2011
    ..Pancreata from patients with higher BMI could obtain higher islet yield in the setting of autologous islet cell transplantation for chronic pancreatitis...
  9. ncbi request reprint Low temperature condition prevents hypoxia-induced islet cell damage and HMGB1 release in a mouse model
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Cell Transplant 21:1361-70. 2012
    ..05). In conclusion, low temperature conditions could prevent hypoxia-induced islet cell damage, inflammatory reactions in islets, and HMGB1 release and expression. Low temperature conditions should improve the efficacy of isolated islets...
  10. ncbi request reprint Large human islets secrete less insulin per islet equivalent than smaller islets in vitro
    Yasutaka Fujita
    Baylor All Saints Islet Cell Laboratory, Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Islets 3:1-5. 2011
    ..This method revealed that large human islets secrete less insulin per IEQ. Thus the distribution of islet size must be monitored when the glucose stimulation test is conducted...
  11. doi request reprint Improving efficacy of clinical islet transplantation with iodixanol-based islet purification, thymoglobulin induction, and blockage of IL-1β and TNF-α
    Shinichi Matsumoto
    Baylor All Saints Islet Cell Laboratory, Fort Worth, TX 76104, USA
    Cell Transplant 20:1641-7. 2011
    ..This protocol enabled us to perform successful single-donor islet transplantations. Further large-scale studies are necessary to confirm these results and clarify the mechanism of each component...
  12. doi request reprint Secretory unit of islet transplant objects (SUITO) index can predict severity of hypoglycemic episodes in clinical islet cell transplantation
    Morihito Takita
    Islet Cell Laboratory, Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Cell Transplant 21:91-8. 2012
    ..521 (p < 0.001) between that of severe events and the SUITO index. The SUITO index could predict the severity of hypoglycemic episodes in type 1 diabetic patients who received islet cell transplantations...
  13. doi request reprint Safety and tolerability of the T-cell depletion protocol coupled with anakinra and etanercept for clinical islet cell transplantation
    Morihito Takita
    Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA
    Clin Transplant 26:E471-84. 2012
    ....
  14. doi request reprint Characterization of human pancreatic progenitor cells
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Cell Transplant 19:879-86. 2010
    ..Although the duplications of these cells were limited, this approach could provide a potential new source of insulin-producing cells for transplantation...
  15. ncbi request reprint Japanese herbal medicine TJ-48 prevents autoimmune diabetes in NOD mice
    Tetsuya Ikemoto
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Am J Chin Med 39:743-56. 2011
    ..The effect of TJ-48 on decreasing Tregs was less apparent in the NOD mice model. TJ-48 inhibited lymphocyte infiltrations into islets, which led to preventing the onset of T1DM in NOD mice...
  16. doi request reprint Impact of tissue volume and purification on clinical autologous islet transplantation for the treatment of chronic pancreatitis
    Shinichi Matsumoto
    Baylor All Saints Islet Cell Laboratory, Fort Worth, TX 76104, USA
    Cell Transplant 21:625-32. 2012
    ..Therefore, islet purification can reduce the risk of complications and may improve clinical outcome for autologous islet transplantation when tissue volume is large...
  17. doi request reprint Seven consecutive successful clinical islet isolations with pancreatic ductal injection
    Shinichi Matsumoto
    Baylor Research Institute, Fort Worth, TX 76104, USA
    Cell Transplant 19:291-7. 2010
    ..Ductal injection significantly improved quantity and quality of isolated islets and resulted in high success rate of clinical islet transplantation. This simple modification will reduce the risk of failure of clinical islet isolation...
  18. doi request reprint New stepwise cooling system for short-term porcine islet preservation
    Tetsuya Ikemoto
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, USA
    Pancreas 39:960-3. 2010
    ..Recently, we developed a new cooling and preservation (Keep and Fresh [KFC]; FUJIYA Co, Tokushima, Japan) system, which can maintain viability of hepatocyte. In this study, we examined the KFC for porcine islet preservation...
  19. pmc Cluster analysis of self-monitoring blood glucose assessments in clinical islet cell transplantation for type 1 diabetes
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX, USA
    Diabetes Care 34:1799-803. 2011
    ..Cluster analysis was performed on the results of self-monitoring of blood glucose (SMBG) to discriminate islet graft function after islet cell transplantation (ICT) in patients with type 1 diabetes...
  20. pmc Establishment of a prolonged pancreas preservation model for islet isolation research in mice
    Takeshi Itoh
    Baylor Research Institute, Dallas, TX, USA
    Islets 3:376-80. 2011
    ..Thus, this model might be useful for prehuman islet isolation screening research, reserving research using human pancreata for the most promising approaches...
  21. doi request reprint Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis
    Morihito Takita
    Baylor Research Institute Fort Worth Campus, Fort Worth, TX 76104, USA
    Pancreas 40:103-8. 2011
    ....
  22. pmc One hundred human pancreatic islet isolations at Baylor Research Institute
    Morihito Takita
    Baylor Research Institute, Fort Worth Campus, Fort Worth, Texas Takita, Matsumoto, Noguchi, Sugimoto, Itoh the Department of Internal Medicine Shimoda, Department of Surgery Lamont, and Division of Gastroenterology Lara, Baylor University Medical Center at Dallas Baylor Institute for Immunology Research, Dallas, Texas Chujo and Baylor Regional Transplant Institute, Dallas, Texas Onaca, Naziruddin, Klintmalm, Levy
    Proc (Bayl Univ Med Cent) 23:341-8. 2010
    ..576 ± 49 × 10(3) IE in autologous ICT (P = 0.59). This retrospective study revealed that the BIIM provided favorable outcomes for both autologous and allogeneic ICT...
  23. pmc Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis
    Morihito Takita
    Baylor Research Institute, Fort Worth Campus, Fort Worth, Texas Takita, Matsumoto, Noguchi, Itoh, Sugimoto Baylor Regional Transplant Institute, Dallas, Texas Naziruddin, Onaca, Levy Department of Internal Medicine Shimoda, Department of Surgery Lamont, and Division of Gastroenterology Lara, Baylor University Medical Center, Dallas, Texas and Baylor Institute for Immunology Research, Dallas, Texas Chujo
    Proc (Bayl Univ Med Cent) 23:115-20. 2010
    ....
  24. doi request reprint Iodixanol-controlled density gradient during islet purification improves recovery rate in human islet isolation
    Hirofumi Noguchi
    Baylor All Saints Medical Center, Baylor Research Institute, Fort Worth, TX 76104, USA
    Transplantation 87:1629-35. 2009
    ..In this study, we evaluated the effectiveness of iodixanol-controlled density gradients on the islet purification step...
  25. doi request reprint CD11b(+) cells in donor-specific transfusion prolonged allogenic skin graft survival through indoleamine 2,3-dioxygenase
    Tetsuya Ikemoto
    Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA Baylor Research Institute, Fort Worth Campus, 1400 Eight Avenue, Fort Worth, TX 76104, USA Department of Digestive and Transplant Surgery, The University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan Electronic address
    Cell Immunol 283:81-90. 2013
    ..Graft survival with DST using IDO antagonist (1MT) were not prolonged. In conclusion, DST allows induction of donor-specific tolerance which involves Foxp3(+)CD4(+)CD25(+) T cells and IDO expression. ..