Research Topics
| JANET STRINGERSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of extracellular calcium in the hippocampus in vivo during epileptiform activity--role of astrocytesJanet L Stringer
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
Epilepsy Res 74:155-62. 2007..The results suggest that maximal decreases in [Ca(2+)](o) occur in the hippocampus in response to burst firing of neurons and that astrocytes play a minimal role in the regulation of [Ca(2+)](o) during epileptiform activity...- During afterdischarges in the young rat in vivo extracellular potassium is not elevated above adult levelsJ L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Brain Res Dev Brain Res 91:136-9. 1996..There was no difference in the peak level of potassium attained during an afterdischarge in any of the age groups tested... - Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous systemJanet L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
J Comp Neurol 471:289-97. 2004..These results suggest that NQO1 has a role in myelination in the central nervous system or in the insulating/wrapping function of glial cells... - Epileptogenic activity of granulomas associated with murine cysticercosisJanet L Stringer
Departments of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Exp Neurol 183:532-6. 2003..Further experiments are needed to dissect out the exact seizure mediator in the granuloma extracts... - Effects of glial toxins on extracellular acidification in the hippocampal CA1 region in vivoJanet L Stringer
Department of Pharmacology and Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
Epilepsy Res 54:163-70. 2003..This acidification may contribute to feedback regulation of neuronal excitability... - Modulation of the in vivo effects of gabapentin by vigabatrin and SKF89976AJanet L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Res 52:129-37. 2002..The data also suggest that the combination of VGB and GBP may be clinically less effective than the use of GBP alone... - Developmental expression of serum response factor in the rat central nervous systemJanet L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Brain Res Dev Brain Res 138:81-6. 2002..These data suggest that SRF has a significant function in the early post-natal development of the CNS... - The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipineJ L Stringer
Depurtncnt of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Res 41:155-62. 2000..However, calcium channel block could still be the basis for the antiepileptic effect of gabapentin and its analogs... - A comparison of topiramate and acetazolamide on seizure duration and paired-pulse inhibition in the dentate gyrus of the ratJ L Stringer
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Epilepsy Res 40:147-53. 2000..These results indicate that topiramate has an anticonvulsant-related effect (increase in paired-pulse inhibition), which may contribute to its antiepileptic effect, that is not dependent on its ability to inhibit carbonic anhydrase... - Ethosuximide specifically antagonizes the effect of pentylenetetrazol in the rat entorhinal cortexJ L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Res 25:69-77. 1996..These results support the hypotheses that ethosuximide can antagonize this effect of PTZ... - Effect of seizures and diuretics on the osmolality of the cerebrospinal fluidJ L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Brain Res 745:328-30. 1997..Furosemide (10 mg/kg) blocked seizure activity by kainic acid, while mannitol (1 g/kg) did not. The results suggest that the antiepileptic effect of furosemide is due to a direct CNS effect not related to a change in CSF osmolality... - Is cell death necessary for hippocampal mossy fiber sprouting?J L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Res 27:67-76. 1997..This supports the hypothesis that alterations in intrinsic neural excitability and impulse activity from the dentate gyrus can result in growth of axonal processes in the adult rat brain... - Regulation of extracellular potassium in the developing hippocampusJ L Stringer
Department of Pharmacology and Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Brain Res Dev Brain Res 110:97-103. 1998.... - The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor receptor activationJ L Stringer
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Res 33:169-76. 1999..These results suggest that gabapentin produces its effect on paired-pulse inhibition independent from the effect of baclofen and not through non-vesicular release of GABA interacting with the GABA(B) receptor system... - Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult ratsXiao yuan Lian
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 27:12007-11. 2007..These data demonstrate that F1,6BP has significant anticonvulsant efficacy... - Anticonvulsant and neuroprotective effects of ginsenosides in ratsXiao-Yuan Lian
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Epilepsy Res 70:244-56. 2006..In addition, all of the ginseng products had significant neuroprotective activity beyond the reduction in seizure severity and duration... - Protective effects of ginseng components in a rodent model of neurodegenerationXiao-Yuan Lian
Department of Pharmacology, Baylor College of Medicine, Houston 77030, USA
Ann Neurol 57:642-8. 2005..The results demonstrate that some of the ginsenosides have neuroprotective activity, and that a partial purification of whole ginseng to concentrate the neuroprotective components may have utility as a neuroprotective agent... - Anticonvulsant activity of ginseng on seizures induced by chemical convulsantsXiao-Yuan Lian
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
Epilepsia 46:15-22. 2005..A partial purification of the whole extract that concentrates the Rb1 and Rb3 ginsenosides has significant anticonvulsant properties... - Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsantsXiao yuan Lian
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Epilepsy Res 60:41-52. 2004..The data demonstrate that inhibition of aconitase in astrocytes lowers the doses of both kainic acid and pilocarpine that will cause behavioral seizures and may increase neuronal vulnerability to seizures... - Astrocytes contribute to regulation of extracellular calcium and potassium in the rat cerebral cortex during spreading depressionXiao-Yuan Lian
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Brain Res 1012:177-84. 2004..These findings demonstrate that astrocytes contribute to the regulation of both potassium and calcium during and after a stress to the ionic homeostatic mechanisms... - Energy failure in astrocytes increases the vulnerability of neurons to spreading depressionXiao yuan Lian
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Eur J Neurosci 19:2446-54. 2004..The neuroprotective effects of dimethyl sulfoxide, deferoxamine and fructose-1,6-bisphosphate suggest that oxidative stress contributes to the neurotoxicity in this situation... - Effects of antiepileptic drugs on extracellular pH regulation in the hippocampal CA1 region in vivoAhmed M Aribi
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA
Epilepsy Res 49:143-51. 2002..The change in alkalinization does not appear to be related to the mechanism of the antiepileptic effect of the drugs that were tested... - Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizuresKaiping Xu
Baylor College of Medicine, Houston, TX 77030, USA
Epilepsy Behav 13:77-82. 2008..The lack of consistent anticonvulsant effect suggests that the antioxidant activity of the herbal preparations cannot account for the delay in seizure onset... - Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's diseaseWei Wang
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Gerontol A Biol Sci Med Sci 63:127-34. 2008..The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene... - Pharmacokinetics of fructose-1,6-diphosphate after intraperitoneal and oral administration to adult ratsKaiping Xu
Department of Pharmacology, Baylor College of Medicine, United States
Pharmacol Res 57:234-8. 2008..Finally, the experiments demonstrate a significant increase in brain levels of FDP after oral administration. These data suggest that an oral formulation of FDP might be developed for treatment of neurological disease...
Research Grants
- IONIC HOMEOSTASIS AND SEIZURE REGULATIONJANET STRINGER; Fiscal Year: 2003..abstract_text> ..
- IONIC HOMEOSTASIS AND SEIZURE REGULATIONJANET STRINGER; Fiscal Year: 2006..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..